{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:39:45Z","timestamp":1761183585862,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02631"],"award-info":[{"award-number":["21H02631"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008529","name":"Chiba University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jphs.2022.05.006","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T20:56:43Z","timestamp":1654289803000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine\/chemokine levels and increased lethality"],"prefix":"10.1016","volume":"150","author":[{"given":"Ai","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Yasue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Hisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Mashimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Kohama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-9727","authenticated-orcid":false,"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2022.05.006_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2022.05.006_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-030-21162-2_5","article-title":"The role of ceramide 1-phosphate in inflammation, cellular proliferation, and wound healing","volume":"1159","author":"Berwick","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jphs.2022.05.006_bib3","doi-asserted-by":"crossref","first-page":"23294","DOI":"10.1074\/jbc.M201535200","article-title":"Ceramide kinase, a novel lipid kinase: molecular cloning and functional characterization","volume":"277","author":"Sugiura","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2022.05.006_bib4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.bcp.2005.12.027","article-title":"Ceramide-1-phosphate activates cytosolic phospholipase A2\u03b1 directly and by PKC pathway","volume":"71","author":"Nakamura","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jphs.2022.05.006_bib5","article-title":"Novel signaling aspects of ceramide 1-phosphate","volume":"1865","author":"Presa","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.jphs.2022.05.006_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2007.09.010","article-title":"The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells","volume":"363","author":"Mitsutake","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2022.05.006_bib7","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.4049\/jimmunol.180.5.3457","article-title":"Neutropenia with impaired immune response to Streptococcus pneumonia in ceramide kinase-deficient mice","volume":"180","author":"Graf","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1248\/bpb.b18-00051","article-title":"Knockout of ceramide kinase aggravates pathological and lethal responses in mice with experimental colitis","volume":"41","author":"Suzuki","year":"2018","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jphs.2022.05.006_bib9","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.febslet.2015.06.045","article-title":"LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNF\u03b1-converting enzyme","volume":"589","author":"Ali","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jphs.2022.05.006_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.33594\/000000040","article-title":"Amitriptyline reduces inflammation and mortality in a murine model of sepsis","volume":"52","author":"Xia","year":"2019","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jphs.2022.05.006_bib11","doi-asserted-by":"crossref","first-page":"L503","DOI":"10.1152\/ajplung.90357.2008","article-title":"Differential regulation of sphingosine kinases 1 and 2 in lung injury","volume":"296","author":"Wadgaonkar","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jphs.2022.05.006_bib12","doi-asserted-by":"crossref","first-page":"L430","DOI":"10.1152\/ajplung.00208.2010","article-title":"Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury","volume":"300","author":"Gowda","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jphs.2022.05.006_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2010.09.041","article-title":"Transcriptional repression of ceramide kinase in LPS-challenged macrophages","volume":"401","author":"Rovina","year":"2010","journal-title":"Biochim Biophys Res Commun"},{"key":"10.1016\/j.jphs.2022.05.006_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152289","article-title":"Different expression of inflammatory cytokines and stress genes in male and female mice in response to a lipopolysaccharide challenge","volume":"11","author":"Everhardt Queen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2022.05.006_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173259","article-title":"Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: relevance to translational research","volume":"881","author":"Saminathan","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jphs.2022.05.006_bib16","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1096\/fj.201601357R","article-title":"Antifibrotic effects of cyclosporine A on TGF-\u03b21-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1\u03b1","volume":"31","author":"Yamazaki","year":"2017","journal-title":"Faseb J"},{"key":"10.1016\/j.jphs.2022.05.006_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fimmu.2016.00424","article-title":"Neutrophil extracellular traps form a barrier between necrotic and viable areas in acute abdominal inflammation","volume":"7","author":"Bilyy","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00024382-200116050-00003","article-title":"Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex\u00a0vivo septic model","volume":"16","author":"Asai","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.jphs.2022.05.006_bib19","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1194\/jlr.M084202","article-title":"Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5","volume":"59","author":"Newcomb","year":"2018","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jphs.2022.05.006_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.yexmp.2012.08.006","article-title":"Fingerprinting of the TLR4-induced acute inflammatory response","volume":"93","author":"Bosmann","year":"2012","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.jphs.2022.05.006_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2019.10.006","article-title":"Widespread time-dependent changes in tissue cytokine concentrations in brain regions during the acute phase of endotoxemia in mice","volume":"76","author":"Kasegawa-Ishii","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jphs.2022.05.006_bib22","doi-asserted-by":"crossref","first-page":"E1213","DOI":"10.1152\/ajpendo.00480.2012","article-title":"Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration","volume":"304","author":"Arana","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jphs.2022.05.006_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.imlet.2015.12.001","article-title":"Exogenous ceramide-1-phosphate (C1P) and phosphor-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors","volume":"169","author":"Katz","year":"2016","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jphs.2022.05.006_bib24","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.170.4.2106","article-title":"IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger","volume":"170","author":"Ferretti","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib25","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.18632\/oncotarget.26919","article-title":"Endotoxin tolerance modulates TREG and TH17 lymphocytes protecting septic mice","volume":"10","author":"Andrade","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.jphs.2022.05.006_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31666-1","article-title":"Sphingosine kinases promote IL-17 expression in human T lymphocytes","volume":"8","author":"Barra","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2022.05.006_bib27","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1002\/jcb.27818","article-title":"Translocation and activation of sphingosine kinase 1 by ceramide-1-phosphate","volume":"120","author":"Nishino","year":"2019","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jphs.2022.05.006_bib28","doi-asserted-by":"crossref","first-page":"42808","DOI":"10.1074\/jbc.M111.310169","article-title":"Ceramide kinase regulates the production of tumor necrosis factor \u03b1 (TNF\u03b1) via inhibition of TNF\u03b1-converting enzyme","volume":"286","author":"Lamour","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2022.05.006_bib29","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.4049\/jimmunol.0902926","article-title":"Ceramide and ceramide 1-phosphate are negative regulators of TNF-\u03b1 production induced by lipopolysaccharide","volume":"185","author":"J\u00f3zefowski","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib30","doi-asserted-by":"crossref","first-page":"21103","DOI":"10.1074\/jbc.M109.080671","article-title":"Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor \u03b1 (TNF\u03b1)-converting enzyme activity and TNF\u03b1 secretion in macrophages","volume":"285","author":"Rozenova","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2022.05.006_bib31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vetimm.2018.09.003","article-title":"C-C motif chemokine ligand (CCL) production in equine peripheral blood mononuclear cells identified by newly generated monoclonal antibodies","volume":"204","author":"Schnabel","year":"2018","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.jphs.2022.05.006_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1094-5539(03)00068-3","article-title":"Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblast functions involved in airway inflammation and remodeling","volume":"16","author":"Sabatini","year":"2003","journal-title":"Pulm Pharmacol Therapeut"},{"key":"10.1016\/j.jphs.2022.05.006_bib33","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cellsig.2004.12.005","article-title":"Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1\u03b2 and TNF-\u03b1 induced production of inflammatory mediators","volume":"17","author":"Billich","year":"2005","journal-title":"Cell Signal"},{"key":"10.1016\/j.jphs.2022.05.006_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092171","article-title":"Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage","volume":"9","author":"Sanner","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2022.05.006_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134608","article-title":"Increased eotaxin and MCP-2 levels in serum from individuals with periodontitis and in human gingival fibroblasts exposed to proinflammatory cytokines","volume":"10","author":"Bostr\u00f6m","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2022.05.006_bib36","doi-asserted-by":"crossref","first-page":"44357","DOI":"10.1074\/jbc.M111.264010","article-title":"Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression","volume":"286","author":"Hankins","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jphs.2022.05.006_bib37","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.4049\/jimmunol.1402681","article-title":"C1P attenuates lipopolysaccharide-induced acute lung injury by preventing NF-\u03baB activation in neutrophils","volume":"196","author":"Baudi\u03b2","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib38","article-title":"Balancing innate immunity and inflammatory state via modulation of neutrophil function: a novel strategy to fight sepsis","volume":"2015","author":"Fang","year":"2015","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.jphs.2022.05.006_bib39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1159\/000447806","article-title":"Acid sphingomyelinase (ASM) is a negative regulator of regulatory T cell (Treg) development","volume":"39","author":"Zhou","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jphs.2022.05.006_bib40","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1194\/jlr.M035683","article-title":"Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase","volume":"54","author":"Mietla","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jphs.2022.05.006_bib41","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4049\/jimmunol.1801674","article-title":"Cyclooxygenase-1 regulates the development of follicular Th cells via prostaglandin E2","volume":"203","author":"Liu","year":"2019","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jphs.2022.05.006_bib42","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1096\/fj.10-179028","article-title":"Sphingosine-1-phosphate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model","volume":"25","author":"Schulze","year":"2011","journal-title":"Faseb J"},{"key":"10.1016\/j.jphs.2022.05.006_bib43","doi-asserted-by":"crossref","first-page":"e2963","DOI":"10.1038\/cddis.2017.360","article-title":"Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases","volume":"8","author":"Bai","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jphs.2022.05.006_bib44","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/infdis\/132.3.316","article-title":"Bacteremia at Boston City Hospital: occurrence and mortality during 12 selected years (1935-1972), with special reference to hospital-acquired cases","volume":"132","author":"McGowan","year":"1975","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jphs.2022.05.006_bib45","first-page":"316","article-title":"Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome)","volume":"132","author":"Bone","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.jphs.2022.05.006_bib46","first-page":"171","article-title":"Sex steroid hormones in circulatory shock, sepsis syndrome, and septic shock","volume":"43","author":"Fourrier","year":"1994","journal-title":"Circ Shock"},{"key":"10.1016\/j.jphs.2022.05.006_bib47","first-page":"295","article-title":"Incidence of mortality in boys and girls after severe thermal burns","volume":"170","author":"Barrow","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.jphs.2022.05.006_bib48","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1996.0114","article-title":"Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation","volume":"8","author":"Wichmann","year":"1996","journal-title":"Cytokine"},{"key":"10.1016\/j.jphs.2022.05.006_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003246-199701000-00021","article-title":"Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males","volume":"25","author":"Zellweger","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jphs.2022.05.006_bib50","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archsurg.133.11.1200","article-title":"Gender differences in human sepsis","volume":"133","author":"Schr\u00f6der","year":"1998","journal-title":"Arch Surg"},{"key":"10.1016\/j.jphs.2022.05.006_bib51","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.febslet.2012.03.032","article-title":"Ceramide kinase deficiency improves diet-induced obesity and insulin resistance","volume":"586","author":"Mitsutake","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jphs.2022.05.006_bib52","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1194\/jlr.D000430","article-title":"Use of high performance chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels","volume":"51","author":"Wijesinghe","year":"2010","journal-title":"J\u00a0Lipid Res"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861322000457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861322000457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:01:29Z","timestamp":1761163289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861322000457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1347861322000457"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2022.05.006","relation":{},"ISSN":["1347-8613"],"issn-type":[{"type":"print","value":"1347-8613"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine\/chemokine levels and increased lethality","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2022.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}