{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:46:23Z","timestamp":1793274383667,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020964","name":"Japan Science and Technology Agency Fusion Oriented REsearch for disruptive Science and Technology","doi-asserted-by":"publisher","award":["JPMJFR234G"],"award-info":[{"award-number":["JPMJFR234G"]}],"id":[{"id":"10.13039\/501100020964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012016","name":"Nipponham Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19617"],"award-info":[{"award-number":["22K19617"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27997"],"award-info":[{"award-number":["23K27997"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiological Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jphyss.2026.100097","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T14:54:58Z","timestamp":1788706498000},"page":"100097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Food allergy-induced anaphylaxis impairs adrenal adrenergic biosynthesis despite preserved vagal afferent\u2013adrenal sympathetic reflex function"],"prefix":"10.1016","volume":"76","author":[{"given":"Marina","family":"Khatun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishat","family":"Akther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-6571","authenticated-orcid":false,"given":"Sajjad","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakurako","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Shimane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanaka","family":"Tameike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0763-2965","authenticated-orcid":false,"given":"Kakeru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Tanida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-5807","authenticated-orcid":false,"given":"Yuta","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-7494","authenticated-orcid":false,"given":"Chikara","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jphyss.2026.100097_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.iac.2011.10.002","article-title":"Food-induced anaphylaxis","volume":"32","author":"Cianferoni","year":"2012","journal-title":"Immunology and Allergy Clinics of North America"},{"key":"10.1016\/j.jphyss.2026.100097_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157785","article-title":"Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond","volume":"22","author":"Nguyen","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.jphyss.2026.100097_bib3","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1136\/bmj.327.7427.1332","article-title":"Adrenaline in the treatment of anaphylaxis: what is the evidence?","volume":"327","author":"McLean-Tooke","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jphyss.2026.100097_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/cea.14565","article-title":"Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis","volume":"55","author":"Sim","year":"2025","journal-title":"Clinical experimental allergy journal British Society Allergy Clinical Immunology"},{"key":"10.1016\/j.jphyss.2026.100097_bib5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3949\/ccjm.57.5.481","article-title":"Adrenergic receptors: structure and function","volume":"57","author":"Graham","year":"1990","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"10.1016\/j.jphyss.2026.100097_bib6","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1111\/j.1365-2222.2004.02106.x","article-title":"Constant infusion of epinephrine, but not bolus treatment, improves haemodynamic recovery in anaphylactic shock in dogs","volume":"34","author":"Mink","year":"2004","journal-title":"Clinical & Experimental Allergy"},{"key":"10.1016\/j.jphyss.2026.100097_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/pr.56.3.1","article-title":"Catecholamine metabolism: a contemporary view with implications for physiology and medicine","volume":"56","author":"Eisenhofer","year":"2004","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.jphyss.2026.100097_bib8","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1152\/ajpregu.00054.2013","article-title":"C1 neurons: the body's EMTs","volume":"305","author":"Guyenet","year":"2013","journal-title":"American journal of physiology. Regulatory, integrative and comparative physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbi.2023.04.003","article-title":"Repeated activation of C1 neurons in medulla oblongata decreases anti-inflammatory effect via the hypofunction of the adrenal gland adrenergic response","volume":"111","author":"Abe","year":"2023","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.jphyss.2026.100097_bib10","doi-asserted-by":"crossref","DOI":"10.1113\/JP284319","article-title":"Hepatic glycogenolysis and hypometabolism induced by chemogenetic stimulation of C1 neurons","author":"Abe","year":"2023","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib11","article-title":"Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury","volume":"118","author":"Tanaka","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jphyss.2026.100097_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104810","article-title":"A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell\/tissue type-dependent action of sulforaphane","volume":"299","author":"Etoh","year":"2023","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jphyss.2026.100097_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1113\/EP086809","article-title":"Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata","volume":"103","author":"Tanida","year":"2018","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib14","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1111\/all.13790","article-title":"Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy","volume":"74","author":"Bosmans","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jphyss.2026.100097_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085888","article-title":"Anti-allergic role of cholinergic neuronal pathway via alpha7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model","volume":"9","author":"Yamamoto","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jphyss.2026.100097_bib16","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI83658","article-title":"Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through alpha7nAChR+ splenocytes","volume":"126","author":"Inoue","year":"2016","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jphyss.2026.100097_bib17","doi-asserted-by":"crossref","first-page":"R337","DOI":"10.1152\/ajpregu.00193.2018","article-title":"Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats","volume":"317","author":"Kuda","year":"2019","journal-title":"American journal of physiology. Regulatory, integrative and comparative physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4168\/aair.2018.10.1.52","article-title":"beta(2)-Adrenoceptor blockade deteriorates systemic anaphylaxis by enhancing hyperpermeability in anesthetized mice","volume":"10","author":"Yang","year":"2018","journal-title":"Allergy, Asthma & Immunology Research"},{"key":"10.1016\/j.jphyss.2026.100097_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/01902148.2013.768720","article-title":"Nitric oxide and beta(2)-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB\/c mice","volume":"39","author":"Shinomiya","year":"2013","journal-title":"Experimental Lung Research"},{"key":"10.1016\/j.jphyss.2026.100097_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1398-9995.1971.tb01304.x","article-title":"The effect of adrenalectomy on protease sensitivity and anaphylactic protease production in the rat","volume":"26","author":"Muszbek","year":"1971","journal-title":"Acta Allergologica"},{"key":"10.1016\/j.jphyss.2026.100097_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0021-8707(51)90032-9","article-title":"The effect of adrenalectomy on experimental hypersensitiveness","volume":"22","author":"Criep","year":"1951","journal-title":"The Journal of Allergy"},{"key":"10.1016\/j.jphyss.2026.100097_bib22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4049\/jimmunol.70.3.199","article-title":"Anaphylactic reactions and concentrations of antibody in rats and rabbits; effect of adrenalectomy and of administration of cortisone","volume":"70","author":"Dews","year":"1953","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.jphyss.2026.100097_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2826.2003.00859.x","article-title":"Metyrapone-induced glucocorticoid depletion modulates tyrosine hydroxylase and phenylethanolamine N-methyltransferase gene expression in the rat adrenal gland by a noncholinergic transsynaptic activation","volume":"15","author":"Laborie","year":"2003","journal-title":"The Journal of Neuroendocrinology"},{"key":"10.1016\/j.jphyss.2026.100097_bib24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1196\/annals.1296.046","article-title":"Molecular regulation of gene expression of catecholamine biosynthetic enzymes by stress: sympathetic ganglia versus adrenal medulla","volume":"1018","author":"Sabban","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jphyss.2026.100097_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1196\/annals.1296.045","article-title":"Quantitative evaluation of catecholamine enzymes gene expression in adrenal medulla and sympathetic Ganglia of stressed rats","volume":"1018","author":"Kvetnansky","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jphyss.2026.100097_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1749-6632.1995.tb44692.x","article-title":"Molecular biology of stress-elicited induction of catecholamine biosynthetic enzymes","volume":"771","author":"Sabban","year":"1995","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jphyss.2026.100097_bib27","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/j.1365-2222.2004.02114.x","article-title":"Expression of tyrosine hydroxylase and neuropeptide tyrosine in mouse sympathetic airway-specific neurons under normal situation and allergic airway inflammation","volume":"34","author":"Dinh","year":"2004","journal-title":"Clinical experimental allergy journal British Society Allergy Clinical Immunology"},{"key":"10.1016\/j.jphyss.2026.100097_bib28","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00109-021-02121-y","article-title":"HIF2alpha regulates the synthesis and release of epinephrine in the adrenal medulla","volume":"99","author":"Watts","year":"2021","journal-title":"Journal of Molecular Medicine"},{"key":"10.1016\/j.jphyss.2026.100097_bib29","doi-asserted-by":"crossref","first-page":"23774","DOI":"10.1074\/jbc.270.40.23774","article-title":"Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene","volume":"270","author":"Norris","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jphyss.2026.100097_bib30","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/ajplegacy.1970.218.4.995","article-title":"Biphasic effect of hypoxia on adrenal catecholamine content","volume":"218","author":"Steinsland","year":"1970","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fphys.2017.00669","article-title":"Mouse Anaphylactic hypotension is characterized by initial baroreflex independent renal sympathoinhibition followed by sustained renal sympathoexcitation","volume":"8","author":"Zhang","year":"2017","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/j.jphyss.2026.100097_bib32","first-page":"513","article-title":"Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses","volume":"109","author":"Yeates","year":"2001","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.jphyss.2026.100097_bib33","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41586-022-04760-8","article-title":"Molecularly defined circuits for cardiovascular and cardiopulmonary control","volume":"606","author":"Veerakumar","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jphyss.2026.100097_bib34","first-page":"362","article-title":"The effect of urethane on pituitary-adrenal function of female rats","volume":"106","author":"Hamstra","year":"1984","journal-title":"Acta Endocrinologica"}],"container-title":["The Journal of Physiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1880654626000430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1880654626000430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:00:03Z","timestamp":1793271603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1880654626000430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1880654626000430"],"URL":"https:\/\/doi.org\/10.1016\/j.jphyss.2026.100097","relation":{},"ISSN":["1880-6546"],"issn-type":[{"value":"1880-6546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Food allergy-induced anaphylaxis impairs adrenal adrenergic biosynthesis despite preserved vagal afferent\u2013adrenal sympathetic reflex function","name":"articletitle","label":"Article Title"},{"value":"The Journal of Physiological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jphyss.2026.100097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The Physiological Society of Japan.","name":"copyright","label":"Copyright"}],"article-number":"100097"}}