{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:20:20Z","timestamp":1776162020388,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23H03332"],"award-info":[{"award-number":["23H03332"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","award":["2020G023"],"award-info":[{"award-number":["2020G023"]}],"id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19756"],"award-info":[{"award-number":["22K19756"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jphs.2026.01.002","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:22:02Z","timestamp":1767889322000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["S-allyl-l-cysteine ameliorates sensorimotor functions after intracerebral hemorrhage in mice concomitantly with prevention of axon tract fragmentation and reduction of brain lesion volume"],"prefix":"10.1016","volume":"160","author":[{"given":"Yuma","family":"Hirata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ushida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunya","family":"Tsujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moe","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Hitora-Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kurauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-3154","authenticated-orcid":false,"given":"Hiroshi","family":"Katsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphs.2026.01.002_bib1","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jphs.2026.01.002_bib2","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/STROKEAHA.121.033849","article-title":"Combatting secondary injury from intracerebral hemorrhage with supplemental antioxidant therapy","volume":"52","author":"Shoamanesh","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jphs.2026.01.002_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/17562864211049208","article-title":"Secondary mechanisms of injury and viable pathophysiological targets in intracerebral hemorrhage","volume":"14","author":"Bautista","year":"2021","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.jphs.2026.01.002_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/ctn9010004","article-title":"Therapeutic role of microglia\/macrophage polarization in intracerebral hemorrhage","volume":"9","author":"Dinc","year":"2025","journal-title":"Clin Transl Neurosci"},{"key":"10.1016\/j.jphs.2026.01.002_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jphs.2024.12.003","article-title":"Thrombin-induced kynurenine 3-monooxygenase causes variations in the kynurenine pathway, leading to neurological deficits in a murine intracerebral hemorrhage model","volume":"157","author":"Ohnishi","year":"2025","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.01.002_bib6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jphs.2025.10.002","article-title":"Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage","volume":"159","author":"Zhang","year":"2025","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.01.002_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.nutres.2011.12.014","article-title":"S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia","volume":"32","author":"Ashafaq","year":"2012","journal-title":"Nutr Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jnc.12986","article-title":"S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo","volume":"133","author":"Shi","year":"2015","journal-title":"J Neurochem"},{"key":"10.1016\/j.jphs.2026.01.002_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2008.12.077","article-title":"S-allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus","volume":"1265","author":"Atif","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jphs.2023.09.007","article-title":"Therapeutic effect of allicin in a mouse model of intracerebral hemorrhage","volume":"153","author":"Atef","year":"2023","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.01.002_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jphs.2025.06.007","article-title":"Formalizing and expanding our ethical framework: introducing the comprehensive ethical guidelines for the Journal of Pharmacological Sciences","volume":"159","author":"Kurokawa","year":"2025","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.01.002_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jneuroim.2019.02.010","article-title":"A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage","volume":"330","author":"Kinoshita","year":"2019","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jphs.2026.01.002_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577195","article-title":"Laquinimod and 3,3'-diindolylemethane alleviate neuropathological events and neurological deficits in a mouse model of intracerebral hemorrhage","volume":"342","author":"Matsumoto","year":"2020","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jphs.2026.01.002_bib14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/jcbfm.2010.80","article-title":"A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice","volume":"31","author":"Matsushita","year":"2011","journal-title":"J Cerebr Blood Flow Metabol"},{"key":"10.1016\/j.jphs.2026.01.002_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15178-7","article-title":"A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice","volume":"12","author":"Kinoshita","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jphs.2026.01.002_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neures.2015.10.006","article-title":"Axonal dysfunction in internal capsule is closely associated with early motor deficits after intracerebral hemorrhage in mice","volume":"106","author":"Hijioka","year":"2016","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuroscience.2025.01.062","article-title":"Inhibition of SUMOylation exacerbates neurological dysfunction and delays hematoma clearance after intracerebral hemorrhage in mice","volume":"568","author":"Kinoshita","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphs.2026.01.002_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/jpet.116.238824","article-title":"Inhibition of leukotriene B4 action mitigates intracerebral hemorrhage-associated pathological events in mice","volume":"360","author":"Hijioka","year":"2017","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.jphs.2026.01.002_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067691","article-title":"MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms","volume":"8","author":"Matsushita","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jphs.2026.01.002_bib20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1034\/j.1600-0404.2002.1o170.x","article-title":"Site of bleeding and early outcome in primary intracerebral hemorrhage","volume":"105","author":"Arboix","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jphs.2026.01.002_bib21","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.87.4.1561","article-title":"Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport","volume":"87","author":"Koo","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jphs.2026.01.002_bib22","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1248\/bpb.b22-00541","article-title":"Distinct pharmacological profiles of monosulfide and trisulfide in an experimental model of intracerebral hemorrhage in mice","volume":"45","author":"Atef","year":"2022","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jphs.2026.01.002_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fncel.2019.00349","article-title":"Exogenous hydrogen sulfide offers neuroprotection on intracerebral hemorrhage injury through modulating endogenous H2S metabolism in mice","volume":"13","author":"Shan","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jphs.2026.01.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146514","article-title":"Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction","volume":"1727","author":"Diao","year":"2020","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ana.25356","article-title":"N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","volume":"84","author":"Karuppagounder","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jphs.2026.01.002_bib26","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1007\/s11064-024-04150-8","article-title":"Menaquinone-4 alleviates neurological deficits associated with intracerebral hemorrhage by preserving corticospinal tract in mice","volume":"49","author":"Ushida","year":"2024","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577786","article-title":"Hydroxychloroquine improves motor function and affords neuroprotection without inhibition of inflammation and autophagy in mice after intracerebral hemorrhage","volume":"362","author":"Yoshimizu","year":"2022","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jphs.2026.01.002_bib28","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1096\/fj.201601377RR","article-title":"A TSPO ligand attenuates brain injury after intracerebral hemorrhage","volume":"31","author":"Li","year":"2017","journal-title":"FASEB J"},{"key":"10.1016\/j.jphs.2026.01.002_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.intimp.2016.06.025","article-title":"Retinoic acid receptor agonist Am80 inhibits CXCL2 production from microglial BV-2 cells via attenuation of NF-\u03baB signaling","volume":"38","author":"Takaoka","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jphs.2026.01.002_bib30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2007.08.058","article-title":"Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment","volume":"1180","author":"Wasserman","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.jphs.2026.01.002_bib31","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200213","article-title":"Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage","volume":"217","author":"Li","year":"2020","journal-title":"J Exp Med"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:21:40Z","timestamp":1776158500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861326000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1347861326000022"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2026.01.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-allyl-l-cysteine ameliorates sensorimotor functions after intracerebral hemorrhage in mice concomitantly with prevention of axon tract fragmentation and reduction of brain lesion volume","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2026.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}