{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:35:56Z","timestamp":1791513356596,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K06904"],"award-info":[{"award-number":["18K06904"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K06586"],"award-info":[{"award-number":["21K06586"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jphs.2024.07.008","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T02:12:49Z","timestamp":1722305569000},"page":"102-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Galantamine suppresses \u03b1-synuclein aggregation by inducing autophagy via the activation of \u03b17 nicotinic acetylcholine receptors"],"prefix":"10.1016","volume":"156","author":[{"given":"Sora","family":"Nozaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hijioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-5171","authenticated-orcid":false,"given":"Xiaopeng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Iwashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji O.","family":"Kamatari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Inden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2024.07.008_bib1","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","article-title":"\u03b1-synucleinopathy phenotypes","volume":"20S1","author":"McCann","year":"2014","journal-title":"Relat Disord"},{"key":"10.1016\/j.jphs.2024.07.008_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.expneurol.2012.11.020","article-title":"Changes in properties of serine 129 phosphorylated \u03b1-synuclein with progression of Lewy-type histopathology in human brains","volume":"240","author":"Walker","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jphs.2024.07.008_bib3","doi-asserted-by":"crossref","first-page":"19213","DOI":"10.1074\/jbc.M110551200","article-title":"Biochemical characterization of the core structure of \u03b1-synuclein filaments","volume":"277","author":"Miake","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jphs.2024.07.008_bib4","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awt037","article-title":"Prion-like spreading of pathological \u03b1-synuclein in brain","volume":"136","author":"Masuda-Suzukake","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.jphs.2024.07.008_bib5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jphs.2024.07.008_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.jphs.2024.07.008_bib7","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jphs.2024.07.008_bib8","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"\u03b1-synuclein locus duplication as a cause of familial Parkinson's disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2024.07.008_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/hmg\/10.9.919","article-title":"Inducible expression of mutant \u03b1-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis","volume":"10","author":"Tanaka","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jphs.2024.07.008_bib10","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1073\/pnas.0409713102","article-title":"Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and \u03b1-synuclein","volume":"102","author":"Fornai","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jphs.2024.07.008_bib11","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.jmb.2020.01.037","article-title":"Autophagy in Parkinson's disease","volume":"432","author":"Hou","year":"2020","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jphs.2024.07.008_bib12","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.nbd.2011.05.022","article-title":"Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease","volume":"43","author":"Tanji","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jphs.2024.07.008_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pneurobio.2004.09.006","article-title":"Neuronal nicotinic receptors: from structure to pathology","volume":"74","author":"Gotti","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jphs.2024.07.008_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ana.410420205","article-title":"Nicotinic receptor stimulation protects neurons against \u03b2-amyloid toxicity","volume":"42","author":"Kihara","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jphs.2024.07.008_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79189-y","article-title":"The neuroprotective effects of activated \u03b17 nicotinic acetylcholine receptor against muant copper\u2013zinc superoxide dismutase 1-mediated toxicity","volume":"10","author":"Ito","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2024.07.008_bib16","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1124\/jpet.102.045773","article-title":"Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors","volume":"305","author":"Samochocki","year":"2003","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.jphs.2024.07.008_bib17","article-title":"Activation of \u03b17-nAChRs promotes the clearance of \u03b1-synuclein and protects against apoptotic cell death induced by exogenous \u03b1-synuclein fibrils","volume":"9","author":"Zhao","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jphs.2024.07.008_bib18","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jphs.2024.07.008_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"\u03b1-synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jphs.2024.07.008_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/srep17625","article-title":"Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients","volume":"5","author":"Araki","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2024.07.008_bib21","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1111\/j.1460-9568.1997.tb01702.x","article-title":"Choline is a selective agonist of a7 nicotinic acetylcholine receptors in the rat brain neurons","volume":"9","author":"Alkondon","year":"1997","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jphs.2024.07.008_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56825","article-title":"\u03b1-synuclein strains that cause distinct pathologies differentially inhibit proteasome","volume":"9","author":"Suzuki","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jphs.2024.07.008_bib23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson's disease: risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jphs.2024.07.008_bib24","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1212\/01.wnl.0000256374.50227.4b","article-title":"Temporal relationship between cigarette smoking and risk of Parkinson disease","volume":"68","author":"Thacker","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jphs.2024.07.008_bib25","doi-asserted-by":"crossref","first-page":"21959","DOI":"10.18632\/aging.104021","article-title":"Multiple System Atrophy (MSA) and smoking: a meta-analysis and mechanistic insights","volume":"12","author":"Tseng","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.jphs.2024.07.008_bib26","first-page":"646","article-title":"Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes","volume":"297","author":"Papke","year":"2001","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.jphs.2024.07.008_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-5793(90)81231-C","article-title":"Methyllycaconitine: a selective probe for neuronal \u03b1-bungarotoxin binding sites","volume":"270","author":"Ward","year":"1990","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jphs.2024.07.008_bib28","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/bph.12247","article-title":"A positive allosteric modulator of \u03b17 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia","volume":"169","author":"Kalappa","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2024.07.008_bib29","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1046\/j.1471-4159.1996.67051953.x","article-title":"Multiple determinants of dihydro-\u03b2-erythroidine sensitivity on rat neuronal nicotinic receptor \u03b1 subunits","volume":"67","author":"Harvey","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.jphs.2024.07.008_bib30","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuint.2007.10.008","article-title":"Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice","volume":"52","author":"Hartmann","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jphs.2024.07.008_bib31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuint.2016.02.008","article-title":"\u03b14 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior","volume":"94","author":"Inden","year":"2016","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jphs.2024.07.008_bib32","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.jphs.2024.07.008_bib33","doi-asserted-by":"crossref","first-page":"22847","DOI":"10.1074\/jbc.M802182200","article-title":"Structural basis for sorting mechanism of p62 in selective autophagy","volume":"283","author":"Ichimura","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jphs.2024.07.008_bib34","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1152\/jn.01079.2002","article-title":"Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons","volume":"90","author":"Beker","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jphs.2024.07.008_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2005.05.009","article-title":"Calmodulin-dependent protein kinase kinase-\u03b2 is an alternative upstream kinase for AMP-activated protein kinase","volume":"2","author":"Hawley","year":"2005","journal-title":"Cell Metabol"},{"key":"10.1016\/j.jphs.2024.07.008_bib36","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1080\/15548627.2021.1898748","article-title":"AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3","volume":"17","author":"Paquette","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jphs.2024.07.008_bib37","doi-asserted-by":"crossref","first-page":"15370","DOI":"10.1074\/jbc.M710209200","article-title":"Protein kinase C\u03b8 is required for autophagy in response to stress in the endoplasmic reticulum","volume":"283","author":"Sakaki","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jphs.2024.07.008_bib38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ceca.2017.08.005","article-title":"The regulation of autophagy by calcium signals: do we have a consensus?","volume":"70","author":"Bootman","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jphs.2024.07.008_bib39","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jphs.2024.07.008_bib40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease","volume":"18","author":"Kr\u00fcger","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.jphs.2024.07.008_bib41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/00001756-199804200-00051","article-title":"The cDNA cloning and ontogeny of mouse alpha-synuclein","volume":"9","author":"Hong","year":"1998","journal-title":"Neuroreport"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861324000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861324000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T23:40:06Z","timestamp":1724456406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861324000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1347861324000537"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2024.07.008","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galantamine suppresses \u03b1-synuclein aggregation by inducing autophagy via the activation of \u03b17 nicotinic acetylcholine receptors","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2024.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}