{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:22:36Z","timestamp":1792786956042,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of the Education Department of Anhui Province","award":["KJ2017A517"],"award-info":[{"award-number":["KJ2017A517"]}]},{"name":"Anhui Science and Technology University Funds","award":["ZRC2013355"],"award-info":[{"award-number":["ZRC2013355"]}],"id":[{"id":"https:\/\/ror.org\/01pn91c28","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jphs.2019.01.007","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T20:08:01Z","timestamp":1549051681000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis"],"prefix":"10.1016","volume":"139","author":[{"given":"Youyi","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggui","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jphs.2019.01.007_bib1","first-page":"49","article-title":"Multicentre experience of a novel treatment for Bph: aquablation\u2013image guided robot-assisted water jet ablation of the prostate","volume":"115","author":"Gilling","year":"2015","journal-title":"BJU Int"},{"issue":"6","key":"10.1016\/j.jphs.2019.01.007_bib2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.urology.2015.07.019","article-title":"Use of medical therapy and success of laser surgery and transurethral resection of the prostate for benign prostatic hyperplasia","volume":"86","author":"Strope","year":"2015","journal-title":"Urology"},{"issue":"10","key":"10.1016\/j.jphs.2019.01.007_bib3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/17425255.2016.1209483","article-title":"Drug interactions between antiretrovirals and drugs used to treat benign prostatic hyperplasia\/lower urinary tract symptoms","volume":"12","author":"Kreutzwiser","year":"2016","journal-title":"Expert Opin Drug Met"},{"issue":"8","key":"10.1016\/j.jphs.2019.01.007_bib4","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3390\/ijms17081339","article-title":"The role of \u03b11-adrenoceptor antagonists in the treatment of prostate and other cancers","volume":"17","author":"Batty","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jphs.2019.01.007_bib5","first-page":"56","article-title":"Adverse effects and safety of 5-alpha reductase inhibitors (finasteride, dutasteride): a systematic review","volume":"9","author":"Hirshburg","year":"2016","journal-title":"J\u00a0Clin Aesthet Dermatol"},{"issue":"16","key":"10.1016\/j.jphs.2019.01.007_bib6","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/pros.21027","article-title":"Inflammation in benign prostatic hyperplasia: a 282 patients' immunohistochemical analysis","volume":"69","author":"Robert","year":"2009","journal-title":"Prostate"},{"issue":"3","key":"10.1016\/j.jphs.2019.01.007_bib7","first-page":"147","article-title":"In\u00a0vitro effects of ancient prescription Bazhengsan against Diplococus gonorrhoeae","volume":"21","author":"Lu","year":"1998","journal-title":"Zhong Yao Cai"},{"issue":"12","key":"10.1016\/j.jphs.2019.01.007_bib8","first-page":"26","article-title":"The effects of Bazheng san on the expressions of bladder IL-6, IL-17, and TGF-\u03b21 on the basis of CG rats suffering from glandular cystitis","volume":"29","author":"You","year":"2015","journal-title":"Chin J Androl"},{"issue":"7","key":"10.1016\/j.jphs.2019.01.007_bib9","first-page":"11","article-title":"The observation of Chinese medicine treatment on prostate hyperplasia in 60 cases","volume":"14","author":"Mao","year":"1998","journal-title":"J\u00a0Practical Tradit Chin Med"},{"issue":"2","key":"10.1016\/j.jphs.2019.01.007_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5534\/wjmh.2013.31.2.150","article-title":"The anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model","volume":"31","author":"Yoon","year":"2013","journal-title":"World J Mens Health"},{"issue":"2","key":"10.1016\/j.jphs.2019.01.007_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1039\/C4FO00472H","article-title":"Antrodan, a \u03b2-glucan obtained from antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia","volume":"6","author":"Peng","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.jphs.2019.01.007_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2016.12.039","article-title":"Anti-inflammatory and antioxidant effect of modified Bazhengsan in a rat model of chronic bacterial prostatitis","volume":"198","author":"Xiong","year":"2017","journal-title":"J\u00a0Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.jphs.2019.01.007_bib13","first-page":"1042","article-title":"Prevalence of inflammation and benign prostatic hyperplasia on autopsy in Asian and Caucasian men","volume":"195","author":"Kaplan","year":"2016","journal-title":"J\u00a0Urol"},{"issue":"5","key":"10.1016\/j.jphs.2019.01.007_bib14","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1476-5381.2011.01332.x","article-title":"Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH)","volume":"163","author":"Oliver","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2019.01.007_bib15","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/01.LAB.0000081388.40145.65","article-title":"Cytokine expression pattern in benign prostatic hyperplasia infiltrating T cells and impact of lymphocytic infiltration on cytokine mRNA profile in prostatic tissue","volume":"83","author":"Steiner","year":"2003","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.jphs.2019.01.007_bib16","first-page":"84","article-title":"Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis","volume":"16","author":"Zhang","year":"2010","journal-title":"Zhonghua Nan ke Xue"},{"issue":"2","key":"10.1016\/j.jphs.2019.01.007_bib17","first-page":"104","article-title":"Relationship between interleukin-8 levels in expressed prostatic secretion and expressions of bFGF and Bcl-2 in benign prostatic hyperplasia","volume":"96","author":"Song","year":"2016","journal-title":"Zhonghua Yixue Zazhi"},{"issue":"3","key":"10.1016\/j.jphs.2019.01.007_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/pros.10238","article-title":"Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate","volume":"56","author":"Steiner","year":"2003","journal-title":"Prostate"},{"issue":"7","key":"10.1016\/j.jphs.2019.01.007_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1593\/neo.07307","article-title":"CCL2 as an important mediator of prostate cancer growth in\u00a0vivo through the regulation of macrophage infiltration","volume":"9","author":"Loberg","year":"2007","journal-title":"Neoplasia"},{"issue":"5","key":"10.1016\/j.jphs.2019.01.007_bib20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1590\/S1677-55382011000500008","article-title":"Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer","volume":"37","author":"Pace","year":"2011","journal-title":"Int Braz J Urol"},{"issue":"3","key":"10.1016\/j.jphs.2019.01.007_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jnutbio.2014.11.008","article-title":"Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing I\u039aB\u03b1\/NF-\u03baB signaling pathway","volume":"26","author":"Jia","year":"2015","journal-title":"J\u00a0Nutr Biochem"},{"issue":"3","key":"10.1016\/j.jphs.2019.01.007_bib22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1248\/cpb.c13-00668","article-title":"Three new lignan glycosides with IL-6 inhibitory activity from Akebia quinata","volume":"62","author":"Jin","year":"2014","journal-title":"Chem Pharm Bull"},{"issue":"1","key":"10.1016\/j.jphs.2019.01.007_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jsbmb.2005.07.005","article-title":"Acteoside and martynoside exhibit estrogenic\/antiestrogenic properties","volume":"98","author":"Papoutsi","year":"2006","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"6\u20137","key":"10.1016\/j.jphs.2019.01.007_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1078\/094471103322331421","article-title":"Effect of naturally occurring triterpenoidsglycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system","volume":"10","author":"Raphael","year":"2003","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jphs.2019.01.007_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-8981(74)90425-2","article-title":"Distribution of the immunoglobulins G, A and M in the prostatic fluid of patients with prostatitis","volume":"57","author":"Gray","year":"1974","journal-title":"Clin Chim Acta"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786131930012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786131930012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T19:35:21Z","timestamp":1553283321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S134786131930012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S134786131930012X"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.01.007","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}