{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:51:51Z","timestamp":1787961111364,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jphs.2018.05.006","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T06:18:35Z","timestamp":1527920315000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts"],"prefix":"10.1016","volume":"137","author":[{"given":"Bao","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2018.05.006_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jphs.2018.05.006_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0008-6363(00)00044-4","article-title":"Angiotensin II, adhesion, and cardiac fibrosis","volume":"46","author":"Schnee","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cardiores.2004.08.020","article-title":"Structural and functional characterisation of cardiac fibroblasts","volume":"65","author":"Camelliti","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II\u2013induced cardiac hypertrophy and G\u03b1q overexpression\u2013induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II\u2013induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"Sadoshima","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786419.2014.934235","article-title":"Glaucocalyxin A: a review","volume":"28","author":"Xiang","year":"2014","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-2999(92)90835-R","article-title":"Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin)","volume":"217","author":"Huang","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jphs.2018.05.006_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02977716","article-title":"Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma plus LPS","volume":"28","author":"Jang","year":"2005","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib9","doi-asserted-by":"crossref","first-page":"e80391","DOI":"10.1371\/journal.pone.0080391","article-title":"Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.05.006_bib10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.phymed.2009.05.003","article-title":"Anti-allergic effects of scoparone on mast cell-mediated allergy model","volume":"16","author":"Choi","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jphs.2018.05.006_bib11","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1038\/emm.2014.113","article-title":"Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells","volume":"47","author":"Park","year":"2015","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jphs.2018.05.006_bib12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ejphar.2013.08.013","article-title":"Levosimendan inhibits interleukin-1\u03b2-induced cell migration and MMP-9 secretion in rat cardiac fibroblasts","volume":"718","author":"Okada","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jphs.2018.05.006_bib13","doi-asserted-by":"crossref","first-page":"33483","DOI":"10.1074\/jbc.M113.504290","article-title":"Akt1 mediates \u03b1-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor","volume":"288","author":"Abdalla","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2018.05.006_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.carpath.2013.01.003","article-title":"Vascular fibrosis in atherosclerosis","volume":"22","author":"Lan","year":"2012","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.jphs.2018.05.006_bib15","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.bcp.2013.02.032","article-title":"Angiotensin II upregulates K Ca 3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts","volume":"85","author":"Wang","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jphs.2018.05.006_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.anes.0000365960.74268.21","article-title":"Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts","volume":"112","author":"Cheng","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jphs.2018.05.006_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1142\/S0192415X11008890","article-title":"Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat cardiac fibroblasts","volume":"39","author":"Chan","year":"2012","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.jphs.2018.05.006_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1536\/ihj.13-288","article-title":"Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction: a report from the Osaka Acute Coronary Insufficiency Study","volume":"55","author":"Hara","year":"2014","journal-title":"Int Heart J"},{"key":"10.1016\/j.jphs.2018.05.006_bib19","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/cvr\/28.11.1679","article-title":"Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits","volume":"28","author":"Chen","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/FJC.0b013e3181d706ae","article-title":"Effects of arginine vasopressin on differentiation of cardiac fibroblasts into myofibroblasts","volume":"55","author":"Yan-Hong","year":"2010","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jphs.2018.05.006_bib21","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1091\/mbc.e07-03-0270","article-title":"p21waf1\/cip1\/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts","volume":"18","author":"Roy","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jphs.2018.05.006_bib22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1093\/ajh\/hpv020","article-title":"Influence of renal sympathetic denervation on cardiac extracellular matrix turnover and cardiac fibrosis","volume":"65","author":"D\u00f6rr","year":"2015","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jphs.2018.05.006_bib23","series-title":"Myocardial Fibrosis and Extracellular Matrix Remodelling in Chronic Heart Failure: Novel Treatment and Monitoring Strategies","author":"Elsik","year":"2010"},{"key":"10.1016\/j.jphs.2018.05.006_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.jphs.2018.05.006_bib25","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.CIR.0000140973.60992.9A","article-title":"Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis","volume":"110","author":"Querejeta","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2018.05.006_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/cvr\/cvr067","article-title":"Angiotensin II increases periostin expression via Ras\/p38 MAPK\/CREB and ERK1\/2\/TGF-\u03b21 pathways in cardiac fibroblasts","volume":"91","author":"Li","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib27","first-page":"97","article-title":"Knockdown of eIF3a ameliorates cardiac fibrosis by inhibiting the TGF-\u03b21\/Smad3 signaling pathway","volume":"62","author":"Li","year":"2016","journal-title":"Cell Molecular Biol"},{"key":"10.1016\/j.jphs.2018.05.006_bib28","first-page":"1","article-title":"Notch3 ameliorates cardiac fibrosis after myocardial infarction by inhibiting the TGF-\u03b21\/smad3 pathway","author":"Zhang","year":"2015","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jphs.2018.05.006_bib29","doi-asserted-by":"crossref","first-page":"e0121312","DOI":"10.1371\/journal.pone.0121312","article-title":"Suppression of TGF-\u03b21\/smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.05.006_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2018.05.006_bib31","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1161\/CIRCULATIONAHA.107.704197","article-title":"Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling","volume":"116","author":"Bujak","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2018.05.006_bib32","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1111\/j.1440-1681.1996.tb02817.x","article-title":"Molecular mechanisms of angiotensin II (AT1a) receptor endocytosis","volume":"3","author":"Thomas","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jphs.2018.05.006_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.HYP.35.1.273","article-title":"Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts","volume":"35","author":"Kawano","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2018.05.006_bib34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0022-2828(95)91983-X","article-title":"Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts","volume":"27","author":"Lee","year":"1995","journal-title":"J\u00a0Mol Cell Cardiol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318300872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318300872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T01:47:29Z","timestamp":1604368049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861318300872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S1347861318300872"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2018.05.006","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2018.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}