{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:23:01Z","timestamp":1778595781291,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008883","name":"Nagoya City University","doi-asserted-by":"publisher","award":["T_R5-2"],"award-info":[{"award-number":["T_R5-2"]}],"id":[{"id":"10.13039\/501100008883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018117","name":"Aichi Health Promotion Foundation","doi-asserted-by":"publisher","award":["20120"],"award-info":[{"award-number":["20120"]}],"id":[{"id":"10.13039\/100018117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2130"],"award-info":[{"award-number":["JPMJSP2130"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMXS0441500025"],"award-info":[{"award-number":["JPMXS0441500025"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018884","name":"Aichi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016981","name":"Pharmaceutical Society of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K02427"],"award-info":[{"award-number":["JP25K02427"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K14414"],"award-info":[{"award-number":["JP23K14414"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23K06174"],"award-info":[{"award-number":["JP 23K06174"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02773"],"award-info":[{"award-number":["JP22H02773"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02787"],"award-info":[{"award-number":["JP22H02787"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023741","name":"University of California-San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jphs.2026.02.002","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:59:12Z","timestamp":1770134352000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic effects of fingolimod through sphingosine-1-phosphate signaling in pulmonary arterial hypertension"],"prefix":"10.1016","volume":"160","author":[{"given":"Moe","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubii","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-176X","authenticated-orcid":false,"given":"Hisao","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.jphs.2026.02.002_bib1","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMra2000348","article-title":"Pulmonary arterial hypertension","volume":"385","author":"Hassoun","year":"2021","journal-title":"N Engl J Med"},{"issue":"1 Suppl","key":"10.1016\/j.jphs.2026.02.002_bib2","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jphs.2026.02.002_bib3","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.3390\/ijms19103162","article-title":"Ion channels in pulmonary hypertension: a therapeutic interest?","volume":"19","author":"Lambert","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jphs.2026.02.002_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1556\/2060.2020.00021","article-title":"Growth factors in pulmonary arterial hypertension: focus on preserving right ventricular function","volume":"107","author":"Cs\u00f3sza","year":"2020","journal-title":"Phys Int"},{"issue":"1","key":"10.1016\/j.jphs.2026.02.002_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jphs.2023.11.004","article-title":"Transient receptor potential melastatin 2 is involved in trinitrobenzene sulfonic acid-induced acute and chronic colitis-associated fibrosis progression in mice","volume":"154","author":"Nakamoto","year":"2024","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jphs.2026.02.002_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jphs.2024.01.001","article-title":"2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction","volume":"154","author":"Kishigami","year":"2024","journal-title":"J Pharmacol Sci"},{"issue":"1 Suppl","key":"10.1016\/j.jphs.2026.02.002_bib7","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","article-title":"Inflammation, growth factors, and pulmonary vascular remodeling","volume":"54","author":"Hassoun","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jphs.2026.02.002_bib8","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3390\/cells9112338","article-title":"Perivascular inflammation in pulmonary arterial hypertension","volume":"9","author":"Hu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jphs.2026.02.002_bib9","article-title":"Role of macrophages in pulmonary arterial hypertension","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jphs.2026.02.002_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176564","article-title":"Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension","volume":"973","author":"Yamamura","year":"2024","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.jphs.2026.02.002_bib11","first-page":"11930","article-title":"Sphingosine kinase 1\/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension","volume":"8","author":"Xing","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"9","key":"10.1016\/j.jphs.2026.02.002_bib12","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.molmed.2017.07.001","article-title":"Sphingosine kinase 1: a potential therapeutic target in pulmonary arterial hypertension?","volume":"23","author":"Pyne","year":"2017","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jphs.2026.02.002_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pharmthera.2017.11.001","article-title":"The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: recent findings and new perspectives","volume":"185","author":"Huwiler","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jphs.2026.02.002_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev-pharmtox-010818-021358","article-title":"Fingolimod: lessons learned and new opportunities for treating multiple sclerosis and other disorders","volume":"59","author":"Chun","year":"2019","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"5","key":"10.1016\/j.jphs.2026.02.002_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12836","article-title":"Sphingosine-1-phosphate receptors and innate immunity","volume":"20","author":"Bryan","year":"2018","journal-title":"Cell Microbiol"},{"issue":"13","key":"10.1016\/j.jphs.2026.02.002_bib16","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.3390\/cells11132058","article-title":"Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives","volume":"11","author":"Bravo","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.jphs.2026.02.002_bib17","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/jcb.21918","article-title":"bFGF induces S1P1 receptor expression and functionality in human pulmonary artery smooth muscle cells","volume":"105","author":"Birker-Robaczewska","year":"2008","journal-title":"J Cell Biochem"},{"issue":"1-2","key":"10.1016\/j.jphs.2026.02.002_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11010-010-0461-2","article-title":"Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation","volume":"342","author":"Harvey","year":"2010","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"10.1016\/j.jphs.2026.02.002_bib19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ahj.2014.06.028","article-title":"Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications","volume":"168","author":"Camm","year":"2014","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.jphs.2026.02.002_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/molpharm.120.000019","article-title":"Transforming growth factor \u03b21 increases expression of contractile genes in human pulmonary arterial smooth muscle cells by potentiating sphingosine-1-phosphate signaling","volume":"100","author":"Ji","year":"2021","journal-title":"Mol Pharmacol"},{"issue":"11","key":"10.1016\/j.jphs.2026.02.002_bib21","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/cbin.11682","article-title":"Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels","volume":"45","author":"Tran","year":"2021","journal-title":"Cell Biol Int"},{"issue":"6463","key":"10.1016\/j.jphs.2026.02.002_bib22","doi-asserted-by":"crossref","first-page":"eaar5551","DOI":"10.1126\/science.aar5551","article-title":"Sphingosine 1-phosphate: lipid signaling in pathology and therapy","volume":"366","author":"Cartier","year":"2019","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.jphs.2026.02.002_bib23","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/17460441.2019.1646244","article-title":"Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis","volume":"14","author":"Volpi","year":"2019","journal-title":"Expet Opin Drug Discov"},{"key":"10.1016\/j.jphs.2026.02.002_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-2377-14-126","article-title":"Fingolimod in a patient with heart failure on the background of pulmonary arterial hypertension and coronary artery disease","volume":"14","author":"Thomas","year":"2014","journal-title":"BMC Neurol"},{"issue":"14","key":"10.1016\/j.jphs.2026.02.002_bib25","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/01.CIR.98.14.1400","article-title":"Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension","volume":"98","author":"Yuan","year":"1998","journal-title":"Circulation"},{"issue":"38","key":"10.1016\/j.jphs.2026.02.002_bib26","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1073\/pnas.0405908101","article-title":"Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension","volume":"101","author":"Yu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jphs.2026.02.002_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/s12885-015-1546-9","article-title":"M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide","volume":"15","author":"Genin","year":"2015","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.jphs.2026.02.002_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jphs.2025.06.007","article-title":"Formalizing and expanding our ethical framework: introducing the comprehensive ethical guidelines for the Journal of pharmacological sciences","volume":"159","author":"Kurokawa","year":"2025","journal-title":"J Pharmacol Sci"},{"issue":"6","key":"10.1016\/j.jphs.2026.02.002_bib29","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","article-title":"Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure","volume":"297","author":"Stenmark","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"10.1016\/j.jphs.2026.02.002_bib30","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1086\/674770","article-title":"A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet?","volume":"3","author":"Maarman","year":"2013","journal-title":"Pulm Circ"},{"issue":"5","key":"10.1016\/j.jphs.2026.02.002_bib31","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/bph.15444","article-title":"Animal models of pulmonary hypertension: getting to the heart of the problem","volume":"179","author":"Dignam","year":"2022","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.jphs.2026.02.002_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jphs.2021.05.012","article-title":"Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats","volume":"147","author":"Kawade","year":"2021","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jphs.2026.02.002_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jphs.2022.12.007","article-title":"Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling","volume":"151","author":"Kawade","year":"2023","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.02.002_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1343804","article-title":"Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension","volume":"11","author":"Shima","year":"2024","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.jphs.2026.02.002_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pharmthera.2005.05.002","article-title":"FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors","volume":"108","author":"Chiba","year":"2005","journal-title":"Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.jphs.2026.02.002_bib36","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41429-020-0351-0","article-title":"Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii","volume":"73","author":"Chiba","year":"2020","journal-title":"J Antibiot (Tokyo)"},{"issue":"8","key":"10.1016\/j.jphs.2026.02.002_bib37","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1161\/ATVBAHA.107.159392","article-title":"Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype","volume":"28","author":"Wamhoff","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.jphs.2026.02.002_bib38","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1164\/rccm.201401-0121OC","article-title":"The sphingosine kinase 1\/sphingosine-1-phosphate pathway in pulmonary arterial hypertension","volume":"190","author":"Chen","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.jphs.2026.02.002_bib39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1086\/687766","article-title":"Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension","volume":"6","author":"Gairhe","year":"2016","journal-title":"Pulm Circ"},{"issue":"12","key":"10.1016\/j.jphs.2026.02.002_bib40","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.biochi.2012.07.002","article-title":"Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1\/S1PR3 pathway","volume":"94","author":"Mousseau","year":"2012","journal-title":"Biochimie"},{"issue":"21","key":"10.1016\/j.jphs.2026.02.002_bib41","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1111\/bph.12620","article-title":"Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization","volume":"171","author":"Sykes","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"24","key":"10.1016\/j.jphs.2026.02.002_bib42","doi-asserted-by":"crossref","first-page":"eabf5325","DOI":"10.1126\/sciadv.abf5325","article-title":"Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias","volume":"7","author":"Maeda","year":"2021","journal-title":"Sci Adv"},{"issue":"4","key":"10.1016\/j.jphs.2026.02.002_bib43","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1476-5381.2012.02032.x","article-title":"Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter\u2122 and Ca2+ release functional assays","volume":"167","author":"Riddy","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jphs.2026.02.002_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.trsl.2021.03.004","article-title":"Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension","volume":"233","author":"Hiraishi","year":"2021","journal-title":"Transl Res"},{"issue":"1","key":"10.1016\/j.jphs.2026.02.002_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2006-10-053884","article-title":"FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia\/lymphoma","volume":"111","author":"Liu","year":"2008","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.jphs.2026.02.002_bib46","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1161\/STROKEAHA.117.018505","article-title":"Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway","volume":"48","author":"Qin","year":"2017","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jphs.2026.02.002_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/bph.15016","article-title":"Current and future treatments of pulmonary arterial hypertension","volume":"178","author":"Sommer","year":"2021","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.jphs.2026.02.002_bib48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/CIRCRESAHA.112.266361","article-title":"Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension","volume":"111","author":"Yamamura","year":"2012","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jphs.2026.02.002_bib49","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/rcmb.2014-0235OC","article-title":"Notch activation of Ca2+ signaling mediates hypoxic pulmonary vasoconstriction and pulmonary hypertension","volume":"53","author":"Smith","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"9","key":"10.1016\/j.jphs.2026.02.002_bib50","doi-asserted-by":"crossref","first-page":"L846","DOI":"10.1152\/ajplung.00050.2016","article-title":"Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension","volume":"310","author":"Tang","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.jphs.2026.02.002_bib51","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.1096\/fj.201802620R","article-title":"Platelet-derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial hypertension","volume":"33","author":"Yamamura","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jphs.2026.02.002_bib52","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2020.10.106","article-title":"The Rho kinase 2 (ROCK2)-Specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension","volume":"534","author":"Yamamura","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.jphs.2026.02.002_bib53","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.jphs.2026.02.002_bib54","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1172\/JCI136068","article-title":"FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages","volume":"130","author":"Bryan","year":"2020","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.jphs.2026.02.002_bib55","article-title":"Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization","volume":"12","author":"Qiu","year":"2025","journal-title":"Genes Dis"},{"issue":"3","key":"10.1016\/j.jphs.2026.02.002_bib56","doi-asserted-by":"crossref","first-page":"F769","DOI":"10.1152\/ajprenal.90530.2008","article-title":"Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5\/6 nephrectomized rats","volume":"297","author":"Schaier","year":"2009","journal-title":"Am J Physiol Ren Physiol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:02:42Z","timestamp":1778594562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861326000101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1347861326000101"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2026.02.002","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic effects of fingolimod through sphingosine-1-phosphate signaling in pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2026.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}