{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:08:13Z","timestamp":1791209293484,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jprot.2012.07.035","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T03:03:05Z","timestamp":1343271785000},"page":"4952-4961","source":"Crossref","is-referenced-by-count":201,"title":["Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor"],"prefix":"10.1016","volume":"75","author":[{"given":"Gregory","family":"Hamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bonnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Legouffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Pamelard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bouzom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Stauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.jprot.2012.07.035_bb0005","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.4155\/bio.11.232","article-title":"MALDI imaging mass spectrometry: bridging biology and chemistry in drug development","volume":"3","author":"Castellino","year":"2011","journal-title":"Bioanalysis"},{"issue":"4","key":"10.1016\/j.jprot.2012.07.035_bb0010","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.apsusc.2008.05.243","article-title":"Quality of surface: the influence of sample preparation on MS-based biomolecular tissue imaging with MALDI-MS and (ME-)SIMS","volume":"255","author":"Heeren","year":"2008","journal-title":"Appl Surf Sci"},{"key":"10.1016\/j.jprot.2012.07.035_bb0015","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1002\/rcm.2747","article-title":"The molecular scanner in microscope mode","volume":"20","author":"Luxembourg","year":"2006","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"20","key":"10.1016\/j.jprot.2012.07.035_bb0020","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1021\/ac060565z","article-title":"MALDI-MS direct tissue analysis of proteins: improving signal sensitivity using organic treatments","volume":"78","author":"Lemaire","year":"2006","journal-title":"Anal Chem"},{"key":"10.1016\/j.jprot.2012.07.035_bb0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/rcm.4891","article-title":"A quantitation method for mass spectrometry imaging","volume":"25","author":"Koeniger","year":"2011","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"7","key":"10.1016\/j.jprot.2012.07.035_bb0030","doi-asserted-by":"crossref","first-page":"e11411","DOI":"10.1371\/journal.pone.0011411","article-title":"Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry","volume":"5","author":"Nilsson","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2012.07.035_bb0035","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/jms.1225","article-title":"Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry","volume":"42","author":"Signor","year":"2007","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.jprot.2012.07.035_bb0040","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/rcm.3377","article-title":"Quantitative analysis of small molecules by desorption electrospray ionization mass spectrometry from polytetrafluoroethylene surfaces","volume":"22","author":"Ifa","year":"2008","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"13","key":"10.1016\/j.jprot.2012.07.035_bb0045","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1021\/ac800546a","article-title":"Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography","volume":"80","author":"Kertesz","year":"2008","journal-title":"Anal Chem"},{"key":"10.1016\/j.jprot.2012.07.035_bb0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-60761-746-4_6","article-title":"Quantitative imaging of chemical composition in single cells by secondary ion mass spectrometry: cisplatin affects calcium stores in renal epithelial cells","volume":"656","author":"Chandra","year":"2010","journal-title":"Methods Mol Biol"},{"issue":"8","key":"10.1016\/j.jprot.2012.07.035_bb0055","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1021\/ac102958x","article-title":"In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry","volume":"83","author":"Shrestha","year":"2011","journal-title":"Anal Chem"},{"issue":"14","key":"10.1016\/j.jprot.2012.07.035_bb0060","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1021\/ac50064a004","article-title":"Guidelines for data acquisition and data quality evaluation in environmental chemistry","volume":"52","author":"MacDougall","year":"1980","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.jprot.2012.07.035_bb0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/ac902065u","article-title":"Automated solvent-free matrix deposition for tissue imaging by mass spectrometry","volume":"82","author":"Trimpin","year":"2009","journal-title":"Anal Chem"},{"key":"10.1016\/j.jprot.2012.07.035_bb0070","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/jms.505","article-title":"Direct tissue analysis using matrix-assisted laser desorption\/ionization mass spectrometry: practical aspects of sample preparation","volume":"38","author":"Schwartz","year":"2003","journal-title":"J Mass Spectrom"},{"issue":"17","key":"10.1016\/j.jprot.2012.07.035_bb0075","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1021\/ac070958d","article-title":"Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry","volume":"79","author":"Baluya","year":"2007","journal-title":"Anal Chem"},{"key":"10.1016\/j.jprot.2012.07.035_bb0080","series-title":"Imaging Mass Spectrometry","first-page":"87","author":"Schuerenberg","year":"2010"},{"issue":"9","key":"10.1016\/j.jprot.2012.07.035_bb0085","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jasms.2007.06.010","article-title":"Sublimation as a method of matrix application for mass spectrometric imaging","volume":"18","author":"Hankin","year":"2007","journal-title":"J Am Soc Mass Spectrom"},{"issue":"6","key":"10.1016\/j.jprot.2012.07.035_bb0090","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.jprot.2010.02.021","article-title":"Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry","volume":"73","author":"V\u00e9gv\u00e1ri","year":"2010","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2012.07.035_bb0095","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/rcm.2498","article-title":"Assessing the properties of internal standards for quantitative matrix-assisted laser desorption\/ionization mass spectrometry of small molecules","volume":"20","author":"Sleno","year":"2006","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"2\u20133","key":"10.1016\/j.jprot.2012.07.035_bb0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijms.2006.10.007","article-title":"Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections","volume":"260","author":"Stoeckli","year":"2007","journal-title":"Int J Mass Spectrom"},{"issue":"24","key":"10.1016\/j.jprot.2012.07.035_bb0110","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1021\/ac202630t","article-title":"Qualitative and Quantitative MALDI Imaging of the Positron Emission Tomography Ligands Raclopride (a D2 Dopamine Antagonist) and SCH 23390 (a D1 Dopamine Antagonist) in Rat Brain Tissue Sections Using a Solvent-Free Dry Matrix Application Method","volume":"83","author":"Goodwin","year":"2012","journal-title":"Anal Chem"},{"issue":"7","key":"10.1016\/j.jprot.2012.07.035_bb0115","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jprot.2011.03.019","article-title":"Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging","volume":"74","author":"Marko-Varga","year":"2011","journal-title":"J Proteomics"},{"issue":"4","key":"10.1016\/j.jprot.2012.07.035_bb0120","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1600-0773.1967.tb00413.x","article-title":"Autoradiographic Distribution studies of adrenergic blocking agents. II. 14C-propranolol, a \u03b2-receptor-type blocker","volume":"25","author":"Masuoka","year":"1967","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1016\/j.jprot.2012.07.035_bb0125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/1099-081X(199911)20:8<369::AID-BDD200>3.0.CO;2-6","article-title":"Pharmacokinetics and tissue distribution of olanzapine in rats","volume":"20","author":"Aravagiri","year":"1999","journal-title":"Biopharm Drug Dispos"},{"issue":"14","key":"10.1016\/j.jprot.2012.07.035_bb0130","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1021\/ac800617s","article-title":"MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue","volume":"80","author":"Cornett","year":"2008","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.jprot.2012.07.035_bb0135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2010.11.005","article-title":"Matrix-assisted laser desorption\/ionization mass spectrometry for quantitative determination of [beta]-blocker drugs in one-drop of human serum sample","volume":"879","author":"Shrivas","year":"2011","journal-title":"J Chromatogr B"},{"issue":"3","key":"10.1016\/j.jprot.2012.07.035_bb0140","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/hrt.28.3.414","article-title":"Effect of propranolol (Inderal) on exercise tolerance in angina pectoris","volume":"28","author":"Hamer","year":"1966","journal-title":"Br Heart J"},{"issue":"14","key":"10.1016\/j.jprot.2012.07.035_bb0145","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1021\/ac100954p","article-title":"Liquid microjunction surface sampling coupled with high-pressure liquid chromatography-electrospray ionization-mass spectrometry for analysis of drugs and metabolites in whole-body thin tissue sections.","volume":"82","author":"Kertesz","year":"2010","journal-title":"Anal Chem"},{"issue":"5","key":"10.1016\/j.jprot.2012.07.035_bb0150","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0731-7085(95)01651-1","article-title":"Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detection","volume":"14","author":"Chiu","year":"1996","journal-title":"J Pharm Biomed Anal"},{"issue":"18","key":"10.1016\/j.jprot.2012.07.035_bb0155","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1021\/ac060788p","article-title":"Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry","volume":"78","author":"Khatib-Shahidi","year":"2006","journal-title":"Anal Chem"},{"issue":"12","key":"10.1016\/j.jprot.2012.07.035_bb0160","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.4155\/bio.11.88","article-title":"MALDI imaging techniques dedicated to drug-distribution studies","volume":"3","author":"Bonnel","year":"2011","journal-title":"Bioanalysis"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391912005659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391912005659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T03:24:04Z","timestamp":1555989844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391912005659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":31,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1874391912005659"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2012.07.035","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}