{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:49:19Z","timestamp":1775911759247,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health and Labour Sciences Research Grants"},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"crossref","award":["16mk0104006h0303"],"award-info":[{"award-number":["16mk0104006h0303"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jphs.2017.01.003","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T10:20:31Z","timestamp":1485598831000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds"],"prefix":"10.1016","volume":"133","author":[{"given":"Mengxuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyoshi","family":"Igata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoi","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ikegaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2017.01.003_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00019052-199704000-00006","article-title":"Mossy fiber reorganization in the epileptic hippocampus","volume":"10","author":"Parent","year":"1997","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jphs.2017.01.003_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(86)91274-6","article-title":"Magnesium-free medium activates seizure-like events in the rat hippocampal slice","volume":"398","author":"Anderson","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2017.01.003_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1749-6632.1995.tb17509.x","article-title":"Excitatory amino acid receptors and their role in epilepsy and cerebral ischemia","volume":"757","author":"Meldrum","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jphs.2017.01.003_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/978-1-4757-6376-8_7","article-title":"GABA and its receptors in epilepsy","volume":"548","author":"Sperk","year":"2004","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jphs.2017.01.003_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.yrtph.2015.05.030","article-title":"Adverse drug reactions for medicine newly approved in Japan from 1999 to 2013: syncope\/loss of consciousness and seizures\/convulsions","volume":"72","author":"Nagayama","year":"2015","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.jphs.2017.01.003_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1212\/WNL.43.3_Part_1.483","article-title":"Status epilepticus at an urban public hospital in the 1980s","volume":"43","author":"Lowenstein","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jphs.2017.01.003_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vascn.2007.04.008","article-title":"Pharmacological validation of a semi-automated in\u00a0vitro hippocampal brain slice assay for assessment of seizure liability","volume":"56","author":"Easter","year":"2007","journal-title":"J\u00a0Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jphs.2017.01.003_bib8","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.451569","article-title":"Dendritic mechanisms underlying penicillin-induced epileptiform activity","volume":"204","author":"Wong","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jphs.2017.01.003_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0006-8993(85)90807-8","article-title":"Induction of epileptiform activity in hippocampal slices by trains of electrical stimuli","volume":"344","author":"Stasheff","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2017.01.003_bib10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/jn.1987.57.3.869","article-title":"Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices","volume":"57","author":"Mody","year":"1987","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.jphs.2017.01.003_bib11","doi-asserted-by":"crossref","first-page":"e0157595","DOI":"10.1371\/journal.pone.0157595","article-title":"A\u00a0computationally efficient filter for reducing shot noise in low S\/N data","volume":"11","author":"Okada","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2017.01.003_bib12","first-page":"5093","article-title":"Caffe: convolutional architecture for fast feature embedding","volume":"140","author":"Jia","year":"2014","journal-title":"arXiv"},{"key":"10.1016\/j.jphs.2017.01.003_bib13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1523\/JNEUROSCI.4514-06.2007","article-title":"Metastability of active CA3 networks","volume":"27","author":"Sasaki","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jphs.2017.01.003_bib14","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1152\/jn.00084.2008","article-title":"Fast and accurate detection of action potentials from somatic calcium fluctuations","volume":"100","author":"Sasaki","year":"2008","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.jphs.2017.01.003_bib15","doi-asserted-by":"crossref","first-page":"21293","DOI":"10.1038\/srep21293","article-title":"Early failures benefit subsequent task performance","volume":"6","author":"Igata","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2017.01.003_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.109922","article-title":"Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy","volume":"205","author":"Ribak","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jphs.2017.01.003_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/epi.13370","article-title":"GABAergic networks jump-start focal seizures","volume":"57","author":"de Curtis","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.jphs.2017.01.003_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0306-4522(03)00559-1","article-title":"Desynchronisation of spontaneously recurrent experimental seizures proceeds with a single rhythm","volume":"121","author":"Nyikos","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphs.2017.01.003_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00611905","article-title":"Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms","volume":"14","author":"Bogentoft","year":"1978","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jphs.2017.01.003_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2125.1979.tb04655.x","article-title":"Cimetidine excretion into breast milk","volume":"7","author":"Somogyi","year":"1979","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jphs.2017.01.003_bib21","first-page":"1853","article-title":"Relationship between intravenous small dextran and blood coagulation\/fibrinolysis","volume":"27","author":"Oda","year":"1978","journal-title":"Shinyaku to Rinsho"},{"key":"10.1016\/j.jphs.2017.01.003_bib22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00004714-198204000-00005","article-title":"Relationship of diazepam serum level to antianxiety effects","volume":"2","author":"Bowden","year":"1982","journal-title":"J\u00a0Clin Psychopharmacol"},{"key":"10.1016\/j.jphs.2017.01.003_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00003088-198510060-00002","article-title":"Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)","volume":"10","author":"Paton","year":"1985","journal-title":"Clin Pharmacokinet"},{"issue":"Suppl.\u00a0B","key":"10.1016\/j.jphs.2017.01.003_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jac\/21.suppl_B.49","article-title":"Pharmacokinetics of intravenous and oral enoxacin in healthy volunteers","volume":"21","author":"Chang","year":"1988","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jphs.2017.01.003_bib25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/00498257309151547","article-title":"The metabolism of ibuprofen","volume":"3","author":"Mills","year":"1973","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jphs.2017.01.003_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00510547","article-title":"Plasma levels of imipramine and desipramine in man after different routes of administration","volume":"290","author":"Nagy","year":"1975","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jphs.2017.01.003_bib27","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-2044.1981.tb08835.x","article-title":"Ketamine on demand for postoperative analgesia","volume":"36","author":"Nimmo","year":"1981","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jphs.2017.01.003_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/syn.20365","article-title":"Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling","volume":"61","author":"Melega","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.jphs.2017.01.003_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1503\/cmaj.092127","article-title":"Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza","volume":"182","author":"Ariano","year":"2010","journal-title":"CMAJ"},{"key":"10.1016\/j.jphs.2017.01.003_bib30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1520\/JFS11070J","article-title":"Fatal strychnine poisoning\u2013a case report and review of the literature","volume":"30","author":"Perper","year":"1985","journal-title":"J\u00a0Forensic Sci"},{"key":"10.1016\/j.jphs.2017.01.003_bib31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3999\/jscpt.16.705","article-title":"Bioequivalence and pharmacokinetics of a new theophylline slow release formulation, E-0686","volume":"16","author":"Morishita","year":"1985","journal-title":"Jpn Soc Clin Pharmacol Ther"},{"key":"10.1016\/j.jphs.2017.01.003_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF03161033","article-title":"Evolving epidemiology of drug-induced seizures reported to a poison control center system","volume":"3","author":"Thundiyil","year":"2007","journal-title":"J\u00a0Med Toxicol"},{"key":"10.1016\/j.jphs.2017.01.003_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0140-6736(85)90270-3","article-title":"Convulsions related to enoxacin","volume":"2","author":"Simpson","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2017.01.003_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0736-4679(93)90244-2","article-title":"Theophylline toxicity","volume":"11","author":"Cooling","year":"1993","journal-title":"J\u00a0Emerg Med"},{"key":"10.1016\/j.jphs.2017.01.003_bib35","first-page":"142","article-title":"Strychnine\u2013a killer from the past","volume":"10","author":"Makarovsky","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jphs.2017.01.003_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1145\/2647868.2654948","article-title":"Deep learning for content-based image retrieval: a comprehensive study","volume":"22","author":"Wan","year":"2014","journal-title":"Proc ACM Int Conf Multimed"},{"key":"10.1016\/j.jphs.2017.01.003_bib37","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2017.01.003_bib38","first-page":"749","article-title":"Isoniazid overdose: recognition and management","volume":"57","author":"Romero","year":"1998","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jphs.2017.01.003_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01059476","article-title":"Plasma and salivary concentrations of isoniazid in man: preliminary findings in two slow acetylator subjects","volume":"3","author":"Boxenbaum","year":"1975","journal-title":"J\u00a0Pharmacokinet Biopharm"},{"key":"10.1016\/j.jphs.2017.01.003_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00542101","article-title":"Single-dose pharmacokinetics of metoclopramide","volume":"20","author":"Ross-Lee","year":"1981","journal-title":"Eur J Clin Pharmacol"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.jphs.2017.01.003_bib41","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.yebeh.2011.08.040","article-title":"A\u00a0machine-learning algorithm for detecting seizure termination in scalp EEG","volume":"22","author":"Shoeb","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.jphs.2017.01.003_bib42","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.tiv.2011.05.015","article-title":"Rapid and accurate assessment of seizure liability of drugs by using an optimal support vector machine method","volume":"25","author":"Zhang","year":"2011","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.jphs.2017.01.003_bib43","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3109\/15563650.2010.527850","article-title":"Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose","volume":"48","author":"Jang","year":"2010","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.jphs.2017.01.003_bib44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0920-1211(91)90003-X","article-title":"Histamine in brain\u2013its role in regulation of seizure susceptibility","volume":"10","author":"Scherkl","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jphs.2017.01.003_bib45","first-page":"289","article-title":"Seizures associated with antidepressants: a review","volume":"54","author":"Rosenstein","year":"1993","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1016\/j.jphs.2017.01.003_bib46","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2165\/0002018-200831120-00006","article-title":"Assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive review","volume":"31","author":"Toovey","year":"2008","journal-title":"Drug Saf"},{"key":"10.1016\/j.jphs.2017.01.003_bib47","first-page":"1840","article-title":"Multi-scale orderless pooling of deep convolutional activation features","volume":"1403","author":"Gong","year":"2014","journal-title":"arXiv"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786131730004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786131730004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T22:25:17Z","timestamp":1568759117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S134786131730004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S134786131730004X"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2017.01.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2017.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}