{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:45:47Z","timestamp":1773279947904,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jphs.2023.01.001","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T16:44:06Z","timestamp":1673455446000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of gene silencer pyrrole-imidazole polyamides targeting GSK3\u03b2 for treatment of polycystic kidney diseases"],"prefix":"10.1016","volume":"151","author":[{"given":"Seishiro","family":"Baba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-054X","authenticated-orcid":false,"given":"Noboru","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tsunemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurie","family":"Akiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9569","key":"10.1016\/j.jphs.2023.01.001_bib1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jphs.2023.01.001_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10038-002-8654-5","article-title":"Genotypes of autosomal dominant polycystic kidney disease in Japanese","volume":"47","author":"Mizoguchi","year":"2002","journal-title":"J\u00a0Hum Genet"},{"issue":"10","key":"10.1016\/j.jphs.2023.01.001_bib3","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","article-title":"The polycystic kidney disease proteins polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia","volume":"13","author":"Yodar","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.jphs.2023.01.001_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.jphs.2023.01.001_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1254\/jphs.FMJ04004X2","article-title":"Molecular mechanisms and drug development in aquaporin water channel disease: molecular mechanism of water channel aquaporin-2 trafficking","volume":"96","author":"Noda","year":"2004","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"7","key":"10.1016\/j.jphs.2023.01.001_bib6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.V1171179","article-title":"cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells","volume":"11","author":"Hanaoka","year":"2000","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.jphs.2023.01.001_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1681\/ASN.2013040398","article-title":"Strategies targeting cAMP signaling in the treatment of polycystic kidney disease","volume":"25","author":"Torres","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.jphs.2023.01.001_bib8","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.tplants.2021.07.017","article-title":"GSK3s: nodes of multilayer regulation of plant development and stress responses","volume":"26","author":"Li","year":"2021","journal-title":"Trends Plant Sci"},{"issue":"6","key":"10.1016\/j.jphs.2023.01.001_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/ki.2014.427","article-title":"Glycogen synthase kinase-3\u03b2 promotes cyst expansion in polycystic kidney disease","volume":"87","author":"Tao","year":"2015","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.jphs.2023.01.001_bib10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","article-title":"The many faces of CREB","volume":"28","author":"Carlezon","year":"2005","journal-title":"Trends Neurosci"},{"issue":"6","key":"10.1016\/j.jphs.2023.01.001_bib11","first-page":"464","article-title":"A\u00a0cAMP and CREB-mediated feed-forward mechanism regulates GSK3\u03b2 in polycystic kidney disease","volume":"8","author":"Kakade","year":"2016","journal-title":"J\u00a0Mol Cell Biol"},{"issue":"6591","key":"10.1016\/j.jphs.2023.01.001_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/382559a0","article-title":"Recognition of DNA by designed ligands at subnanomolar concentrations","volume":"382","author":"Trauger","year":"1996","journal-title":"Nature"},{"issue":"6629","key":"10.1016\/j.jphs.2023.01.001_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/387202a0","article-title":"Regulation of gene expression by small molecules","volume":"387","author":"Gottesfeld","year":"1997","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jphs.2023.01.001_bib14","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1248\/bpb.27.468","article-title":"Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide","volume":"27","author":"Murty","year":"2004","journal-title":"Biol Pharm Bull"},{"issue":"8","key":"10.1016\/j.jphs.2023.01.001_bib15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-5521(97)90243-X","article-title":"On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides","volume":"4","author":"White","year":"1997","journal-title":"Chem Biol"},{"issue":"2","key":"10.1016\/j.jphs.2023.01.001_bib16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1681\/ASN.2005060650","article-title":"Development of gene silencing pyrrole-imidazole polyamide targeted to the TGF-\u03b2 promoter for treatment of progressive renal diseases","volume":"17","author":"Matsuda","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.jphs.2023.01.001_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ki.2010.330","article-title":"Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-\u03b21 promoter","volume":"79","author":"Matsuda","year":"2011","journal-title":"Kidney Int"},{"issue":"17","key":"10.1016\/j.jphs.2023.01.001_bib18","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.3390\/molecules24173178","article-title":"Preclinical study of DNA-recognized peptide compound pyrrole-imidazole polyamide targeting human TGF-\u03b21 promoter for progressive renal diseases in the common marmoset","volume":"24","author":"Otsuki","year":"2019","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jphs.2023.01.001_bib19","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/molecules25040950","article-title":"Contribution of TGF-\u03b21 and effects of gene silencer pyrrole-imidazole polyamides targeting TGF-\u03b21 in diabetic nephropathy","volume":"25","author":"Horikoshi","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jphs.2023.01.001_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10616-017-0133-0","article-title":"A\u00a0new chemical complex can rapidly concentrate lentivirus and significantly enhance gene transduction","volume":"70","author":"Lee","year":"2018","journal-title":"Cytotechnology"},{"issue":"9","key":"10.1016\/j.jphs.2023.01.001_bib21","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0968-0896(01)00262-0","article-title":"Molecular recognition of DNA by small molecules","volume":"9","author":"Dervan","year":"2001","journal-title":"Bioorg Med Chem"},{"issue":"5","key":"10.1016\/j.jphs.2023.01.001_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125295","article-title":"Preclinical study of novel gene silencer pyrrole-imidazole polyamide targeting human TGF-\u03b21 Promoter for hypertrophic scars in a common marmoset primate model","volume":"10","author":"Igarashi","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jphs.2023.01.001_bib23","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1681\/ASN.2006111218","article-title":"Identification of a forskolin-like molecule in human renal cysts","volume":"18","author":"Putnam","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"10","key":"10.1016\/j.jphs.2023.01.001_bib24","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm935","article-title":"Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist","volume":"9","author":"Gattone","year":"2003","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.jphs.2023.01.001_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2215\/CJN.06300615","article-title":"Effect of tolvaptan in autosomal dominant polycystic kidney disease by CKD stage: results from the TEMPO 3:4 trial","volume":"11","author":"Torres","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11-12","key":"10.1016\/j.jphs.2023.01.001_bib26","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jchromb.2009.02.041","article-title":"Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry","volume":"877","author":"Nagashima","year":"2009","journal-title":"J\u00a0Chromatogr B"},{"issue":"5","key":"10.1016\/j.jphs.2023.01.001_bib27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1248\/bpb.32.921","article-title":"Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data","volume":"32","author":"Nagashima","year":"2009","journal-title":"Biol Pharm Bull"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861323000014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861323000014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T15:46:22Z","timestamp":1741967182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861323000014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1347861323000014"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2023.01.001","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of gene silencer pyrrole-imidazole polyamides targeting GSK3\u03b2 for treatment of polycystic kidney diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2023.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}