{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:33:11Z","timestamp":1770064391514,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jphs.2024.07.001","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T06:50:06Z","timestamp":1719903006000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combined antiallodynic effects of Neurotropin\u00ae\u2013tramadol and Neurotropin\u00ae\u2013mirogabalin in rats with L5-spinal nerve ligation"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9520-3413","authenticated-orcid":false,"given":"Yukihiro","family":"Yoshimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Okai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Namba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2024.07.001_bib1","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00415-017-8641-6","article-title":"Advances in understanding nociception and neuropathic pain","volume":"265","author":"St","year":"2018","journal-title":"J Neurol"},{"key":"10.1016\/j.jphs.2024.07.001_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur J Pain"},{"issue":"1","key":"10.1016\/j.jphs.2024.07.001_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"van Hecke","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib6","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat Rev Dis Prim"},{"issue":"2","key":"10.1016\/j.jphs.2024.07.001_bib7","first-page":"512","article-title":"Neuropathic pain. Continuum (minneap minn)","volume":"23","author":"Zilliox","year":"2017","journal-title":"Selected Topics in Outpatient Neurology)"},{"key":"10.1016\/j.jphs.2024.07.001_bib8","series-title":"Guidelines for the Pharmacologic Management of Neuropathic Pain","article-title":"The committee for the guidelines for the pharmacologic management of neuropathic pain of JPSC","year":"2016"},{"key":"10.1016\/j.jphs.2024.07.001_bib9","series-title":"The Committee for Clinical Practice Guideline for Chronic Pain","article-title":"Clinical practice guidelines for the management of chronic painSelected Topic Outpatient Neurol","year":"2018"},{"key":"10.1016\/j.jphs.2024.07.001_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejpain.2009.02.008","article-title":"Toward a definition of pharmacoresistant neuropathic pain","volume":"13","author":"Hansson","year":"2009","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1254\/jphs.FPJ04050X","article-title":"Mechanisms of analgesic action of neurotropin on chronic pain in adjuvant-induced arthritic rat: roles of descending noradrenergic and serotonergic systems","volume":"97","author":"Miura","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.lfs.2012.12.009","article-title":"Combined antiallodynic effect of Neurotropin\u00ae and pregabalin in rats with L5-spinal nerve ligation","volume":"92","author":"Okazaki","year":"2013","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0021-5198(19)48117-1","article-title":"The combined analgesic effect of Neurotropin and amitriptyline in SART-stressed mice","volume":"82","author":"Miura","year":"2000","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jphs.2024.07.001_bib14","first-page":"407","article-title":"Comparisons of the antiallodynic effect of Neurotropin\u00ae (an extract from the inflamed skin of rabbits inoculated with vaccinia virus) with those of anti-inflammatory drugs and anti-depressants in rats with L5-spinal nerve ligation","volume":"15","author":"Okazaki","year":"2008","journal-title":"JJSPC"},{"key":"10.1016\/j.jphs.2024.07.001_bib15","first-page":"1905","article-title":"Combined analgesic effects of nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus and duloxetine in nucleus pulposus implantation and intervertebral disc puncture model rats","volume":"48","author":"Wakita","year":"2020","journal-title":"Jpn Pharmacol Ther"},{"key":"10.1016\/j.jphs.2024.07.001_bib16","first-page":"395","article-title":"Tramadol, pharmacology, side effects, and serotonin syndrome: a review","volume":"18","author":"Beakley","year":"2015","journal-title":"Pain Physician"},{"key":"10.1016\/j.jphs.2024.07.001_bib17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1080\/14737175.2016.1202764","article-title":"Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use","volume":"16","author":"Calandre","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.jphs.2024.07.001_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0021-5198(19)65180-2","article-title":"Decrease in pain threshold in SART stressed mice","volume":"29","author":"Kita","year":"1979","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jphs.2024.07.001_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/jpet.117.247551","article-title":"Binding characteristics and analgesic effects of mirogabalin, a novel ligand for the \u03b12\u03b4 subunit of voltage-gated calcium channels","volume":"365","author":"Domon","year":"2018","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.jphs.2024.07.001_bib21","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1213\/ane.0b013e31817e7a59","article-title":"The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation","volume":"107","author":"Okazaki","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jphs.2024.07.001_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2014.01.007","article-title":"The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia","volume":"562","author":"Kaneko","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jphs.2024.07.001_bib23","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0024-3205(98)00195-7","article-title":"Neurotropin induces antinociceptive effect by enhancing descending pain inhibitory systems involving 5-HT3 and noradrenergic alpha2 receptors in spinal dorsal horn","volume":"62","author":"Kawamura","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1213\/01.ANE.0000160582.25368.B9","article-title":"The antiallodynic and antihyperalgesic effects of neurotropin in mice with spinal nerve ligation","volume":"101","author":"Suzuki","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jphs.2024.07.001_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.lfs.2015.06.013","article-title":"Excitatory effect of Neurotropin\u00ae on noradrenergic neurons in rat locus coeruleus","volume":"136","author":"Okai","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.11154\/pain.23.11","article-title":"Electrophysiological evidence for the involvement of facilitation of descending pain inhibitory system in the antinociceptive action of neurotropin","volume":"23","author":"Okai","year":"2008","journal-title":"Paint Resin"},{"key":"10.1016\/j.jphs.2024.07.001_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1254\/jphs.CR0060032","article-title":"Pharmacological aspects of the effects of tramadol on G-protein coupled receptors","volume":"103","author":"Minami","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopha.2018.12.085","article-title":"An overview of tramadol and its usage in pain management and future perspective","volume":"111","author":"Subedi","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jphs.2024.07.001_bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/pr.112.007138","article-title":"Mu opioids and their receptors: evolution of a concept","volume":"65","author":"Pasternak","year":"2013","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jphs.2024.07.001_bib30","article-title":"Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2024.07.001_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(86)90220-4","article-title":"Desipramine enhances opiate postoperative analgesia","volume":"27","author":"Levine","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.jphs.2024.07.001_bib32","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1213\/ane.0b013e3181b16ff5","article-title":"The synergistic interaction between morphine and maprotiline after intrathecal injection in rats","volume":"109","author":"Pettersen","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jphs.2024.07.001_bib33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1124\/jpet.110.168336","article-title":"Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats","volume":"334","author":"Obata","year":"2010","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.jphs.2024.07.001_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jphs.2021.01.002","article-title":"Mirogabalin activates the descending noradrenergic system by binding to the \u03b12\u03b4-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects","volume":"146","author":"Oyama","year":"2021","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s40261-022-01139-5","article-title":"Efficacy and safety of tramadol hydrochloride twice-daily sustained-release bilayer tablets with an immediate-release component for chronic pain associated with knee osteoarthritis: a randomized, double-blind, placebo-controlled, treatment-withdrawal study","volume":"42","author":"Kawai","year":"2022","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.jphs.2024.07.001_bib36","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1080\/14740338.2023.2193395","article-title":"Safety of mirogabalin and pregabalin in Japanese patients with neuropathic pain: a retrospective cohort study","volume":"22","author":"Nakajima","year":"2023","journal-title":"Expet Opin Drug Saf"},{"key":"10.1016\/j.jphs.2024.07.001_bib37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jdermsci.2024.02.004","article-title":"Combined effect of Neurotropin and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1","volume":"113","author":"Andoh","year":"2024","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jphs.2024.07.001_bib38","series-title":"Drug Synergism And Dose-Effect Data Analysis","author":"Tallarida","year":"2000"},{"key":"10.1016\/j.jphs.2024.07.001_bib39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3959(02)00041-6","article-title":"The interaction index: a measure of drug synergism","volume":"98","author":"Tallarida","year":"2002","journal-title":"Pain"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786132400046X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134786132400046X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T06:25:12Z","timestamp":1722061512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S134786132400046X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S134786132400046X"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2024.07.001","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined antiallodynic effects of Neurotropin\u00ae\u2013tramadol and Neurotropin\u00ae\u2013mirogabalin in rats with L5-spinal nerve ligation","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2024.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}