{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:17:03Z","timestamp":1788365823085,"version":"build-2803163510"},"reference-count":117,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013145","name":"Primary Research and Development Plan of Zhejiang Province","doi-asserted-by":"publisher","award":["2020C03G5263593"],"award-info":[{"award-number":["2020C03G5263593"]}],"id":[{"id":"10.13039\/501100013145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR20H160001"],"award-info":[{"award-number":["LR20H160001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017538","name":"Zhejiang Provincial Ten Thousand Plan for Young Top Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jpha.2025.101514","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:55:53Z","timestamp":1765299353000},"page":"101514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Designing lysate-based hydrogels for on-demand therapy"],"prefix":"10.1016","volume":"16","author":[{"given":"Yang","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-6671","authenticated-orcid":false,"given":"Siteng","family":"Tieng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2025.101514_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.addr.2012.07.015","article-title":"Hydrogels for delivery of bioactive agents: a historical perspective","volume":"65","author":"Lee","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2025.101514_bib2","first-page":"298","article-title":"A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds","volume":"34","author":"Shang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jpha.2025.101514_bib3","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: a review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpha.2025.101514_bib4","article-title":"Ferulic acid incorporated anti-microbial self cross-linking hydrogel: a promising system for moderately exudating wounds","volume":"73","author":"Anjali","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpha.2025.101514_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2217\/rme-2020-0065","article-title":"Platelet lysate: a promising candidate in regenerative medicine","volume":"16","author":"Meftahpour","year":"2021","journal-title":"Regen. Med."},{"key":"10.1016\/j.jpha.2025.101514_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.actbio.2025.07.050","article-title":"Platelet-rich plasma - A comprehensive review of isolation, activation, and application","volume":"204","author":"Rath","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2025.101514_bib7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jcyt.2019.06.006","article-title":"Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy","volume":"21","author":"Bieback","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jpha.2025.101514_bib8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0264-410X(00)00372-8","article-title":"Cancer vaccines","volume":"19","author":"Moingeon","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jpha.2025.101514_bib9","article-title":"Human adipose tissue lysate-based hydrogel for lasting immunomodulation to effectively improve spinal cord injury repair","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jpha.2025.101514_bib10","doi-asserted-by":"crossref","first-page":"121727","DOI":"10.3389\/fendo.2023.1121727","article-title":"The osteocyte and its osteoclastogenic potential","volume":"14","author":"Marahleh","year":"2023","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.jpha.2025.101514_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/curroncol31020079","article-title":"BCG and alternative therapies to BCG therapy for non-muscle-invasive bladder cancer","volume":"31","author":"Lidagoster","year":"2024","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.jpha.2025.101514_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2217\/rme-2020-0065","article-title":"Platelet lysate: a promising candidate in regenerative medicine","volume":"16","author":"Meftahpour","year":"2021","journal-title":"Regen. Med."},{"key":"10.1016\/j.jpha.2025.101514_bib13","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.3390\/cells14221785","article-title":"CpG ODN activates TLR9 and upregulates TLR3 via the p38 MAPK-ATF3 signaling axis to synergistically enhance dendritic cell vaccine efficacy","volume":"14","author":"Zhou","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2025.101514_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.biomaterials.2015.10.065","article-title":"Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?","volume":"76","author":"Burnouf","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101514_bib15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0002-9440(10)64415-X","article-title":"Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice","volume":"161","author":"Kozaki","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jpha.2025.101514_bib16","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1073\/pnas.79.17.5312","article-title":"Serum contains a platelet-derived transforming growth factor","volume":"79","author":"Childs","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpha.2025.101514_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"TGF-\u03b2 signaling in health, disease, and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jpha.2025.101514_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"BDNF - a key transducer of antidepressant effects","volume":"102","author":"Bj\u00f6rkholm","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpha.2025.101514_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/pr.111.005108","article-title":"Brain-derived neurotrophic factor and neuropsychiatric disorders","volume":"64","author":"Autry","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jpha.2025.101514_bib20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity","volume":"38","author":"Kowia\u0144ski","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jpha.2025.101514_bib21","first-page":"86","article-title":"BDNF and activity-dependent synaptic modulation: figure 1, learn","volume":"10","author":"Lu","year":"2003","journal-title":"Mem."},{"key":"10.1016\/j.jpha.2025.101514_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: deciphering communication from the liver","volume":"44","author":"Jensen-Cody","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jpha.2025.101514_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI20660","article-title":"The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity","volume":"113","author":"Clemmons","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jpha.2025.101514_bib24","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2337\/diabetes.50.5.1110","article-title":"Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity","volume":"50","author":"Yakar","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.jpha.2025.101514_bib25","first-page":"11","article-title":"Metabolic effects of IGF-I deficiency: lessons from mouse models","volume":"3","author":"Yakar","year":"2005","journal-title":"Pediatr. Endocr. Rev. P"},{"key":"10.1016\/j.jpha.2025.101514_bib26","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human disease","volume":"438","author":"Alitalo","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2025.101514_bib27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2016.08.054","article-title":"Evidence for pro-angiogenic functions of VEGF-Ax","volume":"167","author":"Xin","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2025.101514_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1479-666X(08)80114-X","article-title":"Epidermal growth factor therapy and wound healing: past, present and future perspectives","volume":"6","author":"Hardwicke","year":"2008","journal-title":"Surgeon"},{"key":"10.1016\/j.jpha.2025.101514_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cllc.2022.11.004","article-title":"Amivantamab, an epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) bispecific antibody, designed to enable multiple mechanisms of action and broad clinical applications","volume":"24","author":"Cho","year":"2023","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.medcli.2014.09.012","article-title":"Epidermal growth factor, innovation and safety","volume":"145","author":"Esquirol Caussa","year":"2015","journal-title":"Med. Clin. (Barc.)"},{"key":"10.1016\/j.jpha.2025.101514_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12272-023-01444-3","article-title":"EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies","volume":"46","author":"Shakhakarmi","year":"2023","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.jpha.2025.101514_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/cancers9050052","article-title":"Epidermal growth factor receptor cell proliferation signaling pathways","volume":"9","author":"Wee","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.jpha.2025.101514_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/scrt540","article-title":"A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement","volume":"6","author":"Luzzani","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jpha.2025.101514_bib34","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/ijms19010212","article-title":"Comparative analysis of different platelet lysates and platelet rich preparations to stimulate tendon cell biology: an in vitro study","volume":"19","author":"Klatte-Schulz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2025.101514_bib35","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1111\/trf.15251","article-title":"A double-virally-inactivated (Intercept\u2013solvent\/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells","volume":"59","author":"Barro","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.jpha.2025.101514_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.21037\/sci.2017.11.01","article-title":"Alopecia and platelet-derived therapies","volume":"4","author":"Cole","year":"2017","journal-title":"Stem Cell Investig"},{"key":"10.1016\/j.jpha.2025.101514_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4252\/wjsc.v8.i2.47","article-title":"Use of platelet lysate for bone regeneration - are we ready for clinical translation?","volume":"8","author":"Altaie","year":"2016","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.jpha.2025.101514_bib38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12943-025-02305-x","article-title":"Advances in cancer immunotherapy: historical perspectives, current developments, and future directions","volume":"24","author":"Zhang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib39","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41586-022-04772-4","article-title":"A vaccine targeting resistant tumours by dual T cell plus NK cell attack","volume":"606","author":"Badrinath","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2025.101514_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41568-019-0162-4","article-title":"Alternative tumour-specific antigens","volume":"19","author":"Smith","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12943-019-1055-6","article-title":"Neoantigen vaccine: an emerging tumor immunotherapy","volume":"18","author":"Peng","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib42","article-title":"Immunotherapy and prevention of cancer by nanovaccines loaded with whole-cell components of tumor tissues or cells","volume":"33","author":"Ma","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jpha.2025.101514_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105511","article-title":"Across-cancer specific immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis","volume":"25","author":"Diao","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.jpha.2025.101514_bib44","article-title":"Rethinking antigen source: cancer vaccines based on whole tumor cell\/tissue lysate or whole tumor cell","volume":"10","author":"Diao","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jpha.2025.101514_bib45","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41573-020-0074-8","article-title":"Antitumour dendritic cell vaccination in a priming and boosting approach","volume":"19","author":"Harari","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpha.2025.101514_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/acs.molpharmaceut.3c00826","article-title":"Tumor cell lysate-based multifunctional nanoparticles facilitate enhanced mRNA delivery and immune stimulation for melanoma gene therapy","volume":"21","author":"Huang","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpha.2025.101514_bib47","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41418-020-00658-y","article-title":"The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses","volume":"28","author":"Aaes","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jpha.2025.101514_bib48","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/antiox13010132","article-title":"The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: The new progress","volume":"13","author":"Lin","year":"2024","journal-title":"Antioxid. Basel Switz"},{"key":"10.1016\/j.jpha.2025.101514_bib49","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0272-6386(99)70375-6","article-title":"Neutrophils and renal failure","volume":"34","author":"Heinzelmann","year":"1999","journal-title":"Am J Kidney Dis."},{"key":"10.1016\/j.jpha.2025.101514_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201904064","article-title":"Adipose-derived biogenic nanoparticles for suppression of inflammation","volume":"16","author":"Tian","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.jpha.2025.101514_bib51","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/term.2843","article-title":"Adipose tissue-derived extracellular matrix hydrogels as a release platform for secreted paracrine factors","volume":"13","author":"Dongen","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.jpha.2025.101514_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/CBB:44:1:139","article-title":"Role of extracellular matrix and its regulators in human airway smooth muscle biology","volume":"44","author":"Parameswaran","year":"2006","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jpha.2025.101514_bib53","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jse.2009.01.013","article-title":"The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon","volume":"18","author":"Ide","year":"2009","journal-title":"J. Shoulder Elb. Surg."},{"key":"10.1016\/j.jpha.2025.101514_bib54","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3390\/ijms23041934","article-title":"Regulation of FGF-2, FGF-18 and transcription factor activity by perlecan in the maturational development of transitional rudiment and growth plate cartilages and in the maintenance of permanent cartilage homeostasis","volume":"23","author":"Hayes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2025.101514_bib55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11914-020-00564-9","article-title":"Osteocyte-mediated translation of mechanical stimuli to cellular signaling and its role in bone and non-bone-related clinical complications","volume":"18","author":"Yan","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.jpha.2025.101514_bib56","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.bbrc.2006.07.146","article-title":"Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation","volume":"348","author":"Vezeridis","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jpha.2025.101514_bib57","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jor.20888","article-title":"Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes","volume":"27","author":"Santos","year":"2009","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jpha.2025.101514_bib58","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/bit.260430706","article-title":"Review: Bone tissue engineering: the role of interstitial fluid flow","volume":"43","author":"Hillsley","year":"1994","journal-title":"Biotechnol. Bioeng"},{"key":"10.1016\/j.jpha.2025.101514_bib59","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.3389\/fimmu.2018.02909","article-title":"Immunomodulation of the tumor microenvironment: turn foe into friend","volume":"9","author":"Locy","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpha.2025.101514_bib60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1586\/eop.11.45","article-title":"Role of macrophages in uveal melanoma","volume":"6","author":"Herwig","year":"2011","journal-title":"Expert Rev. Ophthalmol."},{"key":"10.1016\/j.jpha.2025.101514_bib61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exer.2012.11.012","article-title":"M2\/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles","volume":"107","author":"Herwig","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jpha.2025.101514_bib62","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jhep.2014.10.029","article-title":"Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma","volume":"62","author":"Yeung","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jpha.2025.101514_bib63","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.7150\/thno.20251","article-title":"The anti-tumor effects of M1 macrophage-loaded poly (ethylene glycol) and gelatin-based hydrogels on hepatocellular carcinoma","volume":"7","author":"Guerra","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2025.101514_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132089","article-title":"A cross-linked macropore hydrogel based on M1 macrophage lysate and alginate regulates tumor-associated macrophages for the treatment of melanoma","volume":"269","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpha.2025.101514_bib65","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1021\/acsnano.8b02446","article-title":"M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors","volume":"12","author":"Choo","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2025.101514_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121137","article-title":"M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages","volume":"278","author":"Gunassekaran","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101514_bib67","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41419-019-1459-7","article-title":"Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity","volume":"10","author":"He","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2025.101514_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/stke.442000re1","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: signal transduction during inflammation and host defense","volume":"2000","author":"O'Neill","year":"2000","journal-title":"Sci. STKE"},{"key":"10.1016\/j.jpha.2025.101514_bib69","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ni.2366","article-title":"IL-12 family cytokines: immunological playmakers","volume":"13","author":"Vignali","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jpha.2025.101514_bib70","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1172\/JCI31860","article-title":"Yin and Yang interplay of IFN-gamma in inflammation and autoimmune disease","volume":"117","author":"Zhang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jpha.2025.101514_bib71","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: Signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jpha.2025.101514_bib72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jpha.2025.101514_bib73","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1096\/fasebj.8.15.8001745","article-title":"The interleukin-1 family: 10 years of discovery","volume":"8","author":"Dinarello","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.jpha.2025.101514_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jpha.2025.101514_bib75","first-page":"62","article-title":"Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis, Pulm","volume":"25","author":"Cazzola","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpha.2025.101514_bib76","unstructured":"I. La Mantia, F. Nicolosi, L. Maiolino,, et al., Immunoprofilassi delle infezioni batteriche ricorrenti delle vie respiratorie in et\u00e0 pediatrica: esperienza clinica con un nuovo vaccino immunostimolante, [Immune prevention of recurring bacterial infections of the airwais in childhood: clinical experience of a new immunostimulating vaccine], GIMMOC9 (2007) 1e8."},{"key":"10.1016\/j.jpha.2025.101514_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.13981","article-title":"Efficacy and safety of OM-85 in paediatric recurrent respiratory tract infections which could have a possible protective effect on COVID-19 pandemic: a meta-analysis","volume":"75","author":"Cao","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jpha.2025.101514_bib78","first-page":"7756","article-title":"Prevention of recurrent respiratory tract infections: a literature review of the activity of the bacterial lysate Lantigen B","volume":"27","author":"Braido","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.jpha.2025.101514_bib79","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/ijc.21565","article-title":"T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx","volume":"118","author":"Hoffmann","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib80","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fmicb.2018.00016","article-title":"Bacterial therapy of cancer: promises, limitations, and insights for future directions","volume":"9","author":"Kramer","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jpha.2025.101514_bib81","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0140-6736(98)07422-4","article-title":"BCG immunotherapy of bladder cancer: 20 years on","volume":"353","author":"Alexandroff","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jpha.2025.101514_bib82","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1464-410X.2012.11754.x","article-title":"Bacillus Calmette-Gu\u00e9rin immunotherapy for genitourinary cancer","volume":"112","author":"Gandhi","year":"2013","journal-title":"BJU Int."},{"key":"10.1016\/j.jpha.2025.101514_bib83","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3390\/biomedicines11051245","article-title":"Metallic nanoparticles: their potential role in breast cancer immunotherapy via trained immunity provocation","volume":"11","author":"Zarenezhad","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jpha.2025.101514_bib84","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12967-023-03944-8","article-title":"BCG-induced trained immunity: history, mechanisms and potential applications","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jpha.2025.101514_bib85","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.3390\/molecules25184335","article-title":"Isolation and FTIR-ATR and 1H NMR characterization of alginates from the main alginophyte species of the Atlantic coast of Morocco","volume":"25","author":"Belattmania","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2025.101514_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135019","article-title":"Alginate-based hydrogels mediated biomedical applications: A review","volume":"279","author":"Ren","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpha.2025.101514_bib87","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0142-9612(00)00201-5","article-title":"Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties","volume":"22","author":"Kuo","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101514_bib88","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.4014\/jmb.1701.01025","article-title":"Development of a Spirulina extract\/alginate-imbedded PCL nanofibrous cosmetic patch","volume":"27","author":"Byeon","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jpha.2025.101514_bib89","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jasms.2006.01.002","article-title":"Sequence analysis of alginate-derived oligosaccharides by negative-ion electrospray tandem mass spectrometry","volume":"17","author":"Zhang","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jpha.2025.101514_bib90","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.3390\/molecules24234374","article-title":"Effects of molecular weight and guluronic acid\/mannuronic acid ratio on the rheological behavior and stabilizing property of sodium alginate","volume":"24","author":"Jiao","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2025.101514_bib91","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.3390\/molecules25173981","article-title":"Chitosan: a natural biopolymer with a wide and varied range of applications","volume":"25","author":"Jim\u00e9nez-G\u00f3mez","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2025.101514_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202200372","article-title":"Polysaccharides for medical technology: properties and applications","volume":"23","author":"Sukhavattanakul","year":"2023","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jpha.2025.101514_bib93","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.biomaterials.2009.10.040","article-title":"A biomimetic hydrogel based on methacrylated dextran-graft-lysine and gelatin for 3D smooth muscle cell culture","volume":"31","author":"Liu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101514_bib94","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/polym10070701","article-title":"Hyaluronic acid in the third millennium","volume":"10","author":"Fallacara","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.jpha.2025.101514_bib95","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"key":"10.1016\/j.jpha.2025.101514_bib96","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nbt.1658","article-title":"Proteomics: a pragmatic perspective","volume":"28","author":"Mallick","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jpha.2025.101514_bib97","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/derm.21923","article-title":"Hyaluronic acid: a key molecule in skin aging","volume":"4","author":"Papakonstantinou","year":"2012","journal-title":"Derm. Endocrinol."},{"key":"10.1016\/j.jpha.2025.101514_bib98","doi-asserted-by":"crossref","first-page":"34455","DOI":"10.1021\/acsami.2c08870","article-title":"Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing","volume":"14","author":"Guo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2025.101514_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101808","article-title":"One-step synthesis of multifunctional chitosan hydrogel for full-thickness wound closure and healing","volume":"11","author":"Guo","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jpha.2025.101514_bib100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.actbio.2021.09.024","article-title":"Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration","volume":"136","author":"Zhang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2025.101514_bib101","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/jfb15020049","article-title":"Advanced platelet lysate aerogels: biomaterials for regenerative applications","volume":"15","author":"Tibourtine","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jpha.2025.101514_bib102","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3390\/bioengineering10091044","article-title":"Tunable double-network GelMA\/alginate hydrogels for platelet lysate-derived protein delivery","volume":"10","author":"Marfoglia","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.jpha.2025.101514_bib103","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.exger.2008.07.004","article-title":"Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies?","volume":"43","author":"Lepperdinger","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jpha.2025.101514_bib104","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.actbio.2018.10.031","article-title":"An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells","volume":"83","author":"Jooybar","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2025.101514_bib105","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1021\/am502250r","article-title":"Cellular membrane enrichment of self-assembling D-peptides for cell surface engineering","volume":"6","author":"Wang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2025.101514_bib106","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/mp300504z","article-title":"Retaining antibodies in tumors with a self-assembling injectable system","volume":"10","author":"Wen","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpha.2025.101514_bib107","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1039\/D2NA00911K","article-title":"Sustained release of tumor cell lysate and CpG from an injectable, cytotoxic hydrogel for melanoma immunotherapy","volume":"5","author":"Yang","year":"2023","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.jpha.2025.101514_bib108","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biomaterials.2018.01.004","article-title":"Injectable polypeptide hydrogel for dual delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma","volume":"159","author":"Song","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101514_bib109","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2023.05.005","article-title":"Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy","volume":"358","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2025.101514_bib110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jconrel.2022.09.014","article-title":"Lipopeptide liposomes-loaded hydrogel for multistage transdermal chemotherapy of melanoma","volume":"351","author":"Ni","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2025.101514_bib111","article-title":"Oscillating fluid flow activated osteocyte lysate-based hydrogel for regulating osteoblast\/osteoclast homeostasis to enhance bone repair","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jpha.2025.101514_bib112","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/08853282241268694","article-title":"Sodium alginate hydrogel encapsulating microglia cell lysate subjected to serum starvation for mitigating glioma cells","volume":"39","author":"Luo","year":"2024","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.jpha.2025.101514_bib113","article-title":"Regulation of tumor antigens-dependent immunotherapy via the hybrid M1 macrophage\/tumor lysates hydrogel","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jpha.2025.101514_bib114","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.05.042","article-title":"An injectable nanocomposite hydrogel improves tumor penetration and cancer treatment efficacy","volume":"147","author":"Luo","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2025.101514_bib115","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004133","article-title":"BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma","volume":"10","author":"Kremenovic","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jpha.2025.101514_bib116","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s13287-020-01930-1","article-title":"Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel","volume":"11","author":"Jahangir","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jpha.2025.101514_bib117","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF-\u03b2) isoforms in wound healing and fibrosis","volume":"24","author":"Lichtman","year":"2016","journal-title":"Wound Repair Regen."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925003314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925003314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:24:19Z","timestamp":1788362659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177925003314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":117,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2095177925003314"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101514","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Designing lysate-based hydrogels for on-demand therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101514"}}