{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:07:55Z","timestamp":1790881675756,"version":"4.1.0"},"reference-count":145,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015375","name":"The Affiliated Hospital of Southwest Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024ZKY063"],"award-info":[{"award-number":["2024ZKY063"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jpha.2025.101543","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T23:53:08Z","timestamp":1767397988000},"page":"101543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multifunctional MOF composites for advanced drug identification and screening: Innovations, applications and challenges"],"prefix":"10.1016","volume":"16","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6412-2716","authenticated-orcid":false,"given":"Linyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2025.101543_bib1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.snb.2017.10.180","article-title":"Luminescent mixed-crystal Ln-MOF thin film for the recognition and detection of pharmaceuticals","volume":"257","author":"Gao","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.chemosphere.2019.02.040","article-title":"The detection of drugs of abuse and pharmaceuticals in drinking water using solid-phase extraction and liquid chromatography-mass spectrometry","volume":"223","author":"Peng","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jpha.2025.101543_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/dta.3544","article-title":"Detection of doping peptides and basic drugs in equine urine using liquid chromatography-mass spectrometry","volume":"16","author":"Flores","year":"2024","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpha.2025.101543_bib4","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3390\/nano11071789","article-title":"Rapid Formation of nanoclusters for detection of drugs in urine using surface-enhanced Raman spectroscopy","volume":"11","author":"Chen","year":"2021","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.jpha.2025.101543_bib5","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/378703a0","article-title":"Selective binding and removal of guests in a microporous metal\u2013organic framework","volume":"378","author":"Yaghi","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2025.101543_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00604-022-05597-8","article-title":"Recent research progress in CDs@MOFs composites: Fabrication, property modulation, and application","volume":"190","author":"Wang","year":"2022","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib7","doi-asserted-by":"crossref","first-page":"108506","DOI":"10.1016\/j.microc.2023.108506","article-title":"Simultaneous determination of four aflatoxins using dispersive micro solid phase extraction with magnetic bimetallic MOFs composite as a sorbent and high-performance liquid chromatography with fluorescence detection","volume":"189","author":"Rezaei","year":"2023","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpha.2025.101543_bib8","doi-asserted-by":"crossref","first-page":"29052","DOI":"10.1021\/acsami.6b09893","article-title":"Protein-metal organic framework hybrid composites with intrinsic peroxidase-like activity as a colorimetric biosensing platform","volume":"8","author":"Yin","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2025.101543_bib9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1039\/D1TA06006F","article-title":"Heterostructured hybrids of metal\u2013organic frameworks (MOFs) and covalent-organic frameworks (COFs)","volume":"10","author":"Guo","year":"2022","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.jpha.2025.101543_bib10","doi-asserted-by":"crossref","first-page":"136877","DOI":"10.1016\/j.snb.2024.136877","article-title":"Anchor carbon dots inside NH2-MIL-88B via ship-in-a-bottle strategy for dual signal enhancement in colorimetric-fluorescent sensors","volume":"424","author":"Lu","year":"2025","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s12161-021-02004-5","article-title":"Fluorescence ratio nanoprobe consisting of a carbon nanodots-quantum dots composite for visual detection of folic acid in dry milk powders","volume":"14","author":"He","year":"2021","journal-title":"Food Anal. Methods"},{"key":"10.1016\/j.jpha.2025.101543_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.trac.2017.03.004","article-title":"Magnetic solid-phase extraction using metal-organic frameworks (MOFs) and their derived carbons","volume":"90","author":"Maya","year":"2017","journal-title":"Trac Trends Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib13","doi-asserted-by":"crossref","first-page":"109666","DOI":"10.1016\/j.jece.2023.109666","article-title":"The synthesis, application and mechanism of a novel Zr-based magnetic MOFs adsorption material","volume":"11","author":"Zhou","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jpha.2025.101543_bib14","doi-asserted-by":"crossref","first-page":"17300","DOI":"10.1021\/acs.analchem.4c03627","article-title":"High-efficiency enzyme assay and screening of enzyme-inhibiting nanomaterials using capillary electrophoresis with hierarchically porous metal-organic framework-based immobilized enzyme microreactor","volume":"96","author":"Yan","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jbiotec.2024.06.006","article-title":"Kinetic and stability studies of amino acid metal-organic frameworks for encapsulating of amino acid dehydrogenase","volume":"391","author":"Dong","year":"2024","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jpha.2025.101543_bib16","doi-asserted-by":"crossref","first-page":"464403","DOI":"10.1016\/j.chroma.2023.464403","article-title":"Fabrication of a magnetic metal-organic framework\/covalent organic framework composite for simultaneous magnetic solid-phase extraction of seventeen trace quinolones residues in meats","volume":"1709","author":"Lin","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpha.2025.101543_bib17","doi-asserted-by":"crossref","first-page":"152285","DOI":"10.1016\/j.apsusc.2021.152285","article-title":"Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism","volume":"580","author":"Zhang","year":"2022","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.jpha.2025.101543_bib18","doi-asserted-by":"crossref","first-page":"105967","DOI":"10.1016\/j.jece.2021.105967","article-title":"Photocatalytic degradation of hazardous organic pollutants in water by Fe-MOFs and their composites: A review","volume":"9","author":"Li","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jpha.2025.101543_bib19","doi-asserted-by":"crossref","first-page":"141710","DOI":"10.1016\/j.cej.2023.141710","article-title":"A systematic review of metal organic frameworks materials for heavy metal removal: Synthesis, applications and mechanism","volume":"460","author":"Lin","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101543_bib20","doi-asserted-by":"crossref","first-page":"124144","DOI":"10.1016\/j.seppur.2023.124144","article-title":"An overview of metal-organic frameworks and their magnetic composites for the removal of pollutants","volume":"320","author":"Wang","year":"2023","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.jpha.2025.101543_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ccr.2018.05.004","article-title":"Optimization protocols and improved strategies for metal-organic frameworks for immobilizing enzymes: current development and future challenges","volume":"370","author":"Cui","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jpha.2025.101543_bib22","doi-asserted-by":"crossref","first-page":"140330","DOI":"10.1016\/j.foodchem.2024.140330","article-title":"Recent progress of the research of metal-organic frameworks-molecularly imprinted polymers (MOFs-MIPs) in food safety detection field","volume":"458","author":"Geng","year":"2024","journal-title":"Food Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib23","doi-asserted-by":"crossref","first-page":"126112","DOI":"10.1016\/j.polymer.2023.126112","article-title":"Highly water-stable MOF-74 synthesized by in-situ trace polymer modification","volume":"281","author":"Li","year":"2023","journal-title":"Polymer"},{"key":"10.1016\/j.jpha.2025.101543_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202500277","article-title":"Water-stable MIL-MOFs developed through a novel sacrifice-protection strategy inspired by butterfly wings\u2019 scales for long-term turn-on fluorescence sensing of H2S","volume":"9","author":"Weng","year":"2025","journal-title":"Small Methods"},{"key":"10.1016\/j.jpha.2025.101543_bib25","doi-asserted-by":"crossref","first-page":"107867","DOI":"10.1016\/j.compositesb.2020.107867","volume":"187","author":"Jung","year":"2020","journal-title":"Compos. Part B Eng."},{"key":"10.1016\/j.jpha.2025.101543_bib26","doi-asserted-by":"crossref","first-page":"152351","DOI":"10.1016\/j.scitotenv.2021.152351","article-title":"Recent advances in performance improvement of Metal-organic Frameworks to remove antibiotics: Mechanism and evaluation","volume":"811","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2025.101543_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jhazmat.2018.08.079","article-title":"A novel magnetic MIL-101(Fe)\/TiO2 composite for photo degradation of tetracycline under solar light","volume":"361","author":"He","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s41061-019-0258-z","article-title":"State-of-the-art and prospects of biomolecules: Incorporation in functional metal-organic frameworks","volume":"377","author":"Duan","year":"2019","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib29","doi-asserted-by":"crossref","first-page":"117906","DOI":"10.1016\/j.trac.2024.117906","article-title":"Molecularly imprinted polymers @ metal and covalent organic frameworks: From synthesis to application in analytical chemistry","volume":"179","author":"Nomngongo","year":"2024","journal-title":"Trac Trends Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib30","doi-asserted-by":"crossref","first-page":"107527","DOI":"10.1016\/j.cclet.2022.05.041","article-title":"Applications of metal nanoparticles\/metal-organic frameworks composites in sensing field","volume":"34","author":"Xu","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib31","doi-asserted-by":"crossref","first-page":"1251713","DOI":"10.3389\/fbioe.2023.1251713","article-title":"Metal-organic frameworks\/metal nanoparticles as smart nanosensing interfaces for electrochemical sensors applications: A mini-review","volume":"11","author":"Jiang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jpha.2025.101543_bib32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00604-022-05481-5","article-title":"Sensing performance and mechanism of carbon dots encapsulated into metal-organic frameworks","volume":"189","author":"Yan","year":"2022","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib33","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1039\/C7CS00041C","article-title":"Hybridization of MOFs and polymers","volume":"46","author":"Kitao","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jpha.2025.101543_bib34","doi-asserted-by":"crossref","first-page":"111058","DOI":"10.1016\/j.cclet.2025.111058","article-title":"Metal-organic framework supported carbon quantum dots as white light-emitting phosphor","volume":"36","author":"Tong","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib35","doi-asserted-by":"crossref","first-page":"15508","DOI":"10.1039\/D2TC03414J","article-title":"Construction of carbon dots\/metal\u2013organic framework composite for ratiometric sensing of norfloxacin","volume":"10","author":"Wu","year":"2022","journal-title":"J. Mater. Chem. C"},{"key":"10.1016\/j.jpha.2025.101543_bib36","doi-asserted-by":"crossref","first-page":"107478","DOI":"10.1016\/j.cclet.2022.04.076","article-title":"The fabrication strategies and enhanced performances of metal-organic frameworks and carbon dots composites: State of the art review","volume":"34","author":"Zhang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib37","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1039\/C8TC01018H","article-title":"A carbon dot-encapsulated UiO-type metal organic framework as a multifunctional fluorescent sensor for temperature, metal ion and pH detection","volume":"6","author":"Yao","year":"2018","journal-title":"J. Mater. Chem. C"},{"key":"10.1016\/j.jpha.2025.101543_bib38","doi-asserted-by":"crossref","first-page":"126775","DOI":"10.1016\/j.snb.2019.126775","article-title":"Dual-colored carbon dot encapsulated metal-organic framework for ratiometric detection of glutathione","volume":"297","author":"Jalili","year":"2019","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib39","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1039\/C8CE00955D","article-title":"Carbon dots for promoting the growth of ZIF-8 crystals to obtain fluorescent powders and their application for latent fingerprint imaging","volume":"20","author":"Li","year":"2018","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jpha.2025.101543_bib40","doi-asserted-by":"crossref","first-page":"14318","DOI":"10.1021\/acs.inorgchem.0c02105","article-title":"Synergetic effect of tetraethylammonium bromide addition on the morphology evolution and enhanced photoluminescence of rare-earth metal-organic frameworks","volume":"59","author":"Liu","year":"2020","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib41","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1002\/anie.201702162","article-title":"MOF-templated synthesis of ultrasmall photoluminescent carbon-nanodot arrays for optical applications","volume":"56","author":"Gu","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jpha.2025.101543_bib42","doi-asserted-by":"crossref","first-page":"216116","DOI":"10.1016\/j.ccr.2024.216116","article-title":"Core-shell nanostructured metal-organic frameworks with encapsulated magnetic nanoparticles for magnetically recyclable catalysis","volume":"518","author":"Ke","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jpha.2025.101543_bib43","doi-asserted-by":"crossref","first-page":"124255","DOI":"10.1016\/j.colsurfa.2019.124255","article-title":"CTAB-surface-functionalized magnetic MOF@MOF composite adsorbent for Cr(VI) efficient removal from aqueous solution","volume":"586","author":"Li","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Aspects"},{"key":"10.1016\/j.jpha.2025.101543_bib44","first-page":"3515","article-title":"Recent advances in preparation and applications of magnetic framework composites","volume":"14","author":"Ma","year":"2019","journal-title":"Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib45","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/smll.201400362","article-title":"Magnetic metal-organic frameworks: \u03b3-Fe2O3@MOFs via confined in situ pyrolysis method for drug delivery","volume":"10","author":"Wu","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.jpha.2025.101543_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jssc.2016.09.010","article-title":"Fabrication of core-shell Fe3O4@MIL-100(Fe) magnetic microspheres for the removal of Cr(VI) in aqueous solution","volume":"244","author":"Yang","year":"2016","journal-title":"J. Solid State Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib47","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s10853-018-2835-x","article-title":"Facile synthesis of magnetic macroporous polymer\/MOF composites as separable catalysts","volume":"54","author":"Chen","year":"2019","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.jpha.2025.101543_bib48","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jhazmat.2016.09.026","article-title":"Fabrication of magnetically responsive HKUST-1\/Fe3O4 composites by dry gel conversion for deep desulfurization and denitrogenation","volume":"321","author":"Tan","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib49","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1021\/acs.inorgchem.7b02697","article-title":"Magnetic metal-organic framework composite by fast and facile mechanochemical process","volume":"57","author":"Bellusci","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib50","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/adfm.201202078","article-title":"Magnetic cores with porous coatings: growth of metal-organic frameworks on particles using liquid phase epitaxy","volume":"23","author":"Silvestre","year":"2013","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100985","article-title":"Metal-organic frameworks (MOFs) for biopreservation: from biomacromolecules, living organisms to biological devices","volume":"35","author":"Sun","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.jpha.2025.101543_bib52","doi-asserted-by":"crossref","first-page":"153884","DOI":"10.1016\/j.cej.2024.153884","article-title":"Metal\u2013organic framework-engineered enzyme\/nanozyme composites: Preparation, functionality, and sensing mechanisms","volume":"496","author":"Li","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101543_bib53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11244-006-0025-6","article-title":"Hybrid materials for immobilization of MP-11 catalyst","volume":"38","author":"Pisklak","year":"2006","journal-title":"Top. Catal."},{"key":"10.1016\/j.jpha.2025.101543_bib54","doi-asserted-by":"crossref","first-page":"10382","DOI":"10.1021\/ja2038003","article-title":"Immobilization of MP-11 into a mesoporous metal\u2013organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis","volume":"133","author":"Lykourinou","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2025.101543_bib55","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/cplu.201200186","article-title":"Trypsin-immobilized metal\u2013organic framework as a biocatalyst in proteomics analysis","volume":"77","author":"Shih","year":"2012","journal-title":"ChemPlusChem"},{"key":"10.1016\/j.jpha.2025.101543_bib56","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1039\/D4QI02555E","article-title":"MOF nanozymes: active sites and sensing applications","volume":"12","author":"Zhang","year":"2025","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.jpha.2025.101543_bib57","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1021\/nl5026419","article-title":"One-pot synthesis of protein-embedded metal-organic frameworks with enhanced biological activities","volume":"14","author":"Lyu","year":"2014","journal-title":"Nano Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib58","doi-asserted-by":"crossref","first-page":"11598","DOI":"10.1021\/jacs.5b07463","article-title":"A metal organic framework with spherical protein nodes: rational chemical design of 3D protein crystals","volume":"137","author":"Sontz","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2025.101543_bib59","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1038\/ncomms6979","article-title":"Stable metal-organic frameworks containing single-molecule traps for enzyme encapsulation","volume":"6","author":"Feng","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2025.101543_bib60","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.chempr.2018.03.001","article-title":"Hierarchically engineered mesoporous metal-organic frameworks toward cell-free immobilized enzyme systems","volume":"4","author":"Li","year":"2018","journal-title":"Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib61","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.chempr.2019.03.025","article-title":"Improving the acidic stability of zeolitic imidazolate frameworks by biofunctional molecules","volume":"5","author":"Gao","year":"2019","journal-title":"Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib62","doi-asserted-by":"crossref","first-page":"108051","DOI":"10.1039\/C6RA19976C","article-title":"Covalent immobilization of glucose oxidase on amino MOFs via post-synthetic modification","volume":"6","author":"Tudisco","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2025.101543_bib63","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1039\/C8SC00825F","article-title":"Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8","volume":"9","author":"Maddigan","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jpha.2025.101543_bib64","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/anie.201913231","article-title":"Modulating the biofunctionality of metal-organic-framework-encapsulated enzymes through controllable embedding patterns","volume":"59","author":"Chen","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jpha.2025.101543_bib65","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/jacs.8b10302","article-title":"Enhanced activity of enzymes encapsulated in hydrophilic metal-organic frameworks","volume":"141","author":"Liang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2025.101543_bib66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.micromeso.2004.03.034","article-title":"Metal\u2013organic frameworks: a new class of porous materials","volume":"73","author":"Rowsell","year":"2004","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib67","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00604-021-04832-y","article-title":"Core-shell MOF@COFs used as an adsorbent and matrix for the detection of nonsteroidal anti-inflammatory drugs by MALDI-TOF MS","volume":"188","author":"Zheng","year":"2021","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bios.2018.09.089","article-title":"Novel nanoarchitecture of Co-MOF-on-TPN-COF hybrid: ultralowly sensitive bioplatform of electrochemical aptasensor toward ampicillin","volume":"123","author":"Liu","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101543_bib69","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.inoche.2019.01.040","article-title":"Controlled synthesis of core-shell composites with uniform shells of a covalent organic framework","volume":"101","author":"Yao","year":"2019","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.jpha.2025.101543_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202105002","article-title":"Controllable synthesis of COFs-based multicomponent nanocomposites from core-shell to yolk-shell and hollow-sphere structure for artificial photosynthesis","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib71","doi-asserted-by":"crossref","first-page":"9512","DOI":"10.1002\/anie.201904766","article-title":"A MOF@COF composite with enhanced uptake through interfacial pore generation","volume":"58","author":"Garz\u00f3n-Tovar","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jpha.2025.101543_bib72","doi-asserted-by":"crossref","first-page":"129144","DOI":"10.1016\/j.snb.2020.129144","article-title":"Crystal engineering of MOF@COF core-shell composites for ultra-sensitively electrochemical detection","volume":"329","author":"Zhang","year":"2021","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.aej.2024.05.116","article-title":"Electrochemical sensor based on reduced graphene oxide paste electrode for detection of gemcitabine as a chemotherapy drug in breast cancer","volume":"102","author":"Shi","year":"2024","journal-title":"Alex. Eng. J."},{"key":"10.1016\/j.jpha.2025.101543_bib74","doi-asserted-by":"crossref","first-page":"217002","DOI":"10.1016\/j.ccr.2025.217002","article-title":"Synthesis strategies, functionalization, and biomedical applications of MOF\/MXene hybrid composites","volume":"544","author":"Tran","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jpha.2025.101543_bib75","doi-asserted-by":"crossref","first-page":"108094","DOI":"10.1016\/j.jece.2022.108094","article-title":"Optimized synthesis of molecularly imprinted polymers coated magnetic UIO-66 MOFs for simultaneous specific removal and determination of multi types of macrolide antibiotics in water","volume":"10","author":"Liu","year":"2022","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jpha.2025.101543_bib76","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00604-021-04912-z","article-title":"Amplified electrochemical antibiotic aptasensing based on electrochemically deposited AuNPs coordinated with PEI-functionalized Fe-based metal-organic framework","volume":"188","author":"Zhang","year":"2021","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib77","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1039\/D4CC01875C","article-title":"Interconversion and functional composites of metal-organic frameworks and hydrogen-bonded organic frameworks","volume":"60","author":"Hu","year":"2024","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jpha.2025.101543_bib78","doi-asserted-by":"crossref","first-page":"17570","DOI":"10.1039\/D0NJ03587D","article-title":"The surface-enhanced Raman scattering of all-inorganic perovskite quantum dots of CsPbBr3 encapsulated in a ZIF-8 metal\u2013organic framework","volume":"44","author":"Xin","year":"2020","journal-title":"New J. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib79","doi-asserted-by":"crossref","first-page":"2370243","DOI":"10.1002\/adfm.202370243","article-title":"Wrapping up metal\u2013organic framework crystals with carbon nanotubes (adv. funct. mater. 41\/2023)","volume":"33","author":"Lerma-Berlanga","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib80","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1021\/acsenergylett.0c01148","article-title":"Functionalizing luminescent metal\u2013organic frameworks for enhanced photoluminescence","volume":"5","author":"Liu","year":"2020","journal-title":"ACS Energy Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib81","doi-asserted-by":"crossref","first-page":"120089","DOI":"10.1016\/j.saa.2021.120089","article-title":"A ratiometric fluorescent probe based on carbon dots and gold nanocluster encapsulated metal-organic framework for detection of cephalexin residues in milk","volume":"262","author":"Jalili","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib82","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00604-022-05438-8","article-title":"Carbon dots@Cu metal-organic frameworks hybrids for ratiometric fluorescent determination of pesticide thiophanate-methyl","volume":"189","author":"Yu","year":"2022","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib83","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00604-022-05377-4","article-title":"Fluorescence determination of chloramphenicol in milk powder using carbon dot decorated silver metal-organic frameworks","volume":"189","author":"Wang","year":"2022","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib84","doi-asserted-by":"crossref","first-page":"126763","DOI":"10.1016\/j.talanta.2024.126763","article-title":"A ratiometric fluorescence sensor with different responsive modes based on carbon dots-embedded Tb-MOFs for the determination of norfloxacin and levofloxacin","volume":"280","author":"Chi","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2025.101543_bib85","doi-asserted-by":"crossref","first-page":"125113","DOI":"10.1016\/j.talanta.2023.125113","article-title":"Fabrication of a bifunctional fluorescent chiral composite based on magnetic Fe3O4\/chiral carbon dots@hierarchical porous metal-organic framework","volume":"266","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2025.101543_bib86","doi-asserted-by":"crossref","first-page":"341032","DOI":"10.1016\/j.aca.2023.341032","article-title":"A molecularly imprinted fluorescence sensor for sensitive detection of tetracycline using nitrogen-doped carbon dots-embedded zinc-based metal-organic frameworks as signal-amplifying tags","volume":"1251","author":"Zhang","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib87","doi-asserted-by":"crossref","first-page":"54634","DOI":"10.1021\/acsami.3c11298","article-title":"In situ generated Dye@MOF\/COF heterostructure for fluorescence detection of chloroquine phosphate and folic acid via different luminescent channels","volume":"15","author":"Quan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2025.101543_bib88","doi-asserted-by":"crossref","first-page":"145361","DOI":"10.1016\/j.foodchem.2025.145361","article-title":"An artificial neural network model based on CDs@MOF\/COF composites for the ultra-sensitive fluorescence detection of glyphosate","volume":"492","author":"Hui","year":"2025","journal-title":"Food Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib89","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1021\/acs.cgd.0c00601","article-title":"Recent electrochemical applications of metal\u2013organic framework-based materials","volume":"20","author":"Tajik","year":"2020","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jpha.2025.101543_bib90","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00604-025-07393-6","article-title":"A dual-mode electrochemical and fluorescence aptasensor based on CDs@Cu\/Al-MOF and Ti3C2 for the detection of kanamycin in milk","volume":"192","author":"Li","year":"2025","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib91","doi-asserted-by":"crossref","first-page":"130730","DOI":"10.1016\/j.cej.2021.130730","article-title":"Microcalorimetry-guided pore-microenvironment optimization to improve sensitivity of Ni-MOF electrochemical biosensor for chiral galantamine","volume":"426","author":"Zhang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2025.101543_bib92","doi-asserted-by":"crossref","first-page":"131586","DOI":"10.1016\/j.snb.2022.131586","article-title":"An electrochemical wearable sensor for levodopa quantification in sweat based on a metal\u2013Organic framework\/graphene oxide composite with integrated enzymes","volume":"359","author":"Xiao","year":"2022","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib93","doi-asserted-by":"crossref","first-page":"94907590","DOI":"10.26599\/NR.2025.94907590","article-title":"Integrating Au@MOF@COF nanocomposites for electrochemical aptasensing of trace oxytetracycline","volume":"18","author":"Li","year":"2025","journal-title":"Nano Res"},{"key":"10.1016\/j.jpha.2025.101543_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jelechem.2020.114386","article-title":"Layered construction of nano immuno-hybrid embedded MOF as an electrochemical sensor for rapid quantification of total pesticides load in vegetable extract","volume":"873","author":"Chansi","year":"2020","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib95","doi-asserted-by":"crossref","first-page":"107319","DOI":"10.1016\/j.microc.2022.107319","article-title":"Sulfur nanoparticle-encapsulated MOF and boron nanosheet-ferrocene complex modified electrode platform for ratiometric electrochemical sensing of adriamycin and real-time monitoring of drug release","volume":"177","author":"Yang","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpha.2025.101543_bib96","doi-asserted-by":"crossref","first-page":"111636","DOI":"10.1016\/j.bios.2019.111636","article-title":"Sensitive detection of ketamine with an electrochemical sensor based on UV-induced polymerized molecularly imprinted membranes at graphene and MOFs modified electrode","volume":"143","author":"Fu","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101543_bib97","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00604-023-05751-w","article-title":"Dual-monomer molecularly imprinted electrochemical sensor based on amino-functionalized MOFs and graphene for trace determination of taurine","volume":"190","author":"Duan","year":"2023","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib98","doi-asserted-by":"crossref","first-page":"115217","DOI":"10.1016\/j.jphotochem.2023.115217","article-title":"A smart fluorescent colorimetric dual-response sensing for the determination of tetracycline antibiotics","volume":"447","author":"Yan","year":"2024","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib99","doi-asserted-by":"crossref","first-page":"130277","DOI":"10.1016\/j.jhazmat.2022.130277","article-title":"A versatile platform for colorimetric, fluorescence and photothermal multi-mode glyphosate sensing by carbon dots anchoring ferrocene metal-organic framework nanosheet","volume":"443","author":"Luo","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib100","doi-asserted-by":"crossref","first-page":"142892","DOI":"10.1016\/j.foodchem.2025.142892","article-title":"An ingenious integrated metal-organic frameworks-based ratiometric sensing platform for efficient, sensitive and real-time detection of tetracyclines","volume":"472","author":"Shen","year":"2025","journal-title":"Food Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib101","doi-asserted-by":"crossref","first-page":"110989","DOI":"10.1016\/j.foodcont.2024.110989","article-title":"Colorimetric-ratiometric fluorescence sensors dual-mode detection of ofloxacin based on Fe-Ni bimetallic metal-organic frameworks and carbon dots","volume":"169","author":"Liu","year":"2025","journal-title":"Food Control"},{"key":"10.1016\/j.jpha.2025.101543_bib102","doi-asserted-by":"crossref","first-page":"106242","DOI":"10.1016\/j.microc.2021.106242","article-title":"Colorimetric biosensing of organophosphate pesticides using enzymatic nanoreactor built on zeolitic imdiazolate-8","volume":"166","author":"Kukkar","year":"2021","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpha.2025.101543_bib103","doi-asserted-by":"crossref","first-page":"16383","DOI":"10.1021\/acs.analchem.3c03872","article-title":"Two-site enhanced porphyrinic metal-organic framework nanozymes and nano-\/bioenzyme confined catalysis for colorimetric\/chemiluminescent dual-mode visual biosensing","volume":"95","author":"Chai","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib104","doi-asserted-by":"crossref","first-page":"102322","DOI":"10.1016\/j.fochx.2025.102322","article-title":"Molecularly imprinted MOF nanozymes: Demonstration of smartphone-integrated dual-mode platform for ratiometric fluorescent\/colorimetric detection of chloramphenicol","volume":"26","author":"He","year":"2025","journal-title":"Food Chem. X"},{"key":"10.1016\/j.jpha.2025.101543_bib105","doi-asserted-by":"crossref","first-page":"137445","DOI":"10.1016\/j.snb.2025.137445","article-title":"A dual-mode sensor based on surface molecularly imprinted metal-organic framework for the highly accurate and selective detection of tetracycline","volume":"432","author":"Zhang","year":"2025","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib106","doi-asserted-by":"crossref","first-page":"11046","DOI":"10.1021\/acs.langmuir.5c00536","article-title":"Prussian blue nanosphere\/Fe-metal organic frameworks\/Ce nanocomposite as a colorimetric sensing platform for direct detection in organophosphorus pesticides in fetal bovine serum","volume":"41","author":"Yuan","year":"2025","journal-title":"Langmuir"},{"key":"10.1016\/j.jpha.2025.101543_bib107","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-2614(74)85388-1","article-title":"Raman spectra of pyridine adsorbed at a silver electrode","volume":"26","author":"Fleischmann","year":"1974","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.jpha.2025.101543_bib108","doi-asserted-by":"crossref","first-page":"126434","DOI":"10.1016\/j.saa.2025.126434","article-title":"Magnetic COF on MOF heterojunction assisted surface-enhanced Raman spectroscopy for 17\u03b2-estradiol analysis","volume":"341","author":"Zhao","year":"2025","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib109","doi-asserted-by":"crossref","first-page":"123924","DOI":"10.1016\/j.saa.2024.123924","article-title":"Magnetic solid-phase extraction-based surface-enhanced Raman spectroscopy for label-free therapeutic drug monitoring of carbamazepine and clozapine in human serum","volume":"310","author":"Feng","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib110","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00216-023-04621-x","article-title":"Ultrasensitive SERS substrate for label-free therapeutic drug monitoring of chlorpromazine hydrochloride and aminophylline in human serum","volume":"415","author":"Chen","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib111","doi-asserted-by":"crossref","first-page":"122018","DOI":"10.1016\/j.saa.2022.122018","article-title":"Core-shell Au@MIL-100 (Fe) as an enhanced substrate for flunixin meglumine ultra-sensitive detection","volume":"287","author":"Zhang","year":"2023","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib112","doi-asserted-by":"crossref","first-page":"113109","DOI":"10.1016\/j.bios.2021.113109","article-title":"Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF","volume":"180","author":"Guselnikova","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101543_bib113","doi-asserted-by":"crossref","first-page":"121843","DOI":"10.1016\/j.saa.2022.121843","article-title":"Electrochemical synthesis of Co\/Ni bimetal-organic frameworks: A high-performance SERS platform for detection of tetracycline","volume":"285","author":"Zhao","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib114","doi-asserted-by":"crossref","first-page":"111276","DOI":"10.1016\/j.jece.2023.111276","article-title":"A novel nanogold sol SERS\/RRS dual-mode assay for trace imidacloprid with Ti3C2Tx@Ti-MOFs\/peptide bifunctional nanoprobe","volume":"11","author":"Zhi","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jpha.2025.101543_bib115","doi-asserted-by":"crossref","first-page":"341097","DOI":"10.1016\/j.aca.2023.341097","article-title":"Flexible SERS strip based on HKUST-1(cu)\/biomimetic antibodies composite multilayer for trace determination of ethephon","volume":"1253","author":"Xiu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib116","doi-asserted-by":"crossref","first-page":"138717","DOI":"10.1016\/j.foodchem.2024.138717","article-title":"Ultrasensitive detection strategy for CAP by molecularity imprinted SERS sensor based on multiple synergistic enhancement of SiO2@AuAg with MOFs@Au signal carrier","volume":"445","author":"Zhang","year":"2024","journal-title":"Food Chem"},{"key":"10.1016\/j.jpha.2025.101543_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111801","article-title":"A zirconium-porphyrin MOF-based ratiometric fluorescent biosensor for rapid and ultrasensitive detection of chloramphenicol","volume":"149","author":"Liu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101543_bib118","doi-asserted-by":"crossref","first-page":"122253","DOI":"10.1016\/j.saa.2022.122253","article-title":"Ratiometric fluorescence detection of artemisinin based on photoluminescent Zn-MOF combined with hemin as catalyst","volume":"289","author":"Sun","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpha.2025.101543_bib119","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00216-020-03028-2","article-title":"Electrochemical determination of artemisinin based on signal inhibition for the reduction of hemin","volume":"413","author":"Jiang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib120","doi-asserted-by":"crossref","first-page":"111229","DOI":"10.1016\/j.dyepig.2023.111229","article-title":"Epitaxial self-assembly of Bimetallic MOF heterostructure for fluorescent and colorimetric detection of tetracyclines","volume":"214","author":"Wang","year":"2023","journal-title":"Dyes Pigm"},{"key":"10.1016\/j.jpha.2025.101543_bib121","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envint.2019.01.033","article-title":"Novel sensing platform based on gold nanoparticle-aptamer and Fe-metal-organic framework for multiple antibiotic detection and signal amplification","volume":"125","author":"Li","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.jpha.2025.101543_bib122","doi-asserted-by":"crossref","first-page":"138567","DOI":"10.1016\/j.molstruc.2024.138567","article-title":"Carbon dots-functionalized metal\u2013organic framework for the dual detection of tetracycline and norfloxacin","volume":"1312","author":"Liu","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jpha.2025.101543_bib123","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1039\/D1AN00894C","article-title":"Tetracycline antibiotics and NH(4)(+) detection by Zn-organic framework fluorescent probe","volume":"146","author":"Chen","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.jpha.2025.101543_bib124","doi-asserted-by":"crossref","first-page":"132360","DOI":"10.1016\/j.snb.2022.132360","article-title":"Rapid determination of pesticide residues in fruit and vegetable using Au@AgNPs decorated 2D Ni-MOF nanosheets as efficient surface-enhanced Raman scattering substrate","volume":"369","author":"Lai","year":"2022","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib125","doi-asserted-by":"crossref","first-page":"116022","DOI":"10.1016\/j.bios.2024.116022","article-title":"Generation of a specific aptamer for accurate detection of sarafloxacin based on fluorescent\/colorimetric\/SERS triple-readout sensor","volume":"249","author":"Duan","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2025.101543_bib126","doi-asserted-by":"crossref","first-page":"9990","DOI":"10.1007\/s12274-024-6951-4","article-title":"Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol","volume":"17","author":"Ye","year":"2024","journal-title":"Nano Res."},{"key":"10.1016\/j.jpha.2025.101543_bib127","doi-asserted-by":"crossref","first-page":"139617","DOI":"10.1016\/j.jhazmat.2025.139617","article-title":"Immobilization of enzyme with MOF enhances colorimetric performance for fast, sensitive, and economical detection of chloramphenicol","volume":"497","author":"Ji","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2025.101543_bib128","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.aca.2019.11.042","article-title":"Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: a new platform for efficient ligand discovery from natural herbs","volume":"1099","author":"Chen","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib129","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.3390\/molecules27113475","article-title":"Rapid screening of lipase inhibitors in Scutellaria baicalensis by using porcine pancreatic lipase immobilized on magnetic core-shell metal-organic frameworks","volume":"27","author":"Xu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2025.101543_bib130","doi-asserted-by":"crossref","first-page":"116430","DOI":"10.1016\/j.jpba.2024.116430","article-title":"Integrating sodium cholate-modified MOF hybrid lipase and solubilization of hydrophobic candidates into a step for liganding fishing lipase inhibitors from Nelumbinis Folium","volume":"251","author":"Hu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpha.2025.101543_bib131","doi-asserted-by":"crossref","first-page":"125975","DOI":"10.1016\/j.talanta.2024.125975","article-title":"A dual recognition-based strategy employing Ni-modified metal-organic framework for in situ screening of SIRT1 inhibitors from Chinese herbs","volume":"274","author":"Chen","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2025.101543_bib132","doi-asserted-by":"crossref","first-page":"139985","DOI":"10.1016\/j.ijbiomac.2025.139985","article-title":"Construction of enzyme-MOFs composite with carbon dots: A strategy to enhance the activity and increase the growth rate of the enzyme-ZIF-8 composite","volume":"291","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpha.2025.101543_bib133","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1039\/D4NJ01479K","article-title":"\u03b1-Glucosidase immobilization on the metal\u2013organic framework composite membrane for enzyme inhibitor screening","volume":"48","author":"Wen","year":"2024","journal-title":"New J. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib134","doi-asserted-by":"crossref","first-page":"116037","DOI":"10.1016\/j.jpba.2024.116037","article-title":"Paper-based ligand fishing method for rapid screening and real-time capturing of \u03b1-glucosidase inhibitors from the Chinese herbs","volume":"242","author":"Chen","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpha.2025.101543_bib135","doi-asserted-by":"crossref","first-page":"112811","DOI":"10.1016\/j.jpba.2019.112811","article-title":"Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor","volume":"176","author":"Zhang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpha.2025.101543_bib136","doi-asserted-by":"crossref","first-page":"117520","DOI":"10.1016\/j.trac.2024.117520","article-title":"Recent advances in metal\u2013organic frameworks as emerging platforms for immunoassays","volume":"171","author":"Hu","year":"2024","journal-title":"Trac Trends Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib137","doi-asserted-by":"crossref","first-page":"32769","DOI":"10.1021\/acsami.9b11754","article-title":"Bifunctional hybrid enzyme-catalytic metal organic framework reactors for \u03b1-glucosidase inhibitor screening","volume":"11","author":"Zhong","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2025.101543_bib138","doi-asserted-by":"crossref","first-page":"111847","DOI":"10.1016\/j.colsurfb.2021.111847","article-title":"\u03b1-glucosidase immobilization on magnetic core-shell metal-organic frameworks for inhibitor screening from traditional Chinese medicines","volume":"205","author":"Wan","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jpha.2025.101543_bib139","doi-asserted-by":"crossref","first-page":"124025","DOI":"10.1016\/j.talanta.2022.124025","article-title":"An MnO2-ZIF-67 immobilized acetylcholinesterase method for acetylcholinesterase activity assay and inhibitor screening from Inula macrophylla based on capillary electrophoresis","volume":"253","author":"Liu","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2025.101543_bib140","doi-asserted-by":"crossref","first-page":"340815","DOI":"10.1016\/j.aca.2023.340815","article-title":"Dextran-assisted ultrasonic exfoliation of two-dimensional metal-organic frameworks to evaluate acetylcholinesterase activity and inhibitor screening","volume":"1243","author":"Wang","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpha.2025.101543_bib141","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1021\/acs.analchem.1c05586","article-title":"Metal-organic frameworks-based immobilized enzyme microreactors integrated with capillary electrochromatography for high-efficiency enzyme assay","volume":"94","author":"Liu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib142","doi-asserted-by":"crossref","first-page":"464257","DOI":"10.1016\/j.chroma.2023.464257","article-title":"The screening of lipase inhibitors based on the metal-organic framework Zeolitic Imidazolate Framework-8-immobilized enzyme microreactor","volume":"1706","author":"Li","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpha.2025.101543_bib143","doi-asserted-by":"crossref","first-page":"117067","DOI":"10.1016\/j.jpba.2025.117067","article-title":"Acetylcholinesterase immobilized on MIL-88B-NH2 MOF for rapid screening inhibitors from herbal medicines: Ligand fishing coupled with mass spectrometry","volume":"265","author":"Wang","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpha.2025.101543_bib144","doi-asserted-by":"crossref","first-page":"108183","DOI":"10.1016\/j.bioorg.2025.108183","article-title":"Rapid screening of acetylcholinesterase inhibitors in Qi-Fu-Yin using magnetic metal-organic frameworks immobilized with acetylcholinesterase","volume":"156","author":"Li","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jpha.2025.101543_bib145","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00604-025-07167-0","article-title":"Preparation of immobilized xanthine oxidase with magnetic metal-organic framework and its application in screening of active ingredients in traditional Chinese medicine","volume":"192","author":"Wu","year":"2025","journal-title":"Microchim. Acta"}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925003600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925003600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:24:36Z","timestamp":1788362676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177925003600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":145,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2095177925003600"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101543","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifunctional MOF composites for advanced drug identification and screening: Innovations, applications and challenges","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101543"}}