{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:18:30Z","timestamp":1793751510473,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["ZA2015A33"],"award-info":[{"award-number":["ZA2015A33"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jphs.2017.12.001","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T19:03:13Z","timestamp":1512759793000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis"],"prefix":"10.1016","volume":"137","author":[{"given":"Li","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2017.12.001_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c2661","article-title":"Endometriosis","volume":"340","author":"Harvey","year":"2010","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jphs.2017.12.001_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2478\/pjvs-2014-0028","article-title":"Is adenomyosis a problem in reproduction and fertility?","volume":"17","author":"Korzekwa","year":"2014","journal-title":"Pol J Vet Sci"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bpobgyn.2006.01.012","article-title":"Medical and surgical management of adenomyosis","volume":"20","author":"Farquhar","year":"2006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jmig.2011.04.004","article-title":"Adenomyosis: review of the literature","volume":"18","author":"Garcia","year":"2011","journal-title":"J\u00a0Minim Invasive Gynecol"},{"issue":"7","key":"10.1016\/j.jphs.2017.12.001_bib5","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/j.fertnstert.2010.04.016","article-title":"Enhanced invasion of stromal cells from adenomyosis in a three-dimensional coculture model is augmented by the presence of myocytes from affected uteri","volume":"94","author":"Mehasseb","year":"2010","journal-title":"Fertil Steril"},{"issue":"9","key":"10.1016\/j.jphs.2017.12.001_bib6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1055\/s-0033-1350840","article-title":"Adenomyosis: epidemiology, risk factors, clinical phenotype and surgical and interventional alternatives to hysterectomy","volume":"73","author":"Taran","year":"2013","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.jphs.2017.12.001_bib7","article-title":"Exploratory pharmacokinetics of geniposide in rat model of cerebral ischemia orally administered with or without baicalin and\/or berberine","volume":"2013","author":"Pan","year":"2013","journal-title":"Evid base Compl Alternative Med"},{"issue":"9","key":"10.1016\/j.jphs.2017.12.001_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/CAD.0b013e328330d95b","article-title":"A\u00a0systematic review of the anticancer properties of berberine, a natural product from Chinese herbs","volume":"20","author":"Sun","year":"2009","journal-title":"Anti Canc Drugs"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/JME-16-0139","article-title":"ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis","volume":"57","author":"He","year":"2016","journal-title":"J\u00a0Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.jphs.2017.12.001_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/13880209.2016.1257642","article-title":"Effect of berberine on PPAR\u03b1-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV","volume":"55","author":"Qiu","year":"2017","journal-title":"Pharmaceut Biol"},{"issue":"2","key":"10.1016\/j.jphs.2017.12.001_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1158\/1535-7163.MCT-14-0634","article-title":"Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway","volume":"14","author":"Liu","year":"2015","journal-title":"Mol Canc Therapeut"},{"issue":"8","key":"10.1016\/j.jphs.2017.12.001_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023427","article-title":"Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One."},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1254\/jphs.12052FP","article-title":"Berberine inhibits growth and induces G1 arrest and apoptosis in human cholangiocarcinoma QBC939 cells","volume":"119","author":"He","year":"2012","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"11","key":"10.1016\/j.jphs.2017.12.001_bib14","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3109\/09513590.2012.683062","article-title":"Effect of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with repeated implantation failure","volume":"28","author":"Rajaei","year":"2012","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1016\/j.jphs.2017.12.001_bib15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00404-015-3766-2","article-title":"Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3zeta downregulation","volume":"292","author":"Wan","year":"2015","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/humrep\/del493","article-title":"Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis","volume":"22","author":"Yang","year":"2007","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.jphs.2017.12.001_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.metabol.2008.08.013","article-title":"Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression","volume":"58","author":"Kong","year":"2009","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.jphs.2017.12.001_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1517\/13543776.2013.746314","article-title":"Berberine and its derivatives: a patent review (2009\u20132012)","volume":"23","author":"Singh","year":"2013","journal-title":"Expert Opin Ther Pat"},{"issue":"2","key":"10.1016\/j.jphs.2017.12.001_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/187153008784534330","article-title":"Traditional Chinese medicine in treatment of metabolic syndrome","volume":"8","author":"Yin","year":"2008","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2174\/1871520614666141226124110","article-title":"Berberine exhibits antitumor effects in human ovarian cancer cells","volume":"15","author":"Jin","year":"2015","journal-title":"Anti Canc Agents Med Chem"},{"issue":"8","key":"10.1016\/j.jphs.2017.12.001_bib21","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1158\/1535-7163.MCT-10-0985","article-title":"Berberine suppresses androgen receptor signaling in prostate cancer","volume":"10","author":"Li","year":"2011","journal-title":"Mol Canc Therapeut"},{"issue":"20","key":"10.1016\/j.jphs.2017.12.001_bib22","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1158\/0008-5472.CAN-16-1248","article-title":"Finally, an apoptosis-targeting therapeutic for cancer","volume":"76","author":"Croce","year":"2016","journal-title":"Canc Res"},{"issue":"6","key":"10.1016\/j.jphs.2017.12.001_bib23","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1933719110363618","article-title":"Progesterone inhibits basal and TNF-alpha-induced apoptosis in fetal membranes: a novel mechanism to explain progesterone-mediated prevention of preterm birth","volume":"17","author":"Luo","year":"2010","journal-title":"Reprod Sci"},{"issue":"3","key":"10.1016\/j.jphs.2017.12.001_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nri3607","article-title":"Apoptotic cell clearance: basic biology and therapeutic potential","volume":"14","author":"Poon","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.jphs.2017.12.001_bib25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/molehr\/gah249","article-title":"Bufalin induces apoptosis and the G0\/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis","volume":"11","author":"Nasu","year":"2005","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"10.1016\/j.jphs.2017.12.001_bib26","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1177\/1933719115572479","article-title":"Resveratrol reduces myometrial infiltration, uterine hyperactivity, and stress levels and alleviates generalized hyperalgesia in mice with induced adenomyosis","volume":"22","author":"Zhu","year":"2015","journal-title":"Reprod Sci"},{"issue":"12","key":"10.1016\/j.jphs.2017.12.001_bib27","doi-asserted-by":"crossref","first-page":"E1944","DOI":"10.1210\/jc.2011-1503","article-title":"Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis","volume":"96","author":"Tsuno","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"issue":"5 Pt 1","key":"10.1016\/j.jphs.2017.12.001_bib28","first-page":"850","article-title":"Identification of epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in surgically induced endometriosis in rats","volume":"78","author":"Simms","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.jphs.2017.12.001_bib29","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.fertnstert.2006.04.034","article-title":"Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis","volume":"86","author":"Yang","year":"2006","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000094426","article-title":"Matrix metalloproteinase-2 and -9 expression correlated with angiogenesis in human adenomyosis","volume":"62","author":"Li","year":"2006","journal-title":"Gynecol Obstet Invest"},{"issue":"5 Suppl","key":"10.1016\/j.jphs.2017.12.001_bib31","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.fertnstert.2008.05.090","article-title":"Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis","volume":"91","author":"Yang","year":"2009","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib32","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.fertnstert.2014.12.124","article-title":"Increased expression of p21-activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase-2 and -9 in endometrial cells","volume":"103","author":"Yi","year":"2015","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.jphs.2017.12.001_bib33","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170125","article-title":"SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells","volume":"37","author":"Seo","year":"2017","journal-title":"Biosci Rep"},{"issue":"5","key":"10.1016\/j.jphs.2017.12.001_bib34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1124\/mol.107.042176","article-title":"Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells","volume":"73","author":"Grund","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"9","key":"10.1016\/j.jphs.2017.12.001_bib35","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.freeradbiomed.2012.02.018","article-title":"Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells","volume":"52","author":"Manea","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jphs.2017.12.001_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00441-010-1044-y","article-title":"NF-\u03baB and STAT3 signaling hubs for lung innate immunity","volume":"343","author":"Quinton","year":"2011","journal-title":"Cell Tissue Res"},{"issue":"4","key":"10.1016\/j.jphs.2017.12.001_bib37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1254\/jphs.08R31FM","article-title":"Basic and translational research on proteinase-activated receptors: implication of proteinase\/proteinase-activated receptor in gastrointestinal inflammation","volume":"108","author":"Yoshida","year":"2008","journal-title":"J\u00a0Pharmacol Sci"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861317302049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861317302049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:58:51Z","timestamp":1761163131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861317302049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S1347861317302049"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2017.12.001","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2017.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}