{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:56:43Z","timestamp":1789808203755,"version":"4.0.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pathology Informatics"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.jpi.2023.100300","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T20:38:16Z","timestamp":1676493496000},"page":"100300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Improving Lyme disease testing with data driven test design in pediatrics"],"prefix":"10.1016","volume":"14","author":[{"given":"Mahmoud","family":"Elkhadrawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lopez-Nunez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Akcakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jpi.2023.100300_bb0005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/jme\/tjv037","article-title":"Prevalence rates of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and Babesia microti (Piroplasmida: Babesiidae) in host-seeking Ixodes scapularis (Acari: Ixodidae) from Pennsylvania","volume":"52","author":"Hutchinson","year":"2015","journal-title":"J Med Entomol."},{"issue":"6","key":"10.1016\/j.jpi.2023.100300_bb0010","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jme\/tjv132","article-title":"Seasonal activity, density, and collection efficiency of the blacklegged tick (Ixodes scapularis) (Acari: Ixodidae) in mid-western Pennsylvania","volume":"52","author":"Simmons","year":"2015","journal-title":"J Med Entomol."},{"issue":"3","key":"10.1016\/j.jpi.2023.100300_bb0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/cid\/ciy510","article-title":"Insights from the geographic spread of the Lyme disease epidemic","volume":"68","author":"Eddens","year":"2018","journal-title":"Clin Infect Dis."},{"issue":"1","key":"10.1016\/j.jpi.2023.100300_bb0020","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciaa1215","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 guidelines for the prevention, diagnosis and treatment of Lyme disease","volume":"72","author":"Lantos","year":"2020","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.jpi.2023.100300_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaut.2016.02.005","article-title":"Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis","volume":"69","author":"Crowley","year":"2016","journal-title":"J Autoimmun."},{"issue":"11","key":"10.1016\/j.jpi.2023.100300_bb0030","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/infdis\/jiv310","article-title":"A highly expressed human protein, apolipoprotein B-100, serves as an autoantigen in a subgroup of patients with Lyme disease","volume":"212","author":"Crowley","year":"2015","journal-title":"J Infect Dis."},{"issue":"2","key":"10.1016\/j.jpi.2023.100300_bb0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.clim.2015.07.005","article-title":"Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis","volume":"160","author":"Pianta","year":"2015","journal-title":"Clin Immunol."},{"issue":"7","key":"10.1016\/j.jpi.2023.100300_bb0040","doi-asserted-by":"crossref","first-page":"cix002","DOI":"10.1093\/cid\/cix002","article-title":"T H 17 cytokine responses in Lyme disease correlate with Borrelia burgdorferi antibodies during early infection in patients with erythema migrans and with autoantibodies late in the illness in patients with antibiotic-refractory Lyme arthritis","volume":"64","author":"Strle","year":"2017","journal-title":"Clin Infect Dis."},{"issue":"11","key":"10.1016\/j.jpi.2023.100300_bb0045","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/art.40566","article-title":"Correlation of Lyme disease\u2013associated IgG4 autoantibodies with synovial pathology in antibiotic-refractory Lyme arthritis","volume":"70","author":"Sulka","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.jpi.2023.100300_bb0050","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/ajcp\/aqac080","article-title":"Molecular testing for diagnosis of early Lyme disease","volume":"158","author":"Theel","year":"2022","journal-title":"Am J Clin Pathol."},{"issue":"5","key":"10.1016\/j.jpi.2023.100300_bb0055","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1128\/JCM.03394-15","article-title":"The past, present, and (possible) future of serologic testing for Lyme disease","volume":"54","author":"Theel","year":"2016","journal-title":"J Clin Microbiol."},{"key":"10.1016\/j.jpi.2023.100300_bb0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clinbiochem.2021.02.005","article-title":"Pediatric decision limits for serologic screening of Lyme disease","volume":"91","author":"Lopez-Nunez","year":"2021","journal-title":"Clin Biochem."},{"issue":"4","key":"10.1016\/j.jpi.2023.100300_bb0065","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/153036603322662200","article-title":"Diagnosis of Lyme borreliosis in Europe","volume":"3","author":"Wilske","year":"2003","journal-title":"Vector-borne Zoonot."},{"key":"10.1016\/j.jpi.2023.100300_bb0070","first-page":"1","article-title":"A comparative evaluation of sequential feature selection algorithms","volume":"R0","author":"Aha","year":"1995","journal-title":"Proc Mach Learn Res."},{"issue":"8","key":"10.1016\/j.jpi.2023.100300_bb0075","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/cid\/cix043","article-title":"Evaluation of modified 2-tiered serodiagnostic testing algorithms for early Lyme disease","volume":"64","author":"Branda","year":"2017","journal-title":"Clin Infect Dis."},{"issue":"7","key":"10.1016\/j.jpi.2023.100300_bb0080","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/cid\/cix943","article-title":"Advances in serodiagnostic testing for Lyme disease are at hand","volume":"66","author":"Branda","year":"2017","journal-title":"Clin Infect Dis."}],"container-title":["Journal of Pathology Informatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2153353923001141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2153353923001141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:44:35Z","timestamp":1761871475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2153353923001141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":16,"alternative-id":["S2153353923001141"],"URL":"https:\/\/doi.org\/10.1016\/j.jpi.2023.100300","relation":{},"ISSN":["2153-3539"],"issn-type":[{"value":"2153-3539","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving Lyme disease testing with data driven test design in pediatrics","name":"articletitle","label":"Article Title"},{"value":"Journal of Pathology Informatics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpi.2023.100300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of Association for Pathology Informatics.","name":"copyright","label":"Copyright"}],"article-number":"100300"}}