{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:57:37Z","timestamp":1781841457612,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southwest Medical University China","doi-asserted-by":"publisher","award":["MEPSCKL201301"],"award-info":[{"award-number":["MEPSCKL201301"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2016"],"award-info":[{"award-number":["2016"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2018"],"award-info":[{"award-number":["2018"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010771","name":"Loo and Hans Ostermans Stiftelse","doi-asserted-by":"publisher","award":["2018- 01213"],"award-info":[{"award-number":["2018- 01213"]}],"id":[{"id":"10.13039\/100010771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007508","name":"Sigurt and Elsa Goljes Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hiertas Minne Foundation","doi-asserted-by":"publisher","award":["FO2018-0156"],"award-info":[{"award-number":["FO2018-0156"]}],"id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hiertas Minne Foundation","doi-asserted-by":"publisher","award":["HL027339"],"award-info":[{"award-number":["HL027339"]}],"id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jphs.2019.09.006","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T01:57:49Z","timestamp":1569549469000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation"],"prefix":"10.1016","volume":"141","author":[{"given":"Changyan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Merkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"Duncker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Jamal","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2019.09.006_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phrs.2018.12.009","article-title":"Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update","volume":"141","author":"Zhou","year":"2019","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jphs.2019.09.006_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phrs.2012.09.011","article-title":"Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors","volume":"67","author":"Zhou","year":"2013","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.jphs.2019.09.006_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nm1188","article-title":"Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor","volume":"11","author":"Jankowski","year":"2005","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jphs.2019.09.006_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCRESAHA.116.309726","article-title":"Purinergic signaling in the cardiovascular system","volume":"120","author":"Burnstock","year":"2017","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.jphs.2019.09.006_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123942","article-title":"Altered purinergic receptor sensitivity in type 2 diabetes-associated endothelial dysfunction and Up(4)A-mediated vascular contraction","volume":"19","author":"Mahdi","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jphs.2019.09.006_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2013.06.002","article-title":"Cardiovascular adenosine receptors: expression, actions and interactions","volume":"140","author":"Headrick","year":"2013","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jphs.2019.09.006_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-540-89615-9_6","article-title":"Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology","volume":"193","author":"Mustafa","year":"2009","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2019.09.006_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1476-5381.2010.00937.x","article-title":"Control of vascular tone by purines and pyrimidines","volume":"161","author":"Burnstock","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.jphs.2019.09.006_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1570161114666151202204948","article-title":"Purinergic signalling and endothelium","volume":"14","author":"Burnstock","year":"2016","journal-title":"Curr Vasc Pharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2019.09.006_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11302-017-9563-6","article-title":"Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement","volume":"13","author":"Zhou","year":"2017","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.jphs.2019.09.006_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fphar.2018.00255","article-title":"Uridine adenosine tetraphosphate-induced coronary relaxation is blunted in swine with pressure overload: a role for vasoconstrictor prostanoids","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jphs.2019.09.006_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2013.08.007","article-title":"Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infarct remodeled myocardium is due to reduced P1 receptor activation","volume":"77","author":"Zhou","year":"2013","journal-title":"Pharmacol Res"},{"issue":"6","key":"10.1016\/j.jphs.2019.09.006_bib13","doi-asserted-by":"crossref","first-page":"H2574","DOI":"10.1152\/ajpheart.00912.2004","article-title":"Involvement of p38-mitogen-activated protein kinase in adenosine receptor-mediated relaxation of coronary artery","volume":"288","author":"Teng","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.jphs.2019.09.006_bib14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00005344-200304000-00008","article-title":"Endogenous adenosine increases coronary flow by activation of both A2A and A2B receptors in mice","volume":"41","author":"Talukder","year":"2003","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"issue":"2","key":"10.1016\/j.jphs.2019.09.006_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11302-015-9451-x","article-title":"Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts","volume":"11","author":"Zhou","year":"2015","journal-title":"Purinergic Signal"},{"issue":"10","key":"10.1016\/j.jphs.2019.09.006_bib16","doi-asserted-by":"crossref","first-page":"H1294","DOI":"10.1152\/ajpheart.00637.2012","article-title":"Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia","volume":"304","author":"Sharifi-Sanjani","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.jphs.2019.09.006_bib17","doi-asserted-by":"crossref","first-page":"H2322","DOI":"10.1152\/ajpheart.00052.2011","article-title":"Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A\/2B double-knockout mice","volume":"301","author":"Sanjani","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.jphs.2019.09.006_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1254\/jphs.14171SC","article-title":"Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig","volume":"126","author":"Yamaguchi","year":"2014","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jphs.2019.09.006_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1096\/fj.06-7050com","article-title":"A\u00a0novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release","volume":"21","author":"Rayment","year":"2007","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.jphs.2019.09.006_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11302-014-9428-1","article-title":"Effects of NAD at purine receptors in isolated blood vessels","volume":"11","author":"Alefishat","year":"2015","journal-title":"Purinergic Signal"},{"issue":"7","key":"10.1016\/j.jphs.2019.09.006_bib21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jacc.2018.05.052","article-title":"Erythrocytes from patients with type 2 diabetes induce endothelial dysfunction via arginase I","volume":"72","author":"Zhou","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jphs.2019.09.006_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.phrs.2014.09.004","article-title":"A\u00a0role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries","volume":"90","author":"Wong","year":"2014","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.jphs.2019.09.006_bib23","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1124\/jpet.110.170803","article-title":"Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine","volume":"335","author":"Long","year":"2010","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.jphs.2019.09.006_bib24","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/CIRCRESAHA.116.309491","article-title":"Contribution of KV1.5 channel to hydrogen peroxide-induced human arteriolar dilation and its modulation by coronary artery disease","volume":"120","author":"Nishijima","year":"2017","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jphs.2019.09.006_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/CIRCRESAHA.111.258871","article-title":"H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation","volume":"110","author":"Zhang","year":"2012","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jphs.2019.09.006_bib26","doi-asserted-by":"crossref","first-page":"H1404","DOI":"10.1152\/ajpheart.00696.2006","article-title":"H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular\u00a0smooth muscle","volume":"292","author":"Rogers","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.jphs.2019.09.006_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02750638","article-title":"Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels","volume":"13","author":"Hayabuchi","year":"1998","journal-title":"Heart Vessel"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319357093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861319357093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:59:07Z","timestamp":1761163147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861319357093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1347861319357093"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2019.09.006","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2019.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}