{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:02:55Z","timestamp":1785729775198,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"COLCIENCIAS (Programa Nacional de Formaci\u00f3n de Investigadores-Becas Colciencias","award":["567-2012"],"award-info":[{"award-number":["567-2012"]}]},{"name":"The School of Basic Sciences, Faculty of Health (Universidad del Valle)"},{"name":"Vicerrector\u00eda de Investigaci\u00f3n (Universidad de Costa Rica","award":["741-B3-760"],"award-info":[{"award-number":["741-B3-760"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jprot.2014.11.016","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T02:03:31Z","timestamp":1418004211000},"page":"287-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Proteomic and functional analyses of the venom of Porthidium lansbergii lansbergii (Lansberg's hognose viper) from the Atlantic Department of Colombia"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-1521","authenticated-orcid":false,"given":"Eli\u00e9cer","family":"Jim\u00e9nez-Charris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-717X","authenticated-orcid":false,"given":"Leonel","family":"Montealegre-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Solano-Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mora-Obando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Castro-Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Fierro-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-6469","authenticated-orcid":false,"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2014.11.016_bb0005","series-title":"The Venomous Reptiles of the Western Hemisphere","author":"Campbell","year":"2004"},{"key":"10.1016\/j.jprot.2014.11.016_bb0010","series-title":"Fundamentos de Pediatr\u00eda (Tomo V)","first-page":"73","article-title":"Envenenamiento Of\u00eddico","author":"Otero","year":"2014"},{"key":"10.1016\/j.jprot.2014.11.016_bb0015","first-page":"25","article-title":"Efecto de la toxicidad in vivo e in vitro del veneno de Porthidium lansbergii rozei","volume":"8","author":"Ramos","year":"2010","journal-title":"Comunidad y Salud"},{"key":"10.1016\/j.jprot.2014.11.016_bb0020","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.toxicon.2011.01.003","article-title":"Purification and characterization of a metalloproteinase, Porthidin-1, from the venom of Lansberg's hog-nosed pitvipers (Porthidium lansbergii hutmanni)","volume":"57","author":"Gir\u00f3n","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00277-007-0354-y","article-title":"Inhibition of adrenaline and adenosine diphosphate induced platelet aggregation by Lansberg's hognose pit viper (Porthidium lansbergii hutmanni) venom","volume":"86","author":"Lopez-Johnston","year":"2007","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jprot.2014.11.016_bb0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11239-007-0040-x","article-title":"Inhibition of collagen, and thrombin-induced platelet aggregation by Lansberg's hognose pit viper (Porthidium lansbergii hutmanni) venom","volume":"24","author":"Lopez-Johnston","year":"2007","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jprot.2014.11.016_bb0035","series-title":"Vigilancia y Control en Salud P\u00fablica","article-title":"Informe del evento accidente of\u00eddico final a\u00f1o 2012","author":"Paredes","year":"2012"},{"key":"10.1016\/j.jprot.2014.11.016_bb0040","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0041-0101(02)00104-6","article-title":"Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital","volume":"40","author":"Otero","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0045","series-title":"Manejo del Accidente Of\u00eddico","author":"Escobar","year":"2004"},{"key":"10.1016\/j.jprot.2014.11.016_bb0050","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/molbev\/msh091","article-title":"Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analyses of toxin sequences","volume":"21","author":"Fry","year":"2004","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jprot.2014.11.016_bb0055","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/pmic.200700777","article-title":"Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures","volume":"8","author":"Fox","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxicon.2013.03.020","article-title":"Snake venomics: from the inventory of toxins to biology","volume":"75","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0065","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.jprot.2011.12.016","article-title":"Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: toxicological and taxonomical insights","volume":"75","author":"Lomonte","year":"2012","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jprot.2013.11.005","article-title":"Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom","volume":"96","author":"Mora-Obando","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0075","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1586\/epr.11.61","article-title":"2011. Proteomic tools against the neglected pathology of snake bite envenoming","volume":"8","author":"Calvete","year":"2011","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jprot.2013.10.036","article-title":"Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon","volume":"96","author":"Lomonte","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0085","series-title":"Statistical Methods in Biological Assay","author":"Finney","year":"1971"},{"key":"10.1016\/j.jprot.2014.11.016_bb0090","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0041-0101(86)90089-9","article-title":"Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer","volume":"24","author":"Guti\u00e9rrez","year":"1986","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00916097","article-title":"Host response to Bothrops asper snake venom","volume":"17","author":"Lomonte","year":"1993","journal-title":"Inflammation"},{"key":"10.1016\/j.jprot.2014.11.016_bb0100","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0041-0101(96)00057-8","article-title":"An aqueous endpoint assay of snake venom phospholipase A2","volume":"34","author":"Holzer","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0105","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/0041-0101(87)90136-X","article-title":"Determination of phospholipase A2 activity by a colorimetric assay using a pH indicator","volume":"25","author":"de Ara\u00fajo","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0110","first-page":"949","article-title":"Development of simple standard assay procedures for the characterization of snake venom","volume":"61","author":"Theakston","year":"1983","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jprot.2014.11.016_bb0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biochi.2009.12.006","article-title":"Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization","volume":"92","author":"Fern\u00e1ndez","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2014.11.016_bb0120","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2004.09.031","article-title":"A novel P-I class metalloproteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom","volume":"324","author":"Wang","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jprot.2014.11.016_bb0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biochi.2014.01.008","article-title":"Understanding structural and functional aspects of PII snake venom metalloproteinases: characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis","volume":"101","author":"Camacho","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2014.11.016_bb0130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cbpb.2011.12.010","article-title":"An acidic phospholipase A2 with antibacterial activity from Porthidium nasutum snake venom","volume":"161","author":"Vargas","year":"2012","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.jprot.2014.11.016_bb0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jprot.2014.02.020","article-title":"Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of \"snake venomics\"","volume":"105","author":"Lomonte","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0140","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.febslet.2009.03.029","article-title":"Venom, venomics, antivenomics","volume":"583","author":"Calvete","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jprot.2014.11.016_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxicon.2014.07.012","article-title":"Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia","volume":"90","author":"Salazar-Valenzuela","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0150","first-page":"5","article-title":"Caracter\u00edsticas bioqu\u00edmicas y capacidad neutralizante de cuatro antivenenos polivalentes frente a los efectos farmacol\u00f3gicos y enzim\u00e1ticos del veneno de Bothrops asper y Porthidium nasutum de Antioquia y Choc\u00f3","volume":"15","author":"Otero-Pati\u00f1o","year":"2002","journal-title":"Iatreia"},{"key":"10.1016\/j.jprot.2014.11.016_bb0155","first-page":"1","article-title":"Effects of Lansberg's hognose pit vipers (Porthidium lansbergii hutmanni) venom on renal ultrastructure in experimental mice","volume":"39","author":"Vargas","year":"2011","journal-title":"Acta Sci Vet"},{"key":"10.1016\/j.jprot.2014.11.016_bb0160","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0041-0101(99)00236-6","article-title":"Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica","volume":"38","author":"Bogar\u00edn","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0165","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","article-title":"Snake venom disintegrins: evolution of structure and function","volume":"45","author":"Calvete","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0170","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0041-0101(89)90096-2","article-title":"Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom","volume":"27","author":"Gen\u00e9","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0175","doi-asserted-by":"crossref","first-page":"46304","DOI":"10.1074\/jbc.M403687200","article-title":"A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1","volume":"279","author":"Takahashi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jprot.2014.11.016_bb0180","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.toxicon.2003.11.006","article-title":"Inflammatory effects of snake venom myotoxic phospholipases A2","volume":"42","author":"Texeira","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0185","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-14-531","article-title":"The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms","volume":"14","author":"Margres","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0190","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.toxicon.2011.01.008","article-title":"A high-throughput venom-gland transcriptome for the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes","volume":"57","author":"Rokyta","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0195","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/1471-2164-14-790","article-title":"Quantitative high-throughput profiling of snake venom gland transcriptomes and proteomes (Ovophis okinavensis and Protobothrops flavoviridis)","volume":"14","author":"Aird","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2014.11.016_bb0200","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0041-0101(87)90290-X","article-title":"Isolation and characterization of a phospholipase B from venom of Collett's snake, Pseudechis colletti","volume":"25","author":"Bernheimer","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0205","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0041-0101(01)00232-X","article-title":"Ophidian envenomation strategies and the role of purines","volume":"40","author":"Aird","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0210","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.toxicon.2008.02.019","article-title":"High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry","volume":"51","author":"Menin","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2014.11.016_bb0215","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbrc.2007.11.027","article-title":"Molecular characterization of endogenous snake venom metalloproteinase inhibitors","volume":"365","author":"Wagstaff","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jprot.2014.11.016_bb0220","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/bi00815a005","article-title":"Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom","volume":"9","author":"Ferreira","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.jprot.2014.11.016_bb0225","first-page":"229","article-title":"Accidente of\u00eddico en Antioquia y Choc\u00f3. Aspectos cl\u00ednicos y epidemiol\u00f3gicos (marzo de 1989-febrero de 1990)","volume":"17","author":"Otero","year":"1992","journal-title":"Acta M\u00e9d Colomb"},{"key":"10.1016\/j.jprot.2014.11.016_bb0230","series-title":"Manual para la prevenci\u00f3n y mejoramiento en la atenci\u00f3n del paciente con accidente of\u00eddico","author":"Ayerbe","year":"2009"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391914005508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391914005508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:52:16Z","timestamp":1538009536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391914005508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":46,"alternative-id":["S1874391914005508"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2014.11.016","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and functional analyses of the venom of Porthidium lansbergii lansbergii (Lansberg's hognose viper) from the Atlantic Department of Colombia","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2014.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}