{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:48:14Z","timestamp":1785908894046,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970630"],"award-info":[{"award-number":["81970630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological Sciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jphs.2026.06.009","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:39:10Z","timestamp":1782517150000},"page":"50-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1"],"prefix":"10.1016","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2969-8906","authenticated-orcid":false,"given":"Haoyu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujie","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanzhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jphs.2026.06.009_bib1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12902-024-01803-1","article-title":"Prevalence of diabetes and its associated factors in Cape Verde: an analysis of the 2020 WHO STEPS survey on non-communicable diseases risk factors","volume":"24","author":"Okyere","year":"2024","journal-title":"BMC Endocr Disord"},{"issue":"5","key":"10.1016\/j.jphs.2026.06.009_bib2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","article-title":"Diabetic autonomic neuropathy","volume":"26","author":"Vinik","year":"2003","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.jphs.2026.06.009_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26031094","article-title":"Type 2 diabetes mellitus: new pathogenetic mechanisms, treatment and the Most important complications","volume":"26","author":"M\u0142ynarska","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jphs.2026.06.009_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108792","article-title":"Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db\/db mice","volume":"109","author":"Wang","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jphs.2026.06.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113888","article-title":"Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jphs.2026.06.009_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101678","article-title":"Interrelation between ROS and Ca(2+) in aging and age-related diseases","volume":"36","author":"Madreiter-Sokolowski","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.jphs.2026.06.009_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-981-10-4567-7_13","article-title":"Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes","volume":"997","author":"Rieusset","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jphs.2026.06.009_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107497","article-title":"TRPC channels: structure, function, regulation and recent advances in small molecular probes","volume":"209","author":"Wang","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jphs.2026.06.009_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/978-3-319-05161-1_3","article-title":"TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters)","volume":"223","author":"Shimizu","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jphs.2026.06.009_bib10","article-title":"Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism","volume":"15","author":"Li","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jphs.2026.06.009_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.08.065","article-title":"Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy","volume":"152","author":"Zhou","year":"2022","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.jphs.2026.06.009_bib12","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1158\/0008-5472.CAN-17-2061","article-title":"The NCX1\/TRPC6 complex mediates TGF\u03b2-Driven migration and invasion of human hepatocellular carcinoma cells","volume":"78","author":"Xu","year":"2018","journal-title":"Cancer Res"},{"issue":"Pt A","key":"10.1016\/j.jphs.2026.06.009_bib13","article-title":"Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36\/TRPC6\/NFAT2 signaling in type 2 diabetes mellitus mice","volume":"302","author":"Han","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jphs.2026.06.009_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2026.109072","article-title":"Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis","volume":"276","author":"Fan","year":"2026","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.jphs.2026.06.009_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40170-023-00305-3","article-title":"Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for glycogen storage disease type Ia","volume":"11","author":"Rutten","year":"2023","journal-title":"Cancer Metabol"},{"issue":"43","key":"10.1016\/j.jphs.2026.06.009_bib16","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1038\/s41388-023-02831-2","article-title":"Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development","volume":"42","author":"Yu","year":"2023","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jphs.2026.06.009_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cell.2018.08.017","article-title":"Extracellular matrix remodeling regulates glucose metabolism through TXNIP destabilization","volume":"175","author":"Sullivan","year":"2018","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.jphs.2026.06.009_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2174\/1389450123666220303092324","article-title":"Overview on thioredoxin-interacting protein (TXNIP): a potential target for diabetes intervention","volume":"23","author":"Basnet","year":"2022","journal-title":"Curr Drug Targets"},{"issue":"3","key":"10.1016\/j.jphs.2026.06.009_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.64.3.16","article-title":"SIRT1 inhibits high glucose-induced TXNIP\/NLRP3 inflammasome activation and cataract formation","volume":"64","author":"Lian","year":"2023","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.jphs.2026.06.009_bib20","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1111\/jcmm.16254","article-title":"CircCAMSAP1 promotes hepatocellular carcinoma progression through miR-1294\/GRAMD1A pathway","volume":"25","author":"Luo","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jphs.2026.06.009_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104630","article-title":"Ginsenoside Rg1 and the control of inflammation implications for the therapy of type 2 diabetes: a review of scientific findings and call for further research","volume":"152","author":"Alolga","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jphs.2026.06.009_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1512184","article-title":"Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis","volume":"16","author":"Dan","year":"2025","journal-title":"Front Pharmacol"},{"issue":"20","key":"10.1016\/j.jphs.2026.06.009_bib23","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.7150\/thno.27425","article-title":"miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3","volume":"8","author":"Xu","year":"2018","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.jphs.2026.06.009_bib24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41581-024-00835-z","article-title":"Calcium signalling and transport in the kidney","volume":"20","author":"Staruschenko","year":"2024","journal-title":"Nat Rev Nephrol"},{"issue":"11","key":"10.1016\/j.jphs.2026.06.009_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/membranes13110878","article-title":"The effect of calcium ions on hIAPP channel activity: possible implications in T2DM","volume":"13","author":"Meleleo","year":"2023","journal-title":"Membranes"},{"issue":"4","key":"10.1016\/j.jphs.2026.06.009_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jgr.2021.08.001","article-title":"Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice","volume":"46","author":"Han","year":"2022","journal-title":"J Ginseng Res"},{"issue":"4","key":"10.1016\/j.jphs.2026.06.009_bib27","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1152\/physrev.00042.2022","article-title":"Physiology of intracellular calcium buffering","volume":"103","author":"Eisner","year":"2023","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.jphs.2026.06.009_bib28","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1038\/s41467-022-35242-0","article-title":"TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage","volume":"13","author":"Tang","year":"2022","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jphs.2026.06.009_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000965","article-title":"Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload","volume":"3","author":"Kapur","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"10.1016\/j.jphs.2026.06.009_bib30","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jphs.2026.06.009_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155894","article-title":"Knockout of Trpc6 attenuates T2DM-induced liver injury and inflammation by inhibiting CN-NFAT2-NLRP3 signalling in mice","volume":"269","author":"Liu","year":"2025","journal-title":"Pathol Res Pract"},{"issue":"5","key":"10.1016\/j.jphs.2026.06.009_bib32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12072-020-10071-9","article-title":"Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis","volume":"14","author":"Kumar","year":"2020","journal-title":"Hepatol Int"},{"issue":"3","key":"10.1016\/j.jphs.2026.06.009_bib33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jgr.2022.12.006","article-title":"Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice","volume":"47","author":"Dong","year":"2023","journal-title":"J Ginseng Res"},{"issue":"2","key":"10.1016\/j.jphs.2026.06.009_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12847","article-title":"Melatonin ameliorates myocardial infarction in Obese diabetic individuals: the possible involvement of macrophage apoptotic factors","volume":"74","author":"Maity","year":"2023","journal-title":"J Pineal Res"},{"issue":"4","key":"10.1016\/j.jphs.2026.06.009_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jphs.2026.06.009_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2021.104733","article-title":"TGF-\u03b21 signaling can worsen NAFLD with liver fibrosis backdrop","volume":"124","author":"Ahmed","year":"2022","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.jphs.2026.06.009_bib37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2021.10.002","article-title":"REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-\u03b2\/Smad signaling pathway","volume":"176","author":"Cho","year":"2021","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"10.1016\/j.jphs.2026.06.009_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jphs.2022.10.001","article-title":"Aronia melanocarpa polysaccharide ameliorates liver fibrosis through TGF-\u03b21-mediated the activation of PI3K\/AKT pathway and modulating gut microbiota","volume":"150","author":"Zhao","year":"2022","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jphs.2026.06.009_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.metabol.2017.01.033","article-title":"MondoA\/ChREBP: the usual suspects of transcriptional glucose sensing; implication in pathophysiology","volume":"70","author":"Richards","year":"2017","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.jphs.2026.06.009_bib40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41574-023-00809-4","article-title":"The role of ChREBP in carbohydrate sensing and NAFLD development","volume":"19","author":"R\u00e9gnier","year":"2023","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"10.1016\/j.jphs.2026.06.009_bib41","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","article-title":"TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target","volume":"55","author":"Choi","year":"2023","journal-title":"Exp Mol Med"},{"issue":"3","key":"10.1016\/j.jphs.2026.06.009_bib42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jphs.2025.08.003","article-title":"Protocatechuic aldehyde restrains NLRP3 inflammasome activation to alleviate inflammatory response in sepsis","volume":"159","author":"Li","year":"2025","journal-title":"J Pharmacol Sci"},{"issue":"35","key":"10.1016\/j.jphs.2026.06.009_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116505119","article-title":"Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome","volume":"119","author":"Park","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.jphs.2026.06.009_bib44","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41419-019-1761-4","article-title":"Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jphs.2026.06.009_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102554","article-title":"ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation","volume":"58","author":"Zhang","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jphs.2026.06.009_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153241","article-title":"Enhanced Keap1-Nrf2\/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1\/JNK and Txnip\/NLRP3 inflammasome activation","volume":"71","author":"Lv","year":"2020","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jphs.2026.06.009_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ptr.8034","article-title":"Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome-mediated Caspase-1\/GSDMD pyroptosis pathway","volume":"38","author":"Liu","year":"2024","journal-title":"Phytother Res"},{"issue":"11","key":"10.1016\/j.jphs.2026.06.009_bib48","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.celrep.2018.07.068","article-title":"FXR inhibits endoplasmic reticulum stress-induced NLRP3 inflammasome in hepatocytes and ameliorates liver injury","volume":"24","author":"Han","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jphs.2026.06.009_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2018.02.013","article-title":"Reactive oxygen species promote tubular injury in diabetic nephropathy: the role of the mitochondrial ros-txnip-nlrp3 biological axis","volume":"16","author":"Han","year":"2018","journal-title":"Redox Biol"},{"issue":"11","key":"10.1016\/j.jphs.2026.06.009_bib50","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1161\/01.RES.0000130525.37646.a7","article-title":"Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-Independent manner","volume":"94","author":"Zhang","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jphs.2026.06.009_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102340","article-title":"Electron transfer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis","volume":"53","author":"Xie","year":"2022","journal-title":"Redox Biol"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347861326000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:10:49Z","timestamp":1785906649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347861326000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1347861326000381"],"URL":"https:\/\/doi.org\/10.1016\/j.jphs.2026.06.009","relation":{},"ISSN":["1347-8613"],"issn-type":[{"value":"1347-8613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphs.2026.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Japanese Pharmacological Society.","name":"copyright","label":"Copyright"}]}}