{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:38:27Z","timestamp":1792715907252,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","jprasopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JPRAS Open"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jpra.2026.05.018","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:37:02Z","timestamp":1778859422000},"page":"481-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chitosan in aesthetic practice: A clinical narrative review of skin, scar, and scalp applications"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8491-7323","authenticated-orcid":false,"given":"Olena","family":"Sydorchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeoun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano A.","family":"Lanfranchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuzma","family":"Khobzei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Melnychuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu-Ho","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jpra.2026.05.018_bib0001","doi-asserted-by":"crossref","first-page":"603\u2011632","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and chitosan: properties and applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Prog Polym Sci"},{"issue":"8","key":"10.1016\/j.jpra.2026.05.018_bib0002","doi-asserted-by":"crossref","first-page":"981\u20111014","DOI":"10.1016\/j.progpolymsci.2011.02.001","article-title":"Chitosan\u2014a versatile semi\u2011synthetic polymer in biomedical applications","volume":"36","author":"Dash","year":"2011","journal-title":"Prog Polym Sci"},{"issue":"2","key":"10.1016\/j.jpra.2026.05.018_bib0003","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/polym10020213","article-title":"Cosmetics and cosmeceutical applications of chitin, chitosan, and their derivatives","volume":"10","author":"Aranaz","year":"2018","journal-title":"Polymers (Basel)"},{"issue":"5","key":"10.1016\/j.jpra.2026.05.018_bib0004","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/cosmetics9050099","article-title":"Chitosan: a promising multifunctional cosmetic ingredient for skin and hair care","volume":"9","author":"Guzm\u00e1n","year":"2022","journal-title":"Cosmetics"},{"issue":"3","key":"10.1016\/j.jpra.2026.05.018_bib0005","doi-asserted-by":"crossref","first-page":"165\u2011169","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 Dalton rule for the skin penetration of chemical compounds and drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp Dermatol"},{"issue":"4","key":"10.1016\/j.jpra.2026.05.018_bib0006","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/pharmaceutics9040053","article-title":"An overview of chitosan nanoparticles and its application in non\u2011parenteral drug delivery","volume":"9","author":"Mohammed","year":"2017","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jpra.2026.05.018_bib0007","doi-asserted-by":"crossref","first-page":"51\u201163","DOI":"10.1016\/j.ijfoodmicro.2010.09.012","article-title":"Antimicrobial properties of chitosan and mode of action: a state of the art review","volume":"144","author":"Kong","year":"2010","journal-title":"Int J Food Microbiol"},{"issue":"1","key":"10.1016\/j.jpra.2026.05.018_bib0008","first-page":"19\u201134","article-title":"Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications","volume":"57","author":"Berger","year":"2004","journal-title":"Eur J Pharm Biopharm"},{"issue":"10","key":"10.1016\/j.jpra.2026.05.018_bib0009","doi-asserted-by":"crossref","first-page":"1153\u20111156","DOI":"10.7205\/MILMED-D-11-00150","article-title":"Safety of chitosan bandages in shellfish allergic patients","volume":"176","author":"Waibel","year":"2011","journal-title":"Mil Med"},{"issue":"3","key":"10.1016\/j.jpra.2026.05.018_bib0010","first-page":"941\u2011946","article-title":"Anaphylactic shock after intra\u2011articular injection of chitosan: a case report","volume":"10","author":"Peng","year":"2022","journal-title":"World J Clin Cases"},{"issue":"1","key":"10.1016\/j.jpra.2026.05.018_bib0011","doi-asserted-by":"crossref","first-page":"23\u201130","DOI":"10.1159\/000517965","article-title":"The efficacy and safety of chitosan on facial skin sebum","volume":"35","author":"Theerawattanawit","year":"2022","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.jpra.2026.05.018_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/lsm.70103","article-title":"Hydroxybutyl chitosan hydrogel promotes ablative fractional CO2 laser wound healing: a prospective, randomized, split\u2011face trial and animal model evidence","author":"Wu","year":"2026","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.jpra.2026.05.018_bib0013","article-title":"Comparative efficacy of topical chitosan and minoxidil in hair loss: a controlled study with microneedling","author":"Wan","year":"2025","journal-title":"J Craniofac Surg"},{"issue":"4","key":"10.1016\/j.jpra.2026.05.018_bib0014","doi-asserted-by":"crossref","first-page":"564\u2011569","DOI":"10.1111\/jdv.14722","article-title":"Microneedling for the treatment of hair loss?","volume":"32","author":"Fertig","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jpra.2026.05.018_bib0015","doi-asserted-by":"crossref","first-page":"262\u2011270","DOI":"10.1016\/j.ijbiomac.2020.04.040","article-title":"Chitosan nanoparticles making their way to clinical practice: a feasibility study on their topical use for acne treatment","volume":"156","author":"Abd\u2011Allah","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jpra.2026.05.018_bib0016","article-title":"Chitosan\u2011coated nanostructured lipid carriers for spironolactone delivery for acne treatment: an in vivo multicenter double\u2011blind clinical trial","volume":"258","author":"Cerda\u2011Opazo","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"10.1016\/j.jpra.2026.05.018_bib0017","doi-asserted-by":"crossref","first-page":"1212\u20111231","DOI":"10.1080\/10717544.2022.2058652","article-title":"Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment","volume":"29","author":"Hatem","year":"2022","journal-title":"Drug Deliv"},{"issue":"8","key":"10.1016\/j.jpra.2026.05.018_bib0018","article-title":"Novel chitosan dermal filler with enhanced moldability and elasticity","volume":"22","author":"Cerroni","year":"2022","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.jpra.2026.05.018_bib0019","unstructured":"U.S. Food and Drug Administration. FDA authority over cosmetics. Available at: https:\/\/www.fda.gov\/cosmetics\/cosmetics-laws-regulations\/fda-authority-over-cosmetics. Accessed 16 Feb 2026."},{"key":"10.1016\/j.jpra.2026.05.018_bib0020","unstructured":"European Commission. CosIng\u2014Cosmetic ingredients database (Chitosan entry). Available at: https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/. Accessed 16 Feb 2026."}],"container-title":["JPRAS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587826001889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352587826001889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:46:03Z","timestamp":1792712763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352587826001889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":20,"alternative-id":["S2352587826001889"],"URL":"https:\/\/doi.org\/10.1016\/j.jpra.2026.05.018","relation":{},"ISSN":["2352-5878"],"issn-type":[{"value":"2352-5878","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan in aesthetic practice: A clinical narrative review of skin, scar, and scalp applications","name":"articletitle","label":"Article Title"},{"value":"JPRAS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpra.2026.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}