{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:07:50Z","timestamp":1785420470181,"version":"3.56.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","jprasopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JPRAS Open"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jpra.2026.03.014","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:32:14Z","timestamp":1772926334000},"page":"358-365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between procalcitonin and mortality in patients with necrotizing fasciitis: A single-center retrospective study"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-0318","authenticated-orcid":false,"given":"Alperen S.","family":"Bingoel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Dastagir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib","family":"Dastagir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doha","family":"Obed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpra.2026.03.014_bib0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fsurg.2017.00005","article-title":"Early diagnosis and surgical treatment for necrotizing fasciitis: a multicenter study","volume":"4","author":"Misiakos","year":"2017","journal-title":"Front Surg"},{"issue":"3","key":"10.1016\/j.jpra.2026.03.014_bib0002","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S1473-3099(22)00583-7","article-title":"Necrotising soft-tissue infections","volume":"23","author":"Hua","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.jpra.2026.03.014_bib0003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13017-019-0286-6","article-title":"Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis","volume":"15","author":"Nawijn","year":"2020","journal-title":"World J Emerg Surg"},{"issue":"23","key":"10.1016\/j.jpra.2026.03.014_bib0004","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing soft-tissue infections","volume":"377","author":"Stevens","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpra.2026.03.014_bib0005","doi-asserted-by":"crossref","unstructured":"Wong CH, Khin LW, Heng KS, Tan KC, Low CO. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32(7):1535\u20131541. doi:10.1097\/01.CCM.0000129486.35458.7D","DOI":"10.1097\/01.CCM.0000129486.35458.7D"},{"issue":"4","key":"10.1016\/j.jpra.2026.03.014_bib0006","doi-asserted-by":"crossref","first-page":"684","DOI":"10.5811\/westjem.2017.3.33607","article-title":"Evaluating the laboratory risk indicator to differentiate cellulitis from necrotizing fasciitis in the emergency department","volume":"18","author":"Neeki","year":"2017","journal-title":"WestJEM"},{"issue":"1","key":"10.1016\/j.jpra.2026.03.014_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227748","article-title":"Prospective validation of the laboratory risk indicator for necrotizing fasciitis (LRINEC) score for necrotizing fasciitis of the extremities","volume":"15","author":"Hsiao","year":"2020","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.jpra.2026.03.014_bib0008","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1308\/rcsann.2017.0053","article-title":"Laboratory risk indicator for necrotising fasciitis (LRINEC) score for the assessment of early necrotising fasciitis: a systematic review of the literature","volume":"99","author":"Bechar","year":"2017","journal-title":"Annals"},{"issue":"1","key":"10.1016\/j.jpra.2026.03.014_bib0009","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40560-017-0246-8","article-title":"Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy","volume":"5","author":"Vijayan","year":"2017","journal-title":"J Intensive Care"},{"issue":"3","key":"10.1016\/j.jpra.2026.03.014_bib0010","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SHK.0000000000000305","article-title":"Procalcitonin levels in survivors and nonsurvivors of sepsis: systematic review and meta-analysis","volume":"43","author":"Arora","year":"2015","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.jpra.2026.03.014_bib0011","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.amjsurg.2012.11.024","article-title":"Procalcitonin ratio as a predictor of successful surgical treatment of severe necrotizing soft tissue infections","volume":"206","author":"Friederichs","year":"2013","journal-title":"Am J Surg"},{"issue":"6","key":"10.1016\/j.jpra.2026.03.014_bib0012","first-page":"e2754","article-title":"Diagnosing necrotizing fasciitis using procalcitonin and a laboratory risk indicator: brief overview","volume":"10","author":"Zil-E-Ali","year":"2018","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.jpra.2026.03.014_bib0013","article-title":"Role of procalcitonin for early discrimination between necrotizing fasciitis and cellulitis of the extremities","volume":"16","author":"Vaibhavi","year":"2024","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.jpra.2026.03.014_bib0014","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jamcollsurg.2008.10.032","article-title":"Necrotizing Fasciitis: current concepts and review of the literature","volume":"208","author":"Sarani","year":"2009","journal-title":"J Am Coll Surg"},{"issue":"5","key":"10.1016\/j.jpra.2026.03.014_bib0015","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.injury.2007.10.030","article-title":"Necrotising fasciitis of upper and lower limb: a systematic review","volume":"38","author":"Angoules","year":"2007","journal-title":"Injury"},{"issue":"5","key":"10.1016\/j.jpra.2026.03.014_bib0016","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1473-3099(12)70323-7","article-title":"Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis","volume":"13","author":"Wacker","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"10.1016\/j.jpra.2026.03.014_bib0017","article-title":"Prognostic value of procalcitonin in adult patients with sepsis: a systematic review and meta-analysis","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.jpra.2026.03.014_bib0018","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1473-3099(16)00053-0","article-title":"Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial","volume":"16","author":"De Jong","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"10.1016\/j.jpra.2026.03.014_bib0019","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/sur.2014.249","article-title":"Risk stratification of necrotizing fasciitis based on the initial procalcitonin concentration: a single center observational study","volume":"16","author":"Al-Thani","year":"2015","journal-title":"Surg Infect (Larchmt)"},{"issue":"6","key":"10.1016\/j.jpra.2026.03.014_bib0020","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jiac.2021.01.002","article-title":"Usefulness of serum procalcitonin for necrotizing fasciitis as an early diagnostic tool","volume":"27","author":"Kishino","year":"2021","journal-title":"J Infect Chemother"},{"issue":"1","key":"10.1016\/j.jpra.2026.03.014_bib0021","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2340\/00015555-2465","article-title":"Usefulness of serum procalcitonin for early discrimination between necrotizing fasciitis and Cellulitis","volume":"97","author":"Kato","year":"2017","journal-title":"Acta Derm Venerol"},{"issue":"2","key":"10.1016\/j.jpra.2026.03.014_bib0022","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00068-017-0792-8","article-title":"Necrotizing fasciitis: treatment concepts and clinical results","volume":"44","author":"Leiblein","year":"2018","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"7","key":"10.1016\/j.jpra.2026.03.014_bib0023","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.burns.2017.04.007","article-title":"Free tissue transfer for necrotizing fasciitis reconstruction: a case series","volume":"43","author":"Gawaziuk","year":"2017","journal-title":"Burns"},{"issue":"7","key":"10.1016\/j.jpra.2026.03.014_bib0024","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.burns.2021.01.005","article-title":"Flap coverage for necrotising soft tissue infections: a systematic review","volume":"47","author":"Somasundaram","year":"2021","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.jpra.2026.03.014_bib0025","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/00034894221088179","article-title":"Eight tales of cervical necrotizing fasciitis and free tissue transfer","volume":"132","author":"Rapoport","year":"2023","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["JPRAS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587826001075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587826001075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:10:12Z","timestamp":1785417012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352587826001075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":25,"alternative-id":["S2352587826001075"],"URL":"https:\/\/doi.org\/10.1016\/j.jpra.2026.03.014","relation":{},"ISSN":["2352-5878"],"issn-type":[{"value":"2352-5878","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between procalcitonin and mortality in patients with necrotizing fasciitis: A single-center retrospective study","name":"articletitle","label":"Article Title"},{"value":"JPRAS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpra.2026.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}