{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:51:33Z","timestamp":1762102293514},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JPSP KAKENHI","award":["24890225","15K18865"],"award-info":[{"award-number":["24890225","15K18865"]}]},{"name":"Program for Leading Graduate Schools \u201cHIGO (Health Life Science: Interdisciplinary and Glocal Oriented)\u201d"},{"name":"MEXT, Japan"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jphs.2018.09.004","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T23:21:25Z","timestamp":1537658485000},"page":"167-175","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities"],"prefix":"10.1016","volume":"138","author":[{"given":"Yuki","family":"Kurauchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Noma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Hisatsune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Katsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jphs.2018.09.004_bib1","doi-asserted-by":"crossref","first-page":"C491","DOI":"10.1152\/ajpcell.00359.2015","article-title":"Na + -K + -ATPase, a new class of plasma membrane receptors","volume":"310","author":"Aperia","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"issue":"October","key":"10.1016\/j.jphs.2018.09.004_bib2","article-title":"Transcriptional regulators of Na,K-ATPase subunits","volume":"3","author":"Li","year":"2015","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"10.1016\/j.jphs.2018.09.004_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-3223(94)00201-D","article-title":"The Na,K-ATPase hypothesis for bipolar illness","volume":"37","author":"El-Mallakh","year":"1995","journal-title":"Biol Psychiatry"},{"issue":"5","key":"10.1016\/j.jphs.2018.09.004_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.biopsych.2005.12.021","article-title":"Involvement of Na+, K+-ATPase and endogenous digitalis-like compounds in depressive disorders","volume":"60","author":"Goldstein","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.jphs.2018.09.004_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-3223(97)00343-0","article-title":"Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)","volume":"44","author":"Mynett-Johnson","year":"1998","journal-title":"Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.jphs.2018.09.004_bib6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0006-3223(97)00440-X","article-title":"Alpha2 isoform of the Na,K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals","volume":"44","author":"Rose","year":"1998","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.jphs.2018.09.004_bib7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nrn.2017.24","article-title":"NMDA receptors: linking physiological output to biophysical operation","volume":"18","author":"Iacobucci","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"2 PART 2","key":"10.1016\/j.jphs.2018.09.004_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/01.STR.0000256294.46009.29","article-title":"Ca2+ signals and neuronal death in brain ischemia","volume":"38","author":"Bano","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jphs.2018.09.004_bib9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2014.11.017","article-title":"Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease","volume":"74","author":"Hanson","year":"2015","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.jphs.2018.09.004_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tins.2005.12.001","article-title":"Paradox of Ca2+ signaling, cell death and stroke","volume":"29","author":"MacDonald","year":"2006","journal-title":"Trends Neurosci"},{"issue":"12","key":"10.1016\/j.jphs.2018.09.004_bib11","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/glia.23027","article-title":"Strategies for immunohistochemical protein localization using antibodies: what did we learn from neurotransmitter transporters in glial cells and neurons","volume":"64","author":"Danbolt","year":"2016","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.jphs.2018.09.004_bib12","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/glia.22844","article-title":"Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex","volume":"63","author":"Hanson","year":"2015","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.jphs.2018.09.004_bib13","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/glia.23136","article-title":"Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders","volume":"65","author":"Liu","year":"2017","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.jphs.2018.09.004_bib14","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1471-4159.2000.0751076.x","article-title":"The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures","volume":"75","author":"Perego","year":"2000","journal-title":"J\u00a0Neurochem"},{"issue":"1","key":"10.1016\/j.jphs.2018.09.004_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cne.23450","article-title":"Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus","volume":"522","author":"Schreiner","year":"2014","journal-title":"J\u00a0Comp Neurol"},{"issue":"6","key":"10.1016\/j.jphs.2018.09.004_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098469","article-title":"Role of Na,K-ATPase \u03b11 and \u03b12 isoforms in the support of astrocyte glutamate uptake","volume":"9","author":"Illarionava","year":"2014","journal-title":"PLoS One"},{"issue":"25","key":"10.1016\/j.jphs.2018.09.004_bib17","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1523\/JNEUROSCI.1081-09.2009","article-title":"Glutamate transporter coupling to Na,K-ATPase","volume":"29","author":"Rose","year":"2009","journal-title":"J\u00a0Neurosci"},{"issue":"24","key":"10.1016\/j.jphs.2018.09.004_bib18","doi-asserted-by":"crossref","first-page":"9913","DOI":"10.1523\/JNEUROSCI.5584-12.2013","article-title":"Na+\/K+ ATPase 1 and 3 isoforms are differentially expressed in - and -motoneurons","volume":"33","author":"Edwards","year":"2013","journal-title":"J\u00a0Neurosci"},{"issue":"2","key":"10.1016\/j.jphs.2018.09.004_bib19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S0006-291X(88)80914-8","article-title":"Ouabain sensitivity of the alpha 3 isozyme of rat Na,K-ATPase","volume":"156","author":"Urayama","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.jphs.2018.09.004_bib20","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s10495-015-1144-y","article-title":"Critical role of the \u03b11-Na+, K+-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain","volume":"20","author":"Akimova","year":"2015","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.jphs.2018.09.004_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-2999(00)00790-1","article-title":"Astroglial cell death induced by excessive influx of sodium ions","volume":"408","author":"Takahashi","year":"2000","journal-title":"Eur J Pharmacol"},{"issue":"22","key":"10.1016\/j.jphs.2018.09.004_bib22","first-page":"4","article-title":"Ionic mechanisms of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons","volume":"15","author":"Xiao","year":"2002","journal-title":"J\u00a0Neurosci"},{"issue":"17","key":"10.1016\/j.jphs.2018.09.004_bib23","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1523\/JNEUROSCI.21-17-06512.2001","article-title":"Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat brain","volume":"21","author":"Chen","year":"2001","journal-title":"J\u00a0Neurosci"},{"issue":"4","key":"10.1016\/j.jphs.2018.09.004_bib24","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1750-3639.2008.00226.x","article-title":"Astrocytes are more resistant to focal cerebral ischemia than neurons and die by a delayed necrosis","volume":"19","author":"G\u00fcrer","year":"2009","journal-title":"Brain Pathol"},{"issue":"2","key":"10.1016\/j.jphs.2018.09.004_bib25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2013.11.011","article-title":"Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage","volume":"81","author":"Beppu","year":"2014","journal-title":"Neuron"},{"issue":"50","key":"10.1016\/j.jphs.2018.09.004_bib26","doi-asserted-by":"crossref","first-page":"20720","DOI":"10.1073\/pnas.1213458109","article-title":"Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation","volume":"109","author":"Sasaki","year":"2012","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"10.1016\/j.jphs.2018.09.004_bib27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrd.2017.16","article-title":"Targeting glutamate signalling in depression: progress and prospects","volume":"16","author":"Murrough","year":"2017","journal-title":"Nat Rev Drug Discov"},{"issue":"7321","key":"10.1016\/j.jphs.2018.09.004_bib28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jphs.2018.09.004_bib29","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1523\/JNEUROSCI.4689-05.2006","article-title":"NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes","volume":"26","author":"Lalo","year":"2006","journal-title":"J\u00a0Neurosci"},{"issue":"6","key":"10.1016\/j.jphs.2018.09.004_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tcm.2007.05.001","article-title":"Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation","volume":"17","author":"Straub","year":"2007","journal-title":"Trends Cardiovasc Med"},{"issue":"23","key":"10.1016\/j.jphs.2018.09.004_bib31","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1523\/JNEUROSCI.4498-15.2016","article-title":"Experimental cortical spreading depression induces NMDA receptor dependent potassium currents in microglia","volume":"36","author":"Wendt","year":"2016","journal-title":"J\u00a0Neurosci"},{"issue":"36","key":"10.1016\/j.jphs.2018.09.004_bib32","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J\u00a0Neurosci"},{"issue":"1","key":"10.1016\/j.jphs.2018.09.004_bib33","doi-asserted-by":"crossref","first-page":"F77","DOI":"10.1152\/ajprenal.00581.2009","article-title":"Ouabain stimulates Na-K-ATPase through a sodium\/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells","volume":"299","author":"Holthouser","year":"2010","journal-title":"Am J Physiol Physiol"},{"issue":"October","key":"10.1016\/j.jphs.2018.09.004_bib34","first-page":"1","article-title":"Ouabain mimics low temperature rescue of f508del-CFTR in cystic fibrosis epithelial cells","volume":"3","author":"Zhang","year":"2012","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.jphs.2018.09.004_bib35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1021\/cn5000309","article-title":"Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders","volume":"5","author":"Forlenza","year":"2014","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"10.1016\/j.jphs.2018.09.004_bib36","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1124\/mol.106.024059","article-title":"Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis","volume":"70","author":"Chen","year":"2006","journal-title":"Mol Pharmacol"},{"issue":"Jan","key":"10.1016\/j.jphs.2018.09.004_bib37","first-page":"1","article-title":"Lithium-induced neuroprotection is associated with epigenetic modification of specific BDNF gene promoter and altered expression of apoptotic-regulatory proteins","volume":"9","author":"Dwivedi","year":"2015","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.jphs.2018.09.004_bib38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1471-4159.2002.00957.x","article-title":"Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation","volume":"82","author":"Ghribi","year":"2002","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jphs.2018.09.004_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2016.05.025","article-title":"Na+, K+-ATPase dysfunction causes cerebrovascular endothelial cell degeneration in rat prefrontal cortex slice cultures","author":"Kurauchi","year":"2016","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.jphs.2018.09.004_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1017\/S1461145710000404","article-title":"Excellent lithium responders have normal cognitive functions and plasma BDNF levels","volume":"13","author":"Rybakowski","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2018.09.004_bib41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1471-4159.2007.04593.x","article-title":"Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation","volume":"102","author":"Basselin","year":"2007","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jphs.2018.09.004_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yjmcc.2013.12.017","article-title":"P21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes","volume":"67","author":"DeSantiago","year":"2014","journal-title":"J\u00a0Mol Cell Cardiol"},{"issue":"10","key":"10.1016\/j.jphs.2018.09.004_bib43","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1038\/jcbfm.2011.75","article-title":"Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem\/progenitor cells","volume":"31","author":"Li","year":"2011","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jphs.2018.09.004_bib44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.freeradbiomed.2014.03.036","article-title":"Involvement of Na\/K-ATPase in hydrogen peroxide-induced activation of the Src\/ERK pathway in LLC-PK1 cells","volume":"71","author":"Wang","year":"2014","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"10.1016\/j.jphs.2018.09.004_bib45","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1159\/000453179","article-title":"Up-regulation of excitatory amino acid transporters EAAT3 and EAAT4 by lithium sensitive glycogen synthase kinase GSK3\u00df","volume":"40","author":"Abousaab","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"11","key":"10.1016\/j.jphs.2018.09.004_bib46","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.jcbfm.9600295","article-title":"EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy","volume":"26","author":"Voutsinos-Porche","year":"2006","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"issue":"44","key":"10.1016\/j.jphs.2018.09.004_bib47","doi-asserted-by":"crossref","first-page":"40396","DOI":"10.1074\/jbc.M104926200","article-title":"Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions","volume":"276","author":"Borre","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.jphs.2018.09.004_bib48","doi-asserted-by":"crossref","DOI":"10.1111\/ped.12079","article-title":"Comparative effects of respiratory stimulants on hypoxic neuronal cell injury in SH-SY5Y cells and in hippocampal slice cultures from rat pups","volume":"55","author":"Tanaka","year":"2013","journal-title":"Pediatr Int"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861318301750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T17:51:01Z","timestamp":1544032261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861318301750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S1347861318301750"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2018.09.004","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2018.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}