{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:16:56Z","timestamp":1790817416403,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH Clinical and Translational Science Award program","award":["TR000006"],"award-info":[{"award-number":["TR000006"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jphs.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T16:01:15Z","timestamp":1475769675000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice"],"prefix":"10.1016","volume":"132","author":[{"given":"Shinya","family":"Takigawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Frondorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Hamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2016.09.006_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.11.008","article-title":"Bilateral subdural hematomas in an adult with osteogenesis imperfecta","volume":"18","author":"Eddeine","year":"2009","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jphs.2016.09.006_bib2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2016.09.006_bib3","first-page":"130002","article-title":"Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene causing osteogenesis imperfecta","author":"Aftab","year":"2013","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"10.1016\/j.jphs.2016.09.006_bib4","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3346\/jkms.2013.28.7.1107","article-title":"Osteogenesis imperfecta Type VI with severe bony deformities caused by novel compound heterozygous mutations in SERPINF1","volume":"28","author":"Cho","year":"2013","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.jphs.2016.09.006_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11914-012-0126-z","article-title":"Diagnosis and treatment of osteopenic fractures in children","volume":"10","author":"Mehlman","year":"2012","journal-title":"Curr Osteoporos Rep"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.jphs.2016.09.006_bib6","first-page":"397","article-title":"Osteogenesis imperfect","author":"Ben Amor","year":"2013","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.jphs.2016.09.006_bib7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJM199810013391402","article-title":"Cyclic administration of pamidronate in children with severe osteogenesis imperfecta","volume":"339","author":"Glorieux","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jphs.2016.09.006_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1210\/jc.2008-1531","article-title":"Clinical review 1: bisphosphonate use in childhood osteoporosis","volume":"94","author":"Bachrach","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jphs.2016.09.006_bib9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2165\/11585470-000000000-00000","article-title":"Safety of long-term bisphosphonate therapy for the management of osteoporosis","volume":"71","author":"Lewiecki","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.jphs.2016.09.006_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/03008200903108472","article-title":"RANKL inhibition improves bone properties in a mouse model of osteogenesis imperfecta","volume":"51","author":"Bargman","year":"2010","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jphs.2016.09.006_bib11","first-page":"918","article-title":"Bone and joint diseases in children. Bisphosphonates in osteogenesis imperfect","volume":"20","author":"Yamashita","year":"2010","journal-title":"Clin Calcium"},{"key":"10.1016\/j.jphs.2016.09.006_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.4158\/EP.13.5.513","article-title":"Consensus and controversy regarding osteoporosis in the pediatric population","volume":"13","author":"Bachrach","year":"2007","journal-title":"Endocr Pract"},{"key":"10.1016\/j.jphs.2016.09.006_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1098\/rstb.2000.0761","article-title":"Nuclear magnetic resonance characterization of peptide models of collagen-folding diseases","volume":"356","author":"Buevich","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.jphs.2016.09.006_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00774-007-0825-1","article-title":"Microarray analysis of thapsigargin \u2013 induced stress to the endoplasmic reticulum of mouse osteoblasts","volume":"26","author":"Hamamura","year":"2008","journal-title":"J\u00a0Bone Min Metab"},{"key":"10.1016\/j.jphs.2016.09.006_bib15","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1371\/journal.pgen.0040007","article-title":"ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta","volume":"4","author":"Lisse","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jphs.2016.09.006_bib16","first-page":"91","article-title":"A\u00a0selective inhibitor of eIF2\u03b1 dephosphorylation protects cells from ER stress","volume":"332","author":"Boyce","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jphs.2016.09.006_bib17","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s00774-013-0450-0","article-title":"Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha","volume":"31","author":"Hamamura","year":"2013","journal-title":"J\u00a0Bone Min Metab"},{"key":"10.1016\/j.jphs.2016.09.006_bib18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cellsig.2014.11.020","article-title":"In\u00a0vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz","volume":"27","author":"Hamamura","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.jphs.2016.09.006_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1471-2474-14-197","article-title":"Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells","volume":"14","author":"Yokota","year":"2013","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jphs.2016.09.006_bib20","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2016.09.006_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12020-011-9570-2","article-title":"New understanding and treatments for osteoporosis","volume":"41","author":"Mazziotti","year":"2012","journal-title":"Endocrine"},{"key":"10.1016\/j.jphs.2016.09.006_bib22","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.cellsig.2015.08.014","article-title":"Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13","volume":"27","author":"Xu","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.jphs.2016.09.006_bib23","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.3892\/ijo.2014.2366","article-title":"Attenuation of malignant phenotypes of breast cancer cells through eIF2\u03b1-mediated downregulation of Rac1 signaling","volume":"44","author":"Hamamura","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jphs.2016.09.006_bib24","first-page":"CD005088","article-title":"Bisphosphonate therapy for osteogenesis imperfecta","volume":"8","author":"Phillipi","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jphs.2016.09.006_bib25","first-page":"CD005088","article-title":"Bisphosphonate therapy for osteogenesis imperfecta","volume":"7","author":"Dwan","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jphs.2016.09.006_bib26","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2016.09.006_bib27","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.joca.2013.02.657","article-title":"Salubrinal reduces expression and activity of MMP13 in chondrocytes","volume":"21","author":"Hamamura","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jphs.2016.09.006_bib28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1302\/2046-3758.45.2000378","article-title":"Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis","volume":"4","author":"Hamamura","year":"2015","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jphs.2016.09.006_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S8756-3282(96)00305-5","article-title":"Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta","volume":"19","author":"Saban","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.jphs.2016.09.006_bib30","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/jbmr.2188","article-title":"Bone matrix quality after sclerostin antibody treatment","volume":"29","author":"Ross","year":"2014","journal-title":"J\u00a0Bone Min Res"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316301311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316301311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T05:51:38Z","timestamp":1568440298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861316301311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1347861316301311"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2016.09.006","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}