{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:22:17Z","timestamp":1780917737187,"version":"3.54.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Young Scientist","award":["15K18882 (2015\u20132017)"],"award-info":[{"award-number":["15K18882 (2015\u20132017)"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jphs.2019.07.010","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T02:20:32Z","timestamp":1564453232000},"page":"310-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic deletion of Cav3.2\u00a0T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL\/6 mice"],"prefix":"10.1016","volume":"140","author":[{"given":"Kazuki","family":"Matsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaya","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nene","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Kasanami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyako","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Oita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutaka","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2019.07.010_bib1","article-title":"Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration","author":"Kimura","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2019.07.010_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-3-319-18144-8_11","article-title":"H2S and pain: a novel aspect for processing of somatic, visceral and neuropathic pain signals","volume":"230","author":"Terada","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jphs.2019.07.010_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pain.2008.12.021","article-title":"Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels","volume":"142","author":"Maeda","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2019.07.010_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/gut.2007.144543","article-title":"Luminal hydrogen sulfide plays a pronociceptive role in mouse colon","volume":"58","author":"Matsunami","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jphs.2019.07.010_bib5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1476-5381.2012.02060.x","article-title":"Involvement of the endogenous hydrogen sulfide\/Cav 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice","volume":"167","author":"Matsunami","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2019.07.010_bib6","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/j.1476-5381.2012.01886.x","article-title":"Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice","volume":"166","author":"Okubo","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2019.07.010_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuroscience.2012.05.044","article-title":"H2S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation","volume":"218","author":"Ogawa","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphs.2019.07.010_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046917","article-title":"TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide","volume":"7","author":"Andersson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2019.07.010_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbrc.2014.01.185","article-title":"Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells","volume":"445","author":"Sekiguchi","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2019.07.010_bib10","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1096\/fj.14-257113","article-title":"Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels","volume":"28","author":"Elies","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.jphs.2019.07.010_bib11","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1089\/ars.2012.5041","article-title":"Polysulfides link H2S to protein thiol oxidation","volume":"19","author":"Greiner","year":"2013","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.jphs.2019.07.010_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12035-013-8493-8","article-title":"Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels","volume":"48","author":"Lee","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jphs.2019.07.010_bib13","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/j.pain.0000000000000565","article-title":"Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain","volume":"157","author":"Sekiguchi","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2019.07.010_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pain.2010.04.022","article-title":"Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain","volume":"150","author":"Takahashi","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2019.07.010_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2011.05.004","article-title":"Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats","volume":"188","author":"Okubo","year":"2011","journal-title":"Neuroscience"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319356907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319356907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:59:04Z","timestamp":1761163144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861319356907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1347861319356907"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.07.010","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic deletion of Cav3.2\u00a0T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}