{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:15:02Z","timestamp":1773868502406,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["IA 52242"],"award-info":[{"award-number":["IA 52242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K20363"],"award-info":[{"award-number":["23K20363"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiological Sciences"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jphyss.2025.100051","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:56:31Z","timestamp":1763693791000},"page":"100051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of aortic baroreceptors depresses the somato\u2013lumbar sympathetic reflex, reducing hindlimb muscle contractile force"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-852X","authenticated-orcid":false,"given":"Nobuhiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko H.","family":"Tomioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-1006","authenticated-orcid":false,"given":"Masamichi","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-9223","authenticated-orcid":false,"given":"Hiroshi","family":"Nishimune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-7162","authenticated-orcid":false,"given":"Harumi","family":"Hotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphyss.2025.100051_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.1932.sp002832","article-title":"Discharges in mammalian sympathetic nerves","volume":"74","author":"Adrian","year":"1932","journal-title":"J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/ajplegacy.1941.134.2.359","article-title":"An analysis of hypothalamic cardiovascular control","volume":"134","author":"Pitts","year":"1941","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1748-1716.1946.tb00343.x","article-title":"Efferent impulses in the splanchnic nerve","volume":"11","author":"Gernandt","year":"1946","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.jphyss.2025.100051_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2170\/jjphysiol.48.261","article-title":"Excitation of baroreceptors depresses A- and C-components of the somato-cardiac sympathetic reflex in anesthetized rats","volume":"48","author":"Li","year":"1998","journal-title":"Jpn J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12576-015-0387-2","article-title":"Differential contribution of aortic and carotid sinus baroreflexes to control of heart rate and renal sympathetic nerve activity","volume":"65","author":"Ishii","year":"2015","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.jphyss.2025.100051_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1113\/jphysiol.1971.sp009498","article-title":"The reflex nature of the pressor response to muscular exercise","volume":"215","author":"Coote","year":"1971","journal-title":"J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1972.sp009887","article-title":"Reflex cardiovascular and respiratory responses originating in exercising muscle","volume":"224","author":"McCloskey","year":"1972","journal-title":"J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0046598","article-title":"The impact of somatosensory input on autonomic functions","volume":"130","author":"Sato","year":"1997","journal-title":"Rev. Physiol. Biochem Pharm."},{"key":"10.1016\/j.jphyss.2025.100051_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF00588576","article-title":"Reflex activity of single sympathetic fibres to skeletal muscle produced by electrical stimulation of somatic and vago-depressor afferent nerves in the cat","volume":"332","author":"Koizumi","year":"1972","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.jphyss.2025.100051_bib10","first-page":"1","article-title":"Cardiovascular adjustments induced from the rostral cingulate gyrus with special reference to sympatho-inhibitory mechanisms","volume":"53","author":"L\u00f6fving","year":"1961","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.jphyss.2025.100051_bib11","first-page":"1","article-title":"Circulatory responses to stimulation of somatic afferents with special reference to depressor effects from muscle nerves","volume":"198","author":"Johansson","year":"1962","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.jphyss.2025.100051_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0165-1838(98)00144-1","article-title":"The effect of electro-acupuncture stimulation on the muscle blood flow of the hindlimb in anesthetized rats","volume":"75","author":"Noguchi","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.jphyss.2025.100051_bib13","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1073\/pnas.1524272113","article-title":"Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease","volume":"113","author":"Khan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jphyss.2025.100051_bib14","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3390\/ijms19071935","article-title":"Postnatal development and distribution of sympathetic innervation in mouse skeletal muscle","volume":"19","author":"Straka","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jphyss.2025.100051_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13195","article-title":"The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability","volume":"225","author":"Rodrigues","year":"2019","journal-title":"Acta Physiol. (Oxf. )"},{"key":"10.1016\/j.jphyss.2025.100051_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101305","article-title":"The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia","volume":"67","author":"Delbono","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.jphyss.2025.100051_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.626707","article-title":"Regulatory function of sympathetic innervation on the endo\/lysosomal trafficking of acetylcholine receptor","volume":"12","author":"Straka","year":"2021","journal-title":"Front Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10974-024-09665-9","article-title":"Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction","volume":"45","author":"Rudolf","year":"2024","journal-title":"J. Muscle Res Cell Motil."},{"key":"10.1016\/j.jphyss.2025.100051_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12776","article-title":"Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age-related morphological changes","volume":"17","author":"Snyder-Warwick","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.jphyss.2025.100051_bib20","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/WNR.0000000000002070","article-title":"Identification of adrenergic presynaptic and postsynaptic protein locations at neuromuscular junctions, their decrease during aging, and recovery by nicotinamide mononucleotide administration","volume":"35","author":"Takeno","year":"2024","journal-title":"Neuroreport"},{"key":"10.1016\/j.jphyss.2025.100051_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s12576-021-00799-w","article-title":"Maintenance of contractile force of the hind limb muscles by the somato-lumbar sympathetic reflexes","volume":"71","author":"Hotta","year":"2021","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.jphyss.2025.100051_bib22","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1038\/s41598-023-33821-9","article-title":"Sympathetic modulation of hindlimb muscle contractility is altered in aged rats","volume":"13","author":"Hotta","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jphyss.2025.100051_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nmeth.1857","article-title":"An artery-specific fluorescent dye for studying neurovascular coupling","volume":"9","author":"Shen","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jphyss.2025.100051_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fnins.2017.00473","article-title":"Impaired mitophagy plays a role in denervation of neuromuscular junctions in ALS mice","volume":"11","author":"Rogers","year":"2017","journal-title":"Front Neurosci."},{"key":"10.1016\/j.jphyss.2025.100051_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1013712","article-title":"Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy","volume":"16","author":"Arai","year":"2022","journal-title":"Front Neurosci."},{"key":"10.1016\/j.jphyss.2025.100051_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111131","article-title":"Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging","volume":"40","author":"Ito","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jphyss.2025.100051_bib27","doi-asserted-by":"crossref","first-page":"10101","DOI":"10.1523\/JNEUROSCI.0521-11.2011","article-title":"Molecular microdomains in a sensory terminal, the vestibular calyx ending","volume":"31","author":"Lysakowski","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jphyss.2025.100051_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/joa.13284","article-title":"Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart","volume":"238","author":"Shenton","year":"2021","journal-title":"J. Anat."},{"key":"10.1016\/j.jphyss.2025.100051_bib29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1152\/jappl.1987.63.2.834","article-title":"Effects of blood pressure on force production in cat and human muscle","volume":"63","author":"Hobbs","year":"1987","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.jphyss.2025.100051_bib30","first-page":"H920","article-title":"Inhibition of \u03b12-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle","volume":"266","author":"Thomas","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib31","first-page":"H2335","article-title":"Differential sympathetic outflow elicited by active muscle in rats","volume":"293","author":"Koba","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/01.HYP.30.3.693","article-title":"A descriptive and quantitative light and electron microscopy study of the aortic depressor nerve in normotensive rats","volume":"30","author":"Fazan","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.jphyss.2025.100051_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1098\/rspb.1981.0042","article-title":"Autonomic innervation of receptors and muscle fibres in cat skeletal muscle","volume":"212","author":"Barker","year":"1981","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jphyss.2025.100051_bib34","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1172\/JCI114916","article-title":"Arterial baroreflex buffering of sympathetic activation during exercise-induced elevations in arterial pressure","volume":"86","author":"Scherrer","year":"1990","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.jphyss.2025.100051_bib35","first-page":"H1841","article-title":"Interaction between carotid baroreflex and exercise pressor reflex depends on baroreceptor afferent input","volume":"274","author":"Potts","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.autneu.2008.03.009","article-title":"Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ","volume":"142","author":"Pickering","year":"2008","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.jphyss.2025.100051_bib37","first-page":"R1084","article-title":"Reticulospinal vasomotor neurons in the RVL mediate the somatosympathetic reflex","volume":"256","author":"Morrison","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib38","first-page":"R1464","article-title":"Role of ventrolateral medulla in reflex cardiovascular responses to activation of skin and muscle nerves","volume":"268","author":"Ruggeri","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0361-9230(92)90176-X","article-title":"Properties of ventrolateral medullary neurons that respond to muscular contraction","volume":"28","author":"Bauer","year":"1992","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.jphyss.2025.100051_bib40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0006-8993(99)02217-9","article-title":"Expression of c-Fos-like immunoreactivity in the feline brainstem in response to isometric muscle contraction and baroreceptor reflex changes in arterial pressure","volume":"852","author":"Williams","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.jphyss.2025.100051_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1440-1681.2002.03613.x","article-title":"Neural circuits controlling cardiorespiratory responses: baroreceptor and somatic afferents in the nucleus tractus solitarius","volume":"29","author":"Potts","year":"2002","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib42","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.neuroscience.2006.02.050","article-title":"Barosensory cells in the nucleus tractus solitarius receive convergent input from group III muscle afferents and central command","volume":"140","author":"Degtyarenko","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.jphyss.2025.100051_bib43","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00421-024-05451-0","article-title":"A century of exercise physiology: key concepts in neural control of the circulation","volume":"124","author":"Shoemaker","year":"2024","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/314164a0","article-title":"Firing patterns of motor units in normal rats","volume":"314","author":"Hennig","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.jphyss.2025.100051_bib45","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.3390\/ijms22094611","article-title":"Adrenoceptors modulate cholinergic synaptic transmission at the neuromuscular junction","volume":"22","author":"Bukharaeva","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jphyss.2025.100051_bib46","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1007\/s12035-024-03991-2","article-title":"\u03b22-Adrenergic regulation of the neuromuscular transmission and its lipid-dependent switch","volume":"61","author":"Gafurova","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jphyss.2025.100051_bib47","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0301-0082(00)00055-1","article-title":"Safety factor at the neuromuscular junction","volume":"64","author":"Wood","year":"2001","journal-title":"Prog. Neurobiol."}],"container-title":["The Journal of Physiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1880654625001155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1880654625001155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:08:52Z","timestamp":1773842932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1880654625001155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1880654625001155"],"URL":"https:\/\/doi.org\/10.1016\/j.jphyss.2025.100051","relation":{},"ISSN":["1880-6546"],"issn-type":[{"value":"1880-6546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of aortic baroreceptors depresses the somato\u2013lumbar sympathetic reflex, reducing hindlimb muscle contractile force","name":"articletitle","label":"Article Title"},{"value":"The Journal of Physiological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphyss.2025.100051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The Physiological Society of Japan.","name":"copyright","label":"Copyright"}],"article-number":"100051"}}