{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:30:15Z","timestamp":1792773015089,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","jprasopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JPRAS Open"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jpra.2025.04.007","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T02:47:25Z","timestamp":1744685245000},"page":"529-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genetic variants in the development of autoimmune complaints and capsular contracture in women with breast implants: A systematic review"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0714-0378","authenticated-orcid":false,"given":"Alan","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9774-7230","authenticated-orcid":false,"given":"Daniela","family":"Quibano-Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-6926","authenticated-orcid":false,"given":"Laura","family":"Ortega-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"V\u00e9lez-Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jpra.2025.04.007_bib0001","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-0039-1696985","article-title":"The evolution of breast implants","volume":"33","author":"Kaoutzanis","year":"2019","journal-title":"Semin Plast Surg"},{"key":"10.1016\/j.jpra.2025.04.007_bib0002","unstructured":"ISAPS. Global Statistics. 2022. https:\/\/www.isaps.org\/discover\/about-isaps\/global-statistics\/. [Accessed April 29, 2024]."},{"issue":"8","key":"10.1016\/j.jpra.2025.04.007_bib0003","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/asj\/sjx127","article-title":"What\u2019s your micromort? A patient-oriented analysis of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)","volume":"37","author":"Sieber","year":"2017","journal-title":"Aesthet Surg Jl"},{"issue":"6","key":"10.1016\/j.jpra.2025.04.007_bib0004","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/ije\/dyy217","article-title":"Silicone breast implants and the risk of autoimmune\/rheumatic disorders: A real-world analysis","volume":"47","author":"Watad","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"10","key":"10.1016\/j.jpra.2025.04.007_bib0005","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3390\/biom10101436","article-title":"Classical examples of the concept of the ASIA syndrome","volume":"10","author":"Borba","year":"2020","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.jpra.2025.04.007_bib0006","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.36519","article-title":"Prevalence of local postoperative complications and breast implant illness in women with breast implants","volume":"5","author":"Lieffering","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"6","key":"10.1016\/j.jpra.2025.04.007_bib0007","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00266-018-1211-1","article-title":"The histological composition of capsular contracture focussed on the inner layer of the capsule: An Intra-Donor Baker-I Versus Baker-IV comparison","volume":"42","author":"De Bakker","year":"2018","journal-title":"Aesth Plast Surg"},{"issue":"11","key":"10.1016\/j.jpra.2025.04.007_bib0008","doi-asserted-by":"crossref","first-page":"385","DOI":"10.21037\/atm-23-131","article-title":"Implant-based breast surgery and capsular formation: When, how and why?\u2014A narrative review","volume":"11","author":"Gorgy","year":"2023","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jpra.2025.04.007_bib0009","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.jpra.2025.04.007_bib0010","first-page":"219","article-title":"Meta-analysis: Pitfalls and hints","volume":"5","author":"Greco","year":"2013","journal-title":"Heart Lung Vessel"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0011","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"11","key":"10.1016\/j.jpra.2025.04.007_bib0012","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1002\/art.20587","article-title":"Immunogenetic differences between Caucasian women with and those without silicone implants in whom myositis develops","volume":"50","author":"O\u2019Hanlon","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0013","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","article-title":"ASIA\u2019 \u2013 Autoimmune\/inflammatory syndrome induced by adjuvants","volume":"36","author":"Shoenfeld","year":"2011","journal-title":"J Autoimmunity"},{"issue":"5","key":"10.1016\/j.jpra.2025.04.007_bib0014","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00266-020-01663-9","article-title":"Breast prosthesis syndrome: Pathophysiology and management algorithm","volume":"44","author":"Caravantes-Cortes","year":"2020","journal-title":"Aesth Plast Surg"},{"issue":"9","key":"10.1016\/j.jpra.2025.04.007_bib0015","first-page":"1838","article-title":"Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2 HLA-identical sisters bearing rheumatoid arthritis susceptibility genes","volume":"24","author":"Meier","year":"1997","journal-title":"J Rheumatol"},{"issue":"7","key":"10.1016\/j.jpra.2025.04.007_bib0016","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1097\/00006534-199512000-00001","article-title":"HLA typing in women with breast implants","volume":"96","author":"Young","year":"1995","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jpra.2025.04.007_bib0017","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jbm.a.35958","article-title":"The pathology of the foreign body reaction against biomaterials","volume":"105","author":"Klopfleisch","year":"2017","journal-title":"J Biomedical Materials Res"},{"issue":"16","key":"10.1016\/j.jpra.2025.04.007_bib0018","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.3390\/polym13162731","article-title":"Functionalization of silicone surface with drugs and polymers for regulation of capsular contracture","volume":"13","author":"Faruq","year":"2021","journal-title":"Polymers (Basel)"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0019","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/SAP.0b013e31822284f4","article-title":"Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture: Association of TGF-\u03b2 polymorphisms","volume":"70","author":"Veras-Castillo","year":"2013","journal-title":"Ann Plast Surg"},{"issue":"3","key":"10.1016\/j.jpra.2025.04.007_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/asj\/sjv177","article-title":"The relationship of bacterial biofilms and capsular contracture in breast implants","volume":"36","author":"Ajdic","year":"2016","journal-title":"Aesthet Surg J"},{"issue":"5","key":"10.1016\/j.jpra.2025.04.007_bib0021","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1097\/01.PRS.0000054768.14922.44","article-title":"Detection of subclinical infection in significant breast implant capsules","volume":"111","author":"Pajkos","year":"2003","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jpra.2025.04.007_bib0022","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/PRS.0b013e3181e3b456","article-title":"Subclinical (Biofilm) infection causes capsular contracture in a porcine model following augmentation mammaplasty","volume":"126","author":"Tamboto","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jpra.2025.04.007_bib0023","doi-asserted-by":"crossref","first-page":"ojaf003","DOI":"10.1093\/asjof\/ojaf003","article-title":"Capsular contracture after breast augmentation: A systematic review and meta-analysis","volume":"7","author":"Haas","year":"2025","journal-title":"Aesthet Surg J Open Forum"},{"key":"10.1016\/j.jpra.2025.04.007_bib0024","article-title":"Transcriptome of capsular contracture around breast implants mimics allograft rejection: A matched case-control study","author":"Larsen","year":"2024","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.jpra.2025.04.007_bib0025","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/ijms20020382","article-title":"Cytokine modulation in breast cancer patients undergoing radiotherapy: A revision of the most recent studies","volume":"20","author":"Marconi","year":"2019","journal-title":"IJMS"},{"issue":"2","key":"10.1016\/j.jpra.2025.04.007_bib0026","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/PRS.0b013e3181c82d05","article-title":"Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction","volume":"125","author":"Lipa","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jpra.2025.04.007_bib0027","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.10341","article-title":"Overview of risk factors and prevention of capsular contracture following implant-based breast reconstruction and cosmetic surgery: A systematic review","author":"Luvsannyam","year":"2020","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.jpra.2025.04.007_bib0028","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.sap.0000237680.59808.86","article-title":"Modification of cysteinyl leukotriene receptor expression in capsular contracture: preliminary results","volume":"58","author":"D\u2019Andrea","year":"2007","journal-title":"Ann Plast Surg"},{"issue":"3-4","key":"10.1016\/j.jpra.2025.04.007_bib0029","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000321009","article-title":"Tumour necrosis factor-\u03b1 expression is associated with increased severity of periprosthetic breast capsular contracture","volume":"45","author":"Tan","year":"2010","journal-title":"Eur Surg Res"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/1090820X10391778","article-title":"Hyaluronan, TSG-6, and inter-\u03b1-inhibitor in periprosthetic breast capsules: Reduced levels of free hyaluronan and TSG-6 expression in contracted capsules","volume":"31","author":"Tan","year":"2011","journal-title":"Aesthet Surg J"},{"issue":"5","key":"10.1016\/j.jpra.2025.04.007_bib0031","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/wrr.12077","article-title":"Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome","volume":"21","author":"Kyle","year":"2013","journal-title":"Wound Repair Regen"},{"issue":"13","key":"10.1016\/j.jpra.2025.04.007_bib0032","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1073\/pnas.1203127109","article-title":"Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis","volume":"109","author":"Oyoshi","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0033","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1073\/pnas.1817325115","article-title":"Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis","volume":"116","author":"Duah","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0034","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02508-4","article-title":"Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis","volume":"11","author":"Kremastiotis","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpra.2025.04.007_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114472","article-title":"Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis","volume":"161","author":"Shan","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.jpra.2025.04.007_bib0036","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00266-009-9335-y","article-title":"Effect of tissue inhibitors of metalloproteinases and matrix metalloproteinases on capsular formation around smooth and textured silicone gel implants","volume":"33","author":"Ulrich","year":"2009","journal-title":"Aesth Plast Surg"},{"issue":"2","key":"10.1016\/j.jpra.2025.04.007_bib0037","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis Models Mech"},{"issue":"7","key":"10.1016\/j.jpra.2025.04.007_bib0038","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.4049\/jimmunol.0903008","article-title":"Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates il-13\u2013dependent fibrosis","volume":"184","author":"Madala","year":"2010","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.jpra.2025.04.007_bib0039","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jgm.1009","article-title":"Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats","volume":"9","author":"Hu","year":"2007","journal-title":"J Gene Med"},{"issue":"4","key":"10.1016\/j.jpra.2025.04.007_bib0040","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/iwj.13950","article-title":"TSG-6 inhibits hypertrophic scar fibroblast proliferation by regulating IRE1\u03b1\/TRAF2\/NF-\u03baB signalling","volume":"20","author":"Ma","year":"2022","journal-title":"Int Wound J"},{"issue":"3","key":"10.1016\/j.jpra.2025.04.007_bib0041","article-title":"Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture","volume":"11","author":"Mao","year":"2024","journal-title":"Genes Dis"},{"issue":"1","key":"10.1016\/j.jpra.2025.04.007_bib0042","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/PRS.0000000000009800","article-title":"Silicone breast implant surface texture impacts gene expression in periprosthetic fibrous capsules","volume":"151","author":"Daneshgaran","year":"2023","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"10.1016\/j.jpra.2025.04.007_bib0043","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132131","article-title":"Silicone implants with smooth surfaces induce thinner but denser fibrotic capsules compared to those with textured surfaces in a rodent model","volume":"10","author":"Fischer","year":"2015","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.jpra.2025.04.007_bib0044","doi-asserted-by":"crossref","first-page":"e5802","DOI":"10.1097\/GOX.0000000000005802","article-title":"Implant texture and capsular contracture: A review of cellular and molecular pathways","volume":"12","author":"Wells","year":"2024","journal-title":"Plast Reconstr Surg - Global Open"}],"container-title":["JPRAS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587825000750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587825000750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:06:48Z","timestamp":1792764408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352587825000750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":44,"alternative-id":["S2352587825000750"],"URL":"https:\/\/doi.org\/10.1016\/j.jpra.2025.04.007","relation":{},"ISSN":["2352-5878"],"issn-type":[{"value":"2352-5878","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variants in the development of autoimmune complaints and capsular contracture in women with breast implants: A systematic review","name":"articletitle","label":"Article Title"},{"value":"JPRAS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpra.2025.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}