{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:09:41Z","timestamp":1793740181808,"version":"4.6.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pathology Informatics"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.jpi.2022.100094","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T17:22:38Z","timestamp":1651425758000},"page":"100094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach"],"prefix":"10.1016","volume":"13","author":[{"given":"Jihad","family":"Aljabban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent J.","family":"Borkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Nemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Hashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Aljabban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Boateng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mukhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexter","family":"Hadley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Panahiazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10080","key":"10.1016\/j.jpi.2022.100094_bb0005","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jpi.2022.100094_bb0010","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","author":"Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpi.2022.100094_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.mayocp.2017.04.010","article-title":"Crohn disease: epidemiology, diagnosis, and management","author":"Feuerstein","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jpi.2022.100094_bb0020","doi-asserted-by":"crossref","DOI":"10.1586\/14737159.8.2.199","article-title":"Classification of genetic profiles of Crohn\u2019s disease: a focus on the ATG16L1 gene","author":"Grant","year":"2008","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.jpi.2022.100094_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/S1873-9954(10)70033-1","article-title":"S06 genetic factors conferring an increased susceptibility to develop Crohn\u2019s disease also influence disease phenotype, but are not useful to predict it. Results from the IBDchip European Project","author":"Sans","year":"2010","journal-title":"J Crohn\u2019s Colitis Suppl"},{"key":"10.1016\/j.jpi.2022.100094_bb0030","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpi.2022.100094_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2009.06.005","article-title":"Role of Nod2 in the development of Crohn\u2019s disease","author":"Yamamoto","year":"2009","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jpi.2022.100094_bb0040","doi-asserted-by":"crossref","DOI":"10.12703\/P7-44","article-title":"Pathogenesis of Crohn\u2019s disease","author":"Boyapati","year":"2015","journal-title":"F1000Prime Rep"},{"key":"10.1016\/j.jpi.2022.100094_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jpi.2022.100094_bb0050","doi-asserted-by":"crossref","DOI":"10.1136\/gut.53.1.1","article-title":"Dysbiosis in inflammatory bowel disease","author":"Tamboli","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jpi.2022.100094_bb0055","doi-asserted-by":"crossref","DOI":"10.14309\/crj.2018.56","article-title":"Rapid onset of inflammatory bowel disease after receiving secukinumab infusion","author":"Wang","year":"2018","journal-title":"ACG Case Reports J"},{"key":"10.1016\/j.jpi.2022.100094_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.01.027","article-title":"Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease","author":"Verstockt","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jpi.2022.100094_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.suc.2019.08.001","article-title":"Inflammatory bowel disease presentation and diagnosis","author":"Flynn","year":"2019","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.jpi.2022.100094_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpg.2003.12.008","article-title":"NOD2\/CARD15: Relevance in clinical practice","author":"Vermeire","year":"2004","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jpi.2022.100094_bb0075","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-015-0262-x","article-title":"The clinical characteristics of patients with free perforation in Korean Crohn\u2019s disease: results from the CONNECT study","author":"Doh","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jpi.2022.100094_bb0080","doi-asserted-by":"crossref","DOI":"10.14309\/00000434-201710001-00716","article-title":"Complications of Crohn\u02bcs disease and ulcerative colitis: understanding the lifetime risks","author":"Lichtenstein","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jpi.2022.100094_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jpi.2022.100094_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.125","article-title":"Precision annotation of digital samples in NCBI\u2019s gene expression omnibus","volume":"4","author":"Hadley","year":"2017","journal-title":"Sci Data"},{"key":"10.1016\/j.jpi.2022.100094_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/gut.2005.081950b","article-title":"European evidence based consensus on the diagnosis and management of Crohn\u2019s disease: current management","author":"Travis","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jpi.2022.100094_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/ibd.21208","article-title":"NOD2 status and human ileal gene expression","author":"Hamm","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0105","doi-asserted-by":"crossref","DOI":"10.1002\/ibd.20110","article-title":"Genome-wide gene expression differences in Crohn\u2019s disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis","author":"Wu","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0110","doi-asserted-by":"crossref","DOI":"10.1097\/MIB.0000000000001246","article-title":"Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease","author":"Vancamelbeke","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0115","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpi.2022.100094_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.0000055542.47474.A1","article-title":"Atherosclerosis and inflammatory bowel disease: sharing a common pathogenic pathway?","author":"Danese","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jpi.2022.100094_bb0125","doi-asserted-by":"crossref","DOI":"10.1096\/fj.02-1104fje","article-title":"Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense","author":"Geiszt","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jpi.2022.100094_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/science.1127119","article-title":"Symbiotic bacteria direct expression of an intestinal bactericidal lectin","author":"Cash","year":"2006","journal-title":"Science (80- )"},{"key":"10.1016\/j.jpi.2022.100094_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIII\u03b3 promotes the spatial segregation of microbiota and host in the intestine","author":"Vaishnava","year":"2011","journal-title":"Science (80- )"},{"key":"10.1016\/j.jpi.2022.100094_bb0140","doi-asserted-by":"crossref","DOI":"10.1007\/s00441-013-1592-z","article-title":"REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation","author":"Van Beelen","year":"2013","journal-title":"Cell Tissue Res"},{"issue":"10","key":"10.1016\/j.jpi.2022.100094_bb0145","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0022-2275(20)32205-7","article-title":"Role of ABCG1 and other ABCG family members in lipid metabolism","volume":"42","author":"Schmitz","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jpi.2022.100094_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.1093131","article-title":"Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption","author":"Altmann","year":"2004","journal-title":"Science (80- )"},{"key":"10.1016\/j.jpi.2022.100094_bb0155","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88634","article-title":"FOLH1\/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities","author":"Rais","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jpi.2022.100094_bb0160","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M111.229518","article-title":"SLC6A14 (ATB 0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer","author":"Karunakaran","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpi.2022.100094_bb0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0914904107","article-title":"Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates","author":"Cole","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpi.2022.100094_bb0170","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M116.723973","article-title":"Epithelial cholesterol deficiency attenuates human antigen R-linked pro-inflammatory stimulation via an SREBP2-linked circuit","author":"Park","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpi.2022.100094_bb0175","doi-asserted-by":"crossref","DOI":"10.1097\/MIB.0000000000000515","article-title":"Lipocalin-2 is a disease activity marker in inflammatory bowel disease regulated by IL-17A, IL-22, and TNF-\u03b1 and modulated by IL23R genotype status","author":"Stallhofer","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030261","article-title":"A direct effect of sex hormones on epithelial barrier function in inflammatory bowel disease models","author":"van der Giessen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jpi.2022.100094_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06137-w","article-title":"LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival","author":"Bayrer","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpi.2022.100094_bb0190","series-title":"Handbook of Glycosyltransferases and Related Genes","article-title":"GPI mannose extension (PIGM, PIGV, PIGB, PIGZ)","author":"Kinoshita","year":"2014"},{"key":"10.1016\/j.jpi.2022.100094_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/729172","article-title":"Evidence for a potential role of metallothioneins in inflammatory bowel diseases","author":"Waeytens","year":"2009","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jpi.2022.100094_bb0200","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-015-1732-2","article-title":"The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function","author":"Cuajungco","year":"2016","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1016\/j.jpi.2022.100094_bb0205","doi-asserted-by":"crossref","DOI":"10.2217\/bmm.16.9","article-title":"TNFAIP6 is a potential biomarker of disease activity in inflammatory bowel disease","author":"Yu","year":"2016","journal-title":"Biomark Med"},{"key":"10.1016\/j.jpi.2022.100094_bb0210","article-title":"Exploring the biological function of carboxypeptidase O: analysis of expression and association with chylomicrons and lipid droplets","author":"Nowotny","year":"2020","journal-title":"Digit Commons Andrew Univ"},{"key":"10.1016\/j.jpi.2022.100094_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102347","article-title":"Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice","author":"B\u00e4r","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpi.2022.100094_bb0220","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.061455898","article-title":"Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein","author":"Folli","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpi.2022.100094_bb0225","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.M005363","article-title":"Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride\/fatty acid cycle and development of insulin resistance in mice","author":"Millward","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jpi.2022.100094_bb0230","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.R109.025544","article-title":"Glucose-6-phosphatase catalytic subunit gene family","author":"Hutton","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpi.2022.100094_bb0235","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-003-1192-y","article-title":"The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins","author":"Hediger","year":"2004","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1016\/j.jpi.2022.100094_bb0240","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases","author":"Hayes","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpi.2022.100094_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021199","article-title":"Role of meprins to protect ileal mucosa of Crohn\u2019s disease patients from colonization by adherent-invasive E. coli","author":"Vazeille","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jpi.2022.100094_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/S0300-5089(21)00448-X","article-title":"Studies of family history among patients with inflammatory bowel disease","volume":"9","author":"Farmer","year":"1980","journal-title":"Clin Gastroenterol"},{"key":"10.1016\/j.jpi.2022.100094_bb0255","doi-asserted-by":"crossref","DOI":"10.2183\/pjab.92.423","article-title":"Maintenance of gut homeostasis by the mucosal immune system","author":"Okumura","year":"2016","journal-title":"Proc Japan Acad Ser B Phys Biol Sci"},{"key":"10.1016\/j.jpi.2022.100094_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jpi.2022.100094_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141710","article-title":"Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells","author":"Skovdahl","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jpi.2022.100094_bb0270","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2172-10-54","article-title":"Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria","volume":"10","author":"Sibartie","year":"2009","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jpi.2022.100094_bb0275","article-title":"Modulation of the CCR6-CCl20 axis: a potential therapeutic target in inflammation and cancer","volume":"54","author":"Ranasinghe","year":"2018","journal-title":"Med"},{"key":"10.1016\/j.jpi.2022.100094_bb0280","doi-asserted-by":"crossref","DOI":"10.1097\/MIB.0000000000000035","article-title":"Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease","author":"\u00d8stvik","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0285","doi-asserted-by":"crossref","DOI":"10.1172\/JCI75436","article-title":"Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature","author":"Haberman","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpi.2022.100094_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03766-z","article-title":"Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies","author":"Boyd","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpi.2022.100094_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2021.02.003","article-title":"Lactobacillus acidophilus induces a strain-specific and toll-like receptor 2\u2013dependent enhancement of intestinal epithelial tight junction barrier and protection against intestinal inflammation","volume":"191","author":"Al-Sadi","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpi.2022.100094_bb0300","doi-asserted-by":"crossref","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bite acids","author":"Makishima","year":"1999","journal-title":"Science (80- )"},{"key":"10.1016\/j.jpi.2022.100094_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/S1097-2765(00)00050-2","article-title":"Molecular basis for feedback regulation of bile acid synthesis by nuclear receptos","author":"Lu","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.jpi.2022.100094_bb0310","article-title":"Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn\u2019s disease","author":"Wilson","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpi.2022.100094_bb0315","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.0803978","article-title":"The bile acid receptor FXR is a modulator of intestinal innate immunity","author":"Vavassori","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jpi.2022.100094_bb0320","doi-asserted-by":"crossref","DOI":"10.1136\/gut.2010.212159","article-title":"Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease","author":"Gadaleta","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jpi.2022.100094_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01070","article-title":"Nuclear receptors regulate intestinal inflammation in the context of IBD","author":"Klepsch","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpi.2022.100094_bb0330","doi-asserted-by":"crossref","DOI":"10.1007\/s00011-007-6177-4","article-title":"Disease modifying effect of statins in dextran sulfate sodium model of mouse colitis","volume":"57","author":"Kanagarajan","year":"2008","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jpi.2022.100094_bb0335","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjaa235","article-title":"Association between statin use and inflammatory bowel diseases: results from a Swedish, nationwide, population-based case-control study","volume":"15","author":"Lochhead","year":"2021","journal-title":"J Crohn\u2019s Colitis"},{"key":"10.1016\/j.jpi.2022.100094_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173750","article-title":"Statin use and new-onset of inflammatory bowel disease: a systematic review and meta-analysis of over ten million participants","volume":"891","author":"Bhagavathula","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpi.2022.100094_bb0345","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2019.1629235","article-title":"Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner","author":"Stephens","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jpi.2022.100094_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082244","article-title":"Anti-TNF therapy in Crohn\u2019s disease","author":"Adegbola","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jpi.2022.100094_bb0355","doi-asserted-by":"crossref","DOI":"10.1136\/gut.32.12.1531","article-title":"High circulating concentrations of interleukin-6 in active Crohn\u2019s disease but not ulcerative colitis","author":"Mahida","year":"1991","journal-title":"Gut"},{"key":"10.1016\/j.jpi.2022.100094_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2018.04.008","article-title":"IL-8 antagonist, CXCL8(3-72)K11R\/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis","author":"Walana","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpi.2022.100094_bb0365","article-title":"Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences","author":"Cotton","year":"2016","journal-title":"Int J Interf Cytokine Mediat Res"},{"key":"10.1016\/j.jpi.2022.100094_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2009.08.003","article-title":"The role of chemokines in intestinal inflammation and cancer","author":"Wang","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jpi.2022.100094_bb0375","doi-asserted-by":"crossref","DOI":"10.1189\/jlb.0207118","article-title":"Crucial pathophysiological role of CXCR2 in experimental ulcerative colitis in mice","author":"Buanne","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jpi.2022.100094_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2019.01.005","article-title":"Potential roles and targeted therapy of the CXCLs\/CXCR2 axis in cancer and inflammatory diseases","author":"Cheng","year":"2019","journal-title":"Biochim Biophys Acta - Rev Cancer"},{"key":"10.1016\/j.jpi.2022.100094_bb0385","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2017.00096","article-title":"Factors promoting development of fibrosis in crohn\u2019s disease","author":"Rogler","year":"2017","journal-title":"Front Med"},{"key":"10.1016\/j.jpi.2022.100094_bb0390","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/964131","article-title":"Matrix metalloproteinases in inflammatory bowel disease: an update","author":"O\u2019Sullivan","year":"2015","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jpi.2022.100094_bb0395","doi-asserted-by":"crossref","DOI":"10.1007\/s00441-012-1390-z","article-title":"Proteases and the gut barrier","author":"Biancheri","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jpi.2022.100094_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(99)70339-2","article-title":"Matrix metalloproteinase levels are elevated in inflammatory bowel disease","author":"Baugh","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpi.2022.100094_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.dld.2007.05.010","article-title":"Increased mucosal matrix metalloproteinase-1, \u22122, \u22123 and \u22129 activity in patients with inflammatory bowel disease and the relation with Crohn\u2019s disease phenotype","author":"Meijer","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jpi.2022.100094_bb0410","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2004.04.019","article-title":"Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes","author":"Langmann","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpi.2022.100094_bb0415","article-title":"Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight","author":"Lee","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.jpi.2022.100094_bb0420","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00077.2018","article-title":"Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease","author":"Rankin","year":"2018","journal-title":"Am J Physiol - Gastrointest Liver Physiol"},{"key":"10.1016\/j.jpi.2022.100094_bb0425","article-title":"Overview of biologic therapy for Crohn\u2019s disease","volume":"9","author":"Dryden","year":"2009","journal-title":"Expert Opin Biol Ther"}],"container-title":["Journal of Pathology Informatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2153353922006605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2153353922006605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:48:01Z","timestamp":1761871681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2153353922006605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":85,"alternative-id":["S2153353922006605"],"URL":"https:\/\/doi.org\/10.1016\/j.jpi.2022.100094","relation":{},"ISSN":["2153-3539"],"issn-type":[{"value":"2153-3539","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Pathology Informatics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpi.2022.100094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Association for Pathology Informatics. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100094"}}