{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:28:37Z","timestamp":1791581317436,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31360340"],"award-info":[{"award-number":["31360340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360617"],"award-info":[{"award-number":["81360617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Training Program in Yunnan Province","award":["KKSY201326062"],"award-info":[{"award-number":["KKSY201326062"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plant Physiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jplph.2016.01.017","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T03:25:29Z","timestamp":1456975529000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Nitrate reductase-mediated NO production enhances Cd accumulation in Panax notoginseng roots by affecting root cell wall properties"],"prefix":"10.1016","volume":"193","author":[{"given":"Qi","family":"Kan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zed","family":"Rengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuming","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jplph.2016.01.017_bib0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ecoenv.2013.04.013","article-title":"Exogenous treatment with indole-3-acetic acid and salicylic acid alleviates cadmium toxicity in wheat seedlings","volume":"94","author":"Agami","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jplph.2016.01.017_bib0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.0960-7412.2001.01200.x","article-title":"Divalent cations and polyamines bind to loop 8 of 14-3-3 proteins, modulating their interaction with phosphorylated nitrate reductase","volume":"29","author":"Athwal","year":"2002","journal-title":"Plant J."},{"key":"10.1016\/j.jplph.2016.01.017_bib0015","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/oxfordjournals.pcp.a029303","article-title":"Biological significance of divalent metal ion binding to 14-3-3 proteins in relationship to nitrate reductase inactivation","volume":"39","author":"Athwal","year":"1998","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00037585","article-title":"An improved method for monitoring cell death in cell suspension and leaf disc assays using Evans blue","volume":"39","author":"Baker","year":"1994","journal-title":"Plant Cell Tissue Organ"},{"key":"10.1016\/j.jplph.2016.01.017_bib0025","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1104\/pp.108.133348","article-title":"Nitric oxide contributes to cadmium toxicity in Arabidopsis by promoting cadmium accumulation in roots and by up-regulating genes related to iron uptake","volume":"149","author":"Besson-Bard","year":"2009","journal-title":"Plant Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0003-2697(73)90163-2","article-title":"An improved method for the assay of hydroxylysine","volume":"56","author":"Blumenkrantz","year":"1973","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0035","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/pcp\/pcv038","article-title":"Phosphorylation and interaction with the 14-3-3 protein of the plasma membrane H+-ATPase are involved in the regulation of magnesium-mediated increases in aluminum-induced citrate exudation in broad bean (Vicia faba L)","volume":"56","author":"Chen","year":"2015","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0040","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/07352689.2014.903747","article-title":"Cellular mechanisms in higher plants governing tolerance to cadmium toxicity","volume":"33","author":"Choppala","year":"2014","journal-title":"Crit. Rev. Plant Sci."},{"key":"10.1016\/j.jplph.2016.01.017_bib0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0981-9428(99)80028-X","article-title":"Photosynthetic activities of Pisum sativum seedlings grown in presence of cadmium","volume":"37","author":"Chugh","year":"1999","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/jxb\/erj050","article-title":"Mechanisms for nitric oxide synthesis in plants","volume":"57","author":"Crawford","year":"2006","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0098-8472(98)00058-6","article-title":"Response to cadmium in higher plants","volume":"41","author":"Di Toppi","year":"1999","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0060","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1104\/pp.117.1.293","article-title":"Overexpression of nitrate reductase in tobacco delays drought-induced decreases in nitrate reductase activity and mRNA","volume":"117","author":"Ferrario-Mery","year":"1998","journal-title":"Plant Physiol."},{"issue":"3","key":"10.1016\/j.jplph.2016.01.017_bib0065","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1104\/pp.107.106518","article-title":"Extracellular ATP induces nitric oxide production in tomato cell suspensions","volume":"145","author":"Foresi","year":"2007","journal-title":"Plant Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1104\/pp.117.1.283","article-title":"Drought-induced effects on nitrate reductase activity and mRNA and on the coordination of nitrogen and carbon metabolism in maize leaves","volume":"117","author":"Foyer","year":"1998","journal-title":"Plant Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0075","first-page":"659","article-title":"Special topics: nitric oxide","volume":"57","author":"Furchgott","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(02)02807-7","article-title":"Short-time non-enzymatic nitric oxide synthesis from l-arginine and hydrogen peroxide induced by shock waves treatment","volume":"520","author":"Gotte","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jplph.2016.01.017_bib0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.0021-8782.2001.00008.x","article-title":"Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability","volume":"200","author":"Hamer","year":"2002","journal-title":"J. Anat."},{"key":"10.1016\/j.jplph.2016.01.017_bib0090","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ecoenv.2014.05.021","article-title":"Protective roles of nitric oxide on seed germination and seedling growth of rice (Oryza sativa L.) under cadmium stress","volume":"108","author":"He","year":"2014","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.jplph.2016.01.017_bib0095","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/jexbot\/52.363.1981","article-title":"Post-translational regulation of nitrate reductase: mechanism, physiological relevance and environmental triggers","volume":"52","author":"Kaiser","year":"2001","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/jexbot\/53.370.875","article-title":"Modulation of nitrate reductase: some new insights, an unusual case and a potentially important side reaction","volume":"53","author":"Kaiser","year":"2002","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0105","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.plaphy.2003.09.003","article-title":"Nitric oxide stimulates seed germination and counteracts the inhibitory effect of heavy metals and salinity on root growth of Lupinus luteus","volume":"41","author":"Kopyra","year":"2003","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.plantsci.2005.02.007","article-title":"Nitric oxide protects sunflower leaves against Cd-induced oxidative stress","volume":"165","author":"Laspina","year":"2005","journal-title":"Plant Sci."},{"key":"10.1016\/j.jplph.2016.01.017_bib0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/01904169609365140","article-title":"Analysis of intercellular cadmium forms in roots and leaves of bush bean","volume":"19","author":"Leita","year":"1996","journal-title":"J. Plant Nutr."},{"issue":"4","key":"10.1016\/j.jplph.2016.01.017_bib0120","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1007\/s11033-011-1215-2","article-title":"Molecular characterization of a cucumber nitrate reductase (CsNR) gene under NO3\u2212 stress","volume":"39","author":"Li","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jplph.2016.01.017_bib0125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/pcp\/pcm020","article-title":"Glucose-6-phosphate dehydrogenase plays a pivotal role in nitric oxide-involved defense against oxidative stress under salt stress in red kidney bean roots","volume":"48","author":"Liu","year":"2007","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0130","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.plaphy.2010.09.001","article-title":"Nitric oxide synthase like activity-dependent nitric oxide production protects against chilling-induced oxidative damage in Chorispora bungeana suspension cultured cells","volume":"48","author":"Liu","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0135","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/jexbot\/53.372.1237","article-title":"Hydrogen peroxide and nitric oxide as signalling molecules in plants","volume":"53","author":"Neill","year":"2002","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1469-8137.2003.00804.x","article-title":"Nitric oxide signalling in plants","volume":"159","author":"Neill","year":"2003","journal-title":"New Phytol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02371025","article-title":"The role of the root cell wall in heavy metal tolerance of Athyrium yokosense","volume":"101","author":"Nishizono","year":"1987","journal-title":"Plant Soil"},{"issue":"4","key":"10.1016\/j.jplph.2016.01.017_bib0150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-313X.2002.01442.x","article-title":"Heavy metal toxicity: cadmium permeates through calcium channels and disturbs the plant water status","volume":"32","author":"Perfus-Barbeoch","year":"2002","journal-title":"Plant J."},{"key":"10.1016\/j.jplph.2016.01.017_bib0155","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1744-7909.2008.00759.x","article-title":"Nitric oxide signaling in plant responses to abiotic stresses","volume":"50","author":"Qiao","year":"2008","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0160","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1071\/CP15284","article-title":"Magnesium alleviates plant toxicity of aluminium and heavy metals","volume":"66","author":"Rengel","year":"2015","journal-title":"Crop Pasture Sci."},{"issue":"10","key":"10.1016\/j.jplph.2016.01.017_bib0165","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jipb.12312","article-title":"Glucose alleviates cadmium toxicity by increasing cadmium fixation in root cell wall and sequestration into vacuole in Arabidopsis","volume":"57","author":"Shi","year":"2014","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0170","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.envexpbot.2013.10.001","article-title":"Effects of iron deficiency on subcellular distribution and chemical forms of cadmium in peanut roots in relation to its translocation","volume":"97","author":"Su","year":"2014","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0175","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/nph.12597","article-title":"Nitrate reductase-mediated early nitric oxide burst alleviates oxidative damage induced by aluminum through enhancement of antioxidant defenses in roots of wheat (Triticum aestivum)","volume":"201","author":"Sun","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0180","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0065-2113(08)60593-3","article-title":"Accumulation of cadmium in crop plants and its consequences to human health","volume":"51","author":"Wagner","year":"1993","journal-title":"Adv. Agron."},{"key":"10.1016\/j.jplph.2016.01.017_bib0185","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.envexpbot.2007.10.014","article-title":"Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud","volume":"62","author":"Wang","year":"2008","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.plantsci.2010.05.014","article-title":"Nitrate reductase-dependent nitric oxide production is involved in aluminum tolerance in red kidney bean roots","volume":"179","author":"Wang","year":"2010","journal-title":"Plant Sci."},{"key":"10.1016\/j.jplph.2016.01.017_bib0195","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.plaphy.2003.06.001","article-title":"Model studies on the role of citrate: malate and pectin esterification on the enzymatic degradation of Al- and Ca-pectate gels: possible implications for Al-tolerance","volume":"41","author":"Wehr","year":"2003","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/abio.1996.0206","article-title":"A continuous fluorometric assay for pectin methylesterase","volume":"237","author":"Wojciechowski","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jplph.2016.01.017_bib0205","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00425-009-0984-5","article-title":"Exogenous nitric oxide enhances cadmium tolerance of rice by increasing pectin and hemicellulose contents in root cell wall","volume":"230","author":"Xiong","year":"2009","journal-title":"Planta"},{"key":"10.1016\/j.jplph.2016.01.017_bib0210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11104-009-0011-4","article-title":"Exogenous nitric oxide improves antioxidative capacity and reduces auxin degradation in roots of Medicago truncatula seedlings under cadmium stress","volume":"326","author":"Xu","year":"2010","journal-title":"Plant Soil"},{"key":"10.1016\/j.jplph.2016.01.017_bib0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.chemosphere.2011.11.049","article-title":"Arsenic accumulation and resistance mechanism in Panax notoginseng, a traditional rare medicinal herb","volume":"87","author":"Yan","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.jplph.2016.01.017_bib0220","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1104\/pp.107.111989","article-title":"Cell wall polysaccharides are specifically involved in the exclusion of aluminum from the rice root apex","volume":"146","author":"Yang","year":"2008","journal-title":"Plant Physiol."},{"issue":"4","key":"10.1016\/j.jplph.2016.01.017_bib0225","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/ppl.12005","article-title":"Association of specific pectin methylesterases with Al-induced root elongation inhibition in rice","volume":"148","author":"Yang","year":"2013","journal-title":"Physiol. Plant."},{"key":"10.1016\/j.jplph.2016.01.017_bib0230","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1104\/pp.109.140996","article-title":"Nitrate reductase-dependent nitric oxide production is involved in cold acclimation and freezing tolerance in Arabidopsis","volume":"151","author":"Zhao","year":"2009","journal-title":"Plant Physiol."},{"key":"10.1016\/j.jplph.2016.01.017_bib0235","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jxb\/44.4.773","article-title":"Changes of cell wall composition and polymer size in primary roots of cotton seedlings under high salinity","volume":"44","author":"Zhong","year":"1993","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jplph.2016.01.017_bib0240","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.phytochem.2011.12.004","article-title":"Nitric oxide exacerbates Al-induced inhibition of root elongation in rice bean by affecting cell wall and plasma membrane properties","volume":"76","author":"Zhou","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jplph.2016.01.017_bib0245","series-title":"5th Annual Meeting of Risk Analysis Council of China","article-title":"Health risks of cadmium in traditional Chinese herbal medicine Panax notoginseng in Yunnan authentic region","author":"Zhu","year":"2012"},{"issue":"4","key":"10.1016\/j.jplph.2016.01.017_bib0250","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00425-012-1652-8","article-title":"Cell wall polysaccharides are involved in P-deficiency-induced Cd exclusion in Arabidopsis thaliana","volume":"236","author":"Zhu","year":"2012","journal-title":"Planta"},{"key":"10.1016\/j.jplph.2016.01.017_bib0255","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhazmat.2013.09.018","article-title":"Exogenous auxin alleviates cadmium toxicity in Arabidopsis thaliana by stimulating synthesis of hemicellulose 1 and increasing the cadmium fixation capacity of root cell walls","volume":"263","author":"Zhu","year":"2013","journal-title":"J. Hazard. Mater."}],"container-title":["Journal of Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0176161716000419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0176161716000419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T18:12:05Z","timestamp":1759255925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0176161716000419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":51,"alternative-id":["S0176161716000419"],"URL":"https:\/\/doi.org\/10.1016\/j.jplph.2016.01.017","relation":{},"ISSN":["0176-1617"],"issn-type":[{"value":"0176-1617","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitrate reductase-mediated NO production enhances Cd accumulation in Panax notoginseng roots by affecting root cell wall properties","name":"articletitle","label":"Article Title"},{"value":"Journal of Plant Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jplph.2016.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier GmbH. Published by Elsevier GmbH All rights reserved.","name":"copyright","label":"Copyright"}]}}