{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:21:02Z","timestamp":1777652462978,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,9]],"date-time":"2016-01-09T00:00:00Z","timestamp":1452297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Graduate School of Medical Sciences, Kumamoto University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jphs.2016.01.003","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T07:16:00Z","timestamp":1453274160000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model"],"prefix":"10.1016","volume":"130","author":[{"given":"Yuki","family":"Narita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Uchimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kakizoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Miyasato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Mizumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Morinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Hayata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terumasa","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kadowaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mukoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2016.01.003_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa011303","article-title":"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes","volume":"345","author":"Lewis","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jphs.2016.01.003_bib2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJMoa1007994","article-title":"Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes","volume":"364","author":"Haller","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jphs.2016.01.003_bib3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jphs.2016.01.003_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.jhh.1000732","article-title":"Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function","volume":"13","author":"Fogari","year":"1999","journal-title":"J\u00a0Hum Hypertens"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.jphs.2016.01.003_bib5","first-page":"B54","article-title":"Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes","volume":"23","author":"Estacio","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jphs.2016.01.003_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","article-title":"Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2016.01.003_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00467-003-1377-9","article-title":"Effect of oral camostat mesilate on hematuria and\/or proteinuria in children","volume":"19","author":"Asami","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jphs.2016.01.003_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1056-8727(98)00016-6","article-title":"Effect of camostat mesilate on urinary protein excretion in three patients with advanced diabetic nephropathy","volume":"13","author":"Ikeda","year":"1999","journal-title":"J\u00a0Diabetes Complicat"},{"key":"10.1016\/j.jphs.2016.01.003_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/HJH.0b013e328317a762","article-title":"Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension","volume":"27","author":"Maekawa","year":"2009","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jphs.2016.01.003_bib10","doi-asserted-by":"crossref","first-page":"F1126","DOI":"10.1152\/ajprenal.00706.2011","article-title":"Effect of a serine protease inhibitor on the progression of chronic renal failure","volume":"303","author":"Hayata","year":"2012","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.jphs.2016.01.003_bib11","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1152\/ajprenal.00586.2012","article-title":"The antifibrotic effect of a serine protease inhibitor in the kidney","volume":"305","author":"Morinaga","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.jphs.2016.01.003_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000375308","article-title":"The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects","volume":"129","author":"Ueda","year":"2015","journal-title":"Nephron"},{"key":"10.1016\/j.jphs.2016.01.003_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000183992","article-title":"Animal model of adenine-induced chronic renal failure in rats","volume":"44","author":"Yokozawa","year":"1986","journal-title":"Nephron"},{"key":"10.1016\/j.jphs.2016.01.003_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3317\/jraas.2007.017","article-title":"Renoprotective effects of telmisartan in the 5\/6 nephrectomised rats","volume":"8","author":"Tsunenari","year":"2007","journal-title":"J\u00a0Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.jphs.2016.01.003_bib15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ki.1996.186","article-title":"Advanced oxidation protein products as a novel marker of oxidative stress in uremia","volume":"49","author":"Witko-Sarsat","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.jphs.2016.01.003_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(08)61236-2","article-title":"Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial","volume":"372","author":"Mann","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2016.01.003_bib17","doi-asserted-by":"crossref","first-page":"F1313","DOI":"10.1152\/ajprenal.00521.2014","article-title":"Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease","volume":"307","author":"Shiraishi","year":"2014","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.jphs.2016.01.003_bib18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1291\/hypres.31.745","article-title":"Pioglitazone enhances the antihypertensive and renoprotective effects of candesartan in Zucker obese rats fed a high-protein diet","volume":"31","author":"Namikoshi","year":"2008","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jphs.2016.01.003_bib19","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1159\/000343102","article-title":"Telmisartan attenuates diabetic nephropathy by suppressing oxidative stress in db\/db mice","volume":"121","author":"Sato-Horiguchi","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.jphs.2016.01.003_bib20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.amjhyper.2007.05.007","article-title":"Olmesartan ameliorates renovascular injury and oxidative stress in Zucker obese rats enhanced by dietary protein","volume":"20","author":"Namikoshi","year":"2007","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jphs.2016.01.003_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.intimp.2013.11.018","article-title":"Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats","volume":"18","author":"Gounder","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jphs.2016.01.003_bib22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/01.CIR.103.6.789","article-title":"Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy","volume":"103","author":"Lim","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2016.01.003_bib23","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1097\/01.hjh.0000182521.44440.c5","article-title":"Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats","volume":"23","author":"Lavoie","year":"2005","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jphs.2016.01.003_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000334598","article-title":"Orchiectomy attenuates kidney fibrosis after ureteral obstruction by reduction of oxidative stress in mice","volume":"35","author":"Cho","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jphs.2016.01.003_bib25","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/end.2009.0035","article-title":"Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression","volume":"23","author":"Ozbek","year":"2009","journal-title":"J\u00a0Endourol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316000049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316000049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T03:22:33Z","timestamp":1537068153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861316000049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1347861316000049"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2016.01.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2016.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Japanese Pharmacological Society. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}