{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:49:24Z","timestamp":1790005764757,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24614015"],"award-info":[{"award-number":["JP24614015"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K00846"],"award-info":[{"award-number":["JP15K00846"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K05933"],"award-info":[{"award-number":["JP19K05933"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K00879"],"award-info":[{"award-number":["JP17K00879"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jphs.2021.12.002","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:02:03Z","timestamp":1639083723000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart"],"prefix":"10.1016","volume":"148","author":[{"given":"Makino","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Iesaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2021.12.002_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu10020168","article-title":"Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies","volume":"10","author":"Rosique-Esteban","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jphs.2021.12.002_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000402000","article-title":"Minerals, coronary heart disease and sudden coronary death","volume":"25","author":"Karppanen","year":"1978","journal-title":"Adv Cardiol"},{"key":"10.1016\/j.jphs.2021.12.002_bib3","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.clnu.2017.08.006","article-title":"Dietary magnesium intake and risk of incident coronary heart disease in men: a prospective cohort study","volume":"37","author":"Kokubo","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jphs.2021.12.002_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0002-8703(52)90212-3","article-title":"Water and electrolyte content of cardiac and skeletal muscle in heart failure and myocardial infarction","volume":"43","author":"Iseri","year":"1952","journal-title":"Am Heart J"},{"key":"10.1016\/j.jphs.2021.12.002_bib5","first-page":"95","article-title":"Magnesium status in patients with acute myocardial infarction: a pilot study","volume":"5","author":"Jeppesen","year":"1986","journal-title":"Magnesium"},{"key":"10.1016\/j.jphs.2021.12.002_bib6","first-page":"139","article-title":"Magnesium and blood pressure. I. Animal studies","volume":"5","author":"Rayssiguier","year":"1992","journal-title":"Magnes Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/01.HYP.33.5.1105","article-title":"Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery","volume":"33","author":"Laurant","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2021.12.002_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.lfs.2011.01.027","article-title":"Chronic magnesium deficiency decreases tolerance to hypoxia\/reoxygenation injury in mouse heart","volume":"88","author":"Watanabe","year":"2011","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2021.12.002_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4939-8597-5_8","article-title":"Langendorff perfusion method as an ex\u00a0vivo model to evaluate heart function in rats","volume":"1816","author":"Watanabe","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jphs.2021.12.002_bib10","first-page":"181","article-title":"Mechanisms of cardioprotective effects of magnesium on hypoxia-reoxygenation-induced injury","volume":"9","author":"Watanabe","year":"2004","journal-title":"Exp Clin Cardiol"},{"key":"10.1016\/j.jphs.2021.12.002_bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yjmcc.2008.10.020","article-title":"Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy","volume":"46","author":"Matas","year":"2009","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jphs.2021.12.002_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12576-012-0206-y","article-title":"Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts","volume":"62","author":"Jin","year":"2012","journal-title":"J\u00a0Physiol Sci"},{"key":"10.1016\/j.jphs.2021.12.002_bib13","first-page":"260","article-title":"Mechanisms of intracellular magnesium maintenance in cardiac myocytes under hypoxic conditions","volume":"6","author":"Kato","year":"2013","journal-title":"JMJ"},{"key":"10.1016\/j.jphs.2021.12.002_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s004240000499","article-title":"Intracellular calibration of the fluorescent Mg2+ indicator furaptra in rat ventricular myocytes","volume":"442","author":"Watanabe","year":"2001","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.jphs.2021.12.002_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073171","article-title":"Magnesium homeostasis in cardiac myocytes of Mg-deficient rats","volume":"8","author":"Tashiro","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2021.12.002_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1085\/jgp.20028601","article-title":"Distinct properties of CRAC and MIC channels in RBL cells","volume":"120","author":"Kozak","year":"2002","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jphs.2021.12.002_bib17","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1476-5381.2012.01855.x","article-title":"Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7","volume":"166","author":"Chubanov","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2021.12.002_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2014.11.005","article-title":"The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury","volume":"78","author":"Ong","year":"2015","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jphs.2021.12.002_bib20","first-page":"S234","article-title":"Magnesium influx pathway in cardiomyocytes under hypoxic condition","volume":"63","author":"Kato","year":"2013","journal-title":"J\u00a0Physiol Sci"},{"key":"10.1016\/j.jphs.2021.12.002_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12011-014-9967-x","article-title":"Association between serum magnesium and anemia: China health and nutrition survey","volume":"159","author":"Zhan","year":"2014","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12011-007-0024-x","article-title":"Effect of magnesium supplementation on some plasma elements in athletes at rest and exhaustion","volume":"119","author":"Cinar","year":"2007","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/BF01747829","article-title":"Magnesium deficiency in adult rats promotes the induction of ventricular tachycardia by the administration of epinephrine","volume":"13","author":"Tomiyasu","year":"1998","journal-title":"Heart Ves"},{"key":"10.1016\/j.jphs.2021.12.002_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.HYP.34.2.247","article-title":"Effect of magnesium deficiency on autonomic circulatory regulation in conscious rats","volume":"34","author":"Murasato","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2021.12.002_bib25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0002-8703(84)90572-6","article-title":"Magnesium: nature's physiologic calcium blocker","volume":"108","author":"Iseri","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/j.jphs.2021.12.002_bib26","first-page":"163","article-title":"Reduction of perifusate magnesium alters inotropic response of papillary muscle to ion channel modulators","volume":"18","author":"Manju","year":"2005","journal-title":"Magnes Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1357-2725(96)00124-0","article-title":"Magnesium deficiency-related changes in lipid peroxidation and collagen metabolism in\u00a0vivo in rat heart","volume":"29","author":"Kumar","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jphs.2021.12.002_bib28","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0891-5849(01)00656-6","article-title":"Superoxide-mediated activation of cardiac fibroblasts by serum factors in hypomagnesemia","volume":"31","author":"Kumaran","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jphs.2021.12.002_bib29","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.bpj.2014.09.015","article-title":"Physiological pathway of magnesium influx in rat ventricular myocytes","volume":"107","author":"Tashiro","year":"2014","journal-title":"Biophys J"},{"key":"10.1016\/j.jphs.2021.12.002_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(03)00556-7","article-title":"Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7","volume":"114","author":"Schmitz","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jphs.2021.12.002_bib31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.1163493","article-title":"Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis","volume":"322","author":"Jin","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jphs.2021.12.002_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12576-018-0625-5","article-title":"Modulation of Mg2+ influx and cytoplasmic free Mg2+ concentration in rat ventricular myocytes","volume":"69","author":"Tashiro","year":"2019","journal-title":"J\u00a0Physiol Sci"},{"key":"10.1016\/j.jphs.2021.12.002_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00709-015-0930-2","article-title":"Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease","volume":"254","author":"Rasheed","year":"2017","journal-title":"Protoplasma"},{"key":"10.1016\/j.jphs.2021.12.002_bib34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12031-016-0843-3","article-title":"Prevention of cyclophilin D-mediated mPTP opening using cyclosporine-A alleviates the elevation of necroptosis, autophagy and apoptosis-related markers following global cerebral ischemia-reperfusion","volume":"61","author":"Fakharnia","year":"2017","journal-title":"J\u00a0Mol Neurosci"},{"key":"10.1016\/j.jphs.2021.12.002_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2045-9912-2-20","article-title":"Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore","volume":"2","author":"Zhang","year":"2012","journal-title":"Med Gas Res"},{"key":"10.1016\/j.jphs.2021.12.002_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.12.046","volume":"581","author":"Golshani-Hebroni","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.jphs.2021.12.002_bib37","first-page":"3367","article-title":"LETM1 is required for mitochondrial homeostasis and cellular viability","volume":"19","author":"Li","year":"2019","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jphs.2021.12.002_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123182","article-title":"Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jphs.2021.12.002_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/nu11020455","article-title":"Magnesium: a magic bullet for cardiovascular disease in chronic kidney disease?","volume":"11","author":"Leenders","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jphs.2021.12.002_bib40","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.3390\/nu7075244","article-title":"Optimal dietary and plasma magnesium statuses depend on dietary quality for a reduction in the risk of all-cause mortality in older adults","volume":"7","author":"Huang","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.jphs.2021.12.002_bib41","article-title":"Possible therapeutic effect of magnesium in ocular diseases","volume":"31","author":"Ajith","year":"2019","journal-title":"J\u00a0Basic Clin Physiol Pharmacol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321001171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861321001171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:02:14Z","timestamp":1778594534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861321001171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1347861321001171"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2021.12.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}