{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:40:59Z","timestamp":1792600859096,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YDZJ202201ZYTS286"],"award-info":[{"award-number":["YDZJ202201ZYTS286"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272284"],"award-info":[{"award-number":["82272284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370297"],"award-info":[{"award-number":["82370297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jpha.2026.101590","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:37:58Z","timestamp":1771375078000},"page":"101590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription"],"prefix":"10.1016","volume":"16","author":[{"given":"Weibo","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-1985","authenticated-orcid":false,"given":"Jingling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-8715","authenticated-orcid":false,"given":"Ye","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2026.101590_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113626","article-title":"Navigating psoriasis: from immune mechanisms to natural healing approaches","volume":"144","author":"Kshirsagar","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jpha.2026.101590_bib2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jpha.2026.101590_bib3","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216758","article-title":"FAM3C\/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice","volume":"15","author":"Malik","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jpha.2026.101590_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling pathways and targeted therapies for psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jpha.2026.101590_bib5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jpha.2026.101590_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41392-023-01405-8","article-title":"FBXW7\u03b2 loss-of-function enhances FASN-Mediated lipogenesis and promotes colorectal cancer growth","volume":"8","author":"Wei","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.jpha.2026.101590_bib7","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.7150\/ijbs.85285","article-title":"FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression","volume":"19","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jpha.2026.101590_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.7150\/thno.83051","article-title":"MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-Dependent reprogramming of lipid metabolism","volume":"14","author":"Wang","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2026.101590_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216329","article-title":"Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma","volume":"570","author":"De Martino","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jpha.2026.101590_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41392-022-01219-0","article-title":"Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jpha.2026.101590_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1334844","article-title":"Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis","volume":"15","author":"Seiringer","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpha.2026.101590_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2019.10.017","article-title":"The role of non-coding RNAs in oncology","volume":"179","author":"Slack","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2026.101590_bib13","series-title":"Epigenetics in Allergy and Autoimmunity. Advances in Experimental Medicine and Biology","first-page":"9","article-title":"Epigenetics of psoriasis","author":"Shao","year":"2020"},{"key":"10.1016\/j.jpha.2026.101590_bib14","article-title":"NAT10 promotes gastric cancer liver metastasis by modulation of M2 macrophage polarization and metastatic tumor cell hepatic adhesion","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2026.101590_bib15","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3390\/cells8091035","article-title":"Recent advances on the structure and function of RNA acetyltransferase Kre33\/NAT10","volume":"8","author":"Sleiman","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2026.101590_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12964-023-01417-5","article-title":"Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jpha.2026.101590_bib17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41467-018-03770-3","article-title":"Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome","volume":"9","author":"Balmus","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib18","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1172\/JCI37378","article-title":"CCR6 is required for IL-23-induced psoriasis-like inflammation in mice","volume":"119","author":"Hedrick","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jpha.2026.101590_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2026.101590_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.omtn.2020.01.037","article-title":"The processing, gene regulation, biological functions, and clinical relevance of N4-acetylcytidine on RNA a systematic review","volume":"20","author":"Jin","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jpha.2026.101590_bib21","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/nar\/gkv075","article-title":"Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1\/THUMPD1","volume":"43","author":"Sharma","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jpha.2026.101590_bib22","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1038\/s41467-024-53350-x","article-title":"N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib23","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1038\/s41467-023-40975-7","article-title":"CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications","volume":"14","author":"Gong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib24","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/j.gastro.2024.01.027","article-title":"Oncogenic fatty acid metabolism rewires energy supply chain in gastric carcinogenesis","volume":"166","author":"Won","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpha.2026.101590_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.coi.2017.08.010","article-title":"Revisiting murine models for atopic dermatitis and psoriasis with multipolar cytokine axes","volume":"48","author":"Kabashima","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jpha.2026.101590_bib26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41419-023-06094-3","article-title":"Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis","volume":"14","author":"Lian","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2026.101590_bib27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.clindermatol.2007.08.007","article-title":"Psoriasis: epidemiology","volume":"25","author":"Gudjonsson","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jpha.2026.101590_bib28","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jid.2024.01.004","article-title":"LPCAT1 facilitates keratinocyte hyperproliferation and skin inflammation in psoriasis by regulating GLUT3","volume":"144","author":"Huang","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jpha.2026.101590_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41423-020-0519-3","article-title":"\u201cAutoinflammatory psoriasis\u201d: genetics and biology of pustular psoriasis, cell","volume":"18","author":"Uppala","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jpha.2026.101590_bib30","article-title":"Cutaneous calcium\/calmodulin-dependent protein kinase II-\u03b3\u2013positive sympathetic nerves secreting norepinephrine dictate psoriasis","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2026.101590_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109615","article-title":"Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models","volume":"121","author":"Jiang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpha.2026.101590_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl4336","article-title":"Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders","volume":"10","author":"Tan","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jpha.2026.101590_bib33","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41467-023-39020-4","article-title":"Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis","volume":"14","author":"Ma","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib34","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.7150\/thno.89180","article-title":"Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles","volume":"14","author":"Jiang","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2026.101590_bib35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41419-025-07521-3","article-title":"YAP1 facilitates the pathogenesis of psoriasis via modulating keratinocyte proliferation and inflammation","volume":"16","author":"Huang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2026.101590_bib36","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bbrc.2016.12.092","article-title":"Autoacetylation of NAT10 is critical for its function in rRNA transcription activation","volume":"483","author":"Cai","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib37","doi-asserted-by":"crossref","first-page":"9601","DOI":"10.1093\/nar\/gky777","article-title":"Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress","volume":"46","author":"Liu","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jpha.2026.101590_bib38","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.1252651","article-title":"Chemical inhibition of NAT10 corrects defects of laminopathic cells","volume":"344","author":"Larrieu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jpha.2026.101590_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303113","article-title":"Ac4C enhances the translation efficiency of vegfa mRNA and mediates central sensitization in spinal dorsal horn in neuropathic pain","volume":"10","author":"Xu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2026.101590_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-024-06463-6","article-title":"The implications of FASN in immune cell biology and related diseases","volume":"15","author":"Xiao","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2026.101590_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302705","article-title":"NAT10\/ac4C\/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2026.101590_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41420-024-01805-x","article-title":"\u03b1-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells","volume":"10","author":"Xiang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jpha.2026.101590_bib44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41591-018-0003-0","article-title":"Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpha.2026.101590_bib45","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jid.2021.06.019","article-title":"Mouse models of psoriasis: a comprehensive review","volume":"142","author":"Gangwar","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jpha.2026.101590_bib46","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jpha.2026.101590_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41467-024-44994-w","article-title":"Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade","volume":"15","author":"Francis","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2026.101590_bib48","doi-asserted-by":"crossref","first-page":"418","DOI":"10.23736\/S0392-0488.18.06202-8","article-title":"Psoriasis and the TNF\/IL23\/IL17 axis","volume":"154","author":"Furue","year":"2019","journal-title":"G. Ital. Dermatol. Venereol."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177926000456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177926000456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:57:02Z","timestamp":1792598222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177926000456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2095177926000456"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2026.101590","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2026.101590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101590"}}