{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T21:51:55Z","timestamp":1771797115411,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jphs.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T01:39:36Z","timestamp":1564796376000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Novel mouse model for evaluating in\u00a0vivo efficacy of xCT inhibitor"],"prefix":"10.1016","volume":"140","author":[{"given":"Ryosuke","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Fujieda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamato","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Nagahira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Murakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yukiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2019.07.009_bib1","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","article-title":"Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins","volume":"274","author":"Sato","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2019.07.009_bib2","doi-asserted-by":"crossref","first-page":"37423","DOI":"10.1074\/jbc.M506439200","article-title":"Redox imbalance in cystine\/glutamate transporter-deficient mice","volume":"280","author":"Sato","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2019.07.009_bib3","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.4049\/jimmunol.175.12.7965","article-title":"The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion","volume":"175","author":"Tanja","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2019.07.009_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0005-2736(01)00338-8","article-title":"Human cystine\/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells","volume":"1512","author":"Kim","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jphs.2019.07.009_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/bdd.2020","article-title":"In\u00a0vivo use of the CYP inhibitor 1-aminobenzotriazole to increase long-term exposure in mice","volume":"37","author":"Watanabe","year":"2016","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.jphs.2019.07.009_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1254\/jphs.10310FP","article-title":"A\u00a0negative correlation between expression profiles of runt-related transcription factor-2 and cystine\/glutamate antiporter xCT subunit in ovariectomized mouse bone","volume":"115","author":"Uno","year":"2011","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2019.07.009_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jphs.2019.07.009_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2019.07.009_bib9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2019.07.009_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2019.07.009_bib11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1084\/jem.165.3.628","article-title":"Induction of cystine transport activity in mouse peritoneal macrophages","volume":"165","author":"Watanabe","year":"1987","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jphs.2019.07.009_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2011.01.038","article-title":"CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth","volume":"19","author":"Ishimoto","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jphs.2019.07.009_bib13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.1401108","article-title":"Inhibition of system xc(-) transporter attenuates autoimmune inflammatory demyelination","volume":"195","author":"Evonuk","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2019.07.009_bib14","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1074\/jbc.M114.625053","article-title":"Cystathionine is a novel substrate of cystine\/glutamate transporter: implications for immune function","volume":"290","author":"Kobayashi","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2019.07.009_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00726-011-0864-8","article-title":"The transsulfuration pathway: a source of cysteine for glutathione in astrocytes","volume":"42","author":"McBean","year":"2012","journal-title":"Amino Acids"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319356889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319356889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:58:22Z","timestamp":1761163102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861319356889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1347861319356889"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.07.009","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel mouse model for evaluating in\u00a0vivo efficacy of xCT inhibitor","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}