{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:58:15Z","timestamp":1792058295335,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16136"],"award-info":[{"award-number":["20K16136"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jphs.2021.11.002","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T17:42:57Z","timestamp":1636825377000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model"],"prefix":"10.1016","volume":"148","author":[{"given":"Ryuichi","family":"Kambayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Onozato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Izumi-Nakaseko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2021.11.002_bib1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1161\/CIRCEP.112.970749","article-title":"Distribution and risk profile of paroxysmal, persistent, and permanent atrial fibrillation in routine clinical practice: insight from the real-life global survey evaluating patients with atrial fibrillation international registry","volume":"5","author":"Chiang","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jphs.2021.11.002_bib2","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","volume":"140","author":"January","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2021.11.002_bib3","doi-asserted-by":"crossref","first-page":"581837","DOI":"10.3389\/fphar.2020.581837","article-title":"Revisiting antiarrhythmic drug therapy for atrial fibrillation: reviewing lessons learned and redefining therapeutic paradigms","volume":"11","author":"Geng","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCEP.107.754564","article-title":"Atrial remodeling and atrial fibrillation: mechanisms and implications","volume":"1","author":"Nattel","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jphs.2021.11.002_bib5","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/eurheartj\/ehu028","article-title":"Early management of atrial fibrillation to prevent cardiovascular complications","volume":"35","author":"Nattel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jphs.2021.11.002_bib6","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/01.CIR.0000121736.16643.11","article-title":"Relationships between sinus rhythm, treatment, and survival in the atrial fibrillation follow-up investigation of rhythm management (AFFIRM) study","volume":"109","author":"Corley","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2021.11.002_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00003495-200161020-00011","article-title":"Oseltamivir: a review of its use in influenza","volume":"61","author":"McClellan","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.jphs.2021.11.002_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejphar.2015.06.004","article-title":"Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: comparison to procaine and bupropion","volume":"762","author":"Fukushima","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib9","doi-asserted-by":"crossref","first-page":"593021","DOI":"10.3389\/fphar.2021.593021","article-title":"Translational studies on anti-atrial fibrillatory action of oseltamivir by its in\u00a0vivo and in\u00a0vitro electropharmacological analyses","volume":"12","author":"Kambayashi","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib10","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1248\/bpb.b13-00347","article-title":"Electrophysiological effects of an anti-influenza drug oseltamivir on the Guinea-pig atrium: comparison with those of pilsicainide","volume":"36","author":"Takahara","year":"2013","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jphs.2021.11.002_bib11","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00210-017-1415-y","article-title":"The anti-influenza drug oseltamivir reduces atrial fibrillation in an experimental whole-heart model","volume":"390","author":"Frommeyer","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1254\/jphs.09061SC","article-title":"Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs","volume":"110","author":"Iwasaki","year":"2009","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2021.11.002_bib13","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00210-020-02047-1","article-title":"An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation","volume":"394","author":"Kambayashi","year":"2021","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib14","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s00380-020-01612-1","article-title":"Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent","volume":"35","author":"Kambayashi","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jphs.2021.11.002_bib15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1254\/jjp.88.341","article-title":"Electrophysiological, anatomical and histological remodeling of the heart to AV block enhances susceptibility to arrhythmogenic effects of QT-prolonging drugs","volume":"88","author":"Sugiyama","year":"2002","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1254\/jphs.FP0060945","article-title":"In\u00a0vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogs","volume":"103","author":"Wang","year":"2007","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2021.11.002_bib17","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/bjp.2008.240","article-title":"Sensitive and reliable proarrhythmia in\u00a0vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts","volume":"154","author":"Sugiyama","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib18","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jphs.2021.11.002_bib19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12012-013-9202-6","article-title":"Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in\u00a0vivo and in\u00a0vitro","volume":"13","author":"Kitahara","year":"2013","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jphs.2021.11.002_bib20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0031-6997(24)01385-1","article-title":"G\u00a0protein regulation of potassium ion channels","volume":"50","author":"Yamada","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jphs.2021.11.002_bib21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1254\/jphs.14023FP","article-title":"Termination of aconitine-induced atrial fibrillation by the KACh-channel blocker tertiapin: underlying electrophysiological mechanism","volume":"125","author":"Suzuki","year":"2014","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jphs.2021.11.002_bib22","series-title":"Basic & clinical pharmacology","first-page":"228","article-title":"Agents used in cardiac arrhythmias","author":"Harvey","year":"2018"},{"key":"10.1016\/j.jphs.2021.11.002_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.RES.72.1.75","article-title":"Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide","volume":"72","author":"Jurkiewicz","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.jphs.2021.11.002_bib24","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.CIR.101.22.2631","article-title":"Effects of experimental heart failure on atrial cellular and ionic electrophysiology","volume":"101","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2021.11.002_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.2006.126714","article-title":"Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart","volume":"582","author":"Gaborit","year":"2007","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.jphs.2021.11.002_bib26","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1161\/CIRCULATIONAHA.105.575332","article-title":"The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation","volume":"112","author":"Dobrev","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2021.11.002_bib27","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCULATIONAHA.109.858027","article-title":"Dronedarone","volume":"120","author":"Patel","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jphs.2021.11.002_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00210-004-0957-y","article-title":"Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels","volume":"370","author":"G\u00f6gelein","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/FJC.0b013e31824e1b93","article-title":"Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity","volume":"59","author":"Burashnikov","year":"2012","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jphs.2021.11.002_bib30","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.hrthm.2008.05.020","article-title":"Can inhibition of IKur promote atrial fibrillation?","volume":"5","author":"Burashnikov","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jphs.2021.11.002_bib31","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1128\/AAC.00200-12","article-title":"Safety, tolerability, and pharmacokinetics of intravenous oseltamivir: single- and multiple-dose phase I studies with healthy volunteers","volume":"56","author":"Brennan","year":"2012","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321001092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321001092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:03:44Z","timestamp":1761163424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861321001092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1347861321001092"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2021.11.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2021.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}