{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:48:44Z","timestamp":1773884924366,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017764","name":"Aichi Gakuin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jphs.2025.11.003","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:53:21Z","timestamp":1762768401000},"page":"37-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-4790","authenticated-orcid":false,"given":"Yoshiaki","family":"Ohi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Wakiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jphs.2025.11.003_bib1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jphs.2025.11.003_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neurobiolaging.2017.01.011","article-title":"Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process","volume":"53","author":"Gabelle","year":"2017","journal-title":"Neurobiol Aging"},{"issue":"23","key":"10.1016\/j.jphs.2025.11.003_bib3","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J Neurosci"},{"issue":"7","key":"10.1016\/j.jphs.2025.11.003_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae115","article-title":"Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice","volume":"79","author":"Hu","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jphs.2025.11.003_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114171","article-title":"Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice","volume":"438","author":"Gao","year":"2023","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jphs.2025.11.003_bib6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neurobiolaging.2020.02.020","article-title":"Suvorexant ameliorates cognitive impairments and pathology in APP\/PS1 transgenic mice","volume":"91","author":"Zhou","year":"2020","journal-title":"Neurobiol Aging"},{"issue":"5","key":"10.1016\/j.jphs.2025.11.003_bib7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single app knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jphs.2025.11.003_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105820","article-title":"Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing","volume":"172","author":"Ye","year":"2022","journal-title":"Neurobiol Dis"},{"issue":"17","key":"10.1016\/j.jphs.2025.11.003_bib9","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.jphs.2025.11.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2015.04.028","article-title":"Enhancement of long-term potentiation via muscarinic modulation in the hippocampus of HCNP precursor transgenic mice","volume":"597","author":"Ohi","year":"2015","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.jphs.2025.11.003_bib11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1006\/nbdi.2002.0557","article-title":"Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe\/ind) CRND8 mice","volume":"11","author":"Jolas","year":"2002","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.jphs.2025.11.003_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13195-020-00667-6","article-title":"The two faces of synaptic failure in APPNL\u2212G-F knock-in mice","volume":"12","author":"Latif-Hernandez","year":"2020","journal-title":"Alzheimers Res Ther"},{"issue":"19","key":"10.1016\/j.jphs.2025.11.003_bib13","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1113\/jphysiol.2014.272757","article-title":"Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors","volume":"592","author":"Perin","year":"2014","journal-title":"J Physiol"},{"issue":"5","key":"10.1016\/j.jphs.2025.11.003_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5582\/bst.2021.01245","article-title":"Soluble beta-amyloid impaired the GABA inhibition by mediating KCC2 in early APP\/PS1 mice","volume":"15","author":"Zhou","year":"2021","journal-title":"Biosci Trends"},{"issue":"5955","key":"10.1016\/j.jphs.2025.11.003_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861325001070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861325001070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:20:13Z","timestamp":1773865213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861325001070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1347861325001070"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2025.11.003","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2025.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}