{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:05:24Z","timestamp":1783973124783,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T00:00:00Z","timestamp":1552089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601121"],"award-info":[{"award-number":["81601121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800065"],"award-info":[{"award-number":["81800065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500968"],"award-info":[{"award-number":["31500968"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180616"],"award-info":[{"award-number":["BK20180616"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160193"],"award-info":[{"award-number":["BK20160193"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Natural Science Foundation of Jiangnan University","award":["JUSRP11864"],"award-info":[{"award-number":["JUSRP11864"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jphs.2019.03.002","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T13:05:30Z","timestamp":1552568730000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT\/NF-\u03baB signaling pathway in mice"],"prefix":"10.1016","volume":"139","author":[{"given":"Yunjuan","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoshang","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/17476348.2017.1300533","article-title":"Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the 'bed' that counts and not 'the sleepers'","volume":"11","author":"Tomos","year":"2017","journal-title":"Expert Rev Respir Med"},{"issue":"12","key":"10.1016\/j.jphs.2019.03.002_bib2","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1164\/rccm.201612-2480OC","article-title":"Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis","volume":"196","author":"Ryu","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jphs.2019.03.002_bib3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"22","key":"10.1016\/j.jphs.2019.03.002_bib4","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A\u00a0phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"King","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.jphs.2019.03.002_bib5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12931-018-0907-8","article-title":"Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis","volume":"19","author":"Yoon","year":"2018","journal-title":"Respir Res"},{"issue":"12","key":"10.1016\/j.jphs.2019.03.002_bib6","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.bbadis.2017.09.011","article-title":"BMP7-induced-Pten inhibits Akt and prevents renal fibrosis","volume":"1863","author":"Higgins","year":"2017","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"key":"10.1016\/j.jphs.2019.03.002_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ebiom.2017.03.021","article-title":"Piperine attenuates pathological cardiac fibrosis via PPAR-gamma\/AKT pathways","volume":"18","author":"Ma","year":"2017","journal-title":"EBioMedicine"},{"issue":"16","key":"10.1016\/j.jphs.2019.03.002_bib8","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1111\/bph.13203","article-title":"The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFbeta-induced pulmonary fibrosis","volume":"172","author":"Abdalla","year":"2015","journal-title":"Br J Pharmacol"},{"issue":"32","key":"10.1016\/j.jphs.2019.03.002_bib9","doi-asserted-by":"crossref","first-page":"21369","DOI":"10.1074\/jbc.M109.027433","article-title":"Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt","volume":"284","author":"Wegiel","year":"2009","journal-title":"J\u00a0Biol Chem"},{"issue":"7","key":"10.1016\/j.jphs.2019.03.002_bib10","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/jcmm.13060","article-title":"Signalling pathways involved in hypoxia-induced renal fibrosis","volume":"21","author":"Liu","year":"2017","journal-title":"J\u00a0Cell Mol Med"},{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1165\/rcmb.2005-0424OC","article-title":"Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K\/Akt-NF-kappaB signaling pathway","volume":"35","author":"Tong","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.jphs.2019.03.002_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jat.1249","article-title":"Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats","volume":"28","author":"Chavez","year":"2008","journal-title":"J\u00a0Appl Toxicol"},{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00436-017-5392-3","article-title":"Genistein improves schistosomiasis liver granuloma and fibrosis via dampening NF-\u03baB signaling in mice","volume":"116","author":"Wan","year":"2017","journal-title":"Parasitol Res"},{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11130-010-0192-2","article-title":"Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats","volume":"65","author":"Saravanan","year":"2010","journal-title":"Plant Foods Hum Nutr"},{"issue":"3","key":"10.1016\/j.jphs.2019.03.002_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1471-4159.2010.07145.x","article-title":"Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-l-cysteine treatment in the neuronal culture and APP-Tg mouse model","volume":"117","author":"Ray","year":"2011","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jphs.2019.03.002_bib16","article-title":"Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats","author":"Sathibabu Uddandrao","year":"2018","journal-title":"Eur J Nutr"},{"issue":"11","key":"10.1016\/j.jphs.2019.03.002_bib17","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1177\/0960327116680275","article-title":"S-Allyl cysteine alleviates inflammation by modulating the expression of NF-kappaB during chromium (VI)-induced hepatotoxicity in rats","volume":"36","author":"Anandasadagopan","year":"2017","journal-title":"Hum Exp Toxicol"},{"issue":"12","key":"10.1016\/j.jphs.2019.03.002_bib18","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1021\/jf3002685","article-title":"Nuclear factor kappaB-dependent anti-inflammatory effects of s-allyl cysteine and s-propyl cysteine in kidney of diabetic mice","volume":"60","author":"Mong","year":"2012","journal-title":"J\u00a0Agric Food Chem"},{"issue":"3","key":"10.1016\/j.jphs.2019.03.002_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.5009\/gnl14509","article-title":"Gastroprotective effects of PMK-S005 against ethanol-induced acute gastric damage in rats","volume":"10","author":"Choi","year":"2016","journal-title":"Gut Liver"},{"issue":"5","key":"10.1016\/j.jphs.2019.03.002_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.5009\/gnl15584","article-title":"PMK-S005 alleviates age-related gastric acid secretion, inflammation, and oxidative status in the Rat stomach","volume":"10","author":"Choi","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.jphs.2019.03.002_bib21","doi-asserted-by":"crossref","first-page":"13419","DOI":"10.1038\/srep13419","article-title":"Vagotomy attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"5","author":"Song","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jphs.2019.03.002_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1165\/rcmb.2017-0096ST","article-title":"An official American thoracic society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis","volume":"56","author":"Jenkins","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"10.1016\/j.jphs.2019.03.002_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J\u00a0Clin Pathol"},{"issue":"22","key":"10.1016\/j.jphs.2019.03.002_bib25","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.2174\/092986711796504664","article-title":"The \u201caged garlic extract:\u201d (AGE) and one of its active ingredients S-allyl-l-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD)","volume":"18","author":"Ray","year":"2011","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jphs.2019.03.002_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jphs.2019.03.002_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fmed.2017.00118","article-title":"Exploring animal models that resemble idiopathic pulmonary fibrosis","volume":"4","author":"Tashiro","year":"2017","journal-title":"Front Med"},{"issue":"9","key":"10.1016\/j.jphs.2019.03.002_bib28","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1073\/pnas.092134099","article-title":"Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans","volume":"99","author":"Zuo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jphs.2019.03.002_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin Liver Dis"},{"issue":"1","key":"10.1016\/j.jphs.2019.03.002_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/cimm.2000.1687","article-title":"Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts","volume":"204","author":"Song","year":"2000","journal-title":"Cell Immunol"},{"issue":"5","key":"10.1016\/j.jphs.2019.03.002_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MCP.0b013e328349ac2b","article-title":"Modeling pulmonary fibrosis with bleomycin","volume":"17","author":"Mouratis","year":"2011","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jphs.2019.03.002_bib32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3410\/B2-78","article-title":"Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives","volume":"2","author":"Hinz","year":"2010","journal-title":"F1000 Biol Rep."},{"issue":"1","key":"10.1016\/j.jphs.2019.03.002_bib33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jphs.2014.10.002","article-title":"Significance of nitric oxide synthases: lessons from triple nitric oxide synthases null mice","volume":"127","author":"Tsutsui","year":"2015","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"8","key":"10.1016\/j.jphs.2019.03.002_bib34","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/labinvest.2015.67","article-title":"The role of iNOS in cholesterol-induced liver fibrosis","volume":"95","author":"Anavi","year":"2015","journal-title":"Lab Invest"},{"key":"10.1016\/j.jphs.2019.03.002_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.niox.2016.09.006","article-title":"Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis","volume":"61","author":"Zhang","year":"2016","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jphs.2019.03.002_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.niox.2017.07.005","article-title":"Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: implications for the direct roles of the NO molecule in\u00a0vivo","volume":"70","author":"Chen","year":"2017","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.jphs.2019.03.002_bib37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/hep.25829","article-title":"Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFbeta receptor type II mice","volume":"57","author":"Tsuda","year":"2013","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jphs.2019.03.002_bib38","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/ATVBAHA.112.249706","article-title":"Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis","volume":"32","author":"Li","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"10.1016\/j.jphs.2019.03.002_bib39","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1158\/0008-5472.CAN-06-0743","article-title":"Akt signaling and cancer: surviving but not moving on","volume":"66","author":"Toker","year":"2006","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.jphs.2019.03.002_bib40","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nm.3982","article-title":"An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development","volume":"21","author":"Baek","year":"2015","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.jphs.2019.03.002_bib41","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.1601503","article-title":"AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation","volume":"198","author":"Nie","year":"2017","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.jphs.2019.03.002_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jphs.2018.11.013","article-title":"Daphnetin inhibits high glucose-induced extracellular matrix accumulation, oxidative stress and inflammation in human glomerular mesangial cells","volume":"139","author":"Xu","year":"2019","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.jphs.2019.03.002_bib43","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jphs.2018.02.004","article-title":"Neurotropin inhibits neuroinflammation via suppressing NF-kappaB and MAPKs signaling pathways in lipopolysaccharide-stimulated BV2 cells","volume":"136","author":"Zheng","year":"2018","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"6","key":"10.1016\/j.jphs.2019.03.002_bib44","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.3892\/mmr.2016.5960","article-title":"PI3K\/Akt signaling is involved in the pathogenesis of bleomycin-induced pulmonary fibrosis via regulation of epithelial-mesenchymal transition","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jphs.2019.03.002_bib45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2018.05.186","article-title":"Angptl2 deficiency attenuates paraquat (PQ)-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis through NF-kappaB pathway","volume":"503","author":"Yang","year":"2018","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319300337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319300337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:59:12Z","timestamp":1761163152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861319300337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1347861319300337"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.03.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT\/NF-\u03baB signaling pathway in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}