{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:08:07Z","timestamp":1790730487553,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022XD037"],"award-info":[{"award-number":["2022XD037"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304687"],"award-info":[{"award-number":["82304687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474056"],"award-info":[{"award-number":["82474056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404854"],"award-info":[{"award-number":["82404854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82461160264"],"award-info":[{"award-number":["82461160264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0502605"],"award-info":[{"award-number":["2023ZD0502605"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jpha.2026.101647","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:07:04Z","timestamp":1778137624000},"page":"101647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis"],"prefix":"10.1016","volume":"16","author":[{"given":"Hongzhan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusha","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longshan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-1934","authenticated-orcid":false,"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2026.101647_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-pathmechdis-012419-032824","article-title":"Liver progenitors and adult cell plasticity in hepatic injury and repair: knowns and unknowns","volume":"15","author":"Ko","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jpha.2026.101647_bib2","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jpha.2026.101647_bib3","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1007\/s00204-021-03121-0","article-title":"The application of cytokeratin-18 as a biomarker for drug-induced liver injury","volume":"95","author":"Korver","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jpha.2026.101647_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2025.101496","article-title":"Metabolic heterogeneity, networks, and biomarkers of drug-induced liver injury","volume":"16","author":"Ding","year":"2026","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2026.101647_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/toxics6020024","article-title":"Herb-induced liver injuries in developing nations: an update","volume":"6","author":"Amadi","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.jpha.2026.101647_bib6","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.23937","article-title":"Drug-induced acute liver failure: results of a U.S. multicenter, prospective study","volume":"52","author":"Reuben","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jpha.2026.101647_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/HM9.0000000000000110","article-title":"Regulation and application of Chinese herbs in the US: misuse is the main cause of toxic incidents","volume":"4","author":"Liu","year":"2024","journal-title":"Acupunct. Herb. Med."},{"key":"10.1016\/j.jpha.2026.101647_bib8","first-page":"798","article-title":"Microbiota basis of antidepressant effects of Zhi-zi-chi Decoction: lactobacillus rhamnosus and gut microbiota metabolism","volume":"17","author":"He","year":"2025","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jpha.2026.101647_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156770","article-title":"Gardeniae Fructus extract terminates refractory status epilepticus with a wide time window through inhibiting neuroinflammation","volume":"142","author":"Sun","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2026.101647_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154971","article-title":"Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1\/FXR signaling in bile duct ligation-induced liver fibrosis","volume":"118","author":"Qin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2026.101647_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117061","article-title":"Bidirectional effects of geniposide in liver injury: preclinical evidence construction based on meta-analysis","volume":"319","author":"Zeng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111411","article-title":"Covalent binding of Geniposide metabolites to hepatic proteins: a potential mechanism for its hepatotoxicity","volume":"408","author":"Gao","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jpha.2026.101647_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.eng.2024.10.023","article-title":"Gut microbiota, a potential mediated target for reducing geniposide hepatotoxicity by interacting with isoflavones","volume":"47","author":"Yang","year":"2025","journal-title":"Engineering"},{"key":"10.1016\/j.jpha.2026.101647_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137498","article-title":"Genipin, a natural blue colorant precursor: source, extraction, properties, and applications","volume":"434","author":"Ahmed","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jpha.2026.101647_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104945","article-title":"Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: more friend than foe","volume":"159","author":"Fan","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jpha.2026.101647_bib16","article-title":"Acute and subacute hepatotoxicity of genipin in mice and its potential mechanism","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jpha.2026.101647_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2016.10.007","article-title":"Lysine-and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate","volume":"264","author":"Lin","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jpha.2026.101647_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154172","article-title":"Development of a mechanism-based biomarker for Dioscorea bulbifera L. exposure and hepatotoxicity in rats","volume":"102","author":"Hu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2026.101647_bib19","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1021\/acs.jafc.0c07948","article-title":"Molecular structure of Gardenia Blue pigments by reaction of genipin with benzylamine and amino acids","volume":"69","author":"Tsutsumiuchi","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2026.101647_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.625108","article-title":"Predicting a potential link to antidepressant effect: neuroprotection of Zhi-zi-Chi decoction on glutamate-induced cytotoxicity in PC12 cells","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib21","doi-asserted-by":"crossref","first-page":"13167","DOI":"10.1021\/acs.analchem.7b02684","article-title":"Strategy for hepatotoxicity prediction induced by drug reactive metabolites using human liver microsome and online 2D-nano-LC-MS analysis","volume":"89","author":"Zhuo","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2026.101647_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153656","article-title":"Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response","volume":"90","author":"Luo","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2026.101647_bib23","article-title":"Loss of carbamoyl phosphate synthetase 1 potentiates hepatocellular carcinoma metastasis by reducing aspartate level","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2026.101647_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147182","article-title":"Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a\/SIRT1\/FXR\/p53 axis","volume":"784","author":"Alshehri","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2026.101647_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2019.11.020","article-title":"A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells","volume":"31","author":"Yoo","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.jpha.2026.101647_bib26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41401-025-01622-7","article-title":"Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis","volume":"47","author":"Zhang","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jpha.2026.101647_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102034118","article-title":"HMGB1 released from nociceptors mediates inflammation","volume":"118","author":"Yang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jpha.2026.101647_bib28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/pin.12414","article-title":"Loss of Hep Par 1 immunoreactivity in the livers of patients with carbamoyl phosphate synthetase 1 deficiency","volume":"66","author":"Yamaguchi","year":"2016","journal-title":"Pathol. Int."},{"key":"10.1016\/j.jpha.2026.101647_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13023-023-02800-8","article-title":"Citrulline in the management of patients with urea cycle disorders","volume":"18","author":"Imbard","year":"2023","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jpha.2026.101647_bib30","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s10143-024-03054-z","article-title":"Valproate-induced hyperammonemic encephalopathy in neurosurgical patients: our experience and systematic literature review","volume":"47","author":"Kumarasamy","year":"2024","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.jpha.2026.101647_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.eplepsyres.2019.05.010","article-title":"CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients","volume":"154","author":"Chen","year":"2019","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.jpha.2026.101647_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/st9.0000000000000061","article-title":"Isorhamnetin alleviates pathological damage in influenza A virus strain PR8-induced pneumonia by activating the Nrf2\/HO-1 pathway and suppressing apoptosis","volume":"3","author":"Xu","year":"2025","journal-title":"Sci. Tradit. Chin. Med."},{"key":"10.1016\/j.jpha.2026.101647_bib33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ccr.2011.09.006","article-title":"Renal cyst formation in Fh1-deficient mice is independent of the Hif\/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling","volume":"20","author":"Adam","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jpha.2026.101647_bib34","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.chembiol.2023.07.014","article-title":"Succinylation of a KEAP1 sensor lysine promotes NRF2 activation","volume":"30","author":"Ibrahim","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jpha.2026.101647_bib35","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ana.26555","article-title":"Dimethyl fumarate delays multiple sclerosis in radiologically isolated syndrome","volume":"93","author":"Okuda","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jpha.2026.101647_bib36","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/brain\/awq386","article-title":"Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway","volume":"134","author":"Linker","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jpha.2026.101647_bib37","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3390\/antiox11101924","article-title":"Dimethyl fumarate triggers the antioxidant defense system in human retinal endothelial cells through Nrf2 activation","volume":"11","author":"Manai","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jpha.2026.101647_bib38","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ccell.2014.10.005","article-title":"Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer","volume":"26","author":"Sourbier","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jpha.2026.101647_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112751","article-title":"FOXA2 controls the anti-oxidant response in FH-deficient cells","volume":"42","author":"Rogerson","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jpha.2026.101647_bib40","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.molcel.2022.01.029","article-title":"Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma","volume":"82","author":"Ge","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jpha.2026.101647_bib41","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41556-025-01627-8","article-title":"ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion","volume":"27","author":"Duan","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jpha.2026.101647_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads4957","article-title":"Citrulline regulates macrophage metabolism and inflammation to counter aging in mice","volume":"11","author":"Xie","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jpha.2026.101647_bib43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s10020-025-01100-0","article-title":"Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis","volume":"31","author":"Giroud-Gerbetant","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.jpha.2026.101647_bib44","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1016\/j.scib.2024.09.019","article-title":"Essentiality of SLC7A11-mediated nonessential amino acids in MASLD","volume":"69","author":"Shen","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.jpha.2026.101647_bib45","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/bph.17419","article-title":"The paracetamol metabolite N-acetyl-4-benzoquinoneimine (NAPQI) prevents modulation of Kv7 channels via G-protein coupled receptors by interference with PIP2 and Ca2+ sensitivity","volume":"182","author":"Losgott","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117266","article-title":"Sodium taurocholate co-transporting polypeptide deficiency attenuates acetaminophen-induced hepatotoxicity via regulating expression of drug metabolism enzymes in mice","volume":"497","author":"Yang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1037814","article-title":"Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: a review","volume":"13","author":"Zhuang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2017.09.001","article-title":"Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver","volume":"145","author":"Wang","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jpha.2026.101647_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.apsb.2023.10.017","article-title":"High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice","volume":"14","author":"Chao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpha.2026.101647_bib50","article-title":"Protective role of coenzyme Q10 against isoniazid and rifampicin-induced hepatotoxicity in rats via modulation of PPAR-\u03b3, iNOS, and NF-\u03baB","volume":"39","author":"Udhaya Lavinya","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177926001024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177926001024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:05:40Z","timestamp":1789934740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177926001024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2095177926001024"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2026.101647","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2026.101647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101647"}}