{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:41:33Z","timestamp":1761176493607,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T00:00:00Z","timestamp":1477699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K08285","JP25460111"],"award-info":[{"award-number":["JP16K08285","JP25460111"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jphs.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T04:30:18Z","timestamp":1478147418000},"page":"205-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Defective splicing of the background K+ channel K2P5.1 by the pre-mRNA splicing inhibitor, pladienolide B in lectin-activated mouse splenic CD4+ T cells"],"prefix":"10.1016","volume":"132","author":[{"given":"Kazutaka","family":"Tagishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2016.10.007_bib1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.cell.2012.02.014","article-title":"Splice modulating therapies for human disease","volume":"148","author":"Spitali","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2016.10.007_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrd3823","article-title":"The spliceosome as a target of novel antitumour drugs","volume":"11","author":"Bonnal","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jphs.2016.10.007_bib3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nchembio.2007.16","article-title":"Splicing factor SF3b as a target of the antitumor natural product pladienolide","volume":"23","author":"Kotake","year":"2007","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jphs.2016.10.007_bib4","doi-asserted-by":"crossref","first-page":"34683","DOI":"10.1074\/jbc.M114.590976","article-title":"Identification of small molecule inhibitors of pre-mRNA splicing","volume":"289","author":"Pawellek","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2016.10.007_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pharmthera.2016.02.001","article-title":"Recent advances in therapeutic strategies that focus on the regulation of ion channel expression","volume":"160","author":"Ohya","year":"2016","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jphs.2016.10.007_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00029.2009","article-title":"Molecular background of leak K+ currents: two-pore domain potassium channels","volume":"90","author":"Enyedi","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jphs.2016.10.007_bib7","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/ar3245","article-title":"Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients","volume":"13","author":"Bittner","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jphs.2016.10.007_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fphys.2015.00299","article-title":"Pathophysiological significance of the two-pore domain K+ channel K2P5.1 in splenic CD4+CD25- T cell subset from a chemically-induced murine inflammatory bowel disease model","volume":"6","author":"Nakakura","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.jphs.2016.10.007_bib9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bcp.2015.10.002","article-title":"Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K+ channel K2P5.1 in lymphoid cells and enhancement of its expression by splicing inhibition","volume":"98","author":"Endo","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jphs.2016.10.007_bib10","doi-asserted-by":"crossref","first-page":"16940","DOI":"10.1074\/jbc.M110.184192","article-title":"Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, KCa3.1, in immune function of lymphoid cells","volume":"286","author":"Ohya","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2016.10.007_bib11","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.4049\/jimmunol.1002040","article-title":"Regulatory T cell properties of chicken CD4+CD25+ cells","volume":"186","author":"Shanmugasundaram","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2016.10.007_bib12","doi-asserted-by":"crossref","first-page":"e48379","DOI":"10.1371\/journal.pone.0048379","article-title":"Galectin-9 ameliorates Con A-induced hepatitis by inducing CD4+CD25low\/int effector T-cell apoptosis and increasing regulatory T cell number","volume":"7","author":"Lv","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2016.10.007_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1159\/000443042","article-title":"The volume activated potassium channel KCNK5 is up-regulated in activated human T cells, but volume regulation is impaired","volume":"38","author":"Kirkegaad","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jphs.2016.10.007_bib14","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.4049\/jimmunol.1301829","article-title":"HIF-1\u03b1-mediated upregulation of TASK-2 K+ channels augments Ca2+ signaling in mouse B cells under hypoxia","volume":"193","author":"Shin","year":"2014","journal-title":"J\u00a0Immunol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316301487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861316301487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:14:24Z","timestamp":1761128064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861316301487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1347861316301487"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2016.10.007","relation":{},"ISSN":["1347-8613"],"issn-type":[{"type":"print","value":"1347-8613"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective splicing of the background K+ channel K2P5.1 by the pre-mRNA splicing inhibitor, pladienolide B in lectin-activated mouse splenic CD4+ T cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}