{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:53:28Z","timestamp":1786114408240,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["AD23026319"],"award-info":[{"award-number":["AD23026319"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2022GXNSFDA035072"],"award-info":[{"award-number":["2022GXNSFDA035072"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2021GXNSFFA220003"],"award-info":[{"award-number":["2021GXNSFFA220003"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["AA24011005"],"award-info":[{"award-number":["AA24011005"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22264007"],"award-info":[{"award-number":["22264007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22468016"],"award-info":[{"award-number":["22468016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jpha.2025.101500","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:58:26Z","timestamp":1764291506000},"page":"101500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuproptosis tracker: Visualizing organelle dynamics with a dual-targeted fluorescent probe"],"prefix":"10.1016","volume":"16","author":[{"given":"Furao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbiao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4183","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2025.101500_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.abo3959","article-title":"Copper-induced cell death","volume":"375","author":"Kahlson","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jpha.2025.101500_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: a copper-triggered modality of mitochondrial cell death","volume":"32","author":"Tang","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.jpha.2025.101500_bib3","article-title":"Cell death pathway regulation by functional nanomedicines for robust antitumor immunity","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jpha.2025.101500_bib4","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","article-title":"Cuproptosis: cellular and molecular mechanisms underlying copper-induced cell death","volume":"82","author":"Cobine","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jpha.2025.101500_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41392-022-01014-x","article-title":"Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jpha.2025.101500_bib6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.tibs.2024.04.002","article-title":"Protein lipoylation: Mitochondria, cuproptosis, and beyond","volume":"49","author":"Lin","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jpha.2025.101500_bib7","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1021\/acs.analchem.2c05021","article-title":"Bifunctional single-molecular fluorescent probe: visual detection of mitochondrial SO2 and membrane potential","volume":"95","author":"Ai","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131937","article-title":"A bifunctional fluorescent probe for imaging lipid droplets polarity\/SO2 during ferroptosis","volume":"365","author":"Xie","year":"2022","journal-title":"Sens. Actuators, B Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/procel\/pwae003","article-title":"Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond","volume":"15","author":"Mao","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.jpha.2025.101500_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136470","article-title":"Dynamic monitoring of SO2 changes during ferroptosis using a light-controlled lipid droplets-targeting probe","volume":"420","author":"Wang","year":"2024","journal-title":"Sens. Actuators, B Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib11","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1021\/acs.analchem.1c04806","article-title":"pH-dominated selective imaging of lipid droplets and mitochondria via a polarity-reversible ratiometric fluorescent probe","volume":"94","author":"Bai","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.devcel.2024.01.003","article-title":"A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis","volume":"59","author":"Wang","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jpha.2025.101500_bib13","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1038\/s41467-020-20067-6","article-title":"A dual-labeling probe to track functional mitochondria\u2013lysosome interactions in live cells","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2025.101500_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.139023","article-title":"A multifunctional fluorescent probe for dual-color visualization of intracellular mitochondria and lipid droplets and monitoring of SO2 in vivo","volume":"451","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101500_bib15","article-title":"Mitochondria and myocardial ischemia\/reperfusion injury: effects of Chinese herbal medicine and the underlying mechanisms","volume":"15","author":"Zhang","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2025.101500_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.146749","article-title":"Cuproptosis accompanied by obvious \u2022OH generation revealed with an ultrasensitive NIR fluorescence probe","volume":"476","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101500_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113858","article-title":"Simultaneous visualization and quantification of copper (II) ions in Alzheimer's disease by a near-infrared fluorescence probe","volume":"198","author":"Zhou","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101500_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101144","article-title":"Elucidating the role of artificial intelligence in drug development from the perspective of drug-target interactions","volume":"15","author":"Wang","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2025.101500_bib19","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s11426-024-2493-2","article-title":"AND-logic-gate measurement of bisulfite and viscosity using a dual-lock-and-key fluorescent probe","volume":"68","author":"Liang","year":"2025","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ccr.2019.03.001","article-title":"Reaction-based fluorescent probes for SO2 derivatives and their biological applications","volume":"388","author":"Li","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jpha.2025.101500_bib21","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.cclet.2018.08.012","article-title":"Recent progress in michael addition-based fluorescent probes for sulfur dioxide and its derivatives","volume":"29","author":"Xu","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2025.101500_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134459","article-title":"Ratiometric quantification and visual detection of sulfur dioxide residues using a coumarin-derived fluorescent probe","volume":"395","author":"Mi","year":"2023","journal-title":"Sens. Actuators, B Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib23","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1021\/jacs.0c00992","article-title":"Employing an ICT-FRET integration platform for the real-time tracking of SO2 metabolism in cancer cells and tumor models","volume":"142","author":"Zhang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2025.101500_bib24","doi-asserted-by":"crossref","first-page":"18574","DOI":"10.1021\/acs.analchem.4c05488","article-title":"Dual-response functionalized mitochondrial fluorescent probe for a double whammy monitoring of hypochlorite and sulfur dioxide in heat shock via time scales","volume":"96","author":"Cao","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136291","article-title":"Rational design of an ultrabright quinolinium-fused rhodamine turn-on fluorescent probe for highly sensitive detection of SO2 derivatives: applications in food safety and bioimaging","volume":"480","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101500_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aca.2020.09.002","article-title":"A synergetic FRET\/ICT platform-based fluorescence probe for ratiometric imaging of bisulfite in lipid droplets","volume":"1137","author":"Yan","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpha.2025.101500_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126605","article-title":"A fluorescent probe for detecting bisulfite\/sulfite in lipid droplets and tracking the dynamics of lipid droplets","volume":"279","author":"Huang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2025.101500_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134181","article-title":"Bifunctional fluorescent probe for the recognition of hydrazine and bisulfite in lipid droplets","volume":"393","author":"Han","year":"2023","journal-title":"Sens. Actuators, B Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.137024","article-title":"A multifunctional fluorescent probe for monitoring of SO2 and viscosity and its application in food, ferroptosis, and bioimaging","volume":"426","author":"Yang","year":"2025","journal-title":"Sens. Actuators, B Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib30","article-title":"A colorimetric and ratiometric fluorescent paper chip for biogenic amine monitoring based on a simple pH-sensitive AIEgen","volume":"450","author":"Chen","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101500_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202212980","article-title":"Fast and visual detection of biogenic amines and food freshness based on ICT-induced ratiometric fluorescent probes","volume":"33","author":"Miao","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jpha.2025.101500_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133165","article-title":"A near-infrared fluorescent probe for rapid and on-site detection of sulfur dioxide derivative in biological, food and environmental systems","volume":"465","author":"Shang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101500_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101041","article-title":"Development of a smartphone-integrated handheld automated biochemical analyzer for point-of-care testing of urinary albumin","volume":"15","author":"Wu","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2025.101500_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116778","article-title":"A novel theranostic strategy for myocardial infarction through neutralization of endogenous SO2 using an endoplasmic reticulum-targeted fluorescent probe","volume":"277","author":"Jiang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jpha.2025.101500_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.503","article-title":"Activated aggregation-induced emission therapeutics agents for triggering regulated cell death","volume":"5","author":"Zhao","year":"2024","journal-title":"Aggregate"},{"key":"10.1016\/j.jpha.2025.101500_bib36","article-title":"Nanoparticles synergize ferroptosis and cuproptosis to potentiate cancer immunotherapy","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2025.101500_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122512","article-title":"Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA-cGAS-STING signaling","volume":"307","author":"Yu","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101500_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.484","article-title":"Oxygen-driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy","volume":"5","author":"Pei","year":"2024","journal-title":"Aggregate"},{"key":"10.1016\/j.jpha.2025.101500_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202370152","article-title":"Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jpha.2025.101500_bib40","doi-asserted-by":"crossref","first-page":"8408","DOI":"10.1021\/jacs.2c13694","article-title":"Reversible recognition-based boronic acid probes for glucose detection in live cells and zebrafish","volume":"145","author":"Wang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2025.101500_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172681","article-title":"Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro","volume":"930","author":"Rong","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2025.101500_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112759","article-title":"Transformation of copper oxide nanoparticles as affected by ionic strength and its effects on the toxicity and bioaccumulation of copper in zebrafish embryo","volume":"225","author":"Chao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jpha.2025.101500_bib43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jpha.2020.07.003","article-title":"A pyrene-based ratiometric fluorescent probe with a large Stokes shift for selective detection of hydrogen peroxide in living cells","volume":"10","author":"Chen","year":"2020","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2025.101500_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2025.101204","article-title":"Real-time monitoring and in vivo visualization of acetylcholinesterase activity with a near-infrared fluorescent probe","volume":"15","author":"Zeng","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2025.101500_bib45","article-title":"A universal and programmable platform based on fluorescent peptide-conjugated probes for detection of proteins in organelles of living cells","volume":"63","author":"Wu","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jpha.2025.101500_bib46","article-title":"Multifunctional fluorescent probe for simultaneous detection of ATP, Cys, Hcy, and GSH: advancing insights into epilepsy and liver injury","volume":"12","author":"Yu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jpha.2025.101500_bib47","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s41664-023-00273-z","article-title":"Upconversion nanoparticle-organic dye nanocomposites for chemo- and biosensing","volume":"7","author":"Guo","year":"2023","journal-title":"J. Anal. Test."},{"key":"10.1016\/j.jpha.2025.101500_bib48","article-title":"A druglike ferrostatin-1 analogue as a ferroptosis inhibitor and photoluminescent indicator","volume":"64","author":"Yan","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jpha.2025.101500_bib49","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41565-024-01784-1","article-title":"A cuproptosis nanocapsule for cancer radiotherapy","volume":"19","author":"Liao","year":"2024","journal-title":"Nat. Nanotechnol."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209517792500317X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209517792500317X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:51:56Z","timestamp":1785963116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209517792500317X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S209517792500317X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101500","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cuproptosis tracker: Visualizing organelle dynamics with a dual-targeted fluorescent probe","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101500","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101500"}}