{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:51:46Z","timestamp":1775955106753,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15K14963"],"award-info":[{"award-number":["JP15K14963"]}]},{"name":"JSPS KAKENHI","award":["JP15H04645"],"award-info":[{"award-number":["JP15H04645"]}]},{"name":"JSPS KAKENHI","award":["JP26293020"],"award-info":[{"award-number":["JP26293020"]}]},{"name":"JSPS KAKENHI","award":["JP26670122"],"award-info":[{"award-number":["JP26670122"]}]},{"name":"JSPS KAKENHI","award":["JP17H03989"],"award-info":[{"award-number":["JP17H03989"]}]},{"name":"JSPS KAKENHI","award":["JP17K19488"],"award-info":[{"award-number":["JP17K19488"]}]},{"name":"JSPS KAKENHI","award":["JP18H02574"],"award-info":[{"award-number":["JP18H02574"]}]},{"name":"MEXT KAKENHI","award":["JP15H01288"],"award-info":[{"award-number":["JP15H01288"]}]},{"name":"MEXT KAKENHI","award":["JP15H01286"],"award-info":[{"award-number":["JP15H01286"]}]},{"name":"MEXT KAKENHI","award":["JP18H05416"],"award-info":[{"award-number":["JP18H05416"]}]},{"name":"MEXT KAKENHI","award":["JP19H05218"],"award-info":[{"award-number":["JP19H05218"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18dm0107122h"],"award-info":[{"award-number":["JP18dm0107122h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18dm0207061h"],"award-info":[{"award-number":["JP18dm0207061h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jphs.2019.06.002","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T02:57:47Z","timestamp":1560567467000},"page":"321-324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies"],"prefix":"10.1016","volume":"140","author":[{"given":"Takanobu","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2019.06.002_bib1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 2010","volume":"382","author":"Whiteford","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2019.06.002_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/pcn.12322","article-title":"Schizophrenia in 2020: trends in diagnosis and therapy","volume":"69","author":"Gaebel","year":"2015","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrd.2016.28","article-title":"Altering the course of schizophrenia: progress and perspectives","volume":"15","author":"Millan","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jphs.2019.06.002_bib4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/pcn.12290","article-title":"Glia-related genes and their contribution to schizophrenia","volume":"69","author":"Wang","year":"2015","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/pcn.12823","article-title":"Glutamate hypothesis in schizophrenia","volume":"73","author":"Uno","year":"2019","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-med-050911-161504","article-title":"Update on typical and atypical antipsychotic drugs","volume":"64","author":"Meltzer","year":"2013","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jphs.2019.06.002_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2019.06.002_bib8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2019.06.002_bib9","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.1158799","article-title":"Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons","volume":"321","author":"Dimos","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jphs.2019.06.002_bib10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2008.07.041","article-title":"Disease-specific induced pluripotent stem cells","volume":"134","author":"Park","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2019.06.002_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2019.06.002_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1756-6606-7-22","article-title":"iPS cell technologies: significance and applications to CNS regeneration and disease","volume":"7","author":"Okano","year":"2014","journal-title":"Mol Brain"},{"key":"10.1016\/j.jphs.2019.06.002_bib13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/mp.2011.13","article-title":"Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation","volume":"16","author":"Chiang","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jphs.2019.06.002_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09915","article-title":"Modelling schizophrenia using human induced pluripotent stem cells","volume":"473","author":"Brennand","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2019.06.002_bib15","article-title":"Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia","author":"Balan","year":"2018","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jphs.2019.06.002_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mcn.2015.12.002","article-title":"Modeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons","volume":"73","author":"Habela","year":"2016","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/mp.2017.40","article-title":"Pluripotent stem cells in neuropsychiatric disorders","volume":"22","author":"Soliman","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jphs.2019.06.002_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/pcn.12528","article-title":"Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia","volume":"71","author":"Liu","year":"2017","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/pcn.12606","article-title":"Genetics and epigenetics of autism: a review","volume":"72","author":"Waye","year":"2018","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00441-017-2685-x","article-title":"Autism spectrum disorders and disease modeling using stem cells","volume":"371","author":"Brito","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jphs.2019.06.002_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/pcn.12611","article-title":"Genome-wide association studies of bipolar disorder: a systematic review of recent findings and their clinical implications","volume":"72","author":"Ikeda","year":"2018","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.jphs.2019.06.002_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.schres.2016.10.012","article-title":"Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine","volume":"181","author":"Nakazawa","year":"2017","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jphs.2019.06.002_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature15526","article-title":"Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder","volume":"527","author":"Mertens","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2019.06.002_bib24","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/mp.2014.141","article-title":"Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons","volume":"20","author":"Griesi-Oliveira","year":"2015","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jphs.2019.06.002_bib25","doi-asserted-by":"crossref","first-page":"10594","DOI":"10.1038\/ncomms10594","article-title":"Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders","volume":"7","author":"Nakazawa","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jphs.2019.06.002_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13041-019-0426-7","article-title":"Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations","volume":"12","author":"Iwasawa","year":"2019","journal-title":"Mol Brain"},{"key":"10.1016\/j.jphs.2019.06.002_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scr.2018.08.004","article-title":"Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient","volume":"31","author":"Arioka","year":"2018","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.jphs.2019.06.002_bib28","doi-asserted-by":"crossref","first-page":"e934","DOI":"10.1038\/tp.2016.206","article-title":"Analysis of induced pluripotent stem cells carrying 22q11.2 deletion","volume":"6","author":"Toyoshima","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jphs.2019.06.002_bib29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuron.2013.10.053","article-title":"Increased L1 retrotransposition in the neuronal genome in schizophrenia","volume":"81","author":"Bundo","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jphs.2019.06.002_bib30","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1038\/s41467-018-06515-4","article-title":"Expression-based drug screening of neural progenitor cells from individuals with schizophrenia","volume":"9","author":"Readhead","year":"2018","journal-title":"Nat Commun"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319341672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319341672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T06:33:26Z","timestamp":1571294006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861319341672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1347861319341672"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.06.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}