{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:42:58Z","timestamp":1790664178495,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["23590305"],"award-info":[{"award-number":["23590305"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Education"},{"name":"Promotion Project of Medical Clustering of Okinawa Prefecture"},{"DOI":"10.13039\/501100008768","name":"University of the Ryukyus","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008768","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sumitomo Dainippon Pharma Co"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jphs.2014.10.002","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T16:20:49Z","timestamp":1416327649000},"page":"42-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice"],"prefix":"10.1016","volume":"127","author":[{"given":"Masato","family":"Tsutsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Otsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2014.10.002_bib1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00424-010-0796-2","article-title":"Nitric oxide synthases in the pathogenesis of cardiovascular disease: lessons from genetically modified mice","volume":"459","author":"Shimokawa","year":"2010","journal-title":"Pflugers Archiv"},{"key":"10.1016\/j.jphs.2014.10.002_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.tcm.2008.12.002","article-title":"Spontaneous myocardial infarction and nitric oxide synthase","volume":"18","author":"Tsutsui","year":"2008","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jphs.2014.10.002_bib3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1253\/circj.CJ-09-0208","article-title":"Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice","volume":"73","author":"Tsutsui","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jphs.2014.10.002_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.pharmthera.2010.08.010","article-title":"Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases","volume":"128","author":"Tsutsui","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jphs.2014.10.002_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.pharmtox.44.101802.121844","article-title":"The regulation and pharmacology of endothelial nitric oxide synthase","volume":"46","author":"Dudzinski","year":"2006","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jphs.2014.10.002_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fasebj.12.10.773","article-title":"Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)","volume":"12","author":"Forstermann","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.jphs.2014.10.002_bib7","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1161\/01.ATV.0000190663.88143.97","article-title":"Vascular neuronal NO synthase is selectively upregulated by platelet-derived growth factor","volume":"25","author":"Nakata","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jphs.2014.10.002_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1161\/01.ATV.0000251615.61858.33","article-title":"Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt\/NF-kappaB pathway","volume":"27","author":"Nakata","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.jphs.2014.10.002_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5551\/jat.11.41","article-title":"Neuronal nitric oxide synthase as a novel anti-atherogenic factor","volume":"11","author":"Tsutsui","year":"2004","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"10.1016\/j.jphs.2014.10.002_bib10","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1096\/fj.01-0842com","article-title":"Vascular smooth muscle and nitric oxide synthase","volume":"16","author":"Buchwalow","year":"2002","journal-title":"FASEB Journal"},{"key":"10.1016\/j.jphs.2014.10.002_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0024-3205(96)00287-1","article-title":"Constitutive expression and structural diversity of inducible isoform of nitric oxide synthase in human tissues","volume":"59","author":"Park","year":"1996","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2014.10.002_bib12","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1161\/01.ATV.17.11.2479","article-title":"Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels","volume":"17","author":"Wilcox","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jphs.2014.10.002_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/01.RES.72.2.387","article-title":"NG-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists","volume":"72","author":"Buxton","year":"1993","journal-title":"Circ Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib14","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0022-3565(25)24679-1","article-title":"Effect of substituted arginine compounds on superoxide production in the rabbit aorta","volume":"257","author":"Heim","year":"1991","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jphs.2014.10.002_bib15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0006-291X(92)91266-S","article-title":"The nonspecificity of specific nitric oxide synthase inhibitors","volume":"187","author":"Peterson","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2014.10.002_bib16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/0006-291X(91)91768-8","article-title":"N\u00c9\u00f7-nitro-L-arginine benzyl ester, a potent irreversible inhibitor of endothelium dependent relaxation","volume":"179","author":"Thomas","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2014.10.002_bib17","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1161\/01.CIR.0000029749.16101.44","article-title":"Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice","volume":"106","author":"Suda","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib18","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1161\/01.ATV.0000136656.26019.6e","article-title":"Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice","volume":"24","author":"Suda","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.jphs.2014.10.002_bib19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.CIR.104.3.342","article-title":"Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase","volume":"104","author":"Duplain","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.bi.63.070194.001135","article-title":"Nitric oxide: a physiological messenger molecule","volume":"63","author":"Bredt","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jphs.2014.10.002_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pa.24.040184.001135","article-title":"The role of endothelium in the responses of vascular smooth muscle to drugs","volume":"24","author":"Furchgott","year":"1984","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jphs.2014.10.002_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.pa.30.040190.002535","article-title":"Biosynthesis and metabolism of endothelium-derived nitric oxide","volume":"30","author":"Ignarro","year":"1990","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jphs.2014.10.002_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev."},{"key":"10.1016\/j.jphs.2014.10.002_bib24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/01.CIR.95.5.1101","article-title":"What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle?","volume":"95","author":"Murad","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/jmcc.1998.0841","article-title":"Primary endothelial dysfunction: atherosclerosis","volume":"31","author":"Shimokawa","year":"1999","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib26","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1172\/JCI1293","article-title":"Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice","volume":"101","author":"Moroi","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jphs.2014.10.002_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0092-8674(00)81796-1","article-title":"Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase","volume":"87","author":"Son","year":"1996","journal-title":"Cell."},{"key":"10.1016\/j.jphs.2014.10.002_bib28","doi-asserted-by":"crossref","first-page":"H429","DOI":"10.1152\/ajpheart.00501.2001","article-title":"Neuronal NOS-dependent dilation to flow in coronary arteries of male eNOS-KO mice","volume":"282","author":"Huang","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib29","doi-asserted-by":"crossref","first-page":"H1906","DOI":"10.1152\/ajpheart.2000.279.4.H1906","article-title":"Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice","volume":"279","author":"Lamping","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib30","doi-asserted-by":"crossref","first-page":"10616","DOI":"10.1073\/pnas.0502236102","article-title":"Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms","volume":"102","author":"Morishita","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2014.10.002_bib31","doi-asserted-by":"crossref","first-page":"R628","DOI":"10.1152\/ajpregu.00401.2002","article-title":"Cardiovascular and renal control in NOS-deficient mouse models","volume":"284","author":"Ortiz","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib32","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1096\/fj.02-0155fje","article-title":"Vasculoprotective roles of neuronal nitric oxide synthase","volume":"16","author":"Morishita","year":"2002","journal-title":"FASEB Journal"},{"key":"10.1016\/j.jphs.2014.10.002_bib33","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1161\/CIRCULATIONAHA.107.742692","article-title":"Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms","volume":"117","author":"Nakata","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.RES.0000166325.00383.ed","article-title":"Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis","volume":"96","author":"Sasaguri","year":"2005","journal-title":"Circ Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.niox.2011.06.007","article-title":"Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: involvement of bone marrow-derived cells","volume":"25","author":"Furuno","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jphs.2014.10.002_bib36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.CIR.99.3.361","article-title":"Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery","volume":"99","author":"Laine","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1523-1755.2005.00397.x","article-title":"Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study","volume":"68","author":"Ninomiya","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.jphs.2014.10.002_bib38","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1161\/CIRCULATIONAHA.108.792903","article-title":"Impact of kidney disease and blood pressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal Study","volume":"118","author":"Ninomiya","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5551\/jat.10454","article-title":"Chronic kidney disease, dyslipidemia, and atherosclerosis","volume":"19","author":"Shoji","year":"2012","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"10.1016\/j.jphs.2014.10.002_bib40","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCRESAHA.109.212969","article-title":"Farnesoid X receptor activation prevents the development of vascular calcification in ApoE-\/- mice with chronic kidney disease","volume":"106","author":"Miyazaki-Anzai","year":"2010","journal-title":"Circ Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib41","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ki.2013.9","article-title":"White adipose tissue overproduces the lipid-mobilizing factor zinc alpha2-glycoprotein in chronic kidney disease","volume":"83","author":"Pelletier","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jphs.2014.10.002_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yjmcc.2014.09.021","article-title":"Development of an experimentally useful model of acute myocardial infarction: 2\/3 nephrectomized triple nitric oxide synthases-deficient mouse","volume":"77","author":"Uchida","year":"2014","journal-title":"J\u00a0Moll Cell Cardiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib43","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1253\/circj.CJ-10-0277","article-title":"Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases","volume":"74","author":"Shibata","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.jphs.2014.10.002_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/HYPERTENSIONAHA.108.118026","article-title":"Cornell product left ventricular hypertrophy in electrocardiogram and the risk of stroke in a general population","volume":"53","author":"Ishikawa","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2014.10.002_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1291\/hypres.29.353","article-title":"Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population: NIPPON DATA90","volume":"29","author":"Nakamura","year":"2006","journal-title":"Hypertension Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib46","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/HYPERTENSIONAHA.114.03287","article-title":"Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy","volume":"64","author":"Kamezaki","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2014.10.002_bib47","doi-asserted-by":"crossref","first-page":"6A","DOI":"10.1016\/0735-1097(93)90455-A","article-title":"The epidemiology of heart failure: the Framingham Study","volume":"22","author":"Ho","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jphs.2014.10.002_bib48","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1253\/circj.CJ-08-1073","article-title":"Heart failure with preserved ejection fraction","volume":"73","author":"Yamamoto","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jphs.2014.10.002_bib49","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/hc1102.105289","article-title":"New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function","volume":"105","author":"Zile","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2014.10.002_bib50","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1006\/bbrc.2001.6278","article-title":"Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries","volume":"290","author":"Matoba","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2014.10.002_bib51","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1172\/JCI10506","article-title":"Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice [In Process Citation]","volume":"106","author":"Matoba","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jphs.2014.10.002_bib52","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.20080106","article-title":"Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice","volume":"205","author":"Takaki","year":"2008","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jphs.2014.10.002_bib53","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jphs.2014.10.002_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000099786.99623.EF","article-title":"Adiponectin and metabolic syndrome","volume":"24","author":"Matsuzawa","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.jphs.2014.10.002_bib55","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1253\/circj.71.675","article-title":"Relationship of serum adiponectin level to adverse cardiovascular events in patients who undergo percutaneous coronary intervention","volume":"71","author":"Shioji","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.jphs.2014.10.002_bib56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/cvr\/cvq092","article-title":"Severe Dyslipidemia, Atherosclerosis, and Sudden Cardiac Death in Mice Lacking All NO Synthases Fed a High-Fat Diet","volume":"87","author":"Yatera","year":"2010","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib57","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1073\/pnas.90.24.11603","article-title":"SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element","volume":"90","author":"Hua","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2014.10.002_bib58","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1046\/j.1523-1755.2001.0590041290.x","article-title":"Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction","volume":"59","author":"Miyajima","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.jphs.2014.10.002_bib59","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1681\/ASN.V7102202","article-title":"Nitric oxide generation ameliorates the tubulointerstitial fibrosis of obstructive nephropathy","volume":"7","author":"Morrissey","year":"1996","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jphs.2014.10.002_bib60","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ki.1991.63","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"39","author":"Kuncio","year":"1991","journal-title":"Kidney Int"},{"key":"10.1016\/j.jphs.2014.10.002_bib61","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1254\/jphs.10143FP","article-title":"Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in\u00a0vivo","volume":"114","author":"Morisada","year":"2010","journal-title":"J\u00a0Pharmacol Sci."},{"key":"10.1016\/j.jphs.2014.10.002_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12931-014-0092-3","article-title":"Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice","volume":"15","author":"Noguchi","year":"2014","journal-title":"Respir Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib63","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jbmr.5650100315","article-title":"Expression and functional role of nitric oxide synthase in osteoblast-like cells","volume":"10","author":"Riancho","year":"1995","journal-title":"J\u00a0Bone Miner Res."},{"key":"10.1016\/j.jphs.2014.10.002_bib64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S8756-3282(98)00173-2","article-title":"Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells","volume":"24","author":"MacPherson","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.jphs.2014.10.002_bib65","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1073\/pnas.92.7.2954","article-title":"Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms","volume":"92","author":"Brandi","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2014.10.002_bib66","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1073\/pnas.91.9.3569","article-title":"Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase","volume":"91","author":"Kasten","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2014.10.002_bib67","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1359\/jbmr.080107","article-title":"Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in\u00a0vivo: involvement of the renin-angiotensin system","volume":"23","author":"Sabanai","year":"2008","journal-title":"J\u00a0Bone Miner Res."},{"issue":"Suppl.\u00a0I","key":"10.1016\/j.jphs.2014.10.002_bib68","article-title":"Complete disruption of all nitric oxide synthase genes markedly reduces cerebral infarct size after middle cerebral artery occlusion in mice","volume":"78","author":"Kubota","year":"2014","journal-title":"Circ J"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861314000097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861314000097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:57:42Z","timestamp":1761163062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861314000097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1347861314000097"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2014.10.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2014.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}