{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:03:13Z","timestamp":1769212993790,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jphs.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T19:10:17Z","timestamp":1626981017000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents"],"prefix":"10.1016","volume":"147","author":[{"given":"Yakumo","family":"Aoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Aoshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2021.07.003_bib1","first-page":"379","article-title":"Mechanisms of retinal ganglion specific-cell death in leber hereditary optic neuropathy","volume":"105","author":"Levin","year":"2007","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"9","key":"10.1016\/j.jphs.2021.07.003_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106779","article-title":"Profiling the mitochondrial proteome of leber's hereditary optic neuropathy (LHON) in Thailand: down-regulation of bioenergetics and mitochondrial protein quality control pathways in fibroblasts with the 11778G>.a mutation","volume":"9","author":"Tun","year":"2014","journal-title":"PloS One"},{"issue":"April","key":"10.1016\/j.jphs.2021.07.003_bib3","first-page":"2343","article-title":"Point mutations associated with Leber hereditary optic neuropathy in a Latvian population","volume":"19","author":"Aitullina","year":"2013","journal-title":"Mol Vis"},{"issue":"10","key":"10.1016\/j.jphs.2021.07.003_bib4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s12325-018-0776-z","article-title":"Current and emerging treatment modalities for leber's hereditary optic neuropathy: a review of the literature","volume":"35","author":"Theodorou-Kanakari","year":"2018","journal-title":"Adv Ther"},{"issue":"3","key":"10.1016\/j.jphs.2021.07.003_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017963","article-title":"NQo1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels","volume":"6","author":"Haefeli","year":"2011","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.jphs.2021.07.003_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.22336\/rjo.2019.14","article-title":"Leber's hereditary optic neuropathy \u2013 case discussion","volume":"63","author":"Culea","year":"2019","journal-title":"Rom J Ophthalmol"},{"issue":"9","key":"10.1016\/j.jphs.2021.07.003_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045182","article-title":"Idebenone protects against retinal damage and loss of vision in a mouse model of leber's hereditary optic neuropathy","volume":"7","author":"Heitz","year":"2012","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.jphs.2021.07.003_bib8","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/ejhg.2014.26","article-title":"Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy","volume":"22","author":"Mansergh","year":"2014","journal-title":"Eur J Hum Genet"},{"issue":"23","key":"10.1016\/j.jphs.2021.07.003_bib9","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1074\/jbc.274.23.16188","article-title":"Titrating the effects of mitochondrial complex I impairment in the cell physiology","volume":"274","author":"Barrientos","year":"1999","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.jphs.2021.07.003_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1248\/bpb.b15-00584","article-title":"Neuroprotective effect of ocular hypotensive drugs: latanoprost\/timolol in combination are more effective than each as monotherapy in RGC-5","volume":"39","author":"Fuma","year":"2016","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.jphs.2021.07.003_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1567202614666161117110609","article-title":"Protective effect of bendavia (SS-31) against oxygen\/glucose-deprivation stress-induced mitochondrial damage in human brain microvascular endothelial cells","volume":"14","author":"Imai","year":"2017","journal-title":"Curr Neurovascular Res"},{"issue":"2","key":"10.1016\/j.jphs.2021.07.003_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1124\/jpet.108.148676","article-title":"Edaravone, a free radical scavenger, protects against retinal damage in\u00a0vitro and in\u00a0vivo","volume":"329","author":"Inokuchi","year":"2009","journal-title":"J\u00a0Pharmacol Exp Therapeut"},{"issue":"12","key":"10.1016\/j.jphs.2021.07.003_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015307","article-title":"An Inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal Models of Familial ALS","volume":"5","author":"Shimazawa","year":"2010","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.jphs.2021.07.003_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-57638-y","article-title":"Rotenone-induced inner retinal degeneration via presynaptic activation of voltage-dependent sodium and L-type calcium channels in rats","volume":"10","author":"Sasaoka","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jphs.2021.07.003_bib15","first-page":"185","article-title":"The neuropathology of hereditary optic atrophy (Leber's disase); the first complete anatomic study","volume":"34","author":"John","year":"1958","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.jphs.2021.07.003_bib16","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1167\/iovs.14-14737","article-title":"White matter consequences of retinal receptor and ganglion cell damage","volume":"55","author":"Ogawa","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.jphs.2021.07.003_bib17","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/cdd.2008.43","article-title":"Redox survival signalling in retina-derived 661W cells","volume":"15","author":"Mackey","year":"2008","journal-title":"Cell Death Differ"},{"issue":"11","key":"10.1016\/j.jphs.2021.07.003_bib18","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1093\/brain\/aww222","article-title":"The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress","volume":"139","author":"Chao De La Barca","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.jphs.2021.07.003_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.redox.2015.01.009","article-title":"Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10","volume":"4","author":"Gueven","year":"2015","journal-title":"Redox Biol"},{"issue":"6","key":"10.1016\/j.jphs.2021.07.003_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/cells8060625","article-title":"Glutamate stimulation dysregulates AMPA receptors-induced signal transduction pathway in leber \u2019 s inherited optic neuropathy patient-specific hiPS-drived retinal ganglion cells","volume":"8","author":"Cells","year":"2019","journal-title":"Cells"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321000700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321000700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:01:14Z","timestamp":1761163274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861321000700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1347861321000700"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2021.07.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}