{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:08:54Z","timestamp":1790892534461,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10048"],"award-info":[{"award-number":["24K10048"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jphs.2025.05.017","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T19:18:57Z","timestamp":1748287137000},"page":"336-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["HIF-1\u03b1 stabilization in osteoclasts induces the expression of aerobic glycolysis-related proteins GLUT1, LDHA, and MCT4"],"prefix":"10.1016","volume":"158","author":[{"given":"Tsuyoshi","family":"Nishioku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Momono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyu","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Terazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jphs.2025.05.017_bib1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.abb.2008.03.037","article-title":"Osteoclast lineage and function","volume":"473","author":"V\u00e4\u00e4n\u00e4nen","year":"2008","journal-title":"Arch Biochem Biophys"},{"issue":"6937","key":"10.1016\/j.jphs.2025.05.017_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2025.05.017_bib3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science (Wash D C)"},{"key":"10.1016\/j.jphs.2025.05.017_bib4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jphs.2025.05.017_bib5","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jphs.2025.05.017_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbrc.2005.08.165","article-title":"The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing","volume":"338","author":"Kaelin","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2025.05.017_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/1568009611313030003","article-title":"Oxygen-independent regulation of HIF-1: novel involvement of PI3K\/AKT\/mTOR pathway in cancer","volume":"13","author":"Agani","year":"2013","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.jphs.2025.05.017_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2025.05.017_bib9","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.1308755110","article-title":"HIF1\u03b1 is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis","volume":"110","author":"Miyauchi","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jphs.2025.05.017_bib10","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.21037\/atm-22-4603","article-title":"Hypoxia-inducible factor 1\u03b1 enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway","volume":"10","author":"Wang","year":"2022","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jphs.2025.05.017_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/path.2319","article-title":"Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF","volume":"215","author":"Knowles","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.jphs.2025.05.017_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00259-003-1316-9","article-title":"Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study","volume":"31","author":"Tian","year":"2004","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.jphs.2025.05.017_bib13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1590\/S1807-59322011000600008","article-title":"GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker","volume":"66","author":"Carvalho","year":"2011","journal-title":"Clinics (S\u00e3o Paulo)"},{"key":"10.1016\/j.jphs.2025.05.017_bib14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/jcb.23379","article-title":"Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue","volume":"113","author":"Reinicke","year":"2012","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jphs.2025.05.017_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0959-8049(00)00371-3","article-title":"Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological features","volume":"37","author":"Sakashita","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jphs.2025.05.017_bib16","first-page":"3847","article-title":"The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models","volume":"63","author":"Gatenby","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.jphs.2025.05.017_bib17","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1073\/pnas.0914433107","article-title":"Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression","volume":"107","author":"Le","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jphs.2025.05.017_bib18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2014.03.003","article-title":"Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells","volume":"19","author":"Xie","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jphs.2025.05.017_bib19","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1111\/j.1742-4658.2012.08748.x","article-title":"Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma","volume":"279","author":"Sheng","year":"2012","journal-title":"FEBS J"},{"key":"10.1016\/j.jphs.2025.05.017_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jphs.2025.05.017_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mam.2012.05.003","article-title":"The SLC16 gene family - structure, role and regulation in health and disease","volume":"34","author":"Halestrap","year":"2013","journal-title":"Mol Aspect Med"},{"issue":"Pt 2","key":"10.1016\/j.jphs.2025.05.017_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3430281","article-title":"The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation","volume":"343","author":"Halestrap","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.jphs.2025.05.017_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s004210100516","article-title":"The expression of lactate transporters (MCT1 and MCT4) in heart and muscle","volume":"86","author":"Bonen","year":"2001","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.jphs.2025.05.017_bib24","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism","volume":"281","author":"Ullah","year":"2006","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"10.1016\/j.jphs.2025.05.017_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj3500219","article-title":"The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells","volume":"350","author":"Dimmer","year":"2000","journal-title":"Biochem J"},{"issue":"Pt 2","key":"10.1016\/j.jphs.2025.05.017_bib26","first-page":"285","article-title":"Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle","volume":"529","author":"Manning Fox","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.jphs.2025.05.017_bib27","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00432-014-1888-8","article-title":"Monocarboxylate transporter 4 predicts poor prognosis in hepatocellular carcinoma and is associated with cell proliferation and migration","volume":"141","author":"Gao","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jphs.2025.05.017_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/carcin\/bgx034","article-title":"Enhanced glycolysis, regulated by HIF-1\u03b1 via MCT-4, promotes inflammation in arsenite-induced carcinogenesis","volume":"38","author":"Luo","year":"2017","journal-title":"Carcinogenesis (Eynsham)"},{"key":"10.1016\/j.jphs.2025.05.017_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13054-022-03893-6","article-title":"Immune effects of PI3K\/Akt\/HIF-1\u03b1-regulated glycolysis in polymorphonuclear neutrophils during sepsis","volume":"26","author":"Pan","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.jphs.2025.05.017_bib30","doi-asserted-by":"crossref","first-page":"11058","DOI":"10.1096\/fj.202000771R","article-title":"Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation","volume":"34","author":"Li","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.jphs.2025.05.017_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-77892-4","article-title":"Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis","volume":"10","author":"Taubmann","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2025.05.017_bib32","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.bbrc.2016.03.147","article-title":"CD147 promotes the formation of functional osteoclasts through NFATc1 signalling","volume":"473","author":"Nishioku","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jphs.2025.05.017_bib33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jphs.2023.09.005","article-title":"Lactate dehydrogenase A inhibition prevents RANKL-induced osteoclastogenesis by reducing enhanced glycolysis","volume":"153","author":"Nishioku","year":"2023","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2025.05.017_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.biocel.2004.08.012","article-title":"Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators","volume":"37","author":"D\u00e9ry","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jphs.2025.05.017_bib35","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2012-01-405993","article-title":"Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 \u03b1","volume":"120","author":"McInturff","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jphs.2025.05.017_bib36","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1084\/jem.20112607","article-title":"PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells","volume":"209","author":"Finlay","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jphs.2025.05.017_bib37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2025.05.017_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","article-title":"HIF-1: upstream and downstream of cancer metabolism","volume":"20","author":"Semenza","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.jphs.2025.05.017_bib39","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1159\/000110454","article-title":"Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation","volume":"20","author":"Kim","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jphs.2025.05.017_bib40","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/art.42074","article-title":"Role of lysine-specific demethylase 1 in metabolically integrating osteoclast differentiation and inflammatory bone resorption through hypoxia-inducible factor 1\u03b1 and E2F1","volume":"74","author":"Doi","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jphs.2025.05.017_bib41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.jphs.2025.05.017_bib42","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/jbmr.1976","article-title":"Metabolic regulation of osteoclast differentiation and function","volume":"28","author":"Indo","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jphs.2025.05.017_bib43","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1158\/0008-5472.CAN-05-1235","article-title":"Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity","volume":"65","author":"Kong","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jphs.2025.05.017_bib44","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1128\/MCB.21.10.3436-3444.2001","article-title":"Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells","volume":"21","author":"Seagroves","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jphs.2025.05.017_bib45","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1111\/jcmm.17303","article-title":"Effect of Glut-1 and HIF-1\u03b1 double knockout by CRISPR\/CAS9 on radiosensitivity in laryngeal carcinoma via the PI3K\/Akt\/mTOR pathway","volume":"26","author":"Bao","year":"2022","journal-title":"J Cell Mol Med"},{"issue":"10","key":"10.1016\/j.jphs.2025.05.017_bib46","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.7150\/thno.73746","article-title":"N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jphs.2025.05.017_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13041-020-00601-9","article-title":"Arginine is neuroprotective through suppressing HIF-1\u03b1\/LDHA-mediated inflammatory response after cerebral ischemia\/reperfusion injury","volume":"13","author":"Chen","year":"2020","journal-title":"Mol Brain"},{"key":"10.1016\/j.jphs.2025.05.017_bib48","article-title":"HIF-1\u03b1 mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice","volume":"168","author":"Bie","year":"2023","journal-title":"Bone (Elmsford)"},{"key":"10.1016\/j.jphs.2025.05.017_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1601-6343.2011.01530.x","article-title":"Hypoxia triggers a HIF-mediated differentiation of peripheral blood mononuclear cells into osteoclasts","volume":"15","author":"Dandajena","year":"2012","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.jphs.2025.05.017_bib50","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature13490","article-title":"Functional polarization of tumour-associated macrophages by tumour-derived lactic acid","volume":"513","author":"Colegio","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jphs.2025.05.017_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046571","article-title":"Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells","volume":"7","author":"De Saedeleer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2025.05.017_bib52","article-title":"PD-1+ CD4 T cell immune response is mediated by HIF-1\u03b1\/NFATc1 pathway after P. yoelii infection","volume":"13","author":"Wei","year":"2022","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jphs.2025.05.017_bib53","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153035","article-title":"Osteoclasts adapt to physioxia perturbation through DNA demethylation","volume":"22","author":"Nishikawa","year":"2021","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.jphs.2025.05.017_bib54","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1038\/s41598-022-07521-9","article-title":"Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy","volume":"12","author":"Narazaki","year":"2022","journal-title":"Sci Rep"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861325000623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861325000623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T01:48:29Z","timestamp":1750384109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861325000623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1347861325000623"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2025.05.017","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HIF-1\u03b1 stabilization in osteoclasts induces the expression of aerobic glycolysis-related proteins GLUT1, LDHA, and MCT4","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2025.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}