{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:59Z","timestamp":1791644099117,"version":"4.3.4"},"reference-count":98,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jphs.2014.12.015","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T06:02:59Z","timestamp":1421215379000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease"],"prefix":"10.1016","volume":"127","author":[{"given":"Masaaki","family":"Akagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Akae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Hirashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Fukuishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2014.12.015_bib1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJMra022366","article-title":"Apoptosis and caspases in neurodegenerative diseases","volume":"348","author":"Friedlander","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jphs.2014.12.015_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jnen\/64.4.263","article-title":"The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer's disease","volume":"64","author":"Counts","year":"2005","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.jphs.2014.12.015_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A\u00a0phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jphs.2014.12.015_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.neuropharm.2006.05.014","article-title":"HU0622: a small molecule promoting GAP-43 activation and neurotrophic effects","volume":"51","author":"Uwabe","year":"2006","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.jphs.2014.12.015_bib5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/np300911b","article-title":"Evaluation of constituents of Piper retrofractum fruits on neurotrophic activity","volume":"76","author":"Kubo","year":"2013","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jphs.2014.12.015_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer's disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J\u00a0Neuropath Exp Neurol"},{"key":"10.1016\/j.jphs.2014.12.015_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1471-4159.2011.07213.x","article-title":"Targets for AD treatment: conflicting messages from \u03b3-secretase inhibitors","volume":"117","author":"Sambamurti","year":"2011","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jphs.2014.12.015_bib8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1126\/science.1156609","article-title":"Efficient inhibition of the Alzheimer's disease \u03b2-secretase by membrane targeting","volume":"320","author":"Rajendran","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jphs.2014.12.015_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neulet.2013.03.056","article-title":"Previously not recognized deletion in presenilin-1 (p.Leu174del.) in a patient with early-onset familial Alzheimer's disease","volume":"544","author":"Tiedt","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JAD-2002-4507","article-title":"Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat","volume":"4","author":"Utsuki","year":"2002","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.jphs.2014.12.015_bib11","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12035-012-8328-z","article-title":"Recent advances in \u03b1-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease","volume":"47","author":"Guerrero","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jphs.2014.12.015_bib12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/j.1460-2075.1993.tb05665.x","article-title":"Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament","volume":"12","author":"Novak","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.jphs.2014.12.015_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0925-4439(00)00040-5","article-title":"Oxidative stress in Alzheimer\u00eds disease","volume":"1502","author":"Smith","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jphs.2014.12.015_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1358\/dnp.2007.20.8.1157615","article-title":"Molecular basis of insulin action","volume":"20","author":"Gonzalez-Sanchez","year":"2007","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.jphs.2014.12.015_bib15","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1073\/pnas.0308724101","article-title":"Role for neuronal insulin resistance in neurodegenerative diseases","volume":"101","author":"Schubert","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2014.12.015_bib16","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.10-02-00558.1990","article-title":"Selective and nonselective stimulation of central cholinergic and dopaminergic development in\u00a0vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and insulin-like growth factors I and II","volume":"10","author":"Knusel","year":"1990","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jphs.2014.12.015_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-014-1700-1","article-title":"Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2\/Bax and caspase-3 activation","author":"Mei","year":"2014","journal-title":"Neurol Sci"},{"key":"10.1016\/j.jphs.2014.12.015_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-2999(03)02075-2","article-title":"Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells","volume":"474","author":"Zhai","year":"2003","journal-title":"Eur J Pharmacol"},{"issue":"19","key":"10.1016\/j.jphs.2014.12.015_bib19","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.bmcl.2006.12.041","article-title":"Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons","volume":"17","author":"Tadtong","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"10.1016\/j.jphs.2014.12.015_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2478\/s11658-013-0096-x","article-title":"Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells","volume":"18","author":"Oh-Hashi","year":"2013","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnsyn.2014.00005","article-title":"The BDNF effects on dendric spines of mature hippocampal neurons depend on neuronal activity","volume":"6","author":"Kellner","year":"2014","journal-title":"Front Synaptic Neurosci"},{"issue":"11","key":"10.1016\/j.jphs.2014.12.015_bib22","doi-asserted-by":"crossref","first-page":"e81547","DOI":"10.1371\/journal.pone.0081547","article-title":"In\u00a0vivo regulation of brain-derived neurotrophic factor in dorsal root ganglia is mediated by nerve growth factor-triggered Akt activation during cystitis","volume":"8","author":"Qiao","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jphs.2014.12.015_bib23","doi-asserted-by":"crossref","first-page":"e64755","DOI":"10.1371\/journal.pone.0064755","article-title":"Targeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection","volume":"8","author":"Gransee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2014.12.015_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1326-5-5","article-title":"Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signaling, but not death of septal cholinergic neurons","volume":"5","author":"Lazo","year":"2010","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jphs.2014.12.015_bib25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2013.10.033","article-title":"Copper chelation and exogenous copper affect circadian clock phase resetting in the suprachiasmatic nucleus in\u00a0vitro","volume":"256","author":"Yamada","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphs.2014.12.015_bib26","doi-asserted-by":"crossref","first-page":"694398","DOI":"10.1155\/2013\/694398","article-title":"Protective and antioxidant effects of a chalconoid from Pulicaria incisa on brain astrocytes","volume":"2013","author":"Elmann","year":"2013","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.jphs.2014.12.015_bib27","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.celrep.2014.03.040","article-title":"proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus","volume":"7","author":"Yang","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jphs.2014.12.015_bib28","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1248\/bpb.28.1762","article-title":"Neurotrophic effect of magnolol in the hippocampal CA1 region of senescence -accelerated mice (SAMP1)","volume":"28","author":"Matsui","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jphs.2014.12.015_bib29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2009.09.107","article-title":"Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice","volume":"1305","author":"Matsui","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2014.12.015_bib30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2012.02.010","article-title":"Phenylbutanoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhanced hippocampal neurogenesis in olfactory bulbectomized mice","volume":"513","author":"Matsui","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1254\/jphs.11033SC","article-title":"Protective effect of neurotrophic agent T-817MA against inner ear barotrauma in the guinea pig","volume":"117","author":"Maekawa","year":"2011","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2014.12.015_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00004424-200206000-00003","article-title":"Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats","volume":"37","author":"Lemaire","year":"2002","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jphs.2014.12.015_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/mol.65.1.56","article-title":"Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4- dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration","volume":"65","author":"Kem","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jphs.2014.12.015_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1099-081X(199804)19:3<147::AID-BDD77>3.0.CO;2-9","article-title":"Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition","volume":"19","author":"Mahnir","year":"1998","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.jphs.2014.12.015_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0006-8993(97)00536-2","article-title":"3-[2,4- Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rats \u03b17 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner","volume":"768","author":"Meyer","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2014.12.015_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1254\/jjp.76.23","article-title":"Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils","volume":"76","author":"Nanri","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jphs.2014.12.015_bib37","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.npp.1300028","article-title":"Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers","volume":"28","author":"Kitagawa","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jphs.2014.12.015_bib38","first-page":"395","volume":"vol. 32","author":"Fukuyama","year":"2005"},{"key":"10.1016\/j.jphs.2014.12.015_bib39","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bmcl.2003.11.043","article-title":"TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells","volume":"14","author":"Inoue","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib40","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1055\/s-2004-827179","article-title":"Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons","volume":"70","author":"Zhai","year":"2004","journal-title":"Planta Med"},{"key":"10.1016\/j.jphs.2014.12.015_bib41","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1248\/cpb.45.947","article-title":"a novel polyprenylated phloroglucin derivative, increasing acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures","volume":"45","author":"Fukuyama","year":"1997","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.jphs.2014.12.015_bib42","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1016\/j.tet.2009.08.015","article-title":"Isolation, synthesis, and neurite outgrowth- promoting activity of illicinin A from the flowers of Illicium anisatum","volume":"65","author":"Takaoka","year":"2009","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jphs.2014.12.015_bib43","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1016\/j.tet.2007.03.063","article-title":"Structure and neurotrophic activity aof novel sesqui-neolignans from the pericarps of Illicium fargesii","volume":"63","author":"Moriyama","year":"2007","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jphs.2014.12.015_bib44","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1021\/ol9021029","article-title":"Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi","volume":"11","author":"Kubo","year":"2009","journal-title":"Org Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib45","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1016\/S0040-4039(00)01023-6","article-title":"Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illicium merrillianum","volume":"41","author":"Huang","year":"2000","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib46","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2006-957675","article-title":"Bicycloillicinone asarone acetal: a novel prenylated C6-C3 compound increasing choline acetyltransferase (ChAT) activity from Illicium tashiroi","volume":"63","author":"Fukuyama","year":"1997","journal-title":"Planta Med"},{"key":"10.1016\/j.jphs.2014.12.015_bib47","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1021\/np300287f","article-title":"Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus","volume":"75","author":"Liu","year":"2012","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jphs.2014.12.015_bib48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2005.04.035","article-title":"Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1\/2)","volume":"516","author":"Zhai","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jphs.2014.12.015_bib49","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1039\/p19910002737","article-title":"Novel neurotrophic isocuparane-type dimers, mastigophorenes A, B, C and D, isolated from the liverwort Mastigophora diclados","volume":"1","author":"Fukuyama","year":"1991","journal-title":"J\u00a0Chem Soc Perkin Trans"},{"key":"10.1016\/j.jphs.2014.12.015_bib50","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1021\/np300566y","article-title":"Nerve growth factor-potentiating benzofuran derivatives from the medicinal fungus Phellinus ribis","volume":"75","author":"Liu","year":"2012","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jphs.2014.12.015_bib51","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1248\/cpb.51.1377","article-title":"Structures of 1,4-benzodioxane derivatives from the seeds of Phytolacca americana and their neuritogenic activity in primary cultured rat cortical neurons","volume":"51","author":"Takahashi","year":"2003","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.jphs.2014.12.015_bib52","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1021\/np8004002","article-title":"Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides","volume":"71","author":"Tang","year":"2008","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jphs.2014.12.015_bib53","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3987\/REV-10-671","article-title":"Chemistry and biological activities of vibsane-type diterpenoids","volume":"81","author":"Fukuyama","year":"2010","journal-title":"Heterocycles"},{"key":"10.1016\/j.jphs.2014.12.015_bib54","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1016\/j.bmcl.2010.02.085","article-title":"NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii","volume":"20","author":"Kubo","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-7847.99898","article-title":"Neuroprotective potential of phytochemicals","volume":"6","author":"Kumar","year":"2012","journal-title":"Pharmacogn Rev"},{"issue":"2","key":"10.1016\/j.jphs.2014.12.015_bib56","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-131187","article-title":"In\u00a0vitro evidence that an aqueous extract of Centella asiatica modulates \u03b1-synuclein aggregation dynamics","volume":"39","author":"Berrocal","year":"2014","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.jphs.2014.12.015_bib57","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1111\/j.1471-4159.2009.06069.x","article-title":"A\u00a0traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in\u00a0vitro and in\u00a0vivo","volume":"169","author":"Fujiwara","year":"2009","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jphs.2014.12.015_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.foodchem.2004.11.015","article-title":"Contents of polyphenols in fruit and vegetables","volume":"94","author":"Cieslik","year":"2006","journal-title":"Food Chem"},{"key":"10.1016\/j.jphs.2014.12.015_bib59","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1021\/ac901397c","article-title":"Identification and characterization of polyphenolic antioxidants using on-line liquid chromatography, electrochemistry, and electrospray ionization tandem mass spectrometry","volume":"81","author":"Zettersten","year":"2009","journal-title":"Anal Chem"},{"key":"10.1016\/j.jphs.2014.12.015_bib60","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.neuint.2012.08.012","article-title":"The binding of resveratrol to monomer and fibril amyloid beta","volume":"61","author":"Ge","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jphs.2014.12.015_bib61","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00221-011-2885-7","article-title":"Regulation of alpha-secretase ADAM10 expression and activity","volume":"217","author":"Endres","year":"2012","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jphs.2014.12.015_bib62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuro.2012.09.013","article-title":"Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity","volume":"34","author":"Kang","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jphs.2014.12.015_bib63","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00216-011-4963-x","article-title":"Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in\u00a0vitro methods for characterization of inhibitors","volume":"400","author":"Mancini","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jphs.2014.12.015_bib64","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuint.2011.02.021","article-title":"Conformational transition in the substrate binding domain of \u03b2-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study","volume":"58","author":"Chakraborty","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jphs.2014.12.015_bib65","first-page":"47","article-title":"Geranylgeranyl pyrophosphate stimulates \u03b3-secretase to increase the generation of A\u03b2 and APP-CTF\u03b3","volume":"22","author":"Zhou","year":"2008","journal-title":"Fed Am Soc Exp Biol J"},{"key":"10.1016\/j.jphs.2014.12.015_bib66","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.286.5441.916","article-title":"The presenilins in Alzheimer's disease\u2014proteolysis holds the key","volume":"286","author":"Haass","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jphs.2014.12.015_bib67","doi-asserted-by":"crossref","first-page":"9146","DOI":"10.1021\/jm3003813","article-title":"Liberation of copper from amyloid plaques: making a risk factor useful for Alzheimer's dis- ease treatment","volume":"55","author":"Geng","year":"2012","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jphs.2014.12.015_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neulet.2007.09.042","article-title":"Anti-amyloidogenic activity of S-allyl- L-cysteine and its activity to destabilize Alzheimer's \u03b2-amyloid fibrils in\u00a0vitro","volume":"429","author":"Gupta","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib69","first-page":"679","article-title":"Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease","volume":"36","author":"Chaudhary","year":"2011","journal-title":"J\u00a0Biosci"},{"key":"10.1016\/j.jphs.2014.12.015_bib70","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/cn3000247","article-title":"A\u00a0key role for lysine residues in amyloid \u03b2-protein folding, assembly, and toxicity","volume":"3","author":"Sinha","year":"2012","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.jphs.2014.12.015_bib71","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1747-0285.2005.00318.x","article-title":"Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic inter- actions as a common inhibition mechanism","volume":"67","author":"Porat","year":"2006","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.jphs.2014.12.015_bib72","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/cn200088r","article-title":"\u201cClicked\u201d sugar\u2013curcumin conjugate: modulator of amyloid-\u03b2 and tau peptide aggregation at ultralow concentrations","volume":"2","author":"Dolai","year":"2011","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.jphs.2014.12.015_bib73","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/pro.87","article-title":"9, 10-Anthraquinone hinders beta \u03b2-aggregation: how does a small molecule interfere with A\u03b2-peptide amyloid fibrillation?","volume":"18","author":"Convertino","year":"2009","journal-title":"Protein Sci"},{"key":"10.1016\/j.jphs.2014.12.015_bib74","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid \u03b2 oligomers and fibrils, binds plaques, and reduces amyloid in\u00a0vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2014.12.015_bib75","first-page":"3071","article-title":"Critical evaluation of biodegradable polymers used in nanodrugs","volume":"8","author":"Marin","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.jphs.2014.12.015_bib76","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.bmcl.2007.11.028","article-title":"New polyphenols\u00a0active on \u03b2-amyloid aggregation","volume":"18","author":"Rivi\u00e8re","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib77","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bbadis.2006.03.002","article-title":"Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease","volume":"1762","author":"Ono","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jphs.2014.12.015_bib78","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.bmcl.2010.04.093","article-title":"Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity","volume":"20","author":"Jung","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib79","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/ijms11041321","article-title":"Bioavailability of the polyphenols: status and controversies","volume":"11","author":"D'Archivio","year":"2010","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2014.12.015_bib80","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1248\/yakushi1947.93.4_429","article-title":"Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and honokiol in M.\u00a0obovata and other allied plants","volume":"93","author":"Fujita","year":"1973","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jphs.2014.12.015_bib81","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0960-894X(02)00112-9","article-title":"Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons","volume":"12","author":"Fukuyama","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/np9702446","article-title":"Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine","volume":"61","author":"Maruyama","year":"1998","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jphs.2014.12.015_bib83","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0531-5565(96)00036-8","article-title":"Senescence-accelerated mouse SAM): a novel murine model of senescence","volume":"32","author":"Takeda","year":"1997","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jphs.2014.12.015_bib84","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0197-4580(99)00006-8","article-title":"Age-related defects in lifespan and learning ability in SAMP8 mice","volume":"20","author":"Nomura","year":"1999","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jphs.2014.12.015_bib85","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0006-8993(02)04192-6","article-title":"Cholinergic deficits in the septal-hippocampal pathway of the SAM-P\/8 senescence accelerated mouse","volume":"966","author":"Strong","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2014.12.015_bib86","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1568007023339490","article-title":"Small molecule Trk receptor agonists and other neurotrophic factor mimetics","volume":"1","author":"Pollack","year":"2002","journal-title":"Curr Drug Targets CNS Disord"},{"key":"10.1016\/j.jphs.2014.12.015_bib87","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0959-4388(00)00208-7","article-title":"Trk receptors: mediators of neurotrophin action","volume":"11","author":"Potapoutian","year":"2001","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jphs.2014.12.015_bib88","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000056110","article-title":"Honokiol and magnolol selectively interact with GABAA receptor subtypes in\u00a0vitro","volume":"63","author":"Ai","year":"2001","journal-title":"Pharmacology"},{"key":"10.1016\/j.jphs.2014.12.015_bib89","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.2042-7158.1997.tb06781.x","article-title":"Antiperoxidative activity of neolignans from Magnolia obovata","volume":"49","author":"Haraguchi","year":"1997","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.jphs.2014.12.015_bib90","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-2005-864100","article-title":"Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEK-1 in NF-kappaB activation signaling","volume":"71","author":"Lee","year":"2005","journal-title":"Planta Med"},{"key":"10.1016\/j.jphs.2014.12.015_bib91","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0304-3940(03)00827-9","article-title":"Brain lipid hydroperoxide level increase in senescence-accelerated mice at an early age","volume":"350","author":"Yasui","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jphs.2014.12.015_bib92","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00001756-200102120-00021","article-title":"Olfactory centre in Alzheimer's disease: olfactory bulb is involved in early Braak's stage","volume":"12","author":"Kovacs","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.jphs.2014.12.015_bib93","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jnnp.47.1.56","article-title":"The olfactory bulbs in Alzheimer's disease","volume":"47","author":"Esiri","year":"1984","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jphs.2014.12.015_bib94","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1037\/h0035291","article-title":"Effect of olfactory bulb abiation upon emotionality and muricidal behavior in four rat strains","volume":"34","author":"Thorme","year":"1973","journal-title":"J\u00a0Comp Physiol Psychol"},{"key":"10.1016\/j.jphs.2014.12.015_bib95","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0031-9384(72)90099-6","article-title":"The role of the olfactory system in avoidance learning and activity","volume":"8","author":"Sieck","year":"1972","journal-title":"Physiol Behav"},{"key":"10.1016\/j.jphs.2014.12.015_bib96","first-page":"153","article-title":"Roles of exogenous and endogenous FGF-2 in animal models of depression","volume":"29","author":"Jarosik","year":"2011","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.jphs.2014.12.015_bib97","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(02)00183-3","article-title":"Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy","volume":"138","author":"Hozumi","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jphs.2014.12.015_bib98","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.bmcl.2004.02.067","article-title":"Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan","volume":"14","author":"Esumi","year":"2004","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861315000043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861315000043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:18:11Z","timestamp":1717687091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861315000043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":98,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1347861315000043"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2014.12.015","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2014.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}