{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:31:36Z","timestamp":1785850296270,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373807"],"award-info":[{"award-number":["81373807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jphs.2018.01.003","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T19:56:40Z","timestamp":1517601400000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Oligo-peptide I-C-F-6 inhibits hepatic stellate cell activation and ameliorates CCl 4 -induced liver fibrosis by suppressing NF-\u03baB signaling and Wnt\/\u03b2-catenin signaling"],"prefix":"10.1016","volume":"136","author":[{"given":"Haitao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2018.01.003_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-kappaB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jphs.2018.01.003_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphar.2016.00033","article-title":"Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis","volume":"7","author":"Schon","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jphs.2018.01.003_bib3","doi-asserted-by":"crossref","first-page":"e23943","DOI":"10.1371\/journal.pone.0023943","article-title":"Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer","volume":"6","author":"Philips","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.01.003_bib4","doi-asserted-by":"crossref","first-page":"d808","DOI":"10.2741\/reeves","article-title":"Activation of hepatic stellate cells\u2013a key issue in liver fibrosis","volume":"7","author":"Reeves","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.jphs.2018.01.003_bib5","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jphs.2018.01.003_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2007.12.085","article-title":"Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells","volume":"367","author":"Kordes","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2018.01.003_bib7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.dld.2011.02.016","article-title":"Pokeweed antiviral protein down-regulates Wnt\/beta-catenin signalling to attenuate liver fibrogenesis in\u00a0vitro and in\u00a0vivo","volume":"43","author":"Li","year":"2011","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jphs.2018.01.003_bib8","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1073\/pnas.0909781107","article-title":"Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis","volume":"107","author":"Inokuchi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2018.01.003_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2005.09.040","article-title":"Traditional Chinese medicine Bao Gan Ning increase phosphorylation of CREB in liver fibrosis in\u00a0vivo and in\u00a0vitro","volume":"105","author":"Tan","year":"2006","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jphs.2018.01.003_bib10","first-page":"358","article-title":"[Efficacy and safety of Fufang Biejia Ruangan tablet in patients with chronic hepatitis B complicated with hepatic fibrosis]","volume":"21","author":"Chen","year":"2007","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"10.1016\/j.jphs.2018.01.003_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5582\/ddt.2013.v7.6.248","article-title":"Synthesis of peptides of Carapax trionycis and their inhibitory effects on TGF-beta1-induced hepatic stellate cells","volume":"7","author":"Hu","year":"2013","journal-title":"Drug Discov Ther"},{"key":"10.1016\/j.jphs.2018.01.003_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2013.03.067","article-title":"Effect of bioactive peptide of Carapax trionycis on TGF-beta1-induced intracellular events in hepatic stellate cells","volume":"148","author":"Tang","year":"2013","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jphs.2018.01.003_bib13","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1248\/cpb.c13-00442","article-title":"Protection of a new heptapeptide from Carapax trionycis against carbon tetrachloride-induced acute liver injury in mice","volume":"61","author":"Wang","year":"2013","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.jphs.2018.01.003_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2012-302920","article-title":"Systemic inflammation in absence of gut bacterial translocation in C57BL\/6 mice with cirrhosis","volume":"62","author":"Ubeda","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jphs.2018.01.003_bib15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2018.01.003_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jphs.2018.01.003_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"Friedman","year":"2004","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jphs.2018.01.003_bib18","first-page":"401","article-title":"Migration of hepatic stellate cells in fibrotic microenvironment of diseased liver model","volume":"7","author":"Chang","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.jphs.2018.01.003_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.33549\/physiolres.932289","article-title":"Wnt\/beta-catenin signaling: a promising new target for fibrosis diseases","volume":"61","author":"Guo","year":"2012","journal-title":"Physiol Res"},{"key":"10.1016\/j.jphs.2018.01.003_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7314\/APJCP.2014.15.2.769","article-title":"Fangchinoline inhibits cell proliferation via Akt\/GSK-3beta\/cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells","volume":"15","author":"Wang","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.jphs.2018.01.003_bib21","doi-asserted-by":"crossref","first-page":"e74422","DOI":"10.1371\/journal.pone.0074422","article-title":"Hydrogen sulfide preconditioning protects rat liver against ischemia\/reperfusion injury by activating Akt-GSK-3beta signaling and inhibiting mitochondrial permeability transition","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.01.003_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00383-006-1721-9","article-title":"The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats","volume":"22","author":"Demirbilek","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jphs.2018.01.003_bib23","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00263.2007","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jphs.2018.01.003_bib24","doi-asserted-by":"crossref","first-page":"45888","DOI":"10.1074\/jbc.M105490200","article-title":"Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3","volume":"276","author":"Fu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2018.01.003_bib25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/sj.bjp.0707542","article-title":"Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in\u00a0vitro by blocking NF-kappaB and ERK signalling","volume":"153","author":"Chen","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2018.01.003_bib26","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.3390\/molecules17033155","article-title":"Inhibitory effect of Astragalus polysaccharides on lipopolysaccharide-induced TNF-a and IL-1beta production in THP-1 cells","volume":"17","author":"He","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jphs.2018.01.003_bib27","doi-asserted-by":"crossref","first-page":"e100129","DOI":"10.1371\/journal.pone.0100129","article-title":"A\u00a0boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-kappaB signaling in mice","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.01.003_bib28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.jphs.2018.01.003_bib29","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5009\/gnl.2014.8.3.282","article-title":"Mest attenuates CCl4-induced liver fibrosis in rats by inhibiting the Wnt\/beta-catenin signaling pathway","volume":"8","author":"Li","year":"2014","journal-title":"Gut Liver"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318300070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318300070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T04:56:52Z","timestamp":1603774612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861318300070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1347861318300070"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2018.01.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oligo-peptide I-C-F-6 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing NF-\u03baB signaling and Wnt\/\u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2018.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}