{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:39:16Z","timestamp":1782869956400,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jphs.2018.08.003","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T13:25:29Z","timestamp":1533821129000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u03b11L-adrenoceptors mediate contraction of human erectile tissue"],"prefix":"10.1016","volume":"137","author":[{"given":"Beverley J.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Chapple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisdair L.","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sillar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ","family":"Chess-Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1152\/physrev.1995.75.1.191","article-title":"Physiology of penile erection","volume":"75","author":"Andersson","year":"1995","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib2","first-page":"479","article-title":"Effect of local alpha-adrenergic blockade on human penile erection","volume":"134","author":"Blum","year":"1985","journal-title":"J\u00a0Urol"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1476-5381.1986.tb10191.x","article-title":"Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis","volume":"87","author":"Brindley","year":"1986","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.urology.2013.03.026","article-title":"Effect of selective alpha-blocker tamsulosin on erectile function in patients with lower\u00a0urinary tract symptoms due to benign prostatic hyperplasia","volume":"82","author":"Shelbaia","year":"2013","journal-title":"Urology"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/nau.23015","article-title":"Effects of silodosin, a selective alpha-1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction","volume":"36","author":"Bastaskin","year":"2017","journal-title":"Neurourol Urodyn"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1464-410X.2005.05959.x","article-title":"Beneficial effects of extended-release doxazosin and doxazosin standard on sexual health","volume":"97","author":"Kaplan","year":"2006","journal-title":"BJU Int"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s003450000178","article-title":"Vasomax for the treatment of male erectile dysfunction","volume":"19","author":"Goldstein","year":"2001","journal-title":"World J Urol"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2165\/00003495-200666030-00002","article-title":"Effects of alpha(1)-adrenoceptor antagonists on male sexual function","volume":"66","author":"van Dijk","year":"2006","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1442-2042.2010.02708.x","article-title":"Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia","volume":"18","author":"Yokoyama","year":"2011","journal-title":"Int J Urol"},{"issue":"5","key":"10.1016\/j.jphs.2018.08.003_bib10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.urology.2015.01.011","article-title":"Silodosin causes impaired ejaculation and enlargement of seminal vesicles in sexually active men treated for lower urinary tract symptoms suggestive of benign prostatic hyperplasia","volume":"85","author":"Bozkurt","year":"2015","journal-title":"Urology"},{"issue":"8 suppl 4","key":"10.1016\/j.jphs.2018.08.003_bib11","first-page":"S18","article-title":"Current concepts in ejaculatory dysfunction","author":"Wolters","year":"2006","journal-title":"Rev Urol"},{"issue":"164 suppl 1","key":"10.1016\/j.jphs.2018.08.003_bib12","first-page":"S1","article-title":"Guide to receptors and channels (GRAC), 5th edition","author":"Alexander","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2018.08.003_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-6147(86)90383-4","article-title":"\u03b11-Adrenoceptor subclassification in vascular smooth muscle","volume":"7","author":"Flavahan","year":"1986","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"10.1016\/j.jphs.2018.08.003_bib14","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/sj.bjp.0701207","article-title":"Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification","volume":"121","author":"Ford","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00018-009-0174-4","article-title":"Subtypes of functional alpha1-adrenoceptor","volume":"67","author":"Docherty","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib16","first-page":"145","article-title":"Identification of alpha 1-adrenergic receptor subtypes in human corpus cavernosum tissue and in cultured trabecular smooth muscle cells","volume":"5","author":"Traish","year":"1995","journal-title":"Receptor"},{"issue":"5","key":"10.1016\/j.jphs.2018.08.003_bib17","first-page":"1793","article-title":"Characterization of alpha-adrenoceptor subtypes in the corpus cavernosum of patients undergoing sex change surgery","volume":"162","author":"Goepel","year":"1999","journal-title":"J\u00a0Urol"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1464-410X.2006.05956.x","article-title":"alpha-Adrenoceptor subtypes in isolated corporal tissue from patients undergoing gender re-assignment","volume":"97","author":"El-Gamal","year":"2006","journal-title":"BJU Int"},{"issue":"1\u20132","key":"10.1016\/j.jphs.2018.08.003_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1566-0702(02)00066-8","article-title":"Hormonal influence on expression and functionality of alpha1-adrenoceptor in rat submandibular gland","volume":"103","author":"Anesini","year":"2003","journal-title":"Auton Neurosci"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/10623329809072200","article-title":"Estrogen replacement modulates resistance artery smooth muscle and endothelial alpha2-adrenoceptor reactivity","volume":"6","author":"Ferrer","year":"1998","journal-title":"Endothelium"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00169183","article-title":"Classification of alpha 1-adrenoceptor subtypes","volume":"352","author":"Michel","year":"1995","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0026-895X(25)08700-0","volume":"49","author":"Ford","year":"1996","journal-title":"Mol Pharmacol"},{"issue":"352","key":"10.1016\/j.jphs.2018.08.003_bib23","first-page":"284","article-title":"Identification of the alpha1L-adrenoceptor subtype in human prostate and rat salivary gland using radioligand binding with [3H]tamsulosin","volume":"1997","author":"Mason","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"3\u20134","key":"10.1016\/j.jphs.2018.08.003_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/aap.12023","article-title":"Functional and radioligand binding characterization of the alpha1L-adrenoceptor subtype of the human vas deferens","volume":"34","author":"Davis","year":"2015","journal-title":"Auton Autacoid Pharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2018.08.003_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.ijir.3900653","article-title":"Evaluation of oral ro70-0004\/003, an alpha1A-adrenoceptor antagonist, in the treatment of male erectile dysfunction","volume":"13","author":"Choppin","year":"2001","journal-title":"Int J Impot Res"},{"issue":"6","key":"10.1016\/j.jphs.2018.08.003_bib26","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1476-5381.1995.tb15907.x","article-title":"Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline","volume":"115","author":"Kenny","year":"1995","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.jphs.2018.08.003_bib27","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1476-5381.1996.tb16009.x","article-title":"The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor","volume":"119","author":"Chess-Williams","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2018.08.003_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folins phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1476-5381.1959.tb00928.x","article-title":"Some quantitative uses of drug antagonists","volume":"14","author":"Arunlakshana","year":"1959","journal-title":"Br J Pharmacol Chemother"},{"issue":"23","key":"10.1016\/j.jphs.2018.08.003_bib30","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-3565(25)10708-8","article-title":"A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype","volume":"274","author":"Knepper","year":"1995","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0700907","article-title":"The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes","volume":"120","author":"Noble","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib33","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/j.1476-5381.1995.tb16380.x","article-title":"Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens","volume":"116","author":"Furukawa","year":"1995","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0922-4106(94)90183-X","article-title":"Expression of alpha 1-adrenoceptor subtypes in rat tissues: implications for alpha 1-adrenoceptor classification","volume":"268","author":"Faure","year":"1994","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2018.08.003_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/bjp.2008.245","article-title":"The alpha1A-adrenoceptor gene is required for the alpha1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate","volume":"155","author":"Gray","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"8","key":"10.1016\/j.jphs.2018.08.003_bib36","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/bjp.2008.360","article-title":"Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout","volume":"155","author":"Muramatsu","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.jphs.2018.08.003_bib37","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1476-5381.2011.01663.x","article-title":"What makes the alpha(1A)-adrenoceptor gene express the alpha(1L)-adrenoceptor functional phenotype?","volume":"165","author":"Ventura","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.jphs.2018.08.003_bib38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1254\/jphs.10093FP","article-title":"Identification of cysteine-rich epidermal growth factor-like domain 1alpha (CRELD1alpha) as a novel alpha1A-adrenoceptor-down-regulating protein and establishment of an alpha1L-adrenoceptor-expressing cell line","volume":"113","author":"Nishimune","year":"2010","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"16","key":"10.1016\/j.jphs.2018.08.003_bib39","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.1074\/jbc.M111.322834","article-title":"Identification and profiling of novel alpha1A-adrenoceptor-CXC chemokine receptor 2 heteromer","volume":"287","author":"Mustafa","year":"2012","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.jphs.2018.08.003_bib40","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1476-5381.2011.01591.x","article-title":"Phenotype pharmacology of lower urinary tract alpha(1)-adrenoceptors","volume":"165","author":"Nishimune","year":"2012","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:58:29Z","timestamp":1761163109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861318301348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1347861318301348"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2018.08.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b11L-adrenoceptors mediate contraction of human erectile tissue","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2018.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}