{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:28:56Z","timestamp":1772760536339,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jprot.2012.04.052","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T17:43:05Z","timestamp":1337794985000},"page":"4545-4554","source":"Crossref","is-referenced-by-count":45,"title":["Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2"],"prefix":"10.1016","volume":"75","author":[{"given":"Stefanie M.","family":"Hauck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Hofmaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Dietter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete E.","family":"Swadzba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Blindert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Amann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Behler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Kremmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia A.","family":"Deeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2012.04.052_bb0005","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1074\/mcp.M110.001073","article-title":"Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry","volume":"9","author":"Hauck","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jprot.2012.04.052_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.2042-3306.2010.tb05636.x","article-title":"Equine recurrent uveitis: the viewpoint from the USA","volume":"42","author":"Gilger","year":"2010","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jprot.2012.04.052_bb0015","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.ophtha.2009.05.021","article-title":"Uveitis in a patient treated with Bacille-Calmette-Guerin: possible antigenic mimicry of mycobacterial and retinal antigens","volume":"116","author":"Garip","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jprot.2012.04.052_bb0020","first-page":"178","article-title":"The surgical therapy of equine recurrent uveitis","volume":"20","author":"Werry","year":"1992","journal-title":"Tierarztl Prax"},{"key":"10.1016\/j.jprot.2012.04.052_bb0025","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/pmic.200600795","article-title":"Down-regulation of pigment epithelium-derived factor in uveitic lesion associates with focal vascular endothelial growth factor expression and breakdown of the blood-retinal barrier","volume":"7","author":"Deeg","year":"2007","journal-title":"Proteomics"},{"issue":"4\u20135","key":"10.1016\/j.jprot.2012.04.052_bb0030","first-page":"550","article-title":"How advancement in biological network analysis methods empowers proteomics","volume":"12","author":"Goh","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2012.04.052_bb0035","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.1178158","article-title":"Genome sequence, comparative analysis, and population genetics of the domestic horse","volume":"326","author":"Wade","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jprot.2012.04.052_bb0040","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/pr060668y","article-title":"Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis","volume":"6","author":"Hauck","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2012.04.052_bb0045","first-page":"393","article-title":"Immune responses to retinal autoantigens and peptides in equine recurrent uveitis","volume":"42","author":"Deeg","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1463-5224.2002.00210.x","article-title":"Normal structure and age-related changes of the equine retina","volume":"5","author":"Ehrenhofer","year":"2002","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.jprot.2012.04.052_bb0055","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1074\/mcp.M110.001073","article-title":"Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry","volume":"9","author":"Hauck","year":"2010","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"10.1016\/j.jprot.2012.04.052_bb0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1167\/iovs.09-3850","article-title":"ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations","volume":"51","author":"Kortvely","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0065","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1002\/pmic.200700038","article-title":"A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes","volume":"7","author":"Gloeckner","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2012.04.052_bb0070","doi-asserted-by":"crossref","first-page":"D712","DOI":"10.1093\/nar\/gkq1156","article-title":"ConsensusPathDB: toward a more complete picture of cell biology","volume":"39","author":"Kamburov","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jprot.2012.04.052_bb0075","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/MCB.01211-10","article-title":"Identification of a novel inhibitor of the canonical Wnt pathway","volume":"31","author":"Park","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jprot.2012.04.052_bb0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/path.1711740410","article-title":"Possible role of tissue-bound calcium ions in citrate-mediated high-temperature antigen retrieval","volume":"174","author":"Morgan","year":"1994","journal-title":"J Pathol"},{"key":"10.1016\/j.jprot.2012.04.052_bb0085","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/pmic.200700919","article-title":"Deja vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins","volume":"8","author":"Petrak","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2012.04.052_bb0090","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1021\/pr200654k","article-title":"Sense and nonsense of pathway analysis software in proteomics","volume":"10","author":"M\u00fcller","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2012.04.052_bb0095","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.imbio.2010.02.003","article-title":"Complement factor B expression profile in a spontaneous uveitis model","volume":"215","author":"Zipplies","year":"2010","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.jprot.2012.04.052_bb0100","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1167\/iovs.11-8734","article-title":"Vitreal IgM autoantibodies target neurofilament medium in a spontaneous model for autoimmune uveitis","volume":"53","author":"Swadzba","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0105","doi-asserted-by":"crossref","first-page":"e27674","DOI":"10.1371\/journal.pone.0027674","article-title":"Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling","volume":"6","author":"Deeg","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2012.04.052_bb0110","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/glia.21139","article-title":"Differential expression of inwardly rectifying K+ channels and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Muller glial cell-dependent ion and water homeostasis","volume":"59","author":"Eberhardt","year":"2011","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.jprot.2012.04.052_bb0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nn.3032","article-title":"Transcriptional code and disease map for adult retinal cell types","volume":"15","author":"Siegert","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2121-8-52","article-title":"Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina","volume":"8","author":"Nakamura","year":"2007","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.jprot.2012.04.052_bb0125","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1021\/pr800694y","article-title":"Serum PEDF levels are decreased in a spontaneous animal model for human autoimmune uveitis","volume":"8","author":"Zipplies","year":"2009","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2012.04.052_bb0130","doi-asserted-by":"crossref","unstructured":"Degroote RL, Hauck SM, Kremmer E, Amann B, Ueffing M, Deeg CA. Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis. J Proteomics in press [2012 Jan 28, Epub. ahead of print].","DOI":"10.1016\/j.jprot.2012.01.023"},{"key":"10.1016\/j.jprot.2012.04.052_bb0135","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1074\/mcp.M500352-MCP200","article-title":"Identification and functional validation of novel autoantigens in equine uveitis","volume":"5","author":"Deeg","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jprot.2012.04.052_bb0140","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s00347-011-2406-x","article-title":"Blind spot enlargement syndrome in acute zonal occult outer retinopathy with detection of autoantibodies against the retinal antigens CRALBP and S\u2013Ag","volume":"108","author":"Neutzner","year":"2011","journal-title":"Ophthalmologe"},{"issue":"2","key":"10.1016\/j.jprot.2012.04.052_bb0145","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1439-0396.2011.01147.x","article-title":"Isolation, characterization and establishment of an equine retinal glial cell line: a prerequisite to investigate the physiological function of Muller cells in the retina","volume":"96","author":"Eberhardt","year":"2012","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"10.1016\/j.jprot.2012.04.052_bb0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2042-3306.2010.tb05635.x","article-title":"Equine recurrent uveitis: The European viewpoint","volume":"42","author":"Spiess","year":"2010","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jprot.2012.04.052_bb0155","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1167\/iovs.03-1226","article-title":"The uveitogenic potential of retinal S-antigen in horses","volume":"45","author":"Deeg","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0160","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1167\/iovs.09-4094","article-title":"Kininogen in autoimmune uveitis: decrease in peripheral blood stream versus increase in target tissue","volume":"51","author":"Zipplies","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0165","first-page":"1297","article-title":"Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas","volume":"41","author":"Jones","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2011.09.003","article-title":"Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1\/2 and induction of Bcl-2","volume":"72","author":"Sanchez","year":"2012","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jprot.2012.04.052_bb0175","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbrc.2010.08.043","article-title":"Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling","volume":"400","author":"von Marschall","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jprot.2012.04.052_bb0180","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1242\/dev.065839","article-title":"Secreted frizzled-related proteins are required for Wnt\/\u03b2-catenin signalling activation in the vertebrate optic cup","volume":"138","author":"Esteve","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.jprot.2012.04.052_bb0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncb1811","article-title":"Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction","volume":"11","author":"Kobayashi","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.jprot.2012.04.052_bb0190","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1167\/iovs.10-6475","article-title":"Changes in matrix metalloproteinase network in spontaneous autoimmune uveitis model","volume":"52","author":"Hofmaier","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jprot.2012.04.052_bb0195","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbrc.2011.07.040","article-title":"Wnt\/\u03b2-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity","volume":"412","author":"Zhou","year":"2011","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391912003235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391912003235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T02:03:15Z","timestamp":1561773795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391912003235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":39,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1874391912003235"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2012.04.052","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}