{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:22:38Z","timestamp":1791512558271,"version":"4.3.4"},"reference-count":81,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jphs.2023.12.006","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:31:38Z","timestamp":1703723498000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Taurine deficiency associated with dilated cardiomyopathy and aging"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1023-587X","authenticated-orcid":false,"given":"Takashi","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00726-013-1507-z","article-title":"The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II","volume":"46","author":"Ito","year":"2014","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.jphs.2023.12.006_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrm.2016.29","article-title":"VRACs and other ion channels and transporters in the regulation of cell volume and beyond","volume":"17","author":"Jentsch","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3-4","key":"10.1016\/j.jphs.2023.12.006_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s007260070004","article-title":"Role of osmoregulation in the actions of taurine","volume":"19","author":"Schaffer","year":"2000","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.jphs.2023.12.006_bib4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00726-015-1918-0","article-title":"Role of the osmolyte taurine on the folding of a model protein, hen egg white lysozyme, under a crowding condition","volume":"47","author":"Abe","year":"2015","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00726-017-2499-x","article-title":"Taurine as a water structure breaker and protein stabilizer","volume":"50","author":"Bru\u017adziak","year":"2018","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/Y08-110","article-title":"Role of antioxidant activity of taurine in diabetes","volume":"87","author":"Schaffer","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/wrna.65","article-title":"Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs","volume":"2","author":"Tsutomu","year":"2011","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"49","key":"10.1016\/j.jphs.2023.12.006_bib8","doi-asserted-by":"crossref","first-page":"24770","DOI":"10.1073\/pnas.1916288116","article-title":"N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis","volume":"116","author":"Grevengoed","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.jphs.2023.12.006_bib9","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/metabo11080522","article-title":"N-Acetyltaurine and acetylcarnitine production for the mitochondrial acetyl-CoA regulation in skeletal muscles during endurance exercises","volume":"11","author":"Miyazaki","year":"2021","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61821-6","article-title":"Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats","volume":"10","author":"Miyazaki","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib11","first-page":"91","article-title":"Role of antioxidant activity of taurine in diabetesThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health","volume":"87","author":"Schaffer","year":"2009"},{"key":"10.1016\/j.jphs.2023.12.006_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-0-387-75681-3_7","article-title":"Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice","volume":"643","author":"Ito","year":"2009","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/HYPERTENSIONAHA.115.06624","article-title":"Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study","volume":"67","author":"Sun","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jphs.2023.12.006_bib14","first-page":"2021","article-title":"Endogenous taurine downregulation is required for renal injury in salt-sensitive hypertensive rats via CBS\/H2S inhibition","author":"Huang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"16","key":"10.1016\/j.jphs.2023.12.006_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26164913","article-title":"The role of taurine in mitochondria health: more than just an antioxidant","volume":"26","author":"Jong","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00726-008-0202-y","article-title":"Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels","volume":"37","author":"Stipanuk","year":"2009","journal-title":"Amino Acids"},{"issue":"7","key":"10.1016\/j.jphs.2023.12.006_bib17","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1210\/en.2005-1007","article-title":"Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity","volume":"147","author":"Tsuboyama-Kasaoka","year":"2006","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib18","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3892\/mmr.2020.11321","article-title":"Significance of taurine transporter (TauT) in homeostasis and its layers of regulation","volume":"22","author":"Baliou","year":"2020","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.jphs.2023.12.006_bib19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1291\/hypres.24.453","article-title":"Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-cardiac study","volume":"24","author":"Yamori","year":"2001","journal-title":"Hypertens Res"},{"issue":"4191","key":"10.1016\/j.jphs.2023.12.006_bib20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1138364","article-title":"Retinal degeneration associated with taurine deficiency in the cat","volume":"188","author":"Hayes","year":"1975","journal-title":"Science"},{"issue":"4816","key":"10.1016\/j.jphs.2023.12.006_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1126\/science.3616607","article-title":"Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy","volume":"237","author":"Pion","year":"1987","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jphs.2023.12.006_bib22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.yjmcc.2008.03.001","article-title":"Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy","volume":"44","author":"Ito","year":"2008","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2460\/javma.1992.201.02.275","article-title":"Response of cats with dilated cardiomyopathy to taurine supplementation","volume":"201","author":"Pion","year":"1992","journal-title":"J Am Vet Med Assoc"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib24","first-page":"6","article-title":"Echocardiographic evidence for myocardial failure induced by taurine deficiency in domestic cats","volume":"58","author":"Novotny","year":"1994","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.jphs.2023.12.006_bib25","article-title":"Systolic and diastolic dysfunction of the left ventricle induced by dietary taurine deficiency in cats","volume":"261","author":"Novotny","year":"1991"},{"issue":"2 PART 1","key":"10.1016\/j.jphs.2023.12.006_bib26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0002-8703(91)90724-V","article-title":"Dietary taurine deficiency and dilated cardiomyopathy in the fox","volume":"121","author":"Moise","year":"1991","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.01-0691fje","article-title":"Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice","volume":"16","author":"Heller-Stilb","year":"2002","journal-title":"Faseb J"},{"issue":"9","key":"10.1016\/j.jphs.2023.12.006_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107409","article-title":"Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice","volume":"9","author":"Ito","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jphs.2015.08.007","article-title":"Impact of taurine depletion on glucose control and insulin secretion in mice","volume":"129","author":"Ito","year":"2015","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2023.12.006_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.806798","article-title":"Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II\/III pyramidal neurons","volume":"15","author":"Hosoi","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"10","key":"10.1016\/j.jphs.2023.12.006_bib31","first-page":"4554","article-title":"GABAA receptors and maternally derived taurine regulate the temporal specification of progenitors of excitatory glutamatergic neurons in the mouse developing cortex","volume":"31","author":"Tochitani","year":"2021","journal-title":"Cerebr Cortex"},{"issue":"7","key":"10.1016\/j.jphs.2023.12.006_bib32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3390\/metabo12070631","article-title":"Effects of taurine depletion on body weight and mouse behavior during development","volume":"12","author":"Watanabe","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.jphs.2023.12.006_bib33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0076-6879(07)28025-5","article-title":"Phenotype of the taurine transporter knockout mouse","volume":"428","author":"Warskulat","year":"2007","journal-title":"Methods Enzymol"},{"issue":"10","key":"10.1016\/j.jphs.2023.12.006_bib34","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1248\/bpb.b18-00217","article-title":"Tissue taurine depletion induces profibrotic pattern of gene expression and causes aging-related cardiac fibrosis in heart in mice","volume":"41","author":"Ito","year":"2018","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1079\/BJN19860082","article-title":"Taurine concentrations in the diet, plasma, urine and breast milk of vegans compared with omnivores","volume":"56","author":"Rana","year":"1986","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jphs.2023.12.006_bib36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/978-3-319-15126-7_50","article-title":"Taurine in 24-h urine samples is inversely related to cardiovascular risks of middle aged subjects in 50 populations of the world","volume":"803","author":"Sagara","year":"2015","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"10.1016\/j.jphs.2023.12.006_bib37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/clc.4960080507","article-title":"Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial","volume":"8","author":"Azuma","year":"1985","journal-title":"Clin Cardiol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1253\/jcj.56.95","article-title":"Usefulness of taurine in chronic congestive heart failure and its prospective application","volume":"56","author":"Azuma","year":"1992","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.jphs.2023.12.006_bib39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/0-306-46838-7_66","article-title":"Does the taurine transporter gene play a role in 3P-syndrome?","volume":"483","author":"Han","year":"2000","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13073-017-0410-8","article-title":"Genetics and genomics of dilated cardiomyopathy and systolic heart failure","volume":"9","author":"Tayal","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.jphs.2023.12.006_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.gene.2018.06.019","article-title":"Rare genetic mutations in Pakistani patients with dilated cardiomyopathy","volume":"673","author":"Shakeel","year":"2018","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jphs.2023.12.006_bib42","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/hmg\/ddz303","article-title":"Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency","volume":"29","author":"Ansar","year":"2020","journal-title":"Hum Mol Genet"},{"issue":"10","key":"10.1016\/j.jphs.2023.12.006_bib43","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1096\/fj.201900914RR","article-title":"Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration","volume":"33","author":"Preising","year":"2019","journal-title":"Faseb J"},{"issue":"11","key":"10.1016\/j.jphs.2023.12.006_bib44","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/s41431-020-0671-3","article-title":"Taurine newborn screening to prevent one form of retinal degeneration and cardiomyopathy","volume":"28","author":"Antonarakis","year":"2020","journal-title":"Eur J Hum Genet"},{"issue":"20","key":"10.1016\/j.jphs.2023.12.006_bib45","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1093\/eurheartj\/ehab030","article-title":"Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23","volume":"42","author":"Garnier","year":"2021","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.jphs.2023.12.006_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1113\/jphysiol.2008.164228","article-title":"Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl\u2212-dependent TauT (SLC6A6)","volume":"587","author":"Anderson","year":"2009","journal-title":"J Physiol"},{"issue":"4","key":"10.1016\/j.jphs.2023.12.006_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101800","article-title":"Mammalian monocarboxylate transporter 7 (MCT7\/Slc16a6) is a novel facilitative taurine transporter","volume":"298","author":"Higuchi","year":"2022","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.jphs.2023.12.006_bib48","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1248\/bpb.b16-00597","article-title":"Impact of SLC6A transporters in physiological taurine transport at the blood\u2013retinal barrier and in the liver","volume":"39","author":"Kubo","year":"2016","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jphs.2023.12.006_bib49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-4615-3436-5_19","article-title":"Effects of taurine deficiency on arrhythmogenesis and excitation- contraction coupling in cardiac tissue","volume":"315","author":"Lake","year":"1992","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.jphs.2023.12.006_bib50","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/01.RES.74.6.1210","article-title":"Taurine depletion and excitation-contraction coupling in rat myocardium","volume":"74","author":"Eley","year":"1994","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib51","doi-asserted-by":"crossref","first-page":"H232","DOI":"10.1152\/ajpheart.00497.2014","article-title":"Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts","volume":"308","author":"Ramila","year":"2015","journal-title":"Am J Physiol Circ Physiol"},{"issue":"6","key":"10.1016\/j.jphs.2023.12.006_bib52","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0006-2952(86)90087-0","article-title":"Effect of drug-induced taurine depletion on cardiac contractility and metabolism","volume":"35","author":"Mozaffari","year":"1986","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.jphs.2023.12.006_bib53","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1006\/jmcc.1996.0188","article-title":"Taurine depletion in the intact animal stimulatesin vitroPhosphorylation of an 44-kDa protein present in the mitochondrial fraction of the rat heart","volume":"28","author":"Lombardini","year":"1996","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jphs.2023.12.006_bib54","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/978-1-4899-0117-0_54","article-title":"Increased phosphorylation of specific rat cardiac and retinal proteins in taurine-depleted animals: isolation and identification of the phosphoproteins","volume":"442","author":"Lombardini","year":"1998","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00726-015-2110-2","article-title":"Impaired energy metabolism of the taurine-deficient heart","volume":"48","author":"Schaffer","year":"2016","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib56","first-page":"57","article-title":"Pathway analysis of a transcriptome and metabolite profile to elucidate a compensatory mechanism for taurine deficiency in the heart of taurine transporter knockout mice","volume":"1","author":"Ito","year":"2018","journal-title":"J"},{"issue":"SUPPL. 1","key":"10.1016\/j.jphs.2023.12.006_bib57","first-page":"1","article-title":"A role for taurine in mitochondrial function","volume":"17","author":"Hansen","year":"2010","journal-title":"J Biomed Sci"},{"issue":"23","key":"10.1016\/j.jphs.2023.12.006_bib58","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1093\/emboj\/cdf656","article-title":"Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases","volume":"21","author":"Suzuki","year":"2002","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib59","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.celrep.2017.12.051","article-title":"Defective mitochondrial tRNA taurine modification activates global proteostress and leads to mitochondrial disease","volume":"22","author":"Fakruddin","year":"2018","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/j.jphs.2023.12.006_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9080795","article-title":"Role of mitochondria and endoplasmic reticulum in taurine-deficiency-mediated apoptosis","volume":"9","author":"Jong","year":"2017","journal-title":"Nutrients"},{"issue":"16","key":"10.1016\/j.jphs.2023.12.006_bib61","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.3390\/molecules26164913","article-title":"The role of taurine in mitochondria health: more than just an antioxidant","volume":"26","author":"Jong","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jphs.2023.12.006_bib62","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00424-019-02258-3","article-title":"Mitochondrial dynamics in exercise physiology","volume":"472","author":"Tanaka","year":"2020","journal-title":"Pflugers Arch Eur J Physiol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib63","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00726-017-2498-y","article-title":"Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart","volume":"50","author":"Ito","year":"2018","journal-title":"Amino Acids"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib64","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1096\/fj.03-0496fje","article-title":"Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised","volume":"18","author":"Warskulat","year":"2004","journal-title":"Faseb J"},{"key":"10.1016\/j.jphs.2023.12.006_bib65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4899-0117-0_7","article-title":"The effects of aging on taurine content and biosynthesis in different strains of rats","volume":"442","author":"Eppler","year":"1998","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib66","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0006-2952(01)00647-5","article-title":"Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers","volume":"62","author":"Eppler","year":"2001","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0531-5565(89)90035-1","article-title":"Changes in taurine in aging fruit flies and mice","volume":"24","author":"Massie","year":"1989","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jphs.2023.12.006_bib68","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4899-0182-8_4","article-title":"The effects of taurine in a rodent model of aging","volume":"403","author":"Dawson","year":"1996","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib69","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00726-021-02956-2","article-title":"Age-related decline in the taurine content of the skin in rodents","volume":"53","author":"Yoshimura","year":"2021","journal-title":"Amino Acids"},{"key":"10.1016\/j.jphs.2023.12.006_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111898","article-title":"Protective effect of taurine on UVB-induced skin aging in hairless mice","volume":"141","author":"Yoshimura","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"6649","key":"10.1016\/j.jphs.2023.12.006_bib71","first-page":"380","article-title":"Taurine deficiency as a driver of aging","author":"Singh","year":"2023","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jphs.2023.12.006_bib72","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00726-011-0883-5","article-title":"The potential usefulness of taurine on diabetes mellitus and its complications","volume":"42","author":"Ito","year":"2012","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00726-012-1434-4","article-title":"Potential role of taurine in the prevention of diabetes and metabolic syndrome","volume":"46","author":"Imae","year":"2014","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib74","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00726-012-1432-6","article-title":"Taurine and atherosclerosis","volume":"46","author":"Murakami","year":"2014","journal-title":"Amino Acids"},{"issue":"7","key":"10.1016\/j.jphs.2023.12.006_bib75","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/mnfr.201500067","article-title":"Role of taurine in the pathogenesis of obesity","volume":"59","author":"Murakami","year":"2015","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib76","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00726-012-1381-0","article-title":"Taurine and liver diseases: a focus on the heterogeneous protective properties of taurine","volume":"46","author":"Miyazaki","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.jphs.2023.12.006_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101223","article-title":"Taurine and its analogs in neurological disorders: focus on therapeutic potential and molecular mechanisms","volume":"24","author":"Jakaria","year":"2019","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.jphs.2023.12.006_bib78","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1096\/fj.05-5016fje","article-title":"Chronic liver disease is triggered by taurine transporter knockout in the mouse","volume":"20","author":"Warskulat","year":"2006","journal-title":"Faseb J"},{"issue":"13","key":"10.1016\/j.jphs.2023.12.006_bib79","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1073\/pnas.1813100116","article-title":"Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver","volume":"116","author":"Qvartskhava","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2023.12.006_bib80","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-3-030-93337-1_20","article-title":"Characterization of bone tissue and bone morphology in taurine transporter knockout mice","volume":"1370","author":"Kato","year":"2022","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.jphs.2023.12.006_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117718","article-title":"Knockout of the TauT gene predisposes C57BL\/6 mice to streptozotocin-induced diabetic nephropathy","volume":"10","author":"Han","year":"2015","journal-title":"PLoS One"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861323000749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861323000749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T16:22:39Z","timestamp":1742228559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861323000749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1347861323000749"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2023.12.006","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taurine deficiency associated with dilated cardiomyopathy and aging","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2023.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}