{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:20:30Z","timestamp":1791109230632,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jprot.2009.01.020","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T09:56:22Z","timestamp":1232790982000},"page":"183-199","source":"Crossref","is-referenced-by-count":84,"title":["Antidotes against venomous animals: State of the art and prospectives"],"prefix":"10.1016","volume":"72","author":[{"given":"G.P.","family":"Espino-Solis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ria\u00f1o-Umbarila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Becerril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2009.01.020_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature04328","article-title":"Early evolution of the venom system in lizards and snakes","volume":"439","author":"Fry","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2009.01.020_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jprot.2009.01.008","article-title":"Snake venomics and antivenomics: proteomic tools in the designand control of antivenomsfor the treatment of snakebite envenoming","volume":"72","author":"Guti\u00e9rrez","year":"2009","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: a global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Trop"},{"key":"10.1016\/j.jprot.2009.01.020_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nbt0207-173","article-title":"Bringing antivenoms to Sub-Saharan Africa","volume":"25","author":"Stock","year":"2007","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jprot.2009.01.020_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0041-0101(02)00393-8","article-title":"Report of a WHO workshop on the standardization and control of antivenoms","volume":"41","author":"Theakston","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1081\/CLT-120021115","article-title":"Marine antivenoms","volume":"41","author":"Currie","year":"2003","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1081\/CLT-120021111","article-title":"Antivenoms: editorial commentary","volume":"41","author":"Smith","year":"2003","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1081\/CLT-120021114","article-title":"Antivenom treatment in arachnidism","volume":"41","author":"Isbister","year":"2003","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib9","series-title":"Scorpion Venom Peptides","author":"Possani","year":"2006"},{"key":"10.1016\/j.jprot.2009.01.020_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jms.1389","article-title":"Venomics: unravelling the complexity of animal venoms with mass spectrometry","volume":"43","author":"Escoubas","year":"2008","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.jprot.2009.01.020_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1887.sp000253","article-title":"Experiments on the preventive inoculation of rattlesnake venom","volume":"8","author":"Sewall","year":"1887","journal-title":"J Physiol"},{"key":"10.1016\/j.jprot.2009.01.020_bib12","first-page":"629","article-title":"Contribution a letude de la diphterie","volume":"2","author":"Roux","year":"1888","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.jprot.2009.01.020_bib13","first-page":"1113","article-title":"\u00dcber das zustandeommen der diphterieimmunit\u00e4t und der tetanusimmunit\u00e4t bei thieren","volume":"16","author":"Von Behring","year":"1890","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jprot.2009.01.020_bib14","first-page":"611","article-title":"Proprie\u00c2 te\u00c2s antitoxique du sang des animaux vaccine\u00c2e contre le venin de vipe\u00c1 re. Contribution a l'e\u00c2tude du me\u00c2canisme de la vaccination contre ce venin","volume":"6","author":"Phisalix","year":"1894","journal-title":"Arch de Physiol"},{"key":"10.1016\/j.jprot.2009.01.020_bib15","first-page":"111","article-title":"Sur la proprie\u00c2 te\u00c2 antitoxique du sang des animaux vaccine\u00c2e contre le venin de vipe\u00c1 re","volume":"46","author":"Phisalix","year":"1894","journal-title":"Comptes Rendus de la Socie\u00c2 te\u00c2 de Biologie"},{"key":"10.1016\/j.jprot.2009.01.020_bib16","first-page":"720","article-title":"Propriet\u00e9s du s\u00e9rum des animaux immunis\u00e9s contre le venin des serpents et th\u00e9rapeutique de l'envenimation","volume":"68","author":"Calmette","year":"1894","journal-title":"C R Acad Sci"},{"key":"10.1016\/j.jprot.2009.01.020_bib17","first-page":"257","article-title":"Contribution a l'\u00e9tude du venin des serpents. Immunisation des animaux et traitement de l'envenimation","volume":"8","author":"Calmette","year":"1894","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.jprot.2009.01.020_bib18","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0041-0101(99)00086-0","article-title":"Doctor Albert Calmette 1863\u20131933: founder of antivenomous serotherapy and of antituberculous BCG vaccination","volume":"37","author":"Hawgood","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0041-0101(97)00160-8","article-title":"Venoms, antivenoms and immunotherapy","volume":"36","author":"Chippaux","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib20","series-title":"El Alacran en la historia de Durango","author":"Peschard-Fernandez","year":"2000"},{"key":"10.1016\/j.jprot.2009.01.020_bib21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1098\/rspl.1899.0121","article-title":"On immunity with special reference to cell life","volume":"66","author":"Ehrlich","year":"1900","journal-title":"Proc R Soc Lond"},{"key":"10.1016\/j.jprot.2009.01.020_bib22","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/bi00818a012","article-title":"The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications","volume":"9","author":"Edelman","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.jprot.2009.01.020_bib23","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.180.4088.830","article-title":"Antibody structure and molecular immunology","volume":"180","author":"Edelman","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.jprot.2009.01.020_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/256495a0","article-title":"Continuous cultures of fused cells secreting antibody of predefined specificity","volume":"256","author":"Kohler","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2009.01.020_bib25","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nbt1126","article-title":"Selecting and screening recombinant antibody libraries","volume":"23","author":"Hoogenboom","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jprot.2009.01.020_bib26","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nbt1135","article-title":"Human antibodies from transgenic animals","volume":"23","author":"Lonberg","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jprot.2009.01.020_bib27","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1073\/pnas.81.21.6851","article-title":"Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains","volume":"81","author":"Morrison","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jprot.2009.01.020_bib28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jaci.2005.08.003","article-title":"Selection, design, and engineering of therapeutic antibodies","volume":"116","author":"Presta","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jprot.2009.01.020_bib29","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/jcp.2003.014407","article-title":"Demystified\u2026recombinant antibodies","volume":"57","author":"Smith","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jprot.2009.01.020_bib30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0167-5699(00)01668-6","article-title":"Of mice and men: hybridoma and recombinant antibodies","volume":"21","author":"Little","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.jprot.2009.01.020_bib31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/348552a0","article-title":"Phage antibodies: filamentous phage displaying antibody variable domains","volume":"348","author":"McCafferty","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2009.01.020_bib32","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.4001944","article-title":"Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface","volume":"228","author":"Smith","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.jprot.2009.01.020_bib33","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1111\/j.1742-4658.2005.04687.x","article-title":"A strategy for the generation of specific human antibodies by directed evolution and phage display. An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom","volume":"272","author":"Riano-Umbarila","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.jprot.2009.01.020_bib34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nbt0905-1073","article-title":"Monoclonal antibody successes in the clinic","volume":"23","author":"Reichert","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jprot.2009.01.020_bib35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0021-9258(19)77791-6","article-title":"Chromatography of amino acids on sulfonated polystyrene resins","volume":"192","author":"Moore","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jprot.2009.01.020_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.toxicon.2006.01.013","article-title":"Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venoms","volume":"47","author":"Escoubas","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib37","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jms.1242","article-title":"Snake venomics. Strategy and applications","volume":"42","author":"Calvete","year":"2007","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.jprot.2009.01.020_bib38","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1002\/elps.200305552","article-title":"Proteomics of snake venoms from Elapidae and Viperidae families by multidimensional chromatographic methods","volume":"24","author":"Nawarak","year":"2003","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jprot.2009.01.020_bib39","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/pmic.200700777","article-title":"Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures","volume":"8","author":"Fox","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib40","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/pmic.200700668","article-title":"Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: novel toxins, their function and phylogeny","volume":"8","author":"Olamendi-Portugal","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/pmic.200400931","article-title":"A multifaceted analysis of viperid snake venoms by two-dimensional gel electrophoresis: an approach to understanding venom proteomics","volume":"5","author":"Serrano","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08923970802279019","article-title":"Inhibitors of snake venoms and development of new therapeutics","volume":"30","author":"Sanchez","year":"2008","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0041-0101(00)00165-3","article-title":"Partial characterization of a basic protein from Crotalus molossus molossus (northern blacktail rattlesnake) venom and production of a monoclonal antibody","volume":"39","author":"Sanchez","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0041-0101(99)00134-8","article-title":"Neutralization of the hemorrhagic activity of Bothrops and Lachesis snake venoms by a monoclonal antibody against mutalysin-II","volume":"38","author":"Estevao-Costa","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib45","first-page":"37","article-title":"Snake venom neurotoxins: pharmacological classification","volume":"23","author":"Gawade","year":"2004","journal-title":"J Toxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib46","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1046\/j.1432-1327.1999.00622.x","article-title":"Polypeptide neurotoxins from spider venoms","volume":"264","author":"Grishin","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jprot.2009.01.020_bib47","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0300-9084(00)01166-4","article-title":"Structure and pharmacology of spider venom neurotoxins","volume":"82","author":"Escoubas","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2009.01.020_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2004.02.010","article-title":"Australian funnel-web spiders: master insecticide chemists","volume":"43","author":"Tedford","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"Rash","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1023\/A:1021836403433","article-title":"Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels","volume":"22","author":"Gomez","year":"2002","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.jprot.2009.01.020_bib51","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.toxicon.2004.02.008","article-title":"The multiple actions of black widow spider toxins and their selective use in neurosecretion studies","volume":"43","author":"Ushkaryov","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.toxicon.2004.02.006","article-title":"Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel","volume":"43","author":"Nicholson","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib53","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/pmic.200401096","article-title":"Proteome analysis of brown spider venom: identification of loxnecrogin isoforms in Loxosceles gaucho venom","volume":"5","author":"Machado","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib54","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbt.20244","article-title":"Proteomic analysis of Latrodectus tredecimguttatus venom for uncovering potential latrodectism-related proteins","volume":"22","author":"Duan","year":"2008","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.jprot.2009.01.020_bib55","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1021\/pr0700192","article-title":"Proteomic and peptidomic characterization of the venom from the Chinese bird spider, Ornithoctonus huwena Wang","volume":"6","author":"Yuan","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2009.01.020_bib56","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/pmic.200600785","article-title":"Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao","volume":"7","author":"Liao","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib57","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/cbdv.200690075","article-title":"The venomous secrets of the web droplets from the viscid spiral of the orb-weaver spider Nephila clavipes (Araneae, Tetragnatidae)","volume":"3","author":"Salles","year":"2006","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.jprot.2009.01.020_bib58","first-page":"155","article-title":"Diversity and endemism in tropical versus temperate scorpion communities","volume":"70","author":"Lourenco","year":"1994","journal-title":"Biogeographica"},{"key":"10.1016\/j.jprot.2009.01.020_bib59","article-title":"Alacranismo","volume":"5","author":"Alagon","year":"2003","journal-title":"Pra\u00c2ct Me\u00c2d Efectiva"},{"key":"10.1016\/j.jprot.2009.01.020_bib60","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature07473","article-title":"Deconstructing voltage sensor function and pharmacology in sodium channels","volume":"456","author":"Bosmans","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2009.01.020_bib61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+-channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jprot.2009.01.020_bib62","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2009.01.020_bib63","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neulet.2008.05.088","article-title":"Involvement of phospholipase A2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide","volume":"440","author":"Kanoo","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jprot.2009.01.020_bib64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gene.2007.03.007","article-title":"Sequence analysis and phylogenetic relationship of genes encoding heterodimeric phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus","volume":"396","author":"Valdez-Cruz","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.jprot.2009.01.020_bib65","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cbpc.2008.06.003","article-title":"Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi","volume":"148","author":"Feng","year":"2008","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.jprot.2009.01.020_bib66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cbpc.2006.12.004","article-title":"Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species","volume":"146","author":"Batista","year":"2007","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.jprot.2009.01.020_bib67","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00018-007-7370-x","article-title":"Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms","volume":"65","author":"Diego-Garcia","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jprot.2009.01.020_bib68","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.peptides.2007.10.004","article-title":"Inducible antibacterial response of scorpion venom gland","volume":"28","author":"Gao","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.jprot.2009.01.020_bib69","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bcp.2008.08.018","article-title":"A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus","volume":"76","author":"Corzo","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jprot.2009.01.020_bib70","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.toxicon.2008.03.029","article-title":"Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum","volume":"51","author":"Schwartz","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib71","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/pmic.200700948","article-title":"Proteomic analysis of the venom of Heterometrus longimanus (Asian black scorpion)","volume":"8","author":"Bringans","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib72","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.toxicon.2007.12.012","article-title":"New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom","volume":"51","author":"Oukkache","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib73","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1002\/pmic.200500525","article-title":"Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins","volume":"6","author":"Batista","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib74","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.toxicon.2006.01.015","article-title":"Moving pieces in a taxonomic puzzle: venom 2D-LC\/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones)","volume":"47","author":"Nascimento","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib75","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbapap.2005.08.010","article-title":"Proteomic analysis of the venom and characterization of toxins specific for Na+- and K+-channels from the Colombian scorpion Tityus pachyurus","volume":"1764","author":"Barona","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jprot.2009.01.020_bib76","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jchromb.2003.09.002","article-title":"Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins","volume":"803","author":"Batista","year":"2004","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jprot.2009.01.020_bib77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.toxicon.2003.10.015","article-title":"Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius Hoffmann","volume":"43","author":"Selisko","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib78","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.toxicon.2003.11.024","article-title":"Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments","volume":"43","author":"Aubrey","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib79","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1046\/j.1432-1327.2001.01923.x","article-title":"Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin AahI from the venom of the scorpion Androctonus australis hector","volume":"268","author":"Devaux","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jprot.2009.01.020_bib80","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.bbagen.2006.04.008","article-title":"Expression of recombinant human antibody fragments capable of inhibiting the phospholipase and myotoxic activities of Bothrops jararacussu venom","volume":"1760","author":"Tamarozzi","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jprot.2009.01.020_bib81","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.toxicon.2007.11.014","article-title":"Monoclonal antibody fragment from combinatorial phage display library neutralizes alpha-latrotoxin activity and abolishes black widow spider venom lethality, in mice","volume":"51","author":"Bugli","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib82","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.toxicon.2005.07.014","article-title":"Molecular characterization of a neutralizing murine monoclonal antibody against Tityus serrulatus scorpion venom","volume":"46","author":"Alvarenga","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib83","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/0006-2952(95)02095-0","article-title":"Specificity and binding affinity of an anti-crotoxin combinatorial antibody selected from a phage-displayed library","volume":"50","author":"Meng","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jprot.2009.01.020_bib84","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.toxicon.2007.10.009","article-title":"Neutralization of hemorrhagic snake venom metalloproteinase HR1a from Protobothrops flavoviridis by human monoclonal antibody","volume":"51","author":"Morine","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib85","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.toxicon.2003.09.006","article-title":"Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay","volume":"42","author":"Alvarenga","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib86","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-3083.2000.00709.x","article-title":"Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library","volume":"51","author":"Cardoso","year":"2000","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jprot.2009.01.020_bib87","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1380-2933(97)00068-7","article-title":"Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library","volume":"3","author":"Lafaye","year":"1997","journal-title":"Immunotechnology"},{"key":"10.1016\/j.jprot.2009.01.020_bib88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(99)01179-5","article-title":"Monoclonal antibodies against the Androctonus australis hector scorpion neurotoxin I: characterisation and use for venom neutralisation","volume":"458","author":"Clot-Faybesse","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jprot.2009.01.020_bib89","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1016\/j.molimm.2008.04.011","article-title":"VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'","volume":"45","author":"Hmila","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jprot.2009.01.020_bib90","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-1759(02)00338-1","article-title":"A strategy for inducing an immune response against Androctonus australis scorpion venom toxin I in mice. Production of high-affinity monoclonal antibodies and their use in a sensitive two-site immunometric assay","volume":"271","author":"Devaux","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jprot.2009.01.020_bib91","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s000180300053","article-title":"Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin","volume":"60","author":"Aubrey","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jprot.2009.01.020_bib92","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0041-0101(96)00043-8","article-title":"Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann","volume":"34","author":"Licea","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib93","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jmb.2004.12.060","article-title":"Directed evolution, phage display and combination of evolved mutants: a strategy to recover the neutralization properties of the scFv version of BCF2 a neutralizing monoclonal antibody specific to scorpion toxin Cn2","volume":"346","author":"Juarez-Gonzalez","year":"2005","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jprot.2009.01.020_bib94","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.molimm.2006.05.009","article-title":"The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies","volume":"44","author":"Quintero-Hernandez","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jprot.2009.01.020_bib95","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-5793(98)01647-0","article-title":"A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis Hector","volume":"442","author":"Mousli","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jprot.2009.01.020_bib96","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4049\/jimmunol.141.1.214","article-title":"Monoclonal antibodies to scorpion toxins. Characterization and molecular mechanisms of neutralization","volume":"141","author":"Bahraoui","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.jprot.2009.01.020_bib97","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0041-0101(86)90139-X","article-title":"Large scale purification of toxins from the venom of the scorpion Androctonus australis Hector","volume":"24","author":"Martin","year":"1986","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2009.01.020_bib98","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02906498","article-title":"The amino terminal sequence of several toxins from the venom of the Mexican scorpion Centruroides noxius Hoffmann","volume":"46","author":"Possani","year":"1981","journal-title":"Carlsberg Res Commun"},{"key":"10.1016\/j.jprot.2009.01.020_bib99","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1432-1033.1992.tb16635.x","article-title":"Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann","volume":"204","author":"Zamudio","year":"1992","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jprot.2009.01.020_bib100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2008.08.001","article-title":"Dendritic cells in vivo: a key target for a new vaccine science","volume":"29","author":"Steinman","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jprot.2009.01.020_bib101","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/153685903321538053","article-title":"Rapid monoclonal antibody generation via dendritic cell targeting in vivo","volume":"22","author":"Berry","year":"2003","journal-title":"Hybrid Hybridomics"},{"key":"10.1016\/j.jprot.2009.01.020_bib102","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1073\/pnas.97.2.847","article-title":"Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization","volume":"97","author":"Wang","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jprot.2009.01.020_bib103","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.vetimm.2007.12.004","article-title":"Molecular cloning and characterization of the alphaX subunit from CD11c\/CD18 horse integrin","volume":"122","author":"Espino-Solis","year":"2008","journal-title":"Vet Immunol Immunopathol"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391909000396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391909000396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:04:36Z","timestamp":1684868676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391909000396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S1874391909000396"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2009.01.020","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}