{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:01:46Z","timestamp":1788966106541,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02100\u20133"],"award-info":[{"award-number":["2017\/02100\u20133"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jphs.2021.09.002","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T21:40:13Z","timestamp":1633642813000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts"],"prefix":"10.1016","volume":"148","author":[{"given":"Juliana Prado","family":"Gusson-Zanetoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julliene Stephanie Guaraldi Monteiro","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Bravo","family":"Pic\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Toniol","family":"Cardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janesly","family":"Prates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie Oliveira","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Henrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Maria","family":"Oliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloiza Helena","family":"Tajara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Luis Andrade","family":"e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayanne Larissa","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"da Silva Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosangela Silva","family":"Laurentiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Cristina","family":"Rodrigues-Lisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jphs.2021.09.002_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.hoc.2019.08.019","article-title":"The evolving role of radiotherapy for head and neck cancer","volume":"34","author":"Schwartz","year":"2020","journal-title":"Hematol Oncol Clin N Am"},{"issue":"1","key":"10.1016\/j.jphs.2021.09.002_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/ijms22010247","article-title":"Characterization and differentiation of the tumor microenvironment (TME) of orthotopic and subcutaneously grown head and neck squamous cell carcinoma (HNSCC) in immunocompetent mice","volume":"22","author":"Brand","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2021.09.002_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.drup.2018.09.001","article-title":"Precision medicine in head and neck cancer","volume":"40","author":"Kaidar-Person","year":"2018","journal-title":"Drug Resist Updates"},{"issue":"203","key":"10.1016\/j.jphs.2021.09.002_bib4","first-page":"1","article-title":"Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays","volume":"2012","author":"Resende","year":"2012","journal-title":"BMC Compl Alternative Med"},{"key":"10.1016\/j.jphs.2021.09.002_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/open.201700182","article-title":"Medicinal attributes of lignans extracted from Piper Cubeba: Current Developments","volume":"7","author":"Lima","year":"2018","journal-title":"ChemistryOpen"},{"key":"10.1016\/j.jphs.2021.09.002_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bse.2007.01.003","article-title":"Lignan profile of Piper cubeba, an Indonesian medicinal plant","volume":"35","author":"Elfahmi","year":"2007","journal-title":"Biochem Systemat Ecol"},{"key":"10.1016\/j.jphs.2021.09.002_bib7","first-page":"782","article-title":"Evaluation of the antimycobacterial activity of lignan dihydrocubebina extracted from and its semi - synthetic derivatives","volume":"17","author":"Laurentiz","year":"2015","journal-title":"Braz J Med Plants"},{"key":"10.1016\/j.jphs.2021.09.002_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/15287394.2015.1110067","article-title":"Evaluation of lignan (\u2013)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29)","volume":"79","author":"Niwa","year":"2016","journal-title":"J\u00a0Toxicol Environ Health, Part A"},{"key":"10.1016\/j.jphs.2021.09.002_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1055\/s-0042-101761","article-title":"Hinokinin induces G2\/M arrest and contributes to the antiproliferative effects of doxorubicin in breast cancer cells","volume":"82","author":"Cunha","year":"2016","journal-title":"Planta Med"},{"key":"10.1016\/j.jphs.2021.09.002_bib10","first-page":"42","article-title":"Correla\u00e7\u00e3o entre a express\u00e3o de ciclooxigenase-2, VEGF e KI-67 em carcinomas de c\u00e9lulas escamosas da laringe e hipofaringe com estadiamento TNM","volume":"43","author":"Bonhin","year":"2014","journal-title":"Rev Bras Cir Cabe\u00e7a Pesco\u00e7o"},{"key":"10.1016\/j.jphs.2021.09.002_bib11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.oraloncology.2010.09.005","article-title":"A\u00a0role for COX2- derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation","volume":"46","author":"Abrahao","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jphs.2021.09.002_bib12","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrd4390","article-title":"Is there new hope for therapeutic matrix metalloproteinase inhibition?","volume":"13","author":"Vandenbroucke","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jphs.2021.09.002_bib13","series-title":"Proteome analysis in laryngeal squamous cell carcinoma","author":"Santiago","year":"2018"},{"key":"10.1016\/j.jphs.2021.09.002_bib14","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.2147\/DDDT.S167382","article-title":"Synthesis and anticancer activity of dimeric podophyllotoxin derivatives","volume":"12","author":"Zi","year":"2018","journal-title":"Drug Design Dev Ther"},{"key":"10.1016\/j.jphs.2021.09.002_bib15","first-page":"103","article-title":"A\u00a0comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay","volume":"3","author":"Kobayashi","year":"1995","journal-title":"MMS Commun"},{"key":"10.1016\/j.jphs.2021.09.002_bib16","series-title":"Investigation of gene and protein expression profile of tumor microenvironment components","author":"Cunha","year":"2011"},{"key":"10.1016\/j.jphs.2021.09.002_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jphs.2021.09.002_bib18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.5897\/AJPP2015.4490","article-title":"Cubebin and semisynthetic dibenzyl butyrolactone derivatives: biological activities","volume":"10","author":"Pereira","year":"2016","journal-title":"Afr J Pharm Pharmacol"},{"key":"10.1016\/j.jphs.2021.09.002_bib19","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.bmcl.2016.02.041","article-title":"Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives","volume":"26","author":"Rajalekshmi","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2021.09.002_bib20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bmcl.2004.12.035","article-title":"Synthesis and biological activity evaluation of lignan lactones derived from (-)-cubebin","volume":"15","author":"Da Silva","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2021.09.002_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jat.1616","article-title":"Genotoxic effects of cubebin in somatic cells of mice","volume":"31","author":"Maistro","year":"2011","journal-title":"J\u00a0Appl Toxicol"},{"key":"10.1016\/j.jphs.2021.09.002_bib22","first-page":"1138","article-title":"High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma","volume":"53","author":"Shi","year":"2018","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jphs.2021.09.002_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-008-9847-9","article-title":"shRNA-targeted Cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells","volume":"317","author":"Wang","year":"2008","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.jphs.2021.09.002_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bmcl.2016.11.081","article-title":"In\u00a0vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (\u2212)-cubebin derivatives (\u2212)-hinokinin and (\u2212)-O-benzylcubebin","volume":"27","author":"Lima","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jphs.2021.09.002_bib25","first-page":"18","article-title":"EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer","volume":"431","author":"Semmlinger","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jphs.2021.09.002_bib26","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/labinvest.2012.90","article-title":"Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model","volume":"92","author":"Xin","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jphs.2021.09.002_bib27","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/ijms19041019","article-title":"EP4 as a therapeutic target for aggressive human breast cancer","volume":"19","author":"Majumder","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2021.09.002_bib28","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0959-8049(00)00156-8","article-title":"Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis","volume":"36","author":"Curran","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jphs.2021.09.002_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/0019-509X.98948","article-title":"In\u00a0vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines","volume":"49","author":"Mali","year":"2012","journal-title":"C\u00e2ncer J indiano"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321000888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321000888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:02:20Z","timestamp":1761163340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861321000888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1347861321000888"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2021.09.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2021.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}