{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:58:51Z","timestamp":1788976731508,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jphs.2018.08.013","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T07:49:45Z","timestamp":1538034585000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model"],"prefix":"10.1016","volume":"138","author":[{"given":"Jiadai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena G.","family":"Rybakina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelena A.","family":"Korneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2018.08.013_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1615\/JLongTermEffMedImplants.v14.i4.20","article-title":"Pressure ulcer prevention","volume":"14","author":"Edlich","year":"2004","journal-title":"J\u00a0Long Term Eff Med Implants"},{"key":"10.1016\/j.jphs.2018.08.013_bib2","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1038\/srep04173","article-title":"Potential application of in\u00a0vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model","volume":"4","author":"Kasuya","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2018.08.013_bib3","doi-asserted-by":"crossref","first-page":"H67","DOI":"10.1152\/ajpheart.2001.281.1.H67","article-title":"Pressure ulcer A2A adenosine receptor activation reduces skin pressure ulcer formation and inflammation","volume":"281","author":"Peirce","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jphs.2018.08.013_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08941930490472046","article-title":"Development of a simple, noninvasive, clinically relevant model of pressure ulcers in the mouse","volume":"17","author":"Stadler","year":"2004","journal-title":"J\u00a0Invest Surg: Off J Acad Surg Res"},{"key":"10.1016\/j.jphs.2018.08.013_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/10790268.2007.11753921","article-title":"Animal models in pressure ulcer Research","volume":"30","author":"Salcido","year":"2007","journal-title":"J\u00a0Spinal Cord Med"},{"key":"10.1016\/j.jphs.2018.08.013_bib6","doi-asserted-by":"crossref","first-page":"E2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2018.08.013_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17030284","article-title":"Pressure combined with ischemia\/reperfusion injury induces deep tissue injury via endoplasmic reticulum stress in a rat pressure ulcer model","volume":"17","author":"Cui","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2018.08.013_bib8","first-page":"159","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"17","author":"McCord","year":"1985","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jphs.2018.08.013_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/abbi.2001.2642","article-title":"The neutrophil NADPH oxidase","volume":"397","author":"Babior","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jphs.2018.08.013_bib10","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/jid.2014.515","article-title":"Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury","volume":"135","author":"Uchiyama","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jphs.2018.08.013_bib11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1365-2133.2009.09349.x","article-title":"Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model","volume":"161","author":"Tsutakawa","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jphs.2018.08.013_bib12","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/sj.jid.5701258","article-title":"The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer","volume":"128","author":"Saito","year":"2008","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jphs.2018.08.013_bib13","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/jid.2015.3","article-title":"Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells","volume":"135","author":"Ou","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jphs.2018.08.013_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0041-008X(03)00301-6","article-title":"Cyclooxygenases in the skin: pharmacological and toxicological implications","volume":"192","author":"Lee","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jphs.2018.08.013_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/path.992","article-title":"Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers","volume":"195","author":"Abd-El-Aleem","year":"2001","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jphs.2018.08.013_bib16","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.biopha.2017.09.031","article-title":"Involvement of MAPK\/NF-\u03baB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer","volume":"95","author":"Akanda","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jphs.2018.08.013_bib17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fphys.2015.00293","article-title":"SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression","volume":"6","author":"Sin","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.jphs.2018.08.013_bib18","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1038\/srep09287","article-title":"bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia\/reperfusion via the activation of the PI3K\/Akt\/mTOR pathway","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2018.08.013_bib19","doi-asserted-by":"crossref","first-page":"306421","DOI":"10.1155\/2013\/306421","article-title":"Carbon monoxide protects against hepatic ischemia\/reperfusion injury via ROS-dependent Akt signaling and inhibition of glycogen synthase kinase 3beta","volume":"2013","author":"Kim","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jphs.2018.08.013_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuroscience.2015.11.059","article-title":"Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1\/2)","volume":"314","author":"Mohamed","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphs.2018.08.013_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jss.2013.11.1118","article-title":"Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats","volume":"188","author":"Fu","year":"2014","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jphs.2018.08.013_bib22","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jbiomech.2016.02.028","article-title":"Cell death induced by mechanical compression on engineered muscle results from a gradual physiological mechanism","volume":"49","author":"Wu","year":"2016","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.jphs.2018.08.013_bib23","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1074\/jbc.272.32.19943","article-title":"Tissue-specific pattern of stress kinase activation in ischemic\/reperfused heart and kidney","volume":"272","author":"Yin","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2018.08.013_bib24","doi-asserted-by":"crossref","first-page":"906787","DOI":"10.1155\/2015\/906787","article-title":"Allopurinol protects against ischemia\/reperfusion-induced injury in rat urinary bladders","volume":"2015","author":"Shin","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jphs.2018.08.013_bib25","first-page":"22","article-title":"[Anti-arrhythmia activity of derinat in an experiment]","volume":"67","author":"Sviatkina","year":"2004","journal-title":"Eksp Klin Farmakol"},{"key":"10.1016\/j.jphs.2018.08.013_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11055-010-9270-z","article-title":"Stress-induced changes in the functional activity of the neuroendocrine system: the modulatory activity of derinat","volume":"40","author":"Fomicheva","year":"2010","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.jphs.2018.08.013_bib27","first-page":"45","article-title":"Use of immunomodulator derinat in the treatment of patients with surgical sepsis in traumatic shock","volume":"161","author":"Gromov","year":"2002","journal-title":"Vestn Khir Im I I Grek"},{"key":"10.1016\/j.jphs.2018.08.013_bib28","first-page":"33","article-title":"Clinical efficiency of derinat used to treat chronic adenoiditis in children","author":"Mangushev","year":"2008","journal-title":"Vestn Otorinolaringol"},{"key":"10.1016\/j.jphs.2018.08.013_bib29","first-page":"4","article-title":"Clinical efficacy of immunostimulating drugs in treatment of purulent infections","author":"Zemskov","year":"2011","journal-title":"Khirurgiia (Mosk)"},{"key":"10.1016\/j.jphs.2018.08.013_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jdermsci.2010.02.002","article-title":"Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation","volume":"58","author":"Wang","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jphs.2018.08.013_bib31","first-page":"76","article-title":"Enzyme immunoassay of masked complement component C4 deficiency in patients with urogenital Chlamydia infection","volume":"3","author":"Gora","year":"2011","journal-title":"Zh Mikrobiol Epidemiol Immunobiol"},{"key":"10.1016\/j.jphs.2018.08.013_bib32","first-page":"38","article-title":"Immune status of patients with exacerbation of chronic suppurative otitis media and its correction","volume":"5","author":"Zemskov","year":"2010","journal-title":"Vestn Otorinolaringol"},{"key":"10.1016\/j.jphs.2018.08.013_bib33","doi-asserted-by":"crossref","first-page":"20297","DOI":"10.3390\/molecules201119693","article-title":"Derinat protects skin against ultraviolet-B (UVB)-induced cellular damage","volume":"20","author":"Hsu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jphs.2018.08.013_bib34","first-page":"1113","article-title":"Treatment of ischemic ulcers of the lower limbs with alprostadil (prostaglandin E1)","volume":"30","author":"Tondi","year":"2004","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jphs.2018.08.013_bib35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.burns.2005.04.008","article-title":"A\u00a0basic fibroblast growth factor improved the quality of skin grafting in burn patients","volume":"31","author":"Akita","year":"2005","journal-title":"Burns: J Int Soc Burn Injuries"},{"key":"10.1016\/j.jphs.2018.08.013_bib36","first-page":"68","article-title":"Ischemia-reperfusion injury in chronic pressure ulcer formation a skin model in the rat","volume":"8","author":"Peirce","year":"2000","journal-title":"Wound Heal Soc"},{"key":"10.1016\/j.jphs.2018.08.013_bib37","first-page":"3","article-title":"Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in\u00a0vitro","author":"Li","year":"2013","journal-title":"Med Gas Res"},{"key":"10.1016\/j.jphs.2018.08.013_bib38","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2014.06.020","article-title":"Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis","volume":"74","author":"Tun","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jphs.2018.08.013_bib39","doi-asserted-by":"crossref","first-page":"e7247","DOI":"10.1371\/journal.pone.0007247","article-title":"Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease","volume":"4","author":"Fujita","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.08.013_bib40","doi-asserted-by":"crossref","first-page":"16910","DOI":"10.1038\/srep16910","article-title":"Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress","volume":"5","author":"Zhong","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2018.08.013_bib41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1749-6632.1989.tb24038.x","article-title":"Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity","volume":"557","author":"Kupper","year":"1989","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jphs.2018.08.013_bib42","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2015.09.017","article-title":"Nucleic acid delivery into skin for the treatment of skin disease: proofs-of-concept, potential impact, and remaining challenges","volume":"219","author":"Zakrewsky","year":"2015","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jphs.2018.08.013_bib43","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/jcb.25142","article-title":"Molecular mechanisms underlying the regulation of the MFG-E8 gene promoter activity in physiological and inflammatory conditions","volume":"116","author":"Wang","year":"2015","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jphs.2018.08.013_bib44","doi-asserted-by":"crossref","first-page":"e13167","DOI":"10.14814\/phy2.13167","article-title":"Aldosterone does not alter endothelin B receptor signaling in the inner medullary collecting duct","volume":"5","author":"Ramkumar","year":"2017","journal-title":"Physiol Rep"},{"key":"10.1016\/j.jphs.2018.08.013_bib45","doi-asserted-by":"crossref","first-page":"e0132622","DOI":"10.1371\/journal.pone.0132622","article-title":"Analysis of gene expression in experimental pressure ulcers in the rat with special reference to inflammatory cytokines","volume":"10","author":"Kurose","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2018.08.013_bib46","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J\u00a0Cell Biol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T12:46:54Z","timestamp":1542199614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861318301804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1347861318301804"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2018.08.013","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2018.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}