{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:45:49Z","timestamp":1791380749177,"version":"4.3.3"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372015"],"award-info":[{"award-number":["81372015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Health Bureau Project","award":["2013214"],"award-info":[{"award-number":["2013214"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jphs.2016.02.001","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T17:35:47Z","timestamp":1454952947000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Celastrol, an NF-\u03baB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis"],"prefix":"10.1016","volume":"130","author":[{"given":"Xiaodong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2016.02.001_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12291-010-0074-2","article-title":"BMD and serum intact osteocalcin in postmenopausal osteoporosis women","volume":"26","author":"Jagtap","year":"2011","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.jphs.2016.02.001_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jphs.2016.02.001_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1053\/berh.2001.0153","article-title":"Epidemiology of osteoporosis","volume":"15","author":"Lau","year":"2001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jphs.2016.02.001_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000223695","article-title":"Secondary osteoporosis","volume":"16","author":"Ahmed","year":"2009","journal-title":"Endocr Dev"},{"key":"10.1016\/j.jphs.2016.02.001_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0889-8529(02)00062-2","article-title":"Secondary osteoporosis","volume":"32","author":"Stein","year":"2003","journal-title":"Endocrinol Metab Clin"},{"key":"10.1016\/j.jphs.2016.02.001_bib6","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1210\/jc.2002-020275","article-title":"Yield of laboratory testing to identify secondary contributors to osteoporosis in otherwise healthy women","volume":"87","author":"Cara","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jphs.2016.02.001_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1530\/eje.0.1490209","article-title":"Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis","volume":"149","author":"Giannini","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jphs.2016.02.001_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.joca.2006.06.006","article-title":"Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits","volume":"15","author":"Calvo","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jphs.2016.02.001_bib9","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1186\/ar3103","article-title":"Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis","volume":"12","author":"Bellido","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jphs.2016.02.001_bib10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1254\/jphs.11188SC","article-title":"Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis","volume":"119","author":"Tominari","year":"2012","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00198-010-1319-x","article-title":"Osteoporosis in inflammatory joint diseases","volume":"22","author":"Roux","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jphs.2016.02.001_bib12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.amjmed.2009.01.022","article-title":"Osteoporosis in inflammatory bowel disease","volume":"122","author":"Ali","year":"2009","journal-title":"Am J Med"},{"key":"10.1016\/j.jphs.2016.02.001_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.jphs.2016.02.001_bib14","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.lfs.2007.09.028","article-title":"Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages","volume":"81","author":"Chen","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2174\/156652309788488569","article-title":"Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer","volume":"9","author":"Tas","year":"2009","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.jphs.2016.02.001_bib16","first-page":"S369","article-title":"The role of the NF-KB and Wnt pathways in osteoporosis induced by type II diabetes","volume":"47","author":"Li","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.jphs.2016.02.001_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1254\/jphs.12170FP","article-title":"Anti-neuroinflammatory activity of a novel cannabinoid derivative by inhibiting the NF-\u03baB signaling pathway in lipopolysaccharide- induced BV-2 microglial cells","volume":"121","author":"More","year":"2012","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1254\/jphs.08083FP","article-title":"Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB","volume":"108","author":"Huang","year":"2008","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1254\/jphs.09168FP","article-title":"Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-\u03baB and mitogen-activated protein kinase activity","volume":"112","author":"Yoon","year":"2010","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1254\/jphs.13174FP","article-title":"Genipin inhibits RANKL-induced osteoclast differentiation through proteasome-mediated degradation of c-Fos protein and suppression of NF-\u03baB activation","volume":"124","author":"Lee","year":"2014","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1254\/jphs.09243FP","article-title":"Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis","volume":"112","author":"Inoue","year":"2010","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/ar2819","article-title":"Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfurcompound isolated from garlic via inhibition of NF-\u03baB","volume":"11","author":"Ban","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jphs.2016.02.001_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2010.149013.12","article-title":"Gambogic acid and celastrol are two powerful anti-inflammatory drugs in arthritis","volume":"70","author":"Casc\u00e3o","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jphs.2016.02.001_bib24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1476-5381.2011.01439.x","article-title":"NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action","volume":"164","author":"Jaquet","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2016.02.001_bib25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2016.02.001_bib26","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1074\/jbc.M110.196402","article-title":"Development and characterization of high affinity leptins and leptin antagonists","volume":"286","author":"Michal","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2016.02.001_bib27","first-page":"BR199","article-title":"Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA","volume":"18","author":"Christian","year":"2012","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jphs.2016.02.001_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.etp.2015.01.004","article-title":"Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis","volume":"67","author":"Bauer","year":"2015","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jphs.2016.02.001_bib29","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/clinchem\/47.8.1410","article-title":"Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-tlopeptides","volume":"47","author":"Okabe","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.jphs.2016.02.001_bib30","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1373\/clinchem.2005.051524","article-title":"Serum concentrations of cross-linked N-telopeptides of type I collagen: new marker for bone resorption in hemodialysis patients","volume":"51","author":"Maeno","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.jphs.2016.02.001_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips .2. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J\u00a0Bone Joint Sur"},{"key":"10.1016\/j.jphs.2016.02.001_bib32","doi-asserted-by":"crossref","first-page":"e0130882","DOI":"10.1371\/journal.pone.0130882","article-title":"Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes","volume":"10","author":"Jeong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2016.02.001_bib33","article-title":"Celastrol, an NF-\u03baB inhibitor, improves insulin resistance and attenuates renal injury in db\/db mice","volume":"8","author":"Jung Eun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2016.02.001_bib34","first-page":"1379","article-title":"In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9, and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma","volume":"15","author":"Venugopal","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jphs.2016.02.001_bib35","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.neuropharm.2011.11.014","article-title":"NF-\u03baB knockdown can modulate amphetamine-mediated feeding response","volume":"62","author":"Kuo","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jphs.2016.02.001_bib36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-0028-1082052","article-title":"Effects of leptin on lipid metabolism","volume":"40","author":"Paz-Filho","year":"2008","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.jphs.2016.02.001_bib37","series-title":"Inhibition of NF-\u03baB Signaling as a Strategy in Disease Therapy","author":"Gilmore","year":"2011"},{"key":"10.1016\/j.jphs.2016.02.001_bib38","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.ajpath.2012.08.004","article-title":"Inhibition of NF-\u03baB activation by 4-hydroxynonenal contributes to liver injury in a mouse model of alcoholic liver disease","volume":"181","author":"Xiaobing","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jphs.2016.02.001_bib39","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1073\/pnas.071054298","article-title":"Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway","volume":"98","author":"Forbes","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2016.02.001_bib40","doi-asserted-by":"crossref","first-page":"9706","DOI":"10.1074\/jbc.M109.070706","article-title":"NF-\u03baB activation in hypothalamic POMC neurons is essential in illness-and leptin-induced anorexia","volume":"285","author":"Jang","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2016.02.001_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00198-010-1281-7","article-title":"Bone-seeking labels as markers for bone turnover: validation of urinary excretion in rats","volume":"22","author":"Cheong","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jphs.2016.02.001_bib42","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00216-006-0795-5","article-title":"Labeling the human skeleton with 41Ca to assess changes in bone calcium metabolism","volume":"386","author":"Denk","year":"2006","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jphs.2016.02.001_bib43","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/ajcn\/52.5.878","article-title":"Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females","volume":"52","author":"Matkovic","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jphs.2016.02.001_bib44","first-page":"588","article-title":"Do markers of bone metabolism reflect the presence of a high- or low-turnover state of bone metabolism?","volume":"97","author":"Beate","year":"2002","journal-title":"Med Klin (Munich)"},{"key":"10.1016\/j.jphs.2016.02.001_bib45","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jocn.2010.01.044","article-title":"Changes in bone mineral density and bone metabolism markers in premenopausal women with multiple sclerosis and the relationship to clinical variables","volume":"17","author":"Terzi","year":"2010","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.jphs.2016.02.001_bib46","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1254\/jphs.FM0070218","article-title":"Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis","volume":"106","author":"Suzuki","year":"2008","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2016.02.001_bib47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1590\/S0004-27302010000200018","article-title":"The use of PTH in the treatment of osteoporosis","volume":"54","author":"Borba","year":"2010","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.jphs.2016.02.001_bib48","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.joca.2013.06.030","article-title":"Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis","volume":"21","author":"Bobinac","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jphs.2016.02.001_bib49","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/j.joca.2012.02.177","article-title":"A\u00a0Wnt\/\u00df-catenin negative feedback loop inhibits IL1-induced MMP expression in human articular chondrocytes","volume":"20","author":"Ma","year":"2012","journal-title":"Osteoarthr Cartil"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316000220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316000220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T03:46:33Z","timestamp":1600141593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861316000220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1347861316000220"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2016.02.001","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol, an NF-\u03baB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2016.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}